Bullous pemphigoid in a leg affected with hemiparesia : a possible relation of neurological diseases with bullous pemphigoid?
Identifieur interne : 003846 ( Main/Exploration ); précédent : 003845; suivant : 003847Bullous pemphigoid in a leg affected with hemiparesia : a possible relation of neurological diseases with bullous pemphigoid?
Auteurs : Nicolas Foureur [France] ; Vincent Descamps [France] ; Bénédicte Lebrun-Vignes [France] ; Catherine Picard-Dahan [France] ; Maggy Grossin [France] ; Stéphane Belaich [France] ; Béatrice Crickx [France]Source :
- EJD. European journal of dermatology [ 1167-1122 ] ; 2001.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Association, Personne âgée.
English descriptors
- KwdEn :
Abstract
We report a typical case of bullous pemphigoid (BP) associated with a neurological disorder and study a possible link between neurological disorders and BP. An 84-year-old hemiplegic woman presented with unilateral BP on the hemiparetic side. BP was confirmed by histological and immunofluorescence data. The medical records of the previous 46 consecutive patients with BP were retrospectively analyzed (average age: 79; median age: 85). Thirty of the 46 patients with BP had neurological disorders. These disorders included dementia, epilepsy, multiple sclerosis, cerebral stroke, Parkinson's disease, gonadotropic adenoma, trembling, dyskinesia, lumbar spinal stenosis. In a control group of the 46 consecutive oldest patients (older than 71; average age: 82,5; median age: 80) with another skin disease referred during the previous two-year-period to our one-day-unit only, 13 patients had a neurological disorder. This study demonstrates that there is a high prevalence of neurological disorders in patients with BP (p = 0.0004). A prospective case control study with neurological examination and psychometrical evaluation is warranted to confirm these data. We speculate that neuroautoimmunity associated with the aging process or neurological disorders may be involved in pemphigoid development via an autoimmune response against dystonin which shares homology with bullous pemphigoid antigen 1. Bullous pemphigoid could be considered to be a marker of neurological disorder.
Affiliations:
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type="wicri:Area/Main/Exploration">003846</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Bullous pemphigoid in a leg affected with hemiparesia : a possible relation of neurological diseases with bullous pemphigoid?</title><author><name sortKey="Foureur, Nicolas" sort="Foureur, Nicolas" uniqKey="Foureur N" first="Nicolas" last="Foureur">Nicolas Foureur</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Dermatology, Bichat-Claude-Bernard Hospital, 48, rue Menri-Huchard</s1><s2>75018 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Descamps, Vincent" sort="Descamps, Vincent" uniqKey="Descamps V" first="Vincent" last="Descamps">Vincent Descamps</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Dermatology, Bichat-Claude-Bernard Hospital, 48, rue Menri-Huchard</s1><s2>75018 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Lebrun Vignes, Benedicte" sort="Lebrun Vignes, Benedicte" uniqKey="Lebrun Vignes B" first="Bénédicte" last="Lebrun-Vignes">Bénédicte Lebrun-Vignes</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Dermatology, Bichat-Claude-Bernard Hospital, 48, rue Menri-Huchard</s1><s2>75018 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Picard Dahan, Catherine" sort="Picard Dahan, Catherine" uniqKey="Picard Dahan C" first="Catherine" last="Picard-Dahan">Catherine Picard-Dahan</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Dermatology, Bichat-Claude-Bernard Hospital, 48, rue Menri-Huchard</s1><s2>75018 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Grossin, Maggy" sort="Grossin, Maggy" uniqKey="Grossin M" first="Maggy" last="Grossin">Maggy Grossin</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Anatomopathology, Bichat-Claude-Bernard Hospital, 48, rue Henri-Huchard</s1><s2>75018 Paris</s2><s3>FRA</s3><sZ>5 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Belaich, Stephane" sort="Belaich, Stephane" uniqKey="Belaich S" first="Stéphane" last="Belaich">Stéphane Belaich</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Dermatology, Bichat-Claude-Bernard Hospital, 48, rue Menri-Huchard</s1><s2>75018 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Crickx, Beatrice" sort="Crickx, Beatrice" uniqKey="Crickx B" first="Béatrice" last="Crickx">Béatrice Crickx</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Dermatology, Bichat-Claude-Bernard Hospital, 48, rue Menri-Huchard</s1><s2>75018 Paris</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">EJD. European journal of dermatology</title><title level="j" type="abbreviated">EJD, Eur. j. dermatol.</title><idno type="ISSN">1167-1122</idno><imprint><date when="2001">2001</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">EJD. European journal of dermatology</title><title level="j" type="abbreviated">EJD, Eur. j. dermatol.</title><idno type="ISSN">1167-1122</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Association</term><term>Bullous pemphigoid</term><term>Case study</term><term>Elderly</term><term>Hemiplegia</term><term>Leg</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Pemphigoïde bulleuse</term><term>Jambe</term><term>Association</term><term>Hémiplégie</term><term>Etude cas</term><term>Personne âgée</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Association</term><term>Personne âgée</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We report a typical case of bullous pemphigoid (BP) associated with a neurological disorder and study a possible link between neurological disorders and BP. An 84-year-old hemiplegic woman presented with unilateral BP on the hemiparetic side. BP was confirmed by histological and immunofluorescence data. The medical records of the previous 46 consecutive patients with BP were retrospectively analyzed (average age: 79; median age: 85). Thirty of the 46 patients with BP had neurological disorders. These disorders included dementia, epilepsy, multiple sclerosis, cerebral stroke, Parkinson's disease, gonadotropic adenoma, trembling, dyskinesia, lumbar spinal stenosis. In a control group of the 46 consecutive oldest patients (older than 71; average age: 82,5; median age: 80) with another skin disease referred during the previous two-year-period to our one-day-unit only, 13 patients had a neurological disorder. This study demonstrates that there is a high prevalence of neurological disorders in patients with BP (p = 0.0004). A prospective case control study with neurological examination and psychometrical evaluation is warranted to confirm these data. We speculate that neuroautoimmunity associated with the aging process or neurological disorders may be involved in pemphigoid development via an autoimmune response against dystonin which shares homology with bullous pemphigoid antigen 1. Bullous pemphigoid could be considered to be a marker of neurological disorder.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="France"><region name="Île-de-France"><name sortKey="Foureur, Nicolas" sort="Foureur, Nicolas" uniqKey="Foureur N" first="Nicolas" last="Foureur">Nicolas Foureur</name></region><name sortKey="Belaich, Stephane" sort="Belaich, Stephane" uniqKey="Belaich S" first="Stéphane" last="Belaich">Stéphane Belaich</name><name sortKey="Crickx, Beatrice" sort="Crickx, Beatrice" uniqKey="Crickx B" first="Béatrice" last="Crickx">Béatrice Crickx</name><name sortKey="Descamps, Vincent" sort="Descamps, Vincent" uniqKey="Descamps V" first="Vincent" last="Descamps">Vincent Descamps</name><name sortKey="Grossin, Maggy" sort="Grossin, Maggy" uniqKey="Grossin M" first="Maggy" last="Grossin">Maggy Grossin</name><name sortKey="Lebrun Vignes, Benedicte" sort="Lebrun Vignes, Benedicte" uniqKey="Lebrun Vignes B" first="Bénédicte" last="Lebrun-Vignes">Bénédicte Lebrun-Vignes</name><name sortKey="Picard Dahan, Catherine" sort="Picard Dahan, Catherine" uniqKey="Picard Dahan C" first="Catherine" last="Picard-Dahan">Catherine Picard-Dahan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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