Moderate-Intensity Physical Exercise Protects Against Experimental 6-Hydroxydopamine-Induced Hemiparkinsonism Through Nrf2-Antioxidant Response Element Pathway.
Identifieur interne : 000232 ( Main/Exploration ); précédent : 000231; suivant : 000233Moderate-Intensity Physical Exercise Protects Against Experimental 6-Hydroxydopamine-Induced Hemiparkinsonism Through Nrf2-Antioxidant Response Element Pathway.
Auteurs : Aderbal Silva Aguiar [Brésil] ; Marcelo Duzzioni [Brésil] ; Aline Pertile Remor [Brésil] ; Fabrine Sales Massafera Tristão [France] ; Filipe C. Matheus [Brésil] ; Rita Raisman-Vozari [France] ; Alexandra Latini [Brésil] ; Rui Daniel Prediger [Brésil]Source :
- Neurochemical research [ 1573-6903 ] ; 2016.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : NF-E2-Related Factor 2.
- chemical , toxicity : Oxidopamine.
- etiology : Parkinsonian Disorders.
- metabolism : Parkinsonian Disorders.
- prevention & control : Parkinsonian Disorders.
- Animals, Male, Mice, Mice, Inbred C57BL, Physical Conditioning, Animal.
Abstract
Exercise improves the motor symptoms of patients with Parkinson disease in a palliative manner. Existing evidence demonstrates that exercise induces neuroprotection based on the neurotrophic properties. We investigated the effect of exercise on mitochondrial physiology and oxidative stress in an animal model of hemiparkinsonism.
DOI: 10.1007/s11064-015-1709-8
PubMed: 26323504
Affiliations:
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Le document en format XML
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(LEXDON), Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis</wicri:regionArea><wicri:noRegion>Florianópolis</wicri:noRegion></affiliation></author><author><name sortKey="Duzzioni, Marcelo" sort="Duzzioni, Marcelo" uniqKey="Duzzioni M" first="Marcelo" last="Duzzioni">Marcelo Duzzioni</name><affiliation wicri:level="1"><nlm:affiliation>Laboratório Experimental de Doenças Neurodegenerativas (LEXDON), Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Laboratório Experimental de Doenças Neurodegenerativas (LEXDON), Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis</wicri:regionArea><wicri:noRegion>Florianópolis</wicri:noRegion></affiliation></author><author><name sortKey="Remor, Aline Pertile" sort="Remor, Aline Pertile" uniqKey="Remor A" first="Aline Pertile" last="Remor">Aline Pertile Remor</name><affiliation wicri:level="1"><nlm:affiliation>Laboratório de Bioenergética e Estresse Oxidativo (LABOX), Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Laboratório de Bioenergética e Estresse Oxidativo (LABOX), Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis</wicri:regionArea><wicri:noRegion>Florianópolis</wicri:noRegion></affiliation></author><author><name sortKey="Tristao, Fabrine Sales Massafera" sort="Tristao, Fabrine Sales Massafera" uniqKey="Tristao F" first="Fabrine Sales Massafera" last="Tristão">Fabrine Sales Massafera Tristão</name><affiliation wicri:level="4"><nlm:affiliation>INSERM UMR 975 (ex U679), CNRS UMR 7225, Hôpital de la Salpêtrière-Bâtiment, ICM (Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, CRICM), Thérapeutique Expérimentale de la Neurodégénérescence, Université Pierre et Marie Curie (UPMC), 47 Boulevard de l'Hôpital, 75651, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR 975 (ex U679), CNRS UMR 7225, Hôpital de la Salpêtrière-Bâtiment, ICM (Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, CRICM), Thérapeutique Expérimentale de la Neurodégénérescence, Université Pierre et Marie Curie (UPMC), 47 Boulevard de l'Hôpital, 75651, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation></author><author><name sortKey="Matheus, Filipe C" sort="Matheus, Filipe C" uniqKey="Matheus F" first="Filipe C" last="Matheus">Filipe C. Matheus</name><affiliation wicri:level="1"><nlm:affiliation>Laboratório Experimental de Doenças Neurodegenerativas (LEXDON), Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Laboratório Experimental de Doenças Neurodegenerativas (LEXDON), Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis</wicri:regionArea><wicri:noRegion>Florianópolis</wicri:noRegion></affiliation></author><author><name sortKey="Raisman Vozari, Rita" sort="Raisman Vozari, Rita" uniqKey="Raisman Vozari R" first="Rita" last="Raisman-Vozari">Rita Raisman-Vozari</name><affiliation wicri:level="4"><nlm:affiliation>INSERM UMR 975 (ex U679), CNRS UMR 7225, Hôpital de la Salpêtrière-Bâtiment, ICM (Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, CRICM), Thérapeutique Expérimentale de la Neurodégénérescence, Université Pierre et Marie Curie (UPMC), 47 Boulevard de l'Hôpital, 75651, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR 975 (ex U679), CNRS UMR 7225, Hôpital de la Salpêtrière-Bâtiment, ICM (Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, CRICM), Thérapeutique Expérimentale de la Neurodégénérescence, Université Pierre et Marie Curie (UPMC), 47 Boulevard de l'Hôpital, 75651, Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName><orgName type="university">Université Pierre-et-Marie-Curie</orgName></affiliation></author><author><name sortKey="Latini, Alexandra" sort="Latini, Alexandra" uniqKey="Latini A" first="Alexandra" last="Latini">Alexandra Latini</name><affiliation wicri:level="1"><nlm:affiliation>Laboratório de Bioenergética e Estresse Oxidativo (LABOX), Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Laboratório de Bioenergética e Estresse Oxidativo (LABOX), Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis</wicri:regionArea><wicri:noRegion>Florianópolis</wicri:noRegion></affiliation></author><author><name sortKey="Prediger, Rui Daniel" sort="Prediger, Rui Daniel" uniqKey="Prediger R" first="Rui Daniel" last="Prediger">Rui Daniel Prediger</name><affiliation wicri:level="1"><nlm:affiliation>Laboratório Experimental de Doenças Neurodegenerativas (LEXDON), Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Laboratório Experimental de Doenças Neurodegenerativas (LEXDON), Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis</wicri:regionArea><wicri:noRegion>Florianópolis</wicri:noRegion></affiliation></author></analytic><series><title level="j">Neurochemical research</title><idno type="eISSN">1573-6903</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>NF-E2-Related Factor 2 (metabolism)</term><term>Oxidopamine (toxicity)</term><term>Parkinsonian Disorders (etiology)</term><term>Parkinsonian Disorders (metabolism)</term><term>Parkinsonian Disorders (prevention & control)</term><term>Physical Conditioning, Animal</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>NF-E2-Related Factor 2</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Oxidopamine</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Physical Conditioning, Animal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Exercise improves the motor symptoms of patients with Parkinson disease in a palliative manner. Existing evidence demonstrates that exercise induces neuroprotection based on the neurotrophic properties. We investigated the effect of exercise on mitochondrial physiology and oxidative stress in an animal model of hemiparkinsonism.</div></front></TEI><affiliations><list><country><li>Brésil</li><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement><orgName><li>Université Pierre-et-Marie-Curie</li></orgName></list><tree><country name="Brésil"><noRegion><name sortKey="Aguiar, Aderbal Silva" sort="Aguiar, Aderbal Silva" uniqKey="Aguiar A" first="Aderbal Silva" last="Aguiar">Aderbal Silva Aguiar</name></noRegion><name sortKey="Duzzioni, Marcelo" sort="Duzzioni, Marcelo" uniqKey="Duzzioni M" first="Marcelo" last="Duzzioni">Marcelo Duzzioni</name><name sortKey="Latini, Alexandra" sort="Latini, Alexandra" uniqKey="Latini A" first="Alexandra" last="Latini">Alexandra Latini</name><name sortKey="Matheus, Filipe C" sort="Matheus, Filipe C" uniqKey="Matheus F" first="Filipe C" last="Matheus">Filipe C. Matheus</name><name sortKey="Prediger, Rui Daniel" sort="Prediger, Rui Daniel" uniqKey="Prediger R" first="Rui Daniel" last="Prediger">Rui Daniel Prediger</name><name sortKey="Remor, Aline Pertile" sort="Remor, Aline Pertile" uniqKey="Remor A" first="Aline Pertile" last="Remor">Aline Pertile Remor</name></country><country name="France"><region name="Île-de-France"><name sortKey="Tristao, Fabrine Sales Massafera" sort="Tristao, Fabrine Sales Massafera" uniqKey="Tristao F" first="Fabrine Sales Massafera" last="Tristão">Fabrine Sales Massafera Tristão</name></region><name sortKey="Raisman Vozari, Rita" sort="Raisman Vozari, Rita" uniqKey="Raisman Vozari R" first="Rita" last="Raisman-Vozari">Rita Raisman-Vozari</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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