High frequency stimulation of the subthalamic nucleus increases the extracellular contents of striatal dopamine in normal and partially dopaminergic denervated rats
Identifieur interne : 003829 ( Main/Curation ); précédent : 003828; suivant : 003830High frequency stimulation of the subthalamic nucleus increases the extracellular contents of striatal dopamine in normal and partially dopaminergic denervated rats
Auteurs : Nicolas Bruet [France] ; Francois Windels [France] ; Anne Bertrand [France] ; Claude Feuerstein [France] ; Annie Poupard [France] ; Marc Savasta [France]Source :
- Journal of neuropathology and experimental neurology [ 0022-3069 ] ; 2001.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- 3,4-Dihydroxyphenylacetic Acid (metabolism), Animal, Animals, Corpus Striatum (metabolism), Denervation, Dopamine (metabolism), Dopaminergic transmission, Electric Stimulation (methods), Experimental disease, Extracellular Space (metabolism), HPLC chromatography, High frequency, Instrumental stimulation, Male, Microdialysis, Oxidopamine, Parkinson disease, Pathophysiology, Rat, Rats, Rats, Sprague-Dawley, Reference Values, Subthalamic Nucleus (pathology), Subthalamic Nucleus (physiology), Subthalamic nucleus, Tyrosine 3-Monooxygenase (metabolism).
- MESH :
- chemical , metabolism : 3,4-Dihydroxyphenylacetic Acid, Dopamine, Tyrosine 3-Monooxygenase.
- metabolism : Corpus Striatum, Extracellular Space.
- methods : Electric Stimulation.
- pathology : Subthalamic Nucleus.
- physiology : Subthalamic Nucleus.
- Animals, Denervation, Male, Oxidopamine, Rats, Rats, Sprague-Dawley, Reference Values.
Abstract
The subthalamic nucleus (STN) has come under focus in Parkinson disease (PD) because of recent advances in the understanding of the functional organization of the basal ganglia in normal and pathological conditions, Manipulations of the STN have been described to compensate for some imbalance in motor output of the basal ganglia in animal models of PD and have been proposed as a potential therapeutic target in humans. Indeed, high frequency stimulation (HFS) (130 Hz) of the STN has beneficial effects in severe parkinsonian patients but the precise mechanisms underlying these clinical results remain to be elucidated. To date, very little is known concerning the effect of HFS-STN on striatal dopaminergic transmission. Since it has been reported that dopaminergic medication may be reduced in PD patients under HFS-STN, our goal was to study the effect of HFS-STN on striatal dopamine (DA) transmission by using intracerebral microdialysis in normal and partially DA denervated rats. Our results show that HFS-STN induces a significant increase of extracellular DA in the striatum of normal and partially DA lesioned rats while striatal extracellular levels of DOPAC were not affected. We conclude that HFS-STN acts directly and/or indirectly on striatal DA levels in control or partially DA lesioned rats.
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Pascal:01-0165620Le document en format XML
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Neuroptasticité Fonctionnelles, INSERM U.318-Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, BP 217</s1><s2>38043 Grenoble</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author><author><name sortKey="Windels, Francois" sort="Windels, Francois" uniqKey="Windels F" first="Francois" last="Windels">Francois Windels</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Equipe Neurochimie et Neuroptasticité Fonctionnelles, INSERM U.318-Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, BP 217</s1><s2>38043 Grenoble</s2><s3>FRA</s3><sZ>1 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region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author><author><name sortKey="Feuerstein, Claude" sort="Feuerstein, Claude" uniqKey="Feuerstein C" first="Claude" last="Feuerstein">Claude Feuerstein</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Equipe Neurochimie et Neuroptasticité Fonctionnelles, INSERM U.318-Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, BP 217</s1><s2>38043 Grenoble</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author><author><name sortKey="Poupard, Annie" sort="Poupard, Annie" uniqKey="Poupard A" first="Annie" last="Poupard">Annie Poupard</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Equipe Neurochimie et Neuroptasticité Fonctionnelles, INSERM U.318-Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, BP 217</s1><s2>38043 Grenoble</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author><author><name sortKey="Savasta, Marc" sort="Savasta, Marc" uniqKey="Savasta M" first="Marc" last="Savasta">Marc Savasta</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Equipe Neurochimie et Neuroptasticité Fonctionnelles, INSERM U.318-Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, BP 217</s1><s2>38043 Grenoble</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author></analytic><series><title level="j" type="main">Journal of neuropathology and experimental neurology</title><title level="j" type="abbreviated">J. neuropathol. exp. neurol.</title><idno type="ISSN">0022-3069</idno><imprint><date when="2001">2001</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of neuropathology and experimental neurology</title><title level="j" type="abbreviated">J. neuropathol. exp. neurol.</title><idno type="ISSN">0022-3069</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>3,4-Dihydroxyphenylacetic Acid (metabolism)</term><term>Animal</term><term>Animals</term><term>Corpus Striatum (metabolism)</term><term>Denervation</term><term>Dopamine (metabolism)</term><term>Dopaminergic transmission</term><term>Electric Stimulation (methods)</term><term>Experimental disease</term><term>Extracellular Space (metabolism)</term><term>HPLC chromatography</term><term>High frequency</term><term>Instrumental stimulation</term><term>Male</term><term>Microdialysis</term><term>Oxidopamine</term><term>Parkinson disease</term><term>Pathophysiology</term><term>Rat</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Reference Values</term><term>Subthalamic Nucleus (pathology)</term><term>Subthalamic Nucleus (physiology)</term><term>Subthalamic nucleus</term><term>Tyrosine 3-Monooxygenase (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>3,4-Dihydroxyphenylacetic Acid</term><term>Dopamine</term><term>Tyrosine 3-Monooxygenase</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term><term>Extracellular Space</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electric Stimulation</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Denervation</term><term>Male</term><term>Oxidopamine</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Reference Values</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Noyau sousthalamique</term><term>Stimulation instrumentale</term><term>Haute fréquence</term><term>Chromatographie HPLC</term><term>Microdialyse</term><term>Pathologie expérimentale</term><term>Physiopathologie</term><term>Animal</term><term>Rat</term><term>Transmission dopaminergique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The subthalamic nucleus (STN) has come under focus in Parkinson disease (PD) because of recent advances in the understanding of the functional organization of the basal ganglia in normal and pathological conditions, Manipulations of the STN have been described to compensate for some imbalance in motor output of the basal ganglia in animal models of PD and have been proposed as a potential therapeutic target in humans. Indeed, high frequency stimulation (HFS) (130 Hz) of the STN has beneficial effects in severe parkinsonian patients but the precise mechanisms underlying these clinical results remain to be elucidated. To date, very little is known concerning the effect of HFS-STN on striatal dopaminergic transmission. Since it has been reported that dopaminergic medication may be reduced in PD patients under HFS-STN, our goal was to study the effect of HFS-STN on striatal dopamine (DA) transmission by using intracerebral microdialysis in normal and partially DA denervated rats. Our results show that HFS-STN induces a significant increase of extracellular DA in the striatum of normal and partially DA lesioned rats while striatal extracellular levels of DOPAC were not affected. We conclude that HFS-STN acts directly and/or indirectly on striatal DA levels in control or partially DA lesioned rats.</div></front></TEI><double idat="0022-3069:2001:Bruet N:high:frequency:stimulation"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">High frequency stimulation of the subthalamic nucleus increases the extracellular contents of striatal dopamine in normal and partially dopaminergic denervated rats</title><author><name sortKey="Bruet, Nicolas" sort="Bruet, Nicolas" uniqKey="Bruet N" first="Nicolas" last="Bruet">Nicolas Bruet</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Equipe Neurochimie et Neuroptasticité Fonctionnelles, INSERM U.318-Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, BP 217</s1><s2>38043 Grenoble</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author><author><name sortKey="Windels, Francois" sort="Windels, Francois" uniqKey="Windels F" first="Francois" last="Windels">Francois Windels</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Equipe Neurochimie et Neuroptasticité Fonctionnelles, INSERM U.318-Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, BP 217</s1><s2>38043 Grenoble</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author><author><name sortKey="Bertrand, Anne" sort="Bertrand, Anne" uniqKey="Bertrand A" first="Anne" last="Bertrand">Anne Bertrand</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Equipe Neurochimie et Neuroptasticité Fonctionnelles, INSERM U.318-Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, BP 217</s1><s2>38043 Grenoble</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author><author><name sortKey="Feuerstein, Claude" sort="Feuerstein, Claude" uniqKey="Feuerstein C" first="Claude" last="Feuerstein">Claude Feuerstein</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Equipe Neurochimie et Neuroptasticité Fonctionnelles, INSERM U.318-Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, BP 217</s1><s2>38043 Grenoble</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author><author><name sortKey="Poupard, Annie" sort="Poupard, Annie" uniqKey="Poupard A" first="Annie" last="Poupard">Annie Poupard</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Equipe Neurochimie et Neuroptasticité Fonctionnelles, INSERM U.318-Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, BP 217</s1><s2>38043 Grenoble</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author><author><name sortKey="Savasta, Marc" sort="Savasta, Marc" uniqKey="Savasta M" first="Marc" last="Savasta">Marc Savasta</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Equipe Neurochimie et Neuroptasticité Fonctionnelles, INSERM U.318-Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, BP 217</s1><s2>38043 Grenoble</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">01-0165620</idno><date when="2001">2001</date><idno type="stanalyst">PASCAL 01-0165620 INIST</idno><idno type="RBID">Pascal:01-0165620</idno><idno type="wicri:Area/PascalFrancis/Corpus">001245</idno><idno type="wicri:Area/PascalFrancis/Curation">000193</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001065</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001065</idno><idno type="wicri:doubleKey">0022-3069:2001:Bruet N:high:frequency:stimulation</idno><idno type="wicri:Area/Main/Merge">003E21</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">High frequency stimulation of the subthalamic nucleus increases the extracellular contents of striatal dopamine in normal and partially dopaminergic denervated rats</title><author><name sortKey="Bruet, Nicolas" sort="Bruet, Nicolas" uniqKey="Bruet N" first="Nicolas" last="Bruet">Nicolas Bruet</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Equipe Neurochimie et Neuroptasticité Fonctionnelles, INSERM U.318-Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, BP 217</s1><s2>38043 Grenoble</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author><author><name sortKey="Windels, Francois" sort="Windels, Francois" uniqKey="Windels F" first="Francois" last="Windels">Francois Windels</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Equipe Neurochimie et Neuroptasticité Fonctionnelles, INSERM U.318-Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, BP 217</s1><s2>38043 Grenoble</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author><author><name sortKey="Bertrand, Anne" sort="Bertrand, Anne" uniqKey="Bertrand A" first="Anne" last="Bertrand">Anne Bertrand</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Equipe Neurochimie et Neuroptasticité Fonctionnelles, INSERM U.318-Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, BP 217</s1><s2>38043 Grenoble</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author><author><name sortKey="Feuerstein, Claude" sort="Feuerstein, Claude" uniqKey="Feuerstein C" first="Claude" last="Feuerstein">Claude Feuerstein</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Equipe Neurochimie et Neuroptasticité Fonctionnelles, INSERM U.318-Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, BP 217</s1><s2>38043 Grenoble</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author><author><name sortKey="Poupard, Annie" sort="Poupard, Annie" uniqKey="Poupard A" first="Annie" last="Poupard">Annie Poupard</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Equipe Neurochimie et Neuroptasticité Fonctionnelles, INSERM U.318-Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, BP 217</s1><s2>38043 Grenoble</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author><author><name sortKey="Savasta, Marc" sort="Savasta, Marc" uniqKey="Savasta M" first="Marc" last="Savasta">Marc Savasta</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Equipe Neurochimie et Neuroptasticité Fonctionnelles, INSERM U.318-Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, BP 217</s1><s2>38043 Grenoble</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName><orgName type="university">Université Joseph Fourier</orgName></affiliation></author></analytic><series><title level="j" type="main">Journal of neuropathology and experimental neurology</title><title level="j" type="abbreviated">J. neuropathol. exp. neurol.</title><idno type="ISSN">0022-3069</idno><imprint><date when="2001">2001</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of neuropathology and experimental neurology</title><title level="j" type="abbreviated">J. neuropathol. exp. neurol.</title><idno type="ISSN">0022-3069</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term><term>Dopaminergic transmission</term><term>Experimental disease</term><term>HPLC chromatography</term><term>High frequency</term><term>Instrumental stimulation</term><term>Microdialysis</term><term>Parkinson disease</term><term>Pathophysiology</term><term>Rat</term><term>Subthalamic nucleus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Noyau sousthalamique</term><term>Stimulation instrumentale</term><term>Haute fréquence</term><term>Chromatographie HPLC</term><term>Microdialyse</term><term>Pathologie expérimentale</term><term>Physiopathologie</term><term>Animal</term><term>Rat</term><term>Transmission dopaminergique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The subthalamic nucleus (STN) has come under focus in Parkinson disease (PD) because of recent advances in the understanding of the functional organization of the basal ganglia in normal and pathological conditions, Manipulations of the STN have been described to compensate for some imbalance in motor output of the basal ganglia in animal models of PD and have been proposed as a potential therapeutic target in humans. Indeed, high frequency stimulation (HFS) (130 Hz) of the STN has beneficial effects in severe parkinsonian patients but the precise mechanisms underlying these clinical results remain to be elucidated. To date, very little is known concerning the effect of HFS-STN on striatal dopaminergic transmission. Since it has been reported that dopaminergic medication may be reduced in PD patients under HFS-STN, our goal was to study the effect of HFS-STN on striatal dopamine (DA) transmission by using intracerebral microdialysis in normal and partially DA denervated rats. Our results show that HFS-STN induces a significant increase of extracellular DA in the striatum of normal and partially DA lesioned rats while striatal extracellular levels of DOPAC were not affected. We conclude that HFS-STN acts directly and/or indirectly on striatal DA levels in control or partially DA lesioned rats.</div></front></TEI></INIST><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">High frequency stimulation of the subthalamic nucleus increases the extracellular contents of striatal dopamine in normal and partially dopaminergic denervated rats.</title><author><name sortKey="Bruet, N" sort="Bruet, N" uniqKey="Bruet N" first="N" last="Bruet">N. Bruet</name><affiliation wicri:level="4"><nlm:affiliation>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318--Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318--Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble</wicri:regionArea><wicri:noRegion>CHU de Grenoble</wicri:noRegion><orgName type="university">Université Joseph Fourier</orgName><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Windels, F" sort="Windels, F" uniqKey="Windels F" first="F" last="Windels">F. Windels</name></author><author><name sortKey="Bertrand, A" sort="Bertrand, A" uniqKey="Bertrand A" first="A" last="Bertrand">A. Bertrand</name></author><author><name sortKey="Feuerstein, C" sort="Feuerstein, C" uniqKey="Feuerstein C" first="C" last="Feuerstein">C. Feuerstein</name></author><author><name sortKey="Poupard, A" sort="Poupard, A" uniqKey="Poupard A" first="A" last="Poupard">A. Poupard</name></author><author><name sortKey="Savasta, M" sort="Savasta, M" uniqKey="Savasta M" first="M" last="Savasta">M. Savasta</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2001">2001</date><idno type="RBID">pubmed:11202172</idno><idno type="pmid">11202172</idno><idno type="wicri:Area/PubMed/Corpus">001275</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001275</idno><idno type="wicri:Area/PubMed/Curation">001234</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001234</idno><idno type="wicri:Area/PubMed/Checkpoint">001234</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001234</idno><idno type="wicri:Area/Ncbi/Merge">000171</idno><idno type="wicri:Area/Ncbi/Curation">000171</idno><idno type="wicri:Area/Ncbi/Checkpoint">000171</idno><idno type="wicri:doubleKey">0022-3069:2001:Bruet N:high:frequency:stimulation</idno><idno type="wicri:Area/Main/Merge">003B43</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">High frequency stimulation of the subthalamic nucleus increases the extracellular contents of striatal dopamine in normal and partially dopaminergic denervated rats.</title><author><name sortKey="Bruet, N" sort="Bruet, N" uniqKey="Bruet N" first="N" last="Bruet">N. Bruet</name><affiliation wicri:level="4"><nlm:affiliation>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318--Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Equipe Neurochimie et Neuroplasticité Fonctionnelles, INSERM U.318--Neurosciences Précliniques, Université Joseph Fourier, Pavillon de Neurologie, CHU de Grenoble</wicri:regionArea><wicri:noRegion>CHU de Grenoble</wicri:noRegion><orgName type="university">Université Joseph Fourier</orgName><placeName><settlement type="city">Grenoble</settlement><region type="region" nuts="2">Auvergne-Rhône-Alpes</region><region type="old region" nuts="2">Rhône-Alpes</region></placeName></affiliation></author><author><name sortKey="Windels, F" sort="Windels, F" uniqKey="Windels F" first="F" last="Windels">F. Windels</name></author><author><name sortKey="Bertrand, A" sort="Bertrand, A" uniqKey="Bertrand A" first="A" last="Bertrand">A. Bertrand</name></author><author><name sortKey="Feuerstein, C" sort="Feuerstein, C" uniqKey="Feuerstein C" first="C" last="Feuerstein">C. Feuerstein</name></author><author><name sortKey="Poupard, A" sort="Poupard, A" uniqKey="Poupard A" first="A" last="Poupard">A. Poupard</name></author><author><name sortKey="Savasta, M" sort="Savasta, M" uniqKey="Savasta M" first="M" last="Savasta">M. Savasta</name></author></analytic><series><title level="j">Journal of neuropathology and experimental neurology</title><idno type="ISSN">0022-3069</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>3,4-Dihydroxyphenylacetic Acid (metabolism)</term><term>Animals</term><term>Corpus Striatum (metabolism)</term><term>Denervation</term><term>Dopamine (metabolism)</term><term>Electric Stimulation (methods)</term><term>Extracellular Space (metabolism)</term><term>Male</term><term>Oxidopamine</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Reference Values</term><term>Subthalamic Nucleus (pathology)</term><term>Subthalamic Nucleus (physiology)</term><term>Tyrosine 3-Monooxygenase (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>3,4-Dihydroxyphenylacetic Acid</term><term>Dopamine</term><term>Tyrosine 3-Monooxygenase</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term><term>Extracellular Space</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Electric Stimulation</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Denervation</term><term>Male</term><term>Oxidopamine</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Reference Values</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The subthalamic nucleus (STN) has come under focus in Parkinson disease (PD) because of recent advances in the understanding of the functional organization of the basal ganglia in normal and pathological conditions. Manipulations of the STN have been described to compensate for some imbalance in motor output of the basal ganglia in animal models of PD and have been proposed as a potential therapeutic target in humans. Indeed, high frequency stimulation (HFS) (130 Hz) of the STN has beneficial effects in severe parkinsonian patients but the precise mechanisms underlying these clinical results remain to be elucidated. To date, very little is known concerning the effect of HFS-STN on striatal dopaminergic transmission. Since it has been reported that dopaminergic medication may be reduced in PD patients under HFS-STN, our goal was to study the effect of HFS-STN on striatal dopamine (DA) transmission by using intracerebral microdialysis in normal and partially DA denervated rats. Our results show that HFS STN induces a significant increase of extracellular DA in the striatum of normal and partially DA lesioned rats while striatal extracellular levels of DOPAC were not affected. We conclude that HFS-STN acts directly and/or indirectly on striatal DA levels in control or partially DA lesioned rats.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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