Dementia in Parkinson's disease: Biochemical evidence for cortical involvement using the immunodetection of abnormal tau proteins
Identifieur interne : 004B91 ( Main/Curation ); précédent : 004B90; suivant : 004B92Dementia in Parkinson's disease: Biochemical evidence for cortical involvement using the immunodetection of abnormal tau proteins
Auteurs : Patrick Vermersch ; Patrick Delacourte [France] ; France Javoy-Agid [France] ; Jean-Jacques Hauw [France] ; Yves Agid [France]Source :
- Annals of Neurology [ 0364-5134 ] ; 1993-05.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Adult, Aged, Aged, 80 and over, Alzheimer Disease (pathology), Blotting, Western, Cerebral Cortex (pathology), Complication, Dementia, Dementia (complications), Dementia (pathology), Human, Humans, Immunological investigation, Microtubule associated protein, Occipital Lobe (pathology), Organ Specificity, Parkinson Disease (complications), Parkinson Disease (pathology), Parkinson disease, Pathogenesis, Postmortem, tau Proteins (analysis).
- MESH :
- chemical , analysis : tau Proteins.
- complications : Dementia, Parkinson Disease.
- pathology : Alzheimer Disease, Cerebral Cortex, Dementia, Occipital Lobe, Parkinson Disease.
- Adult, Aged, Aged, 80 and over, Blotting, Western, Humans, Organ Specificity.
Abstract
In order to elucidate the neurochemical basis of the dementia of Parkinson's disease, we compared samples of cerebral cortex from 24 nondemented parkinsonian patients and parkinsonian patients with various degrees of dementia, with those from patients with Alzheimer's disease and control subjects, using a quantitative Western blot analysis. An anti‐paired helical filaments antibody was used for the immunodetection of the abnormally phosphorylated Tau proteins 55,64, and 69, which are known to be specific and reliable biochemical markers of Alzaheimer‐type neurofibrillary degeneration. The frequency and intensity of immunodetection of the abnormal Tau triplet were higher in the demented parkinsonian subgroups than in the nondemented parkinsonian subgroup in the prefrontal area, temporal cortex, and entorhinal cortex but not in either the occipital or the cingular cortex. A quantification of abnormal Tau triplet by densaitometry showed that unlike the results obtained in Alzheimer patients, the intensity of lesions in the cerebral cortex of the most demented parkinsonian patients was more severe in the prefrontal area versus the temporal area. This study (1) gives biochemical evidence for Alzheimer‐type changes in the cortex of demented parkinsonian patients and (2) suggests that lesions of the prefrontal cortex may significantly contribute to the occurrence of cognitive changes at least in some patients with Parkinson's disease.
Url:
DOI: 10.1002/ana.410330506
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Patrick Vermersch<affiliation><wicri:noCountry code="subField">Lille</wicri:noCountry>
</affiliation>
Le document en format XML
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<front><div type="abstract" xml:lang="en">In order to elucidate the neurochemical basis of the dementia of Parkinson's disease, we compared samples of cerebral cortex from 24 nondemented parkinsonian patients and parkinsonian patients with various degrees of dementia, with those from patients with Alzheimer's disease and control subjects, using a quantitative Western blot analysis. An anti‐paired helical filaments antibody was used for the immunodetection of the abnormally phosphorylated Tau proteins 55,64, and 69, which are known to be specific and reliable biochemical markers of Alzaheimer‐type neurofibrillary degeneration. The frequency and intensity of immunodetection of the abnormal Tau triplet were higher in the demented parkinsonian subgroups than in the nondemented parkinsonian subgroup in the prefrontal area, temporal cortex, and entorhinal cortex but not in either the occipital or the cingular cortex. A quantification of abnormal Tau triplet by densaitometry showed that unlike the results obtained in Alzheimer patients, the intensity of lesions in the cerebral cortex of the most demented parkinsonian patients was more severe in the prefrontal area versus the temporal area. This study (1) gives biochemical evidence for Alzheimer‐type changes in the cortex of demented parkinsonian patients and (2) suggests that lesions of the prefrontal cortex may significantly contribute to the occurrence of cognitive changes at least in some patients with Parkinson's disease.</div>
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<keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term>
<term>Homme</term>
<term>Complication</term>
<term>Démence</term>
<term>Pathogénie</term>
<term>Protéine associée tubuline</term>
<term>Exploration immunologique</term>
<term>Postmortem</term>
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<front><div type="abstract" xml:lang="en">In order to elucidate the neurochemical basis of the dementia of Parkinson's disease, we compared samples of cerebral cortex from 24 nondemented parkinsonian patients and parkinsonian patients with various degrees of dementia, with those from patients with Alzheimer's disease and control subjects, using a quantitative Western blot analysis. An anti-paired helical filaments antibody was used for the immunodetection of the abnormally phosphorylated Tau proteins 55, 64, and 69, which are known to be specific and reliable biochemical markers of Alzheimer-type neurofibrillary degeneration</div>
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</author>
<author><name sortKey="Delacourte, Patrick" sort="Delacourte, Patrick" uniqKey="Delacourte P" first="Patrick" last="Delacourte">Patrick Delacourte</name>
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<author><name sortKey="Javoy Gid, France" sort="Javoy Gid, France" uniqKey="Javoy Gid F" first="France" last="Javoy-Agid">France Javoy-Agid</name>
</author>
<author><name sortKey="Hauw, Jean Acques" sort="Hauw, Jean Acques" uniqKey="Hauw J" first="Jean-Jacques" last="Hauw">Jean-Jacques Hauw</name>
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<author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
<affiliation><country>France</country>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
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<author><name sortKey="Delacourte, Patrick" sort="Delacourte, Patrick" uniqKey="Delacourte P" first="Patrick" last="Delacourte">Patrick Delacourte</name>
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<author><name sortKey="Hauw, Jean Acques" sort="Hauw, Jean Acques" uniqKey="Hauw J" first="Jean-Jacques" last="Hauw">Jean-Jacques Hauw</name>
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<series><title level="j">Annals of Neurology</title>
<title level="j" type="sub">Official Journal of the American Neurological Association and the Child Neurology Society</title>
<title level="j" type="abbrev">Ann Neurol.</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Alzheimer Disease (pathology)</term>
<term>Blotting, Western</term>
<term>Cerebral Cortex (pathology)</term>
<term>Dementia (complications)</term>
<term>Dementia (pathology)</term>
<term>Humans</term>
<term>Occipital Lobe (pathology)</term>
<term>Organ Specificity</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (pathology)</term>
<term>tau Proteins (analysis)</term>
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<term>Parkinson Disease</term>
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<term>Cerebral Cortex</term>
<term>Dementia</term>
<term>Occipital Lobe</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Blotting, Western</term>
<term>Humans</term>
<term>Organ Specificity</term>
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<front><div type="abstract" xml:lang="en">In order to elucidate the neurochemical basis of the dementia of Parkinson's disease, we compared samples of cerebral cortex from 24 nondemented parkinsonian patients and parkinsonian patients with various degrees of dementia, with those from patients with Alzheimer's disease and control subjects, using a quantitative Western blot analysis. An anti‐paired helical filaments antibody was used for the immunodetection of the abnormally phosphorylated Tau proteins 55,64, and 69, which are known to be specific and reliable biochemical markers of Alzaheimer‐type neurofibrillary degeneration. The frequency and intensity of immunodetection of the abnormal Tau triplet were higher in the demented parkinsonian subgroups than in the nondemented parkinsonian subgroup in the prefrontal area, temporal cortex, and entorhinal cortex but not in either the occipital or the cingular cortex. A quantification of abnormal Tau triplet by densaitometry showed that unlike the results obtained in Alzheimer patients, the intensity of lesions in the cerebral cortex of the most demented parkinsonian patients was more severe in the prefrontal area versus the temporal area. This study (1) gives biochemical evidence for Alzheimer‐type changes in the cortex of demented parkinsonian patients and (2) suggests that lesions of the prefrontal cortex may significantly contribute to the occurrence of cognitive changes at least in some patients with Parkinson's disease.</div>
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