High frequency stimulation of the subthalamic nucleus increases the extracellular contents of striatal dopamine in normal and partially dopaminergic denervated rats
Identifieur interne : 003829 ( Main/Exploration ); précédent : 003828; suivant : 003830High frequency stimulation of the subthalamic nucleus increases the extracellular contents of striatal dopamine in normal and partially dopaminergic denervated rats
Auteurs : Nicolas Bruet [France] ; Francois Windels [France] ; Anne Bertrand [France] ; Claude Feuerstein [France] ; Annie Poupard [France] ; Marc Savasta [France]Source :
- Journal of neuropathology and experimental neurology [ 0022-3069 ] ; 2001.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- 3,4-Dihydroxyphenylacetic Acid (metabolism), Animal, Animals, Corpus Striatum (metabolism), Denervation, Dopamine (metabolism), Dopaminergic transmission, Electric Stimulation (methods), Experimental disease, Extracellular Space (metabolism), HPLC chromatography, High frequency, Instrumental stimulation, Male, Microdialysis, Oxidopamine, Parkinson disease, Pathophysiology, Rat, Rats, Rats, Sprague-Dawley, Reference Values, Subthalamic Nucleus (pathology), Subthalamic Nucleus (physiology), Subthalamic nucleus, Tyrosine 3-Monooxygenase (metabolism).
- MESH :
- chemical , metabolism : 3,4-Dihydroxyphenylacetic Acid, Dopamine, Tyrosine 3-Monooxygenase.
- metabolism : Corpus Striatum, Extracellular Space.
- methods : Electric Stimulation.
- pathology : Subthalamic Nucleus.
- physiology : Subthalamic Nucleus.
- Animals, Denervation, Male, Oxidopamine, Rats, Rats, Sprague-Dawley, Reference Values.
Abstract
The subthalamic nucleus (STN) has come under focus in Parkinson disease (PD) because of recent advances in the understanding of the functional organization of the basal ganglia in normal and pathological conditions, Manipulations of the STN have been described to compensate for some imbalance in motor output of the basal ganglia in animal models of PD and have been proposed as a potential therapeutic target in humans. Indeed, high frequency stimulation (HFS) (130 Hz) of the STN has beneficial effects in severe parkinsonian patients but the precise mechanisms underlying these clinical results remain to be elucidated. To date, very little is known concerning the effect of HFS-STN on striatal dopaminergic transmission. Since it has been reported that dopaminergic medication may be reduced in PD patients under HFS-STN, our goal was to study the effect of HFS-STN on striatal dopamine (DA) transmission by using intracerebral microdialysis in normal and partially DA denervated rats. Our results show that HFS-STN induces a significant increase of extracellular DA in the striatum of normal and partially DA lesioned rats while striatal extracellular levels of DOPAC were not affected. We conclude that HFS-STN acts directly and/or indirectly on striatal DA levels in control or partially DA lesioned rats.
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">The subthalamic nucleus (STN) has come under focus in Parkinson disease (PD) because of recent advances in the understanding of the functional organization of the basal ganglia in normal and pathological conditions, Manipulations of the STN have been described to compensate for some imbalance in motor output of the basal ganglia in animal models of PD and have been proposed as a potential therapeutic target in humans. Indeed, high frequency stimulation (HFS) (130 Hz) of the STN has beneficial effects in severe parkinsonian patients but the precise mechanisms underlying these clinical results remain to be elucidated. To date, very little is known concerning the effect of HFS-STN on striatal dopaminergic transmission. Since it has been reported that dopaminergic medication may be reduced in PD patients under HFS-STN, our goal was to study the effect of HFS-STN on striatal dopamine (DA) transmission by using intracerebral microdialysis in normal and partially DA denervated rats. Our results show that HFS-STN induces a significant increase of extracellular DA in the striatum of normal and partially DA lesioned rats while striatal extracellular levels of DOPAC were not affected. We conclude that HFS-STN acts directly and/or indirectly on striatal DA levels in control or partially DA lesioned rats.</div>
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