Moderate-Intensity Physical Exercise Protects Against Experimental 6-Hydroxydopamine-Induced Hemiparkinsonism Through Nrf2-Antioxidant Response Element Pathway.
Identifieur interne : 000197 ( PubMed/Curation ); précédent : 000196; suivant : 000198Moderate-Intensity Physical Exercise Protects Against Experimental 6-Hydroxydopamine-Induced Hemiparkinsonism Through Nrf2-Antioxidant Response Element Pathway.
Auteurs : Aderbal Silva Aguiar [Brésil] ; Marcelo Duzzioni [Brésil] ; Aline Pertile Remor [Brésil] ; Fabrine Sales Massafera Tristão [France] ; Filipe C. Matheus [Brésil] ; Rita Raisman-Vozari [France] ; Alexandra Latini [Brésil] ; Rui Daniel Prediger [Brésil]Source :
- Neurochemical research [ 1573-6903 ] ; 2016.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : NF-E2-Related Factor 2.
- chemical , toxicity : Oxidopamine.
- etiology : Parkinsonian Disorders.
- metabolism : Parkinsonian Disorders.
- prevention & control : Parkinsonian Disorders.
- Animals, Male, Mice, Mice, Inbred C57BL, Physical Conditioning, Animal.
Abstract
Exercise improves the motor symptoms of patients with Parkinson disease in a palliative manner. Existing evidence demonstrates that exercise induces neuroprotection based on the neurotrophic properties. We investigated the effect of exercise on mitochondrial physiology and oxidative stress in an animal model of hemiparkinsonism.
DOI: 10.1007/s11064-015-1709-8
PubMed: 26323504
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Pierre et Marie Curie (UPMC), 47 Boulevard de l'Hôpital, 75651, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR 975 (ex U679), CNRS UMR 7225, Hôpital de la Salpêtrière-Bâtiment, ICM (Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, CRICM), Thérapeutique Expérimentale de la Neurodégénérescence, Université Pierre et Marie Curie (UPMC), 47 Boulevard de l'Hôpital, 75651, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Latini, Alexandra" sort="Latini, Alexandra" uniqKey="Latini A" first="Alexandra" last="Latini">Alexandra Latini</name><affiliation wicri:level="1"><nlm:affiliation>Laboratório de Bioenergética e Estresse Oxidativo (LABOX), Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Laboratório de Bioenergética e Estresse Oxidativo 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Federal de Santa Catarina, 88049-900, Florianópolis, Brazil. aderbal.aguiar@ufsc.br.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Laboratório Experimental de Doenças Neurodegenerativas (LEXDON), Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis</wicri:regionArea></affiliation></author><author><name sortKey="Duzzioni, Marcelo" sort="Duzzioni, Marcelo" uniqKey="Duzzioni M" first="Marcelo" last="Duzzioni">Marcelo Duzzioni</name><affiliation wicri:level="1"><nlm:affiliation>Laboratório Experimental de Doenças Neurodegenerativas (LEXDON), Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Laboratório Experimental de Doenças Neurodegenerativas (LEXDON), Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis</wicri:regionArea></affiliation></author><author><name sortKey="Remor, Aline Pertile" sort="Remor, Aline Pertile" uniqKey="Remor A" first="Aline Pertile" last="Remor">Aline Pertile Remor</name><affiliation wicri:level="1"><nlm:affiliation>Laboratório de Bioenergética e Estresse Oxidativo (LABOX), Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Laboratório de Bioenergética e Estresse Oxidativo (LABOX), Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis</wicri:regionArea></affiliation></author><author><name sortKey="Tristao, Fabrine Sales Massafera" sort="Tristao, Fabrine Sales Massafera" uniqKey="Tristao F" first="Fabrine Sales Massafera" last="Tristão">Fabrine Sales Massafera Tristão</name><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR 975 (ex U679), CNRS UMR 7225, Hôpital de la Salpêtrière-Bâtiment, ICM (Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, CRICM), Thérapeutique Expérimentale de la Neurodégénérescence, Université Pierre et Marie Curie (UPMC), 47 Boulevard de l'Hôpital, 75651, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR 975 (ex U679), CNRS UMR 7225, Hôpital de la Salpêtrière-Bâtiment, ICM (Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, CRICM), Thérapeutique Expérimentale de la Neurodégénérescence, Université Pierre et Marie Curie (UPMC), 47 Boulevard de l'Hôpital, 75651, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Matheus, Filipe C" sort="Matheus, Filipe C" uniqKey="Matheus F" first="Filipe C" last="Matheus">Filipe C. Matheus</name><affiliation wicri:level="1"><nlm:affiliation>Laboratório Experimental de Doenças Neurodegenerativas (LEXDON), Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Laboratório Experimental de Doenças Neurodegenerativas (LEXDON), Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis</wicri:regionArea></affiliation></author><author><name sortKey="Raisman Vozari, Rita" sort="Raisman Vozari, Rita" uniqKey="Raisman Vozari R" first="Rita" last="Raisman-Vozari">Rita Raisman-Vozari</name><affiliation wicri:level="1"><nlm:affiliation>INSERM UMR 975 (ex U679), CNRS UMR 7225, Hôpital de la Salpêtrière-Bâtiment, ICM (Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, CRICM), Thérapeutique Expérimentale de la Neurodégénérescence, Université Pierre et Marie Curie (UPMC), 47 Boulevard de l'Hôpital, 75651, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM UMR 975 (ex U679), CNRS UMR 7225, Hôpital de la Salpêtrière-Bâtiment, ICM (Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, CRICM), Thérapeutique Expérimentale de la Neurodégénérescence, Université Pierre et Marie Curie (UPMC), 47 Boulevard de l'Hôpital, 75651, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Latini, Alexandra" sort="Latini, Alexandra" uniqKey="Latini A" first="Alexandra" last="Latini">Alexandra Latini</name><affiliation wicri:level="1"><nlm:affiliation>Laboratório de Bioenergética e Estresse Oxidativo (LABOX), Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Laboratório de Bioenergética e Estresse Oxidativo (LABOX), Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis</wicri:regionArea></affiliation></author><author><name sortKey="Prediger, Rui Daniel" sort="Prediger, Rui Daniel" uniqKey="Prediger R" first="Rui Daniel" last="Prediger">Rui Daniel Prediger</name><affiliation wicri:level="1"><nlm:affiliation>Laboratório Experimental de Doenças Neurodegenerativas (LEXDON), Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Laboratório Experimental de Doenças Neurodegenerativas (LEXDON), Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis</wicri:regionArea></affiliation></author></analytic><series><title level="j">Neurochemical research</title><idno type="eISSN">1573-6903</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>NF-E2-Related Factor 2 (metabolism)</term><term>Oxidopamine (toxicity)</term><term>Parkinsonian Disorders (etiology)</term><term>Parkinsonian Disorders (metabolism)</term><term>Parkinsonian Disorders (prevention & control)</term><term>Physical Conditioning, Animal</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>NF-E2-Related Factor 2</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Oxidopamine</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Parkinsonian Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Male</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Physical Conditioning, Animal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Exercise improves the motor symptoms of patients with Parkinson disease in a palliative manner. Existing evidence demonstrates that exercise induces neuroprotection based on the neurotrophic properties. We investigated the effect of exercise on mitochondrial physiology and oxidative stress in an animal model of hemiparkinsonism.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26323504</PMID><DateCreated><Year>2016</Year><Month>03</Month><Day>02</Day></DateCreated><DateCompleted><Year>2016</Year><Month>11</Month><Day>02</Day></DateCompleted><DateRevised><Year>2016</Year><Month>12</Month><Day>30</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1573-6903</ISSN><JournalIssue CitedMedium="Internet"><Volume>41</Volume><Issue>1-2</Issue><PubDate><Year>2016</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Neurochemical research</Title><ISOAbbreviation>Neurochem. Res.</ISOAbbreviation></Journal><ArticleTitle>Moderate-Intensity Physical Exercise Protects Against Experimental 6-Hydroxydopamine-Induced Hemiparkinsonism Through Nrf2-Antioxidant Response Element Pathway.</ArticleTitle><Pagination><MedlinePgn>64-72</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s11064-015-1709-8</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Exercise improves the motor symptoms of patients with Parkinson disease in a palliative manner. Existing evidence demonstrates that exercise induces neuroprotection based on the neurotrophic properties. We investigated the effect of exercise on mitochondrial physiology and oxidative stress in an animal model of hemiparkinsonism.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">C57BL/6 mice completed a 6-week exercise program on a treadmill. We injected 6-hydroxydopamine (6-OHDA; 4 μg/2 μl) into the midstriatum. The animals progressively developed bradykinesia and R(-)-apomorphine-induced rotations that were attenuated by exercise. Transcriptional activation of protective genes is mediated by the antioxidant response element (ARE). Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) binds to ARE. We investigated the Nrf2-ARE pathway in the striatum of animals.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Exercise protected 6-OHDA-induced loss of tyrosine hydroxylase immunolabeling and activated the Nrf2-ARE pathway in the nigrostriatal pathway. Exercise stimulated mitochondrial biogenesis in the striatum of animals that was more resistant to oxidant 6-OHDA and nitric oxide donor (±)-S-nitroso-N-acetylpenicillamine.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">In mice, exercise activated Nrf2-ARE signaling in the nigrostriatal pathway that was protective against the development of hemiparkinsonism.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Aguiar</LastName><ForeName>Aderbal Silva</ForeName><Initials>AS</Initials><Suffix>Jr</Suffix><Identifier Source="ORCID">http://orcid.org/0000-0002-6825-3333</Identifier><AffiliationInfo><Affiliation>Laboratório Experimental de Doenças Neurodegenerativas (LEXDON), Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis, Brazil. aderbal.aguiar@ufsc.br.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Laboratório de Bioenergética e Estresse Oxidativo (LABOX), Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis, Brazil. aderbal.aguiar@ufsc.br.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Programa de Pós-Graduação em Neurociências, Universidade Federal de Santa Catarina, Florianópolis, Brazil. aderbal.aguiar@ufsc.br.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Duzzioni</LastName><ForeName>Marcelo</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Laboratório Experimental de Doenças Neurodegenerativas (LEXDON), Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Remor</LastName><ForeName>Aline Pertile</ForeName><Initials>AP</Initials><AffiliationInfo><Affiliation>Laboratório de Bioenergética e Estresse Oxidativo (LABOX), Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tristão</LastName><ForeName>Fabrine Sales Massafera</ForeName><Initials>FS</Initials><AffiliationInfo><Affiliation>INSERM UMR 975 (ex U679), CNRS UMR 7225, Hôpital de la Salpêtrière-Bâtiment, ICM (Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, CRICM), Thérapeutique Expérimentale de la Neurodégénérescence, Université Pierre et Marie Curie (UPMC), 47 Boulevard de l'Hôpital, 75651, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matheus</LastName><ForeName>Filipe C</ForeName><Initials>FC</Initials><AffiliationInfo><Affiliation>Laboratório Experimental de Doenças Neurodegenerativas (LEXDON), Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raisman-Vozari</LastName><ForeName>Rita</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>INSERM UMR 975 (ex U679), CNRS UMR 7225, Hôpital de la Salpêtrière-Bâtiment, ICM (Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière, CRICM), Thérapeutique Expérimentale de la Neurodégénérescence, Université Pierre et Marie Curie (UPMC), 47 Boulevard de l'Hôpital, 75651, Paris, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Latini</LastName><ForeName>Alexandra</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Laboratório de Bioenergética e Estresse Oxidativo (LABOX), Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Prediger</LastName><ForeName>Rui Daniel</ForeName><Initials>RD</Initials><AffiliationInfo><Affiliation>Laboratório Experimental de Doenças Neurodegenerativas (LEXDON), Departamento de Farmacologia, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, 88049-900, Florianópolis, Brazil.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>09</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Neurochem Res</MedlineTA><NlmUniqueID>7613461</NlmUniqueID><ISSNLinking>0364-3190</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051267">NF-E2-Related Factor 2</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C495636">Nfe2l2 protein, mouse</NameOfSubstance></Chemical><Chemical><RegistryNumber>8HW4YBZ748</RegistryNumber><NameOfSubstance UI="D016627">Oxidopamine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051267" MajorTopicYN="N">NF-E2-Related Factor 2</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016627" MajorTopicYN="N">Oxidopamine</DescriptorName><QualifierName UI="Q000633" MajorTopicYN="Y">toxicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020734" MajorTopicYN="N">Parkinsonian Disorders</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000517" MajorTopicYN="Y">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010805" MajorTopicYN="Y">Physical Conditioning, Animal</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">6-OHDA</Keyword><Keyword MajorTopicYN="N">Exercise</Keyword><Keyword MajorTopicYN="N">Mitochondria</Keyword><Keyword MajorTopicYN="N">Neuroprotection</Keyword><Keyword MajorTopicYN="N">Nrf2/ARE</Keyword><Keyword MajorTopicYN="N">Parkinson’s disease</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate 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