Presynaptic dopaminergic function in the striatum of schizophrenic patients
Identifieur interne : 000B21 ( Istex/Curation ); précédent : 000B20; suivant : 000B22Presynaptic dopaminergic function in the striatum of schizophrenic patients
Auteurs : Marie-Hélène Dao-Castellana [France] ; Marie-Laure Paillère-Martinot [France] ; Philippe Hantraye [France] ; Dominique Attar-Lévy [France] ; Philippe Rémy [France] ; Christian Crouzel [France] ; Eric Artiges [France] ; André Féline [France] ; André Syrota [France] ; Jean-Luc Martinot [France]Source :
- Schizophrenia Research [ 0920-9964 ] ; 1997.
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Abstract
Abstract: The dopaminergic hypothesis of schizophrenia postulates increased brain dopaminergic activity. Two previous studies reported increased 18F-DOPA uptake with positron emission tomography in schizophrenic patients (n = 5, n = 7). In the present study, striatal dopaminergic function was assessed in vivo in six untreated schizophrenics and seven control subjects, comparable for age and sex. The 18F-fluoro-L-DOPA (18F-DOPA) uptake rate constant Ki was determined in the caudate and putamen using coregistered positron emission tomography and magnetic resonance imaging. No difference between groups for mean Ki was found. The variability of the 18F-DOPA uptake values was higher in the caudate (p<0.01) and in the putamen (p<0.001) in schizophrenic patients than in control subjects, suggesting that schizophrenia is a disorder involving heterogeneous states of the striatal presynaptic dopaminergic function.
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DOI: 10.1016/S0920-9964(96)00102-8
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wicri:level="1"><mods:affiliation>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service Hospitalier Frédéric Joliot, CEA, INSERM U 334 and CNRS URA1285, Orsay</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Hôpital A. Chenevier, Créteil, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Hôpital A. Chenevier, Créteil</wicri:regionArea></affiliation><affiliation><mods:affiliation>Corresponding author. Service Hospitalier Frédéric Joliot, C.E.A., 4 place du Général Leclerc, 91406 Orsay, France. Fax: +33 69 867768.</mods:affiliation></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: martinot@uriens.shfj.cea.fr</mods:affiliation><country wicri:rule="url">France</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Schizophrenia Research</title><title level="j" type="abbrev">SCHRES</title><idno type="ISSN">0920-9964</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997">1997</date><biblScope unit="volume">23</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="167">167</biblScope><biblScope unit="page" to="174">174</biblScope></imprint><idno type="ISSN">0920-9964</idno></series><idno type="istex">28121A469906EDF10A6C0E7957A0D44EE9D577C3</idno><idno type="DOI">10.1016/S0920-9964(96)00102-8</idno><idno type="PII">S0920-9964(96)00102-8</idno><idno type="ArticleID">96001028</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0920-9964</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>18F-DOPA</term><term>Dopamine</term><term>PET</term><term>Schizophrenia</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The dopaminergic hypothesis of schizophrenia postulates increased brain dopaminergic activity. Two previous studies reported increased 18F-DOPA uptake with positron emission tomography in schizophrenic patients (n = 5, n = 7). In the present study, striatal dopaminergic function was assessed in vivo in six untreated schizophrenics and seven control subjects, comparable for age and sex. The 18F-fluoro-L-DOPA (18F-DOPA) uptake rate constant Ki was determined in the caudate and putamen using coregistered positron emission tomography and magnetic resonance imaging. No difference between groups for mean Ki was found. The variability of the 18F-DOPA uptake values was higher in the caudate (p<0.01) and in the putamen (p<0.001) in schizophrenic patients than in control subjects, suggesting that schizophrenia is a disorder involving heterogeneous states of the striatal presynaptic dopaminergic function.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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