Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease
Identifieur interne : 000C72 ( PascalFrancis/Corpus ); précédent : 000C71; suivant : 000C73Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease
Auteurs : Maria Martinez ; Alexis Brice ; Jenny R. Vaughan ; Alexander Zimprich ; Monique M. B. Breteler ; Giuseppe Meco ; Alessandro Filla ; Matthew J. Fatter ; Christine Betard ; Andrew Singleton ; John Hardy ; Giuseppe De Michele ; Vincenzo Bonifati ; Ben A. Oostra ; Thomas Gasser ; Nick W. Wood ; Alexandra DürrSource :
- American journal of medical genetics [ 0148-7299 ] ; 2005.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Analysis of the apolipoprotein E genotype in sibpairs with Parkinson's disease showed the E4 allele was over represented in those who shared the adjacent chromosome 19 markers. This suggests that apolipoprotein E4 is responsible for the linkage peak in this region and that it is a modest risk factor for Parkinson's disease.
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Format Inist (serveur)
| NO : | PASCAL 05-0303643 INIST |
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| ET : | Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease |
| AU : | MARTINEZ (Maria); BRICE (Alexis); VAUGHAN (Jenny R.); ZIMPRICH (Alexander); BRETELER (Monique M. B.); MECO (Giuseppe); FILLA (Alessandro); FATTER (Matthew J.); BETARD (Christine); SINGLETON (Andrew); HARDY (John); DE MICHELE (Giuseppe); BONIFATI (Vincenzo); OOSTRA (Ben A.); GASSER (Thomas); WOOD (Nick W.); DÜRR (Alexandra) |
| AF : | INSERM EMI00-06, 523 Place des Terrasses de l'Agora/Evry/France (1 aut.); INSERM U289 and Département de Ge'ne'tique, Cytoge'ne'tique et Embryologie, Hôpital La Pitité-Salpêtrière/Paris/France (2 aut., 17 aut.); Department of Neurology, Charing Cross Hospital/London/Royaume-Uni (3 aut.); Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research, University of Tübingen/Tübingen/Allemagne (4 aut., 15 aut.); Department of Epidemiology and Biostatistics, Erasmus MC/Rotterdam/Pays-Bas (5 aut.); Department of Neurological Sciences, La Sapienza University/Rome/Italie (6 aut., 13 aut.); Department of Neurological Sciences, Federico II University/Naples/Italie (7 aut., 12 aut.); Neurogenetics Laboratory, Mayo Clinic Jacksonville/Florida/Etats-Unis (8 aut.); Centre National de Génotypage/Evry/France (9 aut.); Laboratory of Neurogenetics, National Institute on Aging, NIH/Bethesda, Maryland/Etats-Unis (10 aut., 11 aut.); Department of Clinical Genetics, Erasmus MC/Rotterdam/Pays-Bas (14 aut.); Department of Molecular Neuroscience, Institute of Neurology, University College London/London/Royaume-Uni (16 aut.) |
| DT : | Publication en série; Niveau analytique |
| SO : | American journal of medical genetics; ISSN 0148-7299; Coden AJMGDA; Etats-Unis; Da. 2005; Vol. 136B; No. 1; Pp. 72-74; Bibl. 11 ref. |
| LA : | Anglais |
| EA : | Analysis of the apolipoprotein E genotype in sibpairs with Parkinson's disease showed the E4 allele was over represented in those who shared the adjacent chromosome 19 markers. This suggests that apolipoprotein E4 is responsible for the linkage peak in this region and that it is a modest risk factor for Parkinson's disease. |
| CC : | 002B23A; 002B17G; 002B17A01 |
| FD : | Parkinson maladie; Apolipoprotéine E; Chromosome F19; Pathogénie; Déterminisme génétique; Liaison génétique; Carte génétique; Génétique; Homme |
| FG : | Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie; Système nerveux pathologie |
| ED : | Parkinson disease; Apolipoprotein E; Chromosome F19; Pathogenesis; Genetic determinism; Genetic linkage; Genetic mapping; Genetics; Human |
| EG : | Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Nervous system diseases |
| SD : | Parkinson enfermedad; Apolipoproteína E; Cromosoma F19; Patogenia; Determinismo genético; Ligamiento genético; Mapa genético; Genética; Hombre |
| LO : | INIST-17405.354000138545350120 |
| ID : | 05-0303643 |
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Pascal:05-0303643Le document en format XML
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Oostra</name><affiliation><inist:fA14 i1="11"><s1>Department of Clinical Genetics, Erasmus MC</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>14 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name><affiliation><inist:fA14 i1="04"><s1>Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research, University of Tübingen</s1><s2>Tübingen</s2><s3>DEU</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Wood, Nick W" sort="Wood, Nick W" uniqKey="Wood N" first="Nick W." last="Wood">Nick W. Wood</name><affiliation><inist:fA14 i1="12"><s1>Department of Molecular Neuroscience, Institute of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>16 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Dürr">Alexandra Dürr</name><affiliation><inist:fA14 i1="02"><s1>INSERM U289 and Département de Ge'ne'tique, Cytoge'ne'tique et Embryologie, Hôpital La Pitité-Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">05-0303643</idno><date when="2005">2005</date><idno type="stanalyst">PASCAL 05-0303643 INIST</idno><idno type="RBID">Pascal:05-0303643</idno><idno type="wicri:Area/PascalFrancis/Corpus">000C72</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease</title><author><name sortKey="Martinez, Maria" sort="Martinez, Maria" uniqKey="Martinez M" first="Maria" last="Martinez">Maria Martinez</name><affiliation><inist:fA14 i1="01"><s1>INSERM EMI00-06, 523 Place des Terrasses de l'Agora</s1><s2>Evry</s2><s3>FRA</s3><sZ>1 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Brice, Alexis" sort="Brice, Alexis" uniqKey="Brice A" first="Alexis" last="Brice">Alexis Brice</name><affiliation><inist:fA14 i1="02"><s1>INSERM U289 and Département de Ge'ne'tique, Cytoge'ne'tique et Embryologie, Hôpital La Pitité-Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Vaughan, Jenny R" sort="Vaughan, Jenny R" uniqKey="Vaughan J" first="Jenny R." last="Vaughan">Jenny R. Vaughan</name><affiliation><inist:fA14 i1="03"><s1>Department of Neurology, Charing Cross Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Zimprich, Alexander" sort="Zimprich, Alexander" uniqKey="Zimprich A" first="Alexander" last="Zimprich">Alexander Zimprich</name><affiliation><inist:fA14 i1="04"><s1>Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research, University of Tübingen</s1><s2>Tübingen</s2><s3>DEU</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Breteler, Monique M B" sort="Breteler, Monique M B" uniqKey="Breteler M" first="Monique M. B." last="Breteler">Monique M. B. Breteler</name><affiliation><inist:fA14 i1="05"><s1>Department of Epidemiology and Biostatistics, Erasmus MC</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>5 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Meco, Giuseppe" sort="Meco, Giuseppe" uniqKey="Meco G" first="Giuseppe" last="Meco">Giuseppe Meco</name><affiliation><inist:fA14 i1="06"><s1>Department of Neurological Sciences, La Sapienza University</s1><s2>Rome</s2><s3>ITA</s3><sZ>6 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Filla, Alessandro" sort="Filla, Alessandro" uniqKey="Filla A" first="Alessandro" last="Filla">Alessandro Filla</name><affiliation><inist:fA14 i1="07"><s1>Department of Neurological Sciences, Federico II University</s1><s2>Naples</s2><s3>ITA</s3><sZ>7 aut.</sZ><sZ>12 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Fatter, Matthew J" sort="Fatter, Matthew J" uniqKey="Fatter M" first="Matthew J." last="Fatter">Matthew J. Fatter</name><affiliation><inist:fA14 i1="08"><s1>Neurogenetics Laboratory, Mayo Clinic Jacksonville</s1><s2>Florida</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Betard, Christine" sort="Betard, Christine" uniqKey="Betard C" first="Christine" last="Betard">Christine Betard</name><affiliation><inist:fA14 i1="09"><s1>Centre National de Génotypage</s1><s2>Evry</s2><s3>FRA</s3><sZ>9 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Singleton, Andrew" sort="Singleton, Andrew" uniqKey="Singleton A" first="Andrew" last="Singleton">Andrew Singleton</name><affiliation><inist:fA14 i1="10"><s1>Laboratory of Neurogenetics, National Institute on Aging, NIH</s1><s2>Bethesda, Maryland</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Hardy, John" sort="Hardy, John" uniqKey="Hardy J" first="John" last="Hardy">John Hardy</name><affiliation><inist:fA14 i1="10"><s1>Laboratory of Neurogenetics, National Institute on Aging, NIH</s1><s2>Bethesda, Maryland</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="De Michele, Giuseppe" sort="De Michele, Giuseppe" uniqKey="De Michele G" first="Giuseppe" last="De Michele">Giuseppe De Michele</name><affiliation><inist:fA14 i1="07"><s1>Department of Neurological Sciences, Federico II University</s1><s2>Naples</s2><s3>ITA</s3><sZ>7 aut.</sZ><sZ>12 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Bonifati, Vincenzo" sort="Bonifati, Vincenzo" uniqKey="Bonifati V" first="Vincenzo" last="Bonifati">Vincenzo Bonifati</name><affiliation><inist:fA14 i1="06"><s1>Department of Neurological Sciences, La Sapienza University</s1><s2>Rome</s2><s3>ITA</s3><sZ>6 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Oostra, Ben A" sort="Oostra, Ben A" uniqKey="Oostra B" first="Ben A." last="Oostra">Ben A. Oostra</name><affiliation><inist:fA14 i1="11"><s1>Department of Clinical Genetics, Erasmus MC</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>14 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Gasser, Thomas" sort="Gasser, Thomas" uniqKey="Gasser T" first="Thomas" last="Gasser">Thomas Gasser</name><affiliation><inist:fA14 i1="04"><s1>Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research, University of Tübingen</s1><s2>Tübingen</s2><s3>DEU</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Wood, Nick W" sort="Wood, Nick W" uniqKey="Wood N" first="Nick W." last="Wood">Nick W. Wood</name><affiliation><inist:fA14 i1="12"><s1>Department of Molecular Neuroscience, Institute of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>16 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Durr, Alexandra" sort="Durr, Alexandra" uniqKey="Durr A" first="Alexandra" last="Dürr">Alexandra Dürr</name><affiliation><inist:fA14 i1="02"><s1>INSERM U289 and Département de Ge'ne'tique, Cytoge'ne'tique et Embryologie, Hôpital La Pitité-Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>17 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">American journal of medical genetics</title><title level="j" type="abbreviated">Am. j. med. genet.</title><idno type="ISSN">0148-7299</idno><imprint><date when="2005">2005</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">American journal of medical genetics</title><title level="j" type="abbreviated">Am. j. med. genet.</title><idno type="ISSN">0148-7299</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Apolipoprotein E</term><term>Chromosome F19</term><term>Genetic determinism</term><term>Genetic linkage</term><term>Genetic mapping</term><term>Genetics</term><term>Human</term><term>Parkinson disease</term><term>Pathogenesis</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Apolipoprotéine E</term><term>Chromosome F19</term><term>Pathogénie</term><term>Déterminisme génétique</term><term>Liaison génétique</term><term>Carte génétique</term><term>Génétique</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Analysis of the apolipoprotein E genotype in sibpairs with Parkinson's disease showed the E4 allele was over represented in those who shared the adjacent chromosome 19 markers. This suggests that apolipoprotein E4 is responsible for the linkage peak in this region and that it is a modest risk factor for Parkinson's disease.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0148-7299</s0></fA01><fA02 i1="01"><s0>AJMGDA</s0></fA02><fA03 i2="1"><s0>Am. j. med. genet.</s0></fA03><fA05><s2>136B</s2></fA05><fA06><s2>1</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease</s1></fA08><fA11 i1="01" i2="1"><s1>MARTINEZ (Maria)</s1></fA11><fA11 i1="02" i2="1"><s1>BRICE (Alexis)</s1></fA11><fA11 i1="03" i2="1"><s1>VAUGHAN (Jenny R.)</s1></fA11><fA11 i1="04" i2="1"><s1>ZIMPRICH (Alexander)</s1></fA11><fA11 i1="05" i2="1"><s1>BRETELER (Monique M. B.)</s1></fA11><fA11 i1="06" i2="1"><s1>MECO (Giuseppe)</s1></fA11><fA11 i1="07" i2="1"><s1>FILLA (Alessandro)</s1></fA11><fA11 i1="08" i2="1"><s1>FATTER (Matthew J.)</s1></fA11><fA11 i1="09" i2="1"><s1>BETARD (Christine)</s1></fA11><fA11 i1="10" i2="1"><s1>SINGLETON (Andrew)</s1></fA11><fA11 i1="11" i2="1"><s1>HARDY (John)</s1></fA11><fA11 i1="12" i2="1"><s1>DE MICHELE (Giuseppe)</s1></fA11><fA11 i1="13" i2="1"><s1>BONIFATI (Vincenzo)</s1></fA11><fA11 i1="14" i2="1"><s1>OOSTRA (Ben A.)</s1></fA11><fA11 i1="15" i2="1"><s1>GASSER (Thomas)</s1></fA11><fA11 i1="16" i2="1"><s1>WOOD (Nick W.)</s1></fA11><fA11 i1="17" i2="1"><s1>DÜRR (Alexandra)</s1></fA11><fA14 i1="01"><s1>INSERM EMI00-06, 523 Place des Terrasses de l'Agora</s1><s2>Evry</s2><s3>FRA</s3><sZ>1 aut.</sZ></fA14><fA14 i1="02"><s1>INSERM U289 and Département de Ge'ne'tique, Cytoge'ne'tique et Embryologie, Hôpital La Pitité-Salpêtrière</s1><s2>Paris</s2><s3>FRA</s3><sZ>2 aut.</sZ><sZ>17 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Neurology, Charing Cross Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research, University of Tübingen</s1><s2>Tübingen</s2><s3>DEU</s3><sZ>4 aut.</sZ><sZ>15 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Epidemiology and Biostatistics, Erasmus MC</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>5 aut.</sZ></fA14><fA14 i1="06"><s1>Department of Neurological Sciences, La Sapienza University</s1><s2>Rome</s2><s3>ITA</s3><sZ>6 aut.</sZ><sZ>13 aut.</sZ></fA14><fA14 i1="07"><s1>Department of Neurological Sciences, Federico II University</s1><s2>Naples</s2><s3>ITA</s3><sZ>7 aut.</sZ><sZ>12 aut.</sZ></fA14><fA14 i1="08"><s1>Neurogenetics Laboratory, Mayo Clinic Jacksonville</s1><s2>Florida</s2><s3>USA</s3><sZ>8 aut.</sZ></fA14><fA14 i1="09"><s1>Centre National de Génotypage</s1><s2>Evry</s2><s3>FRA</s3><sZ>9 aut.</sZ></fA14><fA14 i1="10"><s1>Laboratory of Neurogenetics, National Institute on Aging, NIH</s1><s2>Bethesda, Maryland</s2><s3>USA</s3><sZ>10 aut.</sZ><sZ>11 aut.</sZ></fA14><fA14 i1="11"><s1>Department of Clinical Genetics, Erasmus MC</s1><s2>Rotterdam</s2><s3>NLD</s3><sZ>14 aut.</sZ></fA14><fA14 i1="12"><s1>Department of Molecular Neuroscience, Institute of Neurology, University College London</s1><s2>London</s2><s3>GBR</s3><sZ>16 aut.</sZ></fA14><fA17 i1="01" i2="1"><s1>French Parkinson's Disease Genetics Study Group and the European Consortium on Genetic Susceptibility in Parkinson's Disease</s1><s3>INC</s3></fA17><fA20><s1>72-74</s1></fA20><fA21><s1>2005</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>17405</s2><s5>354000138545350120</s5></fA43><fA44><s0>0000</s0><s1>© 2005 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>11 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>05-0303643</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>American journal of medical genetics</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Analysis of the apolipoprotein E genotype in sibpairs with Parkinson's disease showed the E4 allele was over represented in those who shared the adjacent chromosome 19 markers. This suggests that apolipoprotein E4 is responsible for the linkage peak in this region and that it is a modest risk factor for Parkinson's disease.</s0></fC01><fC02 i1="01" i2="X"><s0>002B23A</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC02 i1="03" i2="X"><s0>002B17A01</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Parkinson maladie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Apolipoprotéine E</s0><s5>09</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Apolipoprotein E</s0><s5>09</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Apolipoproteína E</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Chromosome F19</s0><s5>10</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Chromosome F19</s0><s5>10</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Cromosoma F19</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Pathogénie</s0><s5>11</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Pathogenesis</s0><s5>11</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Patogenia</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Déterminisme génétique</s0><s5>12</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Genetic determinism</s0><s5>12</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Determinismo genético</s0><s5>12</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Liaison génétique</s0><s5>13</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Genetic linkage</s0><s5>13</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Ligamiento genético</s0><s5>13</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Carte génétique</s0><s5>14</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Genetic mapping</s0><s5>14</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Mapa genético</s0><s5>14</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Génétique</s0><s5>17</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Genetics</s0><s5>17</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Genética</s0><s5>17</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Homme</s0><s5>18</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Human</s0><s5>18</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Hombre</s0><s5>18</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Encéphale pathologie</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>41</s5></fC07><fN21><s1>213</s1></fN21></pA></standard><server><NO>PASCAL 05-0303643 INIST</NO><ET>Apolipoprotein E4 is probably responsible for the chromosome 19 linkage peak for Parkinson's disease</ET><AU>MARTINEZ (Maria); BRICE (Alexis); VAUGHAN (Jenny R.); ZIMPRICH (Alexander); BRETELER (Monique M. B.); MECO (Giuseppe); FILLA (Alessandro); FATTER (Matthew J.); BETARD (Christine); SINGLETON (Andrew); HARDY (John); DE MICHELE (Giuseppe); BONIFATI (Vincenzo); OOSTRA (Ben A.); GASSER (Thomas); WOOD (Nick W.); DÜRR (Alexandra)</AU><AF>INSERM EMI00-06, 523 Place des Terrasses de l'Agora/Evry/France (1 aut.); INSERM U289 and Département de Ge'ne'tique, Cytoge'ne'tique et Embryologie, Hôpital La Pitité-Salpêtrière/Paris/France (2 aut., 17 aut.); Department of Neurology, Charing Cross Hospital/London/Royaume-Uni (3 aut.); Department of Neurodegenerative Diseases, Hertie-Institute for Clinical Brain Research, University of Tübingen/Tübingen/Allemagne (4 aut., 15 aut.); Department of Epidemiology and Biostatistics, Erasmus MC/Rotterdam/Pays-Bas (5 aut.); Department of Neurological Sciences, La Sapienza University/Rome/Italie (6 aut., 13 aut.); Department of Neurological Sciences, Federico II University/Naples/Italie (7 aut., 12 aut.); Neurogenetics Laboratory, Mayo Clinic Jacksonville/Florida/Etats-Unis (8 aut.); Centre National de Génotypage/Evry/France (9 aut.); Laboratory of Neurogenetics, National Institute on Aging, NIH/Bethesda, Maryland/Etats-Unis (10 aut., 11 aut.); Department of Clinical Genetics, Erasmus MC/Rotterdam/Pays-Bas (14 aut.); Department of Molecular Neuroscience, Institute of Neurology, University College London/London/Royaume-Uni (16 aut.)</AF><DT>Publication en série; Niveau analytique</DT><SO>American journal of medical genetics; ISSN 0148-7299; Coden AJMGDA; Etats-Unis; Da. 2005; Vol. 136B; No. 1; Pp. 72-74; Bibl. 11 ref.</SO><LA>Anglais</LA><EA>Analysis of the apolipoprotein E genotype in sibpairs with Parkinson's disease showed the E4 allele was over represented in those who shared the adjacent chromosome 19 markers. This suggests that apolipoprotein E4 is responsible for the linkage peak in this region and that it is a modest risk factor for Parkinson's disease.</EA><CC>002B23A; 002B17G; 002B17A01</CC><FD>Parkinson maladie; Apolipoprotéine E; Chromosome F19; Pathogénie; Déterminisme génétique; Liaison génétique; Carte génétique; Génétique; Homme</FD><FG>Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie; Système nerveux pathologie</FG><ED>Parkinson disease; Apolipoprotein E; Chromosome F19; Pathogenesis; Genetic determinism; Genetic linkage; Genetic mapping; Genetics; Human</ED><EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Nervous system diseases</EG><SD>Parkinson enfermedad; Apolipoproteína E; Cromosoma F19; Patogenia; Determinismo genético; Ligamiento genético; Mapa genético; Genética; Hombre</SD><LO>INIST-17405.354000138545350120</LO><ID>05-0303643</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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