Presynaptic dopaminergic function in the striatum of schizophrenic patients
Identifieur interne : 000B21 ( Istex/Curation ); précédent : 000B20; suivant : 000B22Presynaptic dopaminergic function in the striatum of schizophrenic patients
Auteurs : Marie-Hélène Dao-Castellana [France] ; Marie-Laure Paillère-Martinot [France] ; Philippe Hantraye [France] ; Dominique Attar-Lévy [France] ; Philippe Rémy [France] ; Christian Crouzel [France] ; Eric Artiges [France] ; André Féline [France] ; André Syrota [France] ; Jean-Luc Martinot [France]Source :
- Schizophrenia Research [ 0920-9964 ] ; 1997.
English descriptors
- KwdEn :
Abstract
Abstract: The dopaminergic hypothesis of schizophrenia postulates increased brain dopaminergic activity. Two previous studies reported increased 18F-DOPA uptake with positron emission tomography in schizophrenic patients (n = 5, n = 7). In the present study, striatal dopaminergic function was assessed in vivo in six untreated schizophrenics and seven control subjects, comparable for age and sex. The 18F-fluoro-L-DOPA (18F-DOPA) uptake rate constant Ki was determined in the caudate and putamen using coregistered positron emission tomography and magnetic resonance imaging. No difference between groups for mean Ki was found. The variability of the 18F-DOPA uptake values was higher in the caudate (p<0.01) and in the putamen (p<0.001) in schizophrenic patients than in control subjects, suggesting that schizophrenia is a disorder involving heterogeneous states of the striatal presynaptic dopaminergic function.
Url:
DOI: 10.1016/S0920-9964(96)00102-8
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000B23
Links to Exploration step
ISTEX:28121A469906EDF10A6C0E7957A0D44EE9D577C3Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Presynaptic dopaminergic function in the striatum of schizophrenic patients</title>
<author><name sortKey="Dao Castellana, Marie Helene" sort="Dao Castellana, Marie Helene" uniqKey="Dao Castellana M" first="Marie-Hélène" last="Dao-Castellana">Marie-Hélène Dao-Castellana</name>
<affiliation wicri:level="1"><mods:affiliation>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>ASM13, Association Santé Mentale 13ème arrondissement, Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>ASM13, Association Santé Mentale 13ème arrondissement, Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Paillere Martinot, Marie Laure" sort="Paillere Martinot, Marie Laure" uniqKey="Paillere Martinot M" first="Marie-Laure" last="Paillère-Martinot">Marie-Laure Paillère-Martinot</name>
<affiliation wicri:level="1"><mods:affiliation>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>ASM13, Association Santé Mentale 13ème arrondissement, Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>ASM13, Association Santé Mentale 13ème arrondissement, Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hantraye, Philippe" sort="Hantraye, Philippe" uniqKey="Hantraye P" first="Philippe" last="Hantraye">Philippe Hantraye</name>
<affiliation wicri:level="1"><mods:affiliation>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Attar Levy, Dominique" sort="Attar Levy, Dominique" uniqKey="Attar Levy D" first="Dominique" last="Attar-Lévy">Dominique Attar-Lévy</name>
<affiliation wicri:level="1"><mods:affiliation>SHU Hôpital Sainte-Anne, Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>SHU Hôpital Sainte-Anne, Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Rémy">Philippe Rémy</name>
<affiliation wicri:level="1"><mods:affiliation>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Crouzel, Christian" sort="Crouzel, Christian" uniqKey="Crouzel C" first="Christian" last="Crouzel">Christian Crouzel</name>
<affiliation wicri:level="1"><mods:affiliation>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Artiges, Eric" sort="Artiges, Eric" uniqKey="Artiges E" first="Eric" last="Artiges">Eric Artiges</name>
<affiliation wicri:level="1"><mods:affiliation>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Feline, Andre" sort="Feline, Andre" uniqKey="Feline A" first="André" last="Féline">André Féline</name>
<affiliation wicri:level="1"><mods:affiliation>Hôpital Bicêtre, Le Kremlin-Bicêtre, Bicêtre, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hôpital Bicêtre, Le Kremlin-Bicêtre, Bicêtre</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Syrota, Andre" sort="Syrota, Andre" uniqKey="Syrota A" first="André" last="Syrota">André Syrota</name>
<affiliation wicri:level="1"><mods:affiliation>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Martinot, Jean Luc" sort="Martinot, Jean Luc" uniqKey="Martinot J" first="Jean-Luc" last="Martinot">Jean-Luc Martinot</name>
<affiliation wicri:level="1"><mods:affiliation>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Hôpital A. Chenevier, Créteil, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hôpital A. Chenevier, Créteil</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>Corresponding author. Service Hospitalier Frédéric Joliot, C.E.A., 4 place du Général Leclerc, 91406 Orsay, France. Fax: +33 69 867768.</mods:affiliation>
<wicri:noCountry code="subField">867768.</wicri:noCountry>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>E-mail: martinot@uriens.shfj.cea.fr</mods:affiliation>
<country wicri:rule="url">France</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:28121A469906EDF10A6C0E7957A0D44EE9D577C3</idno>
<date when="1997" year="1997">1997</date>
<idno type="doi">10.1016/S0920-9964(96)00102-8</idno>
<idno type="url">https://api.istex.fr/document/28121A469906EDF10A6C0E7957A0D44EE9D577C3/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000B23</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000B23</idno>
<idno type="wicri:Area/Istex/Curation">000B21</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Presynaptic dopaminergic function in the striatum of schizophrenic patients</title>
<author><name sortKey="Dao Castellana, Marie Helene" sort="Dao Castellana, Marie Helene" uniqKey="Dao Castellana M" first="Marie-Hélène" last="Dao-Castellana">Marie-Hélène Dao-Castellana</name>
<affiliation wicri:level="1"><mods:affiliation>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>ASM13, Association Santé Mentale 13ème arrondissement, Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>ASM13, Association Santé Mentale 13ème arrondissement, Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Paillere Martinot, Marie Laure" sort="Paillere Martinot, Marie Laure" uniqKey="Paillere Martinot M" first="Marie-Laure" last="Paillère-Martinot">Marie-Laure Paillère-Martinot</name>
<affiliation wicri:level="1"><mods:affiliation>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>ASM13, Association Santé Mentale 13ème arrondissement, Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>ASM13, Association Santé Mentale 13ème arrondissement, Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hantraye, Philippe" sort="Hantraye, Philippe" uniqKey="Hantraye P" first="Philippe" last="Hantraye">Philippe Hantraye</name>
<affiliation wicri:level="1"><mods:affiliation>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Attar Levy, Dominique" sort="Attar Levy, Dominique" uniqKey="Attar Levy D" first="Dominique" last="Attar-Lévy">Dominique Attar-Lévy</name>
<affiliation wicri:level="1"><mods:affiliation>SHU Hôpital Sainte-Anne, Paris, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>SHU Hôpital Sainte-Anne, Paris</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Remy, Philippe" sort="Remy, Philippe" uniqKey="Remy P" first="Philippe" last="Rémy">Philippe Rémy</name>
<affiliation wicri:level="1"><mods:affiliation>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Crouzel, Christian" sort="Crouzel, Christian" uniqKey="Crouzel C" first="Christian" last="Crouzel">Christian Crouzel</name>
<affiliation wicri:level="1"><mods:affiliation>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Artiges, Eric" sort="Artiges, Eric" uniqKey="Artiges E" first="Eric" last="Artiges">Eric Artiges</name>
<affiliation wicri:level="1"><mods:affiliation>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Feline, Andre" sort="Feline, Andre" uniqKey="Feline A" first="André" last="Féline">André Féline</name>
<affiliation wicri:level="1"><mods:affiliation>Hôpital Bicêtre, Le Kremlin-Bicêtre, Bicêtre, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hôpital Bicêtre, Le Kremlin-Bicêtre, Bicêtre</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Syrota, Andre" sort="Syrota, Andre" uniqKey="Syrota A" first="André" last="Syrota">André Syrota</name>
<affiliation wicri:level="1"><mods:affiliation>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Martinot, Jean Luc" sort="Martinot, Jean Luc" uniqKey="Martinot J" first="Jean-Luc" last="Martinot">Jean-Luc Martinot</name>
<affiliation wicri:level="1"><mods:affiliation>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>Hôpital A. Chenevier, Créteil, France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Hôpital A. Chenevier, Créteil</wicri:regionArea>
</affiliation>
<affiliation><mods:affiliation>Corresponding author. Service Hospitalier Frédéric Joliot, C.E.A., 4 place du Général Leclerc, 91406 Orsay, France. Fax: +33 69 867768.</mods:affiliation>
</affiliation>
<affiliation wicri:level="1"><mods:affiliation>E-mail: martinot@uriens.shfj.cea.fr</mods:affiliation>
<country wicri:rule="url">France</country>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Schizophrenia Research</title>
<title level="j" type="abbrev">SCHRES</title>
<idno type="ISSN">0920-9964</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1997">1997</date>
<biblScope unit="volume">23</biblScope>
<biblScope unit="issue">2</biblScope>
<biblScope unit="page" from="167">167</biblScope>
<biblScope unit="page" to="174">174</biblScope>
</imprint>
<idno type="ISSN">0920-9964</idno>
</series>
<idno type="istex">28121A469906EDF10A6C0E7957A0D44EE9D577C3</idno>
<idno type="DOI">10.1016/S0920-9964(96)00102-8</idno>
<idno type="PII">S0920-9964(96)00102-8</idno>
<idno type="ArticleID">96001028</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0920-9964</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>18F-DOPA</term>
<term>Dopamine</term>
<term>PET</term>
<term>Schizophrenia</term>
</keywords>
</textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Abstract: The dopaminergic hypothesis of schizophrenia postulates increased brain dopaminergic activity. Two previous studies reported increased 18F-DOPA uptake with positron emission tomography in schizophrenic patients (n = 5, n = 7). In the present study, striatal dopaminergic function was assessed in vivo in six untreated schizophrenics and seven control subjects, comparable for age and sex. The 18F-fluoro-L-DOPA (18F-DOPA) uptake rate constant Ki was determined in the caudate and putamen using coregistered positron emission tomography and magnetic resonance imaging. No difference between groups for mean Ki was found. The variability of the 18F-DOPA uptake values was higher in the caudate (p<0.01) and in the putamen (p<0.001) in schizophrenic patients than in control subjects, suggesting that schizophrenia is a disorder involving heterogeneous states of the striatal presynaptic dopaminergic function.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B21 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 000B21 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Istex |étape= Curation |type= RBID |clé= ISTEX:28121A469906EDF10A6C0E7957A0D44EE9D577C3 |texte= Presynaptic dopaminergic function in the striatum of schizophrenic patients }}
![]() | This area was generated with Dilib version V0.6.29. | ![]() |