Comparative study of the effects of isatin, an endogenous MAO-inhibitor, and selegiline on bradykinesia and dopamine levels in a rat model of Parkinson's disease induced by the Japanese encephalitis virus
Identifieur interne : 003029 ( Main/Exploration ); précédent : 003028; suivant : 003030Comparative study of the effects of isatin, an endogenous MAO-inhibitor, and selegiline on bradykinesia and dopamine levels in a rat model of Parkinson's disease induced by the Japanese encephalitis virus
Auteurs : N. Hamaue [Japon] ; M. Minami [Japon] ; M. Terado [Japon] ; M. Hirafuji [Japon] ; T. Endo [Japon] ; M. Machida [Japon] ; T. Hiroshige [Japon] ; A. Ogata [Japon] ; K. Tashiro [Japon] ; H. Saito [Japon] ; S. H. Parvez [France]Source :
- Neurotoxicology : (Park Forest South) [ 0161-813X ] ; 2004.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Neurologie, Toxicologie.
English descriptors
- KwdEn :
Abstract
We previously reported that exogenously administered isatin, an endogenous monoamine oxidase (MAO) inhibitor, significantly increased acetylcholine (ACh) and dopamine (DA) levels in the rat striatum. Selegiline [(-)-deprenil] was developed as a MAO-B inhibitor more than 30 years ago and widely used in the treatment of Parkinson's disease. Effects of isatin orselegiline were investigated in Japanese encephalitis virus (JEV)-induced post-encephalitic parkinsonism rats by a pole test for detecting motor activity and by the determination of biogenic amine levels. Motor activity of JEV-induced rats receiving isatin (100 mg/kg per day for 1 week, i.p.) or selegiline (0.2 mg/kg per day for I week, i.p.) was significantly improved compared with that of untreated JEV-infected rats. Both isatin and selegiline prevented the decrease in striatal DA levels in JEV-rats. The increased turnover of DA (DOPAC/DA) induced by JEV was significantly inhibited by isatin, but not by selegiline. These results suggested that exogenously administered isatin and selegiline can improve JEV-induced parkinsonism by increasing DA concentrations in the striatum.
Affiliations:
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amine oxidase (flavin-containing)</term>
<term>Animal model</term>
<term>Catecholamine</term>
<term>Comparative study</term>
<term>Dopamine</term>
<term>Dopamine agonist</term>
<term>Endogenous</term>
<term>Enzyme inhibitor</term>
<term>Japanese encephalitis</term>
<term>MAO B inhibitor</term>
<term>Neurology</term>
<term>Parkinson disease</term>
<term>Rat</term>
<term>Selegiline</term>
<term>Toxicology</term>
<term>Virus</term>
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<term>IMAO B</term>
<term>Amine oxidase (flavin-containing)</term>
<term>Endogène</term>
<term>Inhibiteur enzyme</term>
<term>Catécholamine</term>
<term>Sélégiline</term>
<term>Stimulant dopaminergique</term>
<term>Parkinson maladie</term>
<term>Dopamine</term>
<term>Modèle animal</term>
<term>Encéphalite japonaise</term>
<term>Rat</term>
<term>Virus</term>
<term>Neurologie</term>
<term>Toxicologie</term>
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<front><div type="abstract" xml:lang="en">We previously reported that exogenously administered isatin, an endogenous monoamine oxidase (MAO) inhibitor, significantly increased acetylcholine (ACh) and dopamine (DA) levels in the rat striatum. Selegiline [(-)-deprenil] was developed as a MAO-B inhibitor more than 30 years ago and widely used in the treatment of Parkinson's disease. Effects of isatin orselegiline were investigated in Japanese encephalitis virus (JEV)-induced post-encephalitic parkinsonism rats by a pole test for detecting motor activity and by the determination of biogenic amine levels. Motor activity of JEV-induced rats receiving isatin (100 mg/kg per day for 1 week, i.p.) or selegiline (0.2 mg/kg per day for I week, i.p.) was significantly improved compared with that of untreated JEV-infected rats. Both isatin and selegiline prevented the decrease in striatal DA levels in JEV-rats. The increased turnover of DA (DOPAC/DA) induced by JEV was significantly inhibited by isatin, but not by selegiline. These results suggested that exogenously administered isatin and selegiline can improve JEV-induced parkinsonism by increasing DA concentrations in the striatum.</div>
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<name sortKey="Terado, M" sort="Terado, M" uniqKey="Terado M" first="M." last="Terado">M. Terado</name>
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<country name="France"><region name="Île-de-France"><name sortKey="Parvez, S H" sort="Parvez, S H" uniqKey="Parvez S" first="S. H." last="Parvez">S. H. Parvez</name>
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