ParkinsonFranceV1, Main, Exploration, bibRecord, 003E82

The relation of putamen and caudate nucleus 18F-Dopa uptake to motor and cognitive performances in Parkinson's disease

Identifieur interne : 003E82 ( Main/Exploration ); précédent : 003E81; suivant : 003E83

The relation of putamen and caudate nucleus 18F-Dopa uptake to motor and cognitive performances in Parkinson's disease

Auteurs : E. Broussolle [France] ; C. Dentresangle [France] ; P. Landais [France] ; L. Garcia-Larrea [France] ; P. Pollak [France] ; B. Croisile [France] ; O. Hibert [France] ; F. Bonnefoi [France] ; G. Galy [France] ; J. C. Froment [France] ; D. Comar [France]

Source :

Journal of the neurological sciences [ 0022-510X ] ; 1999.

RBID : Pascal:99-0417801

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Tomoscintigraphie, Positon, Noyau caudé, Putamen, Potentiel évoqué cognitif, Exploration, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Adult, Affect (physiology), Aged, Analysis of Variance, Case-Control Studies, Caudate Nucleus (diagnostic imaging), Caudate Nucleus (metabolism), Caudate Nucleus (physiopathology), Caudate nucleus, Cognition (physiology), Dopamine Agents (pharmacology), Emission tomography, Event evoked potential, Event-Related Potentials, P300, Exploration, Female, Human, Humans, Levodopa (pharmacokinetics), Male, Middle Aged, Motor Skills Disorders (physiopathology), Parkinson Disease (diagnostic imaging), Parkinson Disease (metabolism), Parkinson Disease (physiopathology), Parkinson disease, Positron, Putamen, Putamen (diagnostic imaging), Putamen (metabolism), Putamen (physiopathology), Tomography, Emission-Computed.
MESH :
- chemical , pharmacokinetics : Levodopa.
- chemical , pharmacology : Dopamine Agents.
- diagnostic imaging : Caudate Nucleus, Parkinson Disease, Putamen.
- metabolism : Caudate Nucleus, Parkinson Disease, Putamen.
- physiology : Affect, Cognition.
- physiopathology : Caudate Nucleus, Motor Skills Disorders, Parkinson Disease, Putamen.
- Adult, Aged, Analysis of Variance, Case-Control Studies, Event-Related Potentials, P300, Female, Humans, Male, Middle Aged, Tomography, Emission-Computed.

Abstract

The contribution of striatal (caudate nucleus-putamen) dopaminergic deficiency to the severity of motor signs is well established in Parkinson's disease (PD), while its role in the occurrence of cognitive and mood changes remains unresolved. We therefore measured in 27 non-demented PD patients and 10 age-matched controls striatal uptake of [¹⁸F]-6-fluoro-L-Dopa (F-Dopa) with PET, and mood (Beck depression), memory (Grober-Buschke), frontal executive functions (verbal fluency and Wisconsin card sorting), and attentional processing of sensory stimuli (N2-P3 auditory event-related potentials - ERPs). Locomotor disability of patients was assessed by Hoehn and Yahr score and Unified Parkinson's Disease Rating Scale (UPDRS). ANOVA showed that memory, but neither frontal lobe functions nor ERPs, was significantly altered in PD patients, whereas indices of depression were found only in advanced PD. The F-Dopa rate constant K_i was significantly reduced in the striatum, more in putamen than caudate nucleus, and inversely correlated with disease duration. A significant inverse correlation was found between both putamen and caudate nucleus K_i and Hoehn and Yahr score, and between putamen - but not caudate nucleus K_i - and UPDRS motor score. Principal components analysis (PCA) of PD patients K_i values and mood, cognitive and ERP parameters gave a three-factor solution. Variables contributing to factor 1 were memory score and N2-P3 ERP latencies, those to factor 2 were striatal K_i values, and those to factor 3 frontal executive performances. Depression did not segregate with any variable. Our findings suggest that unlike locomotor disability, cognitive abilities and mood state of non-demented PD patients are for the most part unrelated to striatal dopaminergic depletion and may result from dysfunction of extra-striatal dopaminergic or from non-dopaminergic systems.

Affiliations:

Le document en format XML

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F-Dopa uptake to motor and cognitive performances in Parkinson's disease</title>
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F-Dopa uptake to motor and cognitive performances in Parkinson's disease</title>
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</affiliation>
</author>
<author><name sortKey="Hibert, O" sort="Hibert, O" uniqKey="Hibert O" first="O." last="Hibert">O. Hibert</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Laboratory of Neuropsychology, Cognitive Functions, Language and Memory, Hôpital Neurologique Pierre Wertheimer</s1>
<s2>Lyon</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bonnefoi, F" sort="Bonnefoi, F" uniqKey="Bonnefoi F" first="F." last="Bonnefoi">F. Bonnefoi</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CERMEP Cyclotron Unit, Hôpital Neurologique Pierre Wertheimer</s1>
<s2>Lyon</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Galy, G" sort="Galy, G" uniqKey="Galy G" first="G." last="Galy">G. Galy</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CERMEP Cyclotron Unit, Hôpital Neurologique Pierre Wertheimer</s1>
<s2>Lyon</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Froment, J C" sort="Froment, J C" uniqKey="Froment J" first="J. C." last="Froment">J. C. Froment</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Neuroradiology, Hôpital Neurologique Pierre Wertheimer</s1>
<s2>Lyon</s2>
<s3>FRA</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Comar, D" sort="Comar, D" uniqKey="Comar D" first="D." last="Comar">D. Comar</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CERMEP Cyclotron Unit, Hôpital Neurologique Pierre Wertheimer</s1>
<s2>Lyon</s2>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of the neurological sciences</title>
<title level="j" type="abbreviated">J. neurol. sci.</title>
<idno type="ISSN">0022-510X</idno>
<imprint><date when="1999">1999</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of the neurological sciences</title>
<title level="j" type="abbreviated">J. neurol. sci.</title>
<idno type="ISSN">0022-510X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Affect (physiology)</term>
<term>Aged</term>
<term>Analysis of Variance</term>
<term>Case-Control Studies</term>
<term>Caudate Nucleus (diagnostic imaging)</term>
<term>Caudate Nucleus (metabolism)</term>
<term>Caudate Nucleus (physiopathology)</term>
<term>Caudate nucleus</term>
<term>Cognition (physiology)</term>
<term>Dopamine Agents (pharmacology)</term>
<term>Emission tomography</term>
<term>Event evoked potential</term>
<term>Event-Related Potentials, P300</term>
<term>Exploration</term>
<term>Female</term>
<term>Human</term>
<term>Humans</term>
<term>Levodopa (pharmacokinetics)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Motor Skills Disorders (physiopathology)</term>
<term>Parkinson Disease (diagnostic imaging)</term>
<term>Parkinson Disease (metabolism)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson disease</term>
<term>Positron</term>
<term>Putamen</term>
<term>Putamen (diagnostic imaging)</term>
<term>Putamen (metabolism)</term>
<term>Putamen (physiopathology)</term>
<term>Tomography, Emission-Computed</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Levodopa</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Dopamine Agents</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Caudate Nucleus</term>
<term>Parkinson Disease</term>
<term>Putamen</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Caudate Nucleus</term>
<term>Parkinson Disease</term>
<term>Putamen</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Affect</term>
<term>Cognition</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Caudate Nucleus</term>
<term>Motor Skills Disorders</term>
<term>Parkinson Disease</term>
<term>Putamen</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Analysis of Variance</term>
<term>Case-Control Studies</term>
<term>Event-Related Potentials, P300</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Tomography, Emission-Computed</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Tomoscintigraphie</term>
<term>Positon</term>
<term>Noyau caudé</term>
<term>Putamen</term>
<term>Potentiel évoqué cognitif</term>
<term>Exploration</term>
<term>Homme</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The contribution of striatal (caudate nucleus-putamen) dopaminergic deficiency to the severity of motor signs is well established in Parkinson's disease (PD), while its role in the occurrence of cognitive and mood changes remains unresolved. We therefore measured in 27 non-demented PD patients and 10 age-matched controls striatal uptake of [<sup>18</sup>
F]-6-fluoro-L-Dopa (F-Dopa) with PET, and mood (Beck depression), memory (Grober-Buschke), frontal executive functions (verbal fluency and Wisconsin card sorting), and attentional processing of sensory stimuli (N2-P3 auditory event-related potentials - ERPs). Locomotor disability of patients was assessed by Hoehn and Yahr score and Unified Parkinson's Disease Rating Scale (UPDRS). ANOVA showed that memory, but neither frontal lobe functions nor ERPs, was significantly altered in PD patients, whereas indices of depression were found only in advanced PD. The F-Dopa rate constant K<sub>i</sub>
 was significantly reduced in the striatum, more in putamen than caudate nucleus, and inversely correlated with disease duration. A significant inverse correlation was found between both putamen and caudate nucleus K<sub>i</sub>
 and Hoehn and Yahr score, and between putamen - but not caudate nucleus K<sub>i</sub>
 - and UPDRS motor score. Principal components analysis (PCA) of PD patients K<sub>i</sub>
 values and mood, cognitive and ERP parameters gave a three-factor solution. Variables contributing to factor 1 were memory score and N2-P3 ERP latencies, those to factor 2 were striatal K<sub>i</sub>
 values, and those to factor 3 frontal executive performances. Depression did not segregate with any variable. Our findings suggest that unlike locomotor disability, cognitive abilities and mood state of non-demented PD patients are for the most part unrelated to striatal dopaminergic depletion and may result from dysfunction of extra-striatal dopaminergic or from non-dopaminergic systems.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Auvergne-Rhône-Alpes</li>
<li>Rhône-Alpes</li>
</region>
<settlement><li>Grenoble</li>
<li>Lyon</li>
</settlement>
<orgName><li>Université Joseph Fourier</li>
</orgName>
</list>
<tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Broussolle, E" sort="Broussolle, E" uniqKey="Broussolle E" first="E." last="Broussolle">E. Broussolle</name>
</region>
<name sortKey="Bonnefoi, F" sort="Bonnefoi, F" uniqKey="Bonnefoi F" first="F." last="Bonnefoi">F. Bonnefoi</name>
<name sortKey="Broussolle, E" sort="Broussolle, E" uniqKey="Broussolle E" first="E." last="Broussolle">E. Broussolle</name>
<name sortKey="Broussolle, E" sort="Broussolle, E" uniqKey="Broussolle E" first="E." last="Broussolle">E. Broussolle</name>
<name sortKey="Comar, D" sort="Comar, D" uniqKey="Comar D" first="D." last="Comar">D. Comar</name>
<name sortKey="Croisile, B" sort="Croisile, B" uniqKey="Croisile B" first="B." last="Croisile">B. Croisile</name>
<name sortKey="Dentresangle, C" sort="Dentresangle, C" uniqKey="Dentresangle C" first="C." last="Dentresangle">C. Dentresangle</name>
<name sortKey="Dentresangle, C" sort="Dentresangle, C" uniqKey="Dentresangle C" first="C." last="Dentresangle">C. Dentresangle</name>
<name sortKey="Froment, J C" sort="Froment, J C" uniqKey="Froment J" first="J. C." last="Froment">J. C. Froment</name>
<name sortKey="Galy, G" sort="Galy, G" uniqKey="Galy G" first="G." last="Galy">G. Galy</name>
<name sortKey="Garcia Larrea, L" sort="Garcia Larrea, L" uniqKey="Garcia Larrea L" first="L." last="Garcia-Larrea">L. Garcia-Larrea</name>
<name sortKey="Garcia Larrea, L" sort="Garcia Larrea, L" uniqKey="Garcia Larrea L" first="L." last="Garcia-Larrea">L. Garcia-Larrea</name>
<name sortKey="Hibert, O" sort="Hibert, O" uniqKey="Hibert O" first="O." last="Hibert">O. Hibert</name>
<name sortKey="Landais, P" sort="Landais, P" uniqKey="Landais P" first="P." last="Landais">P. Landais</name>
<name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P." last="Pollak">P. Pollak</name>
</country>
</tree>
</affiliations>
</record>

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La maladie de Parkinson en France (serveur d'exploration)

The relation of putamen and caudate nucleus 18F-Dopa uptake to motor and cognitive performances in Parkinson's disease

The relation of putamen and caudate nucleus 18F-Dopa uptake to motor and cognitive performances in Parkinson's disease

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	La maladie de Parkinson en France (serveur d'exploration)
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