Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease
Identifieur interne : 002D94 ( Main/Exploration ); précédent : 002D93; suivant : 002D95Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease
Auteurs : Maria Martinez [France] ; Alexis Brice [France] ; Jenny R. Vaughan [Royaume-Uni] ; Alexander Zimprich [Allemagne] ; Monique M. B. Breteler [Pays-Bas] ; Giuseppe Meco [Italie] ; Alessandro Filla [Italie] ; Matthew J. Fatter [États-Unis] ; Christine Betard [France] ; Andrew Singleton [États-Unis] ; John Hardy [États-Unis] ; Giuseppe De Michele [Italie] ; Vincenzo Bonifati [Italie] ; Ben A. Oostra [Pays-Bas] ; Thomas Gasser [Allemagne] ; Nick W. Wood [Royaume-Uni] ; Alexandra Dürr [France]Source :
- American journal of medical genetics [ 0148-7299 ] ; 2005.
Descripteurs français
- Pascal (Inist)
- Wicri :
English descriptors
- KwdEn :
Abstract
Analysis of the apolipoprotein E genotype in sibpairs with Parkinson's disease showed the E4 allele was over represented in those who shared the adjacent chromosome 19 markers. This suggests that apolipoprotein E4 is responsible for the linkage peak in this region and that it is a modest risk factor for Parkinson's disease.
Affiliations:
- Allemagne, France, Italie, Pays-Bas, Royaume-Uni, États-Unis
- Angleterre, Bade-Wurtemberg, District de Tübingen, Floride, Grand Londres, Hollande-Méridionale, Latium, Maryland, Île-de-France
- Londres, Paris, Rome, Rotterdam, Tübingen, Évry (Essonne)
- University College de Londres
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000C72
- to stream PascalFrancis, to step Curation: 000762
- to stream PascalFrancis, to step Checkpoint: 000B54
- to stream Main, to step Merge: 003177
- to stream Main, to step Curation: 002D94
Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease</title>
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<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>INSERM U289 and Département de Ge'ne'tique, Cytoge'ne'tique et Embryologie, Hôpital La Pitité-Salpêtrière</s1>
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<author><name sortKey="Zimprich, Alexander" sort="Zimprich, Alexander" uniqKey="Zimprich A" first="Alexander" last="Zimprich">Alexander Zimprich</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research, University of Tübingen</s1>
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<author><name sortKey="Betard, Christine" sort="Betard, Christine" uniqKey="Betard C" first="Christine" last="Betard">Christine Betard</name>
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<author><name sortKey="De Michele, Giuseppe" sort="De Michele, Giuseppe" uniqKey="De Michele G" first="Giuseppe" last="De Michele">Giuseppe De Michele</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Neurological Sciences, Federico II University</s1>
<s2>Naples</s2>
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<sZ>12 aut.</sZ>
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<author><name sortKey="Bonifati, Vincenzo" sort="Bonifati, Vincenzo" uniqKey="Bonifati V" first="Vincenzo" last="Bonifati">Vincenzo Bonifati</name>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>Department of Neurological Sciences, La Sapienza University</s1>
<s2>Rome</s2>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name>
<affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Department of Clinical Genetics, Erasmus MC</s1>
<s2>Rotterdam</s2>
<s3>NLD</s3>
<sZ>14 aut.</sZ>
</inist:fA14>
<country>Pays-Bas</country>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research, University of Tübingen</s1>
<s2>Tübingen</s2>
<s3>DEU</s3>
<sZ>4 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Tübingen</region>
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<author><name sortKey="Wood, Nick W" sort="Wood, Nick W" uniqKey="Wood N" first="Nick W." last="Wood">Nick W. Wood</name>
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<s2>London</s2>
<s3>GBR</s3>
<sZ>16 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
<orgName type="university">University College de Londres</orgName>
</affiliation>
</author>
<author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Dürr">Alexandra Dürr</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>INSERM U289 and Département de Ge'ne'tique, Cytoge'ne'tique et Embryologie, Hôpital La Pitité-Salpêtrière</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>2 aut.</sZ>
<sZ>17 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">American journal of medical genetics</title>
<title level="j" type="abbreviated">Am. j. med. genet.</title>
<idno type="ISSN">0148-7299</idno>
<imprint><date when="2005">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">American journal of medical genetics</title>
<title level="j" type="abbreviated">Am. j. med. genet.</title>
<idno type="ISSN">0148-7299</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Apolipoprotein E</term>
<term>Chromosome F19</term>
<term>Genetic determinism</term>
<term>Genetic linkage</term>
<term>Genetic mapping</term>
<term>Genetics</term>
<term>Human</term>
<term>Parkinson disease</term>
<term>Pathogenesis</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Apolipoprotéine E</term>
<term>Chromosome F19</term>
<term>Pathogénie</term>
<term>Déterminisme génétique</term>
<term>Liaison génétique</term>
<term>Carte génétique</term>
<term>Génétique</term>
<term>Homme</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Génétique</term>
<term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Analysis of the apolipoprotein E genotype in sibpairs with Parkinson's disease showed the E4 allele was over represented in those who shared the adjacent chromosome 19 markers. This suggests that apolipoprotein E4 is responsible for the linkage peak in this region and that it is a modest risk factor for Parkinson's disease.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>France</li>
<li>Italie</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Bade-Wurtemberg</li>
<li>District de Tübingen</li>
<li>Floride</li>
<li>Grand Londres</li>
<li>Hollande-Méridionale</li>
<li>Latium</li>
<li>Maryland</li>
<li>Île-de-France</li>
</region>
<settlement><li>Londres</li>
<li>Paris</li>
<li>Rome</li>
<li>Rotterdam</li>
<li>Tübingen</li>
<li>Évry (Essonne)</li>
</settlement>
<orgName><li>University College de Londres</li>
</orgName>
</list>
<tree><country name="France"><region name="Île-de-France"><name sortKey="Martinez, Maria" sort="Martinez, Maria" uniqKey="Martinez M" first="Maria" last="Martinez">Maria Martinez</name>
</region>
<name sortKey="Betard, Christine" sort="Betard, Christine" uniqKey="Betard C" first="Christine" last="Betard">Christine Betard</name>
<name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name>
<name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Dürr">Alexandra Dürr</name>
</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Vaughan, Jenny R" sort="Vaughan, Jenny R" uniqKey="Vaughan J" first="Jenny R." last="Vaughan">Jenny R. Vaughan</name>
</region>
<name sortKey="Wood, Nick W" sort="Wood, Nick W" uniqKey="Wood N" first="Nick W." last="Wood">Nick W. Wood</name>
</country>
<country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Zimprich, Alexander" sort="Zimprich, Alexander" uniqKey="Zimprich A" first="Alexander" last="Zimprich">Alexander Zimprich</name>
</region>
<name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name>
</country>
<country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M. B." last="Breteler">Monique M. B. Breteler</name>
</region>
<name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name>
</country>
<country name="Italie"><region name="Latium"><name sortKey="Meco, Giuseppe" sort="Meco, Giuseppe" uniqKey="Meco G" first="Giuseppe" last="Meco">Giuseppe Meco</name>
</region>
<name sortKey="Bonifati, Vincenzo" sort="Bonifati, Vincenzo" uniqKey="Bonifati V" first="Vincenzo" last="Bonifati">Vincenzo Bonifati</name>
<name sortKey="De Michele, Giuseppe" sort="De Michele, Giuseppe" uniqKey="De Michele G" first="Giuseppe" last="De Michele">Giuseppe De Michele</name>
<name sortKey="Filla, Alessandro" sort="Filla, Alessandro" uniqKey="Filla A" first="Alessandro" last="Filla">Alessandro Filla</name>
</country>
<country name="États-Unis"><region name="Floride"><name sortKey="Fatter, Matthew J" sort="Fatter, Matthew J" uniqKey="Fatter M" first="Matthew J." last="Fatter">Matthew J. Fatter</name>
</region>
<name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name>
<name sortKey="Singleton, Andrew" sort="Singleton, Andrew" uniqKey="Singleton A" first="Andrew" last="Singleton">Andrew Singleton</name>
</country>
</tree>
</affiliations>
</record>
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