The relation of putamen and caudate nucleus 18F-Dopa uptake to motor and cognitive performances in Parkinson's disease
Identifieur interne : 001296 ( PascalFrancis/Checkpoint ); précédent : 001295; suivant : 001297The relation of putamen and caudate nucleus 18F-Dopa uptake to motor and cognitive performances in Parkinson's disease
Auteurs : E. Broussolle [France] ; C. Dentresangle [France] ; P. Landais [France] ; L. Garcia-Larrea [France] ; P. Pollak [France] ; B. Croisile [France] ; O. Hibert [France] ; F. Bonnefoi [France] ; G. Galy [France] ; J. C. Froment [France] ; D. Comar [France]Source :
- Journal of the neurological sciences [ 0022-510X ] ; 1999.
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Abstract
The contribution of striatal (caudate nucleus-putamen) dopaminergic deficiency to the severity of motor signs is well established in Parkinson's disease (PD), while its role in the occurrence of cognitive and mood changes remains unresolved. We therefore measured in 27 non-demented PD patients and 10 age-matched controls striatal uptake of [18F]-6-fluoro-L-Dopa (F-Dopa) with PET, and mood (Beck depression), memory (Grober-Buschke), frontal executive functions (verbal fluency and Wisconsin card sorting), and attentional processing of sensory stimuli (N2-P3 auditory event-related potentials - ERPs). Locomotor disability of patients was assessed by Hoehn and Yahr score and Unified Parkinson's Disease Rating Scale (UPDRS). ANOVA showed that memory, but neither frontal lobe functions nor ERPs, was significantly altered in PD patients, whereas indices of depression were found only in advanced PD. The F-Dopa rate constant Ki was significantly reduced in the striatum, more in putamen than caudate nucleus, and inversely correlated with disease duration. A significant inverse correlation was found between both putamen and caudate nucleus Ki and Hoehn and Yahr score, and between putamen - but not caudate nucleus Ki - and UPDRS motor score. Principal components analysis (PCA) of PD patients Ki values and mood, cognitive and ERP parameters gave a three-factor solution. Variables contributing to factor 1 were memory score and N2-P3 ERP latencies, those to factor 2 were striatal Ki values, and those to factor 3 frontal executive performances. Depression did not segregate with any variable. Our findings suggest that unlike locomotor disability, cognitive abilities and mood state of non-demented PD patients are for the most part unrelated to striatal dopaminergic depletion and may result from dysfunction of extra-striatal dopaminergic or from non-dopaminergic systems.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">The relation of putamen and caudate nucleus <sup>18</sup>F-Dopa uptake to motor and cognitive performances in Parkinson's disease</title><author><name sortKey="Broussolle, E" sort="Broussolle, E" uniqKey="Broussolle E" first="E." last="Broussolle">E. Broussolle</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Hôpital Neurologique Pierre Wertheimer, 59 boulevard Pinel</s1><s2>69003, Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CERMEP Cyclotron Unit, Hôpital Neurologique Pierre Wertheimer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>UPRES EA 1880, Functional Neurology, Université Claude Bernard Lyon I</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Dentresangle, C" sort="Dentresangle, C" uniqKey="Dentresangle C" first="C." last="Dentresangle">C. Dentresangle</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CERMEP Cyclotron Unit, Hôpital Neurologique Pierre Wertheimer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>CNRS UMR 55-42, Laennec Faculty of Medicine, Université Claude Bernard Lyon I</s1><s2>Lyon</s2><s3>FRA</s3><sZ>2 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Landais, P" sort="Landais, P" uniqKey="Landais P" first="P." last="Landais">P. Landais</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CERMEP Cyclotron Unit, Hôpital Neurologique Pierre Wertheimer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Garcia Larrea, L" sort="Garcia Larrea, L" uniqKey="Garcia Larrea L" first="L." last="Garcia-Larrea">L. Garcia-Larrea</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CERMEP Cyclotron Unit, Hôpital Neurologique Pierre Wertheimer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>UPRES EA 1880, Functional Neurology, Université Claude Bernard Lyon I</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P." last="Pollak">P. Pollak</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Clinical and Biological Neurosciences, Université Joseph Fourier</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author><author><name sortKey="Croisile, B" sort="Croisile, B" uniqKey="Croisile B" first="B." last="Croisile">B. Croisile</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Laboratory of Neuropsychology, Cognitive Functions, Language and Memory, Hôpital Neurologique Pierre Wertheimer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Hibert, O" sort="Hibert, O" uniqKey="Hibert O" first="O." last="Hibert">O. Hibert</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Laboratory of Neuropsychology, Cognitive Functions, Language and Memory, Hôpital Neurologique Pierre Wertheimer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Bonnefoi, F" sort="Bonnefoi, F" uniqKey="Bonnefoi F" first="F." last="Bonnefoi">F. Bonnefoi</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CERMEP Cyclotron Unit, Hôpital Neurologique Pierre Wertheimer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Galy, G" sort="Galy, G" uniqKey="Galy G" first="G." last="Galy">G. Galy</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CERMEP Cyclotron Unit, Hôpital Neurologique Pierre Wertheimer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Froment, J C" sort="Froment, J C" uniqKey="Froment J" first="J. C." last="Froment">J. C. Froment</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Neuroradiology, Hôpital Neurologique Pierre Wertheimer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Comar, D" sort="Comar, D" uniqKey="Comar D" first="D." last="Comar">D. Comar</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CERMEP Cyclotron Unit, Hôpital Neurologique Pierre Wertheimer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">99-0417801</idno><date when="1999">1999</date><idno type="stanalyst">PASCAL 99-0417801 INIST</idno><idno type="RBID">Pascal:99-0417801</idno><idno type="wicri:Area/PascalFrancis/Corpus">001476</idno><idno type="wicri:Area/PascalFrancis/Curation">001B69</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001296</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001296</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The relation of putamen and caudate nucleus <sup>18</sup>F-Dopa uptake to motor and cognitive performances in Parkinson's disease</title><author><name sortKey="Broussolle, E" sort="Broussolle, E" uniqKey="Broussolle E" first="E." last="Broussolle">E. Broussolle</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Neurology, Hôpital Neurologique Pierre Wertheimer, 59 boulevard Pinel</s1><s2>69003, Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CERMEP Cyclotron Unit, Hôpital Neurologique Pierre Wertheimer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>UPRES EA 1880, Functional Neurology, Université Claude Bernard Lyon I</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Dentresangle, C" sort="Dentresangle, C" uniqKey="Dentresangle C" first="C." last="Dentresangle">C. Dentresangle</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CERMEP Cyclotron Unit, Hôpital Neurologique Pierre Wertheimer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>CNRS UMR 55-42, Laennec Faculty of Medicine, Université Claude Bernard Lyon I</s1><s2>Lyon</s2><s3>FRA</s3><sZ>2 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Landais, P" sort="Landais, P" uniqKey="Landais P" first="P." last="Landais">P. Landais</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CERMEP Cyclotron Unit, Hôpital Neurologique Pierre Wertheimer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Garcia Larrea, L" sort="Garcia Larrea, L" uniqKey="Garcia Larrea L" first="L." last="Garcia-Larrea">L. Garcia-Larrea</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CERMEP Cyclotron Unit, Hôpital Neurologique Pierre Wertheimer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>UPRES EA 1880, Functional Neurology, Université Claude Bernard Lyon I</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P." last="Pollak">P. Pollak</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Clinical and Biological Neurosciences, Université Joseph Fourier</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author><author><name sortKey="Croisile, B" sort="Croisile, B" uniqKey="Croisile B" first="B." last="Croisile">B. Croisile</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Laboratory of Neuropsychology, Cognitive Functions, Language and Memory, Hôpital Neurologique Pierre Wertheimer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Hibert, O" sort="Hibert, O" uniqKey="Hibert O" first="O." last="Hibert">O. Hibert</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Laboratory of Neuropsychology, Cognitive Functions, Language and Memory, Hôpital Neurologique Pierre Wertheimer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Bonnefoi, F" sort="Bonnefoi, F" uniqKey="Bonnefoi F" first="F." last="Bonnefoi">F. Bonnefoi</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CERMEP Cyclotron Unit, Hôpital Neurologique Pierre Wertheimer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Galy, G" sort="Galy, G" uniqKey="Galy G" first="G." last="Galy">G. Galy</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CERMEP Cyclotron Unit, Hôpital Neurologique Pierre Wertheimer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Froment, J C" sort="Froment, J C" uniqKey="Froment J" first="J. C." last="Froment">J. C. Froment</name><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Department of Neuroradiology, Hôpital Neurologique Pierre Wertheimer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Comar, D" sort="Comar, D" uniqKey="Comar D" first="D." last="Comar">D. Comar</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>CERMEP Cyclotron Unit, Hôpital Neurologique Pierre Wertheimer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Journal of the neurological sciences</title><title level="j" type="abbreviated">J. neurol. sci.</title><idno type="ISSN">0022-510X</idno><imprint><date when="1999">1999</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of the neurological sciences</title><title level="j" type="abbreviated">J. neurol. sci.</title><idno type="ISSN">0022-510X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Caudate nucleus</term><term>Emission tomography</term><term>Event evoked potential</term><term>Exploration</term><term>Human</term><term>Parkinson disease</term><term>Positron</term><term>Putamen</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Tomoscintigraphie</term><term>Positon</term><term>Noyau caudé</term><term>Putamen</term><term>Potentiel évoqué cognitif</term><term>Exploration</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The contribution of striatal (caudate nucleus-putamen) dopaminergic deficiency to the severity of motor signs is well established in Parkinson's disease (PD), while its role in the occurrence of cognitive and mood changes remains unresolved. We therefore measured in 27 non-demented PD patients and 10 age-matched controls striatal uptake of [<sup>18</sup>F]-6-fluoro-L-Dopa (F-Dopa) with PET, and mood (Beck depression), memory (Grober-Buschke), frontal executive functions (verbal fluency and Wisconsin card sorting), and attentional processing of sensory stimuli (N2-P3 auditory event-related potentials - ERPs). Locomotor disability of patients was assessed by Hoehn and Yahr score and Unified Parkinson's Disease Rating Scale (UPDRS). ANOVA showed that memory, but neither frontal lobe functions nor ERPs, was significantly altered in PD patients, whereas indices of depression were found only in advanced PD. The F-Dopa rate constant K<sub>i</sub> was significantly reduced in the striatum, more in putamen than caudate nucleus, and inversely correlated with disease duration. A significant inverse correlation was found between both putamen and caudate nucleus K<sub>i</sub> and Hoehn and Yahr score, and between putamen - but not caudate nucleus K<sub>i</sub> - and UPDRS motor score. Principal components analysis (PCA) of PD patients K<sub>i</sub> values and mood, cognitive and ERP parameters gave a three-factor solution. Variables contributing to factor 1 were memory score and N2-P3 ERP latencies, those to factor 2 were striatal K<sub>i</sub> values, and those to factor 3 frontal executive performances. Depression did not segregate with any variable. Our findings suggest that unlike locomotor disability, cognitive abilities and mood state of non-demented PD patients are for the most part unrelated to striatal dopaminergic depletion and may result from dysfunction of extra-striatal dopaminergic or from non-dopaminergic systems.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-510X</s0></fA01><fA02 i1="01"><s0>JNSCAG</s0></fA02><fA03 i2="1"><s0>J. neurol. sci.</s0></fA03><fA05><s2>166</s2></fA05><fA06><s2>2</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>The relation of putamen and caudate nucleus <sup>18</sup>F-Dopa uptake to motor and cognitive performances in Parkinson's disease</s1></fA08><fA11 i1="01" i2="1"><s1>BROUSSOLLE (E.)</s1></fA11><fA11 i1="02" i2="1"><s1>DENTRESANGLE (C.)</s1></fA11><fA11 i1="03" i2="1"><s1>LANDAIS (P.)</s1></fA11><fA11 i1="04" i2="1"><s1>GARCIA-LARREA (L.)</s1></fA11><fA11 i1="05" i2="1"><s1>POLLAK (P.)</s1></fA11><fA11 i1="06" i2="1"><s1>CROISILE (B.)</s1></fA11><fA11 i1="07" i2="1"><s1>HIBERT (O.)</s1></fA11><fA11 i1="08" i2="1"><s1>BONNEFOI (F.)</s1></fA11><fA11 i1="09" i2="1"><s1>GALY (G.)</s1></fA11><fA11 i1="10" i2="1"><s1>FROMENT (J. C.)</s1></fA11><fA11 i1="11" i2="1"><s1>COMAR (D.)</s1></fA11><fA14 i1="01"><s1>Department of Neurology, Hôpital Neurologique Pierre Wertheimer, 59 boulevard Pinel</s1><s2>69003, Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ></fA14><fA14 i1="02"><s1>CERMEP Cyclotron Unit, Hôpital Neurologique Pierre Wertheimer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>11 aut.</sZ></fA14><fA14 i1="03"><s1>UPRES EA 1880, Functional Neurology, Université Claude Bernard Lyon I</s1><s2>Lyon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></fA14><fA14 i1="04"><s1>CNRS UMR 55-42, Laennec Faculty of Medicine, Université Claude Bernard Lyon I</s1><s2>Lyon</s2><s3>FRA</s3><sZ>2 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Clinical and Biological Neurosciences, Université Joseph Fourier</s1><s2>Grenoble</s2><s3>FRA</s3><sZ>5 aut.</sZ></fA14><fA14 i1="06"><s1>Laboratory of Neuropsychology, Cognitive Functions, Language and Memory, Hôpital Neurologique Pierre Wertheimer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="07"><s1>Department of Neuroradiology, Hôpital Neurologique Pierre Wertheimer</s1><s2>Lyon</s2><s3>FRA</s3><sZ>10 aut.</sZ></fA14><fA20><s1>141-151</s1></fA20><fA21><s1>1999</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>12185</s2><s5>354000089516760110</s5></fA43><fA44><s0>0000</s0><s1>© 1999 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>67 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>99-0417801</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Journal of the neurological sciences</s0></fA64><fA66 i1="01"><s0>IRL</s0></fA66><fC01 i1="01" l="ENG"><s0>The contribution of striatal (caudate nucleus-putamen) dopaminergic deficiency to the severity of motor signs is well established in Parkinson's disease (PD), while its role in the occurrence of cognitive and mood changes remains unresolved. We therefore measured in 27 non-demented PD patients and 10 age-matched controls striatal uptake of [<sup>18</sup>F]-6-fluoro-L-Dopa (F-Dopa) with PET, and mood (Beck depression), memory (Grober-Buschke), frontal executive functions (verbal fluency and Wisconsin card sorting), and attentional processing of sensory stimuli (N2-P3 auditory event-related potentials - ERPs). Locomotor disability of patients was assessed by Hoehn and Yahr score and Unified Parkinson's Disease Rating Scale (UPDRS). ANOVA showed that memory, but neither frontal lobe functions nor ERPs, was significantly altered in PD patients, whereas indices of depression were found only in advanced PD. The F-Dopa rate constant K<sub>i</sub> was significantly reduced in the striatum, more in putamen than caudate nucleus, and inversely correlated with disease duration. A significant inverse correlation was found between both putamen and caudate nucleus K<sub>i</sub> and Hoehn and Yahr score, and between putamen - but not caudate nucleus K<sub>i</sub> - and UPDRS motor score. Principal components analysis (PCA) of PD patients K<sub>i</sub> values and mood, cognitive and ERP parameters gave a three-factor solution. Variables contributing to factor 1 were memory score and N2-P3 ERP latencies, those to factor 2 were striatal K<sub>i</sub> values, and those to factor 3 frontal executive performances. Depression did not segregate with any variable. Our findings suggest that unlike locomotor disability, cognitive abilities and mood state of non-demented PD patients are for the most part unrelated to striatal dopaminergic depletion and may result from dysfunction of extra-striatal dopaminergic or from non-dopaminergic systems.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Parkinson maladie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Tomoscintigraphie</s0><s5>04</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Emission tomography</s0><s5>04</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Tomocentelleografía</s0><s5>04</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Positon</s0><s5>05</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Positron</s0><s5>05</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Positrón</s0><s5>05</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Noyau caudé</s0><s5>07</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Caudate nucleus</s0><s5>07</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Núcleo caudado</s0><s5>07</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Putamen</s0><s5>08</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Putamen</s0><s5>08</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Putamen</s0><s5>08</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Potentiel évoqué cognitif</s0><s5>10</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Event evoked potential</s0><s5>10</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Potencial evocado cognitivo</s0><s5>10</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Exploration</s0><s5>17</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Exploration</s0><s5>17</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Exploración</s0><s5>17</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Homme</s0><s5>20</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Human</s0><s5>20</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Hombre</s0><s5>20</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Encéphale pathologie</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>41</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Exploration radioisotopique</s0><s5>45</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Radionuclide study</s0><s5>45</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Exploración radioisotópica</s0><s5>45</s5></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Encéphale</s0><s5>53</s5></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Brain (vertebrata)</s0><s5>53</s5></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Encéfalo</s0><s5>53</s5></fC07><fC07 i1="08" i2="X" l="FRE"><s0>Electrodiagnostic</s0><s5>61</s5></fC07><fC07 i1="08" i2="X" l="ENG"><s0>Electrodiagnosis</s0><s5>61</s5></fC07><fC07 i1="08" i2="X" l="SPA"><s0>Electrodiagnóstico</s0><s5>61</s5></fC07><fN21><s1>270</s1></fN21></pA></standard></inist><affiliations><list><country><li>France</li></country><region><li>Auvergne-Rhône-Alpes</li><li>Rhône-Alpes</li></region><settlement><li>Grenoble</li><li>Lyon</li></settlement><orgName><li>Université Joseph Fourier</li></orgName></list><tree><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Broussolle, E" sort="Broussolle, E" uniqKey="Broussolle E" first="E." last="Broussolle">E. Broussolle</name></region><name sortKey="Bonnefoi, F" sort="Bonnefoi, F" uniqKey="Bonnefoi F" first="F." last="Bonnefoi">F. Bonnefoi</name><name sortKey="Broussolle, E" sort="Broussolle, E" uniqKey="Broussolle E" first="E." last="Broussolle">E. Broussolle</name><name sortKey="Broussolle, E" sort="Broussolle, E" uniqKey="Broussolle E" first="E." last="Broussolle">E. Broussolle</name><name sortKey="Comar, D" sort="Comar, D" uniqKey="Comar D" first="D." last="Comar">D. Comar</name><name sortKey="Croisile, B" sort="Croisile, B" uniqKey="Croisile B" first="B." last="Croisile">B. Croisile</name><name sortKey="Dentresangle, C" sort="Dentresangle, C" uniqKey="Dentresangle C" first="C." last="Dentresangle">C. Dentresangle</name><name sortKey="Dentresangle, C" sort="Dentresangle, C" uniqKey="Dentresangle C" first="C." last="Dentresangle">C. Dentresangle</name><name sortKey="Froment, J C" sort="Froment, J C" uniqKey="Froment J" first="J. C." last="Froment">J. C. Froment</name><name sortKey="Galy, G" sort="Galy, G" uniqKey="Galy G" first="G." last="Galy">G. Galy</name><name sortKey="Garcia Larrea, L" sort="Garcia Larrea, L" uniqKey="Garcia Larrea L" first="L." last="Garcia-Larrea">L. Garcia-Larrea</name><name sortKey="Garcia Larrea, L" sort="Garcia Larrea, L" uniqKey="Garcia Larrea L" first="L." last="Garcia-Larrea">L. Garcia-Larrea</name><name sortKey="Hibert, O" sort="Hibert, O" uniqKey="Hibert O" first="O." last="Hibert">O. Hibert</name><name sortKey="Landais, P" sort="Landais, P" uniqKey="Landais P" first="P." last="Landais">P. Landais</name><name sortKey="Pollak, P" sort="Pollak, P" uniqKey="Pollak P" first="P." last="Pollak">P. Pollak</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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