Sonic hedgehog is a neuromodulator in the adult subthalamic nucleus.
Identifieur interne : 003062 ( Main/Exploration ); précédent : 003061; suivant : 003063Sonic hedgehog is a neuromodulator in the adult subthalamic nucleus.
Auteurs : Erwan Bezard [France] ; Jerome Baufreton ; Geraint Owens ; Alan R. Crossman ; Hank Dudek ; Anne Taupignon ; Jonathan M. BrotchieSource :
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology [ 1530-6860 ] ; 2003.
English descriptors
- KwdEn :
- Animals, Cells, Cultured, Electric Conductivity, Globus Pallidus (metabolism), Hedgehog Proteins, Models, Neurological, Neurons (drug effects), Neurons (physiology), Neurotransmitter Agents (genetics), Neurotransmitter Agents (metabolism), Neurotransmitter Agents (pharmacology), Parkinson Disease (genetics), Parkinson Disease (metabolism), Patch-Clamp Techniques, RNA, Messenger (metabolism), Rats, Subthalamic Nucleus (cytology), Subthalamic Nucleus (drug effects), Subthalamic Nucleus (physiology), Trans-Activators (genetics), Trans-Activators (metabolism), Trans-Activators (pharmacology).
- MESH :
- chemical , genetics : Neurotransmitter Agents, Trans-Activators.
- chemical , metabolism : Neurotransmitter Agents, RNA, Messenger, Trans-Activators.
- chemical , pharmacology : Neurotransmitter Agents, Trans-Activators.
- chemical : Hedgehog Proteins.
- cytology : Subthalamic Nucleus.
- drug effects : Neurons, Subthalamic Nucleus.
- genetics : Parkinson Disease.
- metabolism : Globus Pallidus, Parkinson Disease.
- physiology : Neurons, Subthalamic Nucleus.
- Animals, Cells, Cultured, Electric Conductivity, Models, Neurological, Patch-Clamp Techniques, Rats.
Abstract
It is well established that members of the hedgehog family are involved in tissue patterning during development. We herein show that sonic hedgehog signaling molecules are differentially regulated by dopamine depletion in the basal ganglia of adult animals and specifically that sonic hedgehog levels are reduced in an animal model of Parkinson's disease. In addition, we show that sonic hedgehog protein inhibits electrical activity in the subthalamic nucleus, a key element of basal ganglia, within minutes of application. As the subthalamic nucleus is overactive in parkinsonism, we suggest that enhancement of sonic hedgehog signaling in the subthalamic nucleus may be of therapeutic value in Parkinson's disease.
DOI: 10.1096/fj.03-0291fje
PubMed: 14525941
Affiliations:
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Crossman</name></author><author><name sortKey="Dudek, Hank" sort="Dudek, Hank" uniqKey="Dudek H" first="Hank" last="Dudek">Hank Dudek</name></author><author><name sortKey="Taupignon, Anne" sort="Taupignon, Anne" uniqKey="Taupignon A" first="Anne" last="Taupignon">Anne Taupignon</name></author><author><name sortKey="Brotchie, Jonathan M" sort="Brotchie, Jonathan M" uniqKey="Brotchie J" first="Jonathan M" last="Brotchie">Jonathan M. Brotchie</name></author></analytic><series><title level="j">FASEB journal : official publication of the Federation of American Societies for Experimental Biology</title><idno type="eISSN">1530-6860</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Electric Conductivity</term><term>Globus Pallidus (metabolism)</term><term>Hedgehog Proteins</term><term>Models, Neurological</term><term>Neurons (drug effects)</term><term>Neurons (physiology)</term><term>Neurotransmitter Agents (genetics)</term><term>Neurotransmitter Agents (metabolism)</term><term>Neurotransmitter Agents (pharmacology)</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (metabolism)</term><term>Patch-Clamp Techniques</term><term>RNA, Messenger (metabolism)</term><term>Rats</term><term>Subthalamic Nucleus (cytology)</term><term>Subthalamic Nucleus (drug effects)</term><term>Subthalamic Nucleus (physiology)</term><term>Trans-Activators (genetics)</term><term>Trans-Activators (metabolism)</term><term>Trans-Activators (pharmacology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Neurotransmitter Agents</term><term>Trans-Activators</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Neurotransmitter Agents</term><term>RNA, Messenger</term><term>Trans-Activators</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Neurotransmitter Agents</term><term>Trans-Activators</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Hedgehog Proteins</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Neurons</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Globus Pallidus</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Neurons</term><term>Subthalamic Nucleus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Electric Conductivity</term><term>Models, Neurological</term><term>Patch-Clamp Techniques</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">It is well established that members of the hedgehog family are involved in tissue patterning during development. We herein show that sonic hedgehog signaling molecules are differentially regulated by dopamine depletion in the basal ganglia of adult animals and specifically that sonic hedgehog levels are reduced in an animal model of Parkinson's disease. In addition, we show that sonic hedgehog protein inhibits electrical activity in the subthalamic nucleus, a key element of basal ganglia, within minutes of application. As the subthalamic nucleus is overactive in parkinsonism, we suggest that enhancement of sonic hedgehog signaling in the subthalamic nucleus may be of therapeutic value in Parkinson's disease.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Aquitaine</li><li>Nouvelle-Aquitaine</li></region><settlement><li>Bordeaux</li></settlement></list><tree><noCountry><name sortKey="Baufreton, Jerome" sort="Baufreton, Jerome" uniqKey="Baufreton J" first="Jerome" last="Baufreton">Jerome Baufreton</name><name sortKey="Brotchie, Jonathan M" sort="Brotchie, Jonathan M" uniqKey="Brotchie J" first="Jonathan M" last="Brotchie">Jonathan M. Brotchie</name><name sortKey="Crossman, Alan R" sort="Crossman, Alan R" uniqKey="Crossman A" first="Alan R" last="Crossman">Alan R. Crossman</name><name sortKey="Dudek, Hank" sort="Dudek, Hank" uniqKey="Dudek H" first="Hank" last="Dudek">Hank Dudek</name><name sortKey="Owens, Geraint" sort="Owens, Geraint" uniqKey="Owens G" first="Geraint" last="Owens">Geraint Owens</name><name sortKey="Taupignon, Anne" sort="Taupignon, Anne" uniqKey="Taupignon A" first="Anne" last="Taupignon">Anne Taupignon</name></noCountry><country name="France"><region name="Nouvelle-Aquitaine"><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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