Differential modulation of hepatic cytochrome P‐450 enzymes in rat and syrian hamster by 4′‐trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl
Identifieur interne : 004A29 ( Main/Curation ); précédent : 004A28; suivant : 004A30Differential modulation of hepatic cytochrome P‐450 enzymes in rat and syrian hamster by 4′‐trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl
Auteurs : Marie-Hélène Bani [France] ; Marie-Hélène Narbonne [France] ; Morio Fukuhara [Japon] ; Fusao Ushio [Japon] ; Larry W. Robertson [États-Unis]Source :
- Journal of Biochemical Toxicology [ 0887-2082 ] ; 1994-10.
English descriptors
- KwdEn :
Abstract
The effects of a single injection (40 mg/kg) of 4′‐trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl (CF3) on hepatic cytochrome P‐450 monooxygenases were assessed in rat and syrian hamster. The CF3 treatment significantly increased the total amount of cytochrome P‐450 in both species. In rats, CF3 treatment caused marked increases in ethoxyresorufin O‐deethylase (EROD), arylhydrocarbon hydroxylase (AHH), and testosterone 7α‐hydroxylase activities but significantly reduced the activities of benzphetamine N‐demethylase (BzND), erythromycin N‐demethylase (ErND), testosterone 6β, 16α, and 16β‐hydroxylases, and formation of androstenedione. Administration of CF3 to hamsters strongly induced the activities of EROD, AHH, BzND, testosterone 15α, and 16α‐hydroxylases, and androstenedione production, whereas ErND, testosterone 6β, and 7α‐hydroxylases were decreased. Administration of CF3 to rats induced the CYP1A family proteins and CYP2A1, while CF3 reduced the level of CYP2B1, and, to a lesser extent, of CYP6β2. In hamsters, CF3 treatment significantly induced the CYP1A2, CYP2A1, CYP2A8, and CYP2B1 isozymes, whereas the CYP6β2 level was decreased. The ability of hepatic microsomes to activate aflatoxin B1 and benzo(a)pyrene was elevated by CF3 treatment in hamsters, while activation of aflatoxin B1 was decreased in microsomes from CF3‐treated rats. These results showed differences in the CF3‐induced pattern of rat and hamster cytochrome P‐450 monooxygenases.
Url:
DOI: 10.1002/jbt.2570090504
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001442
- to stream Istex, to step Curation: Pour aller vers cette notice dans l'étape Curation :001440
- to stream Istex, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001A79
- to stream Main, to step Merge: Pour aller vers cette notice dans l'étape Curation :005383
Links to Exploration step
ISTEX:B008AF1592C7A972C513D27AEAFC4B06293EC1AELe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Differential modulation of hepatic cytochrome P‐450 enzymes in rat and syrian hamster by 4′‐trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl</title><author><name sortKey="Bani, Marie Elene" sort="Bani, Marie Elene" uniqKey="Bani M" first="Marie-Hélène" last="Bani">Marie-Hélène Bani</name></author><author><name sortKey="Narbonne, Marie Elene" sort="Narbonne, Marie Elene" uniqKey="Narbonne M" first="Marie-Hélène" last="Narbonne">Marie-Hélène Narbonne</name></author><author><name sortKey="Fukuhara, Morio" sort="Fukuhara, Morio" uniqKey="Fukuhara M" first="Morio" last="Fukuhara">Morio Fukuhara</name></author><author><name sortKey="Ushio, Fusao" sort="Ushio, Fusao" uniqKey="Ushio F" first="Fusao" last="Ushio">Fusao Ushio</name></author><author><name sortKey="Robertson, Larry W" sort="Robertson, Larry W" uniqKey="Robertson L" first="Larry W." last="Robertson">Larry W. Robertson</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B008AF1592C7A972C513D27AEAFC4B06293EC1AE</idno><date when="1994" year="1994">1994</date><idno type="doi">10.1002/jbt.2570090504</idno><idno type="url">https://api.istex.fr/document/B008AF1592C7A972C513D27AEAFC4B06293EC1AE/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001442</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001442</idno><idno type="wicri:Area/Istex/Curation">001440</idno><idno type="wicri:Area/Istex/Checkpoint">001A79</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001A79</idno><idno type="wicri:doubleKey">0887-2082:1994:Bani M:differential:modulation:of</idno><idno type="wicri:Area/Main/Merge">005383</idno><idno type="wicri:Area/Main/Curation">004A29</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Differential modulation of hepatic cytochrome P‐450 enzymes in rat and syrian hamster by 4′‐trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl</title><author><name sortKey="Bani, Marie Elene" sort="Bani, Marie Elene" uniqKey="Bani M" first="Marie-Hélène" last="Bani">Marie-Hélène Bani</name><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Toxicologie Alimentaire, Université Bordeaux I, 33405 Talence</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Talence</settlement></placeName><orgName type="university">Université Bordeaux I</orgName></affiliation></author><author><name sortKey="Narbonne, Marie Elene" sort="Narbonne, Marie Elene" uniqKey="Narbonne M" first="Marie-Hélène" last="Narbonne">Marie-Hélène Narbonne</name><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Toxicologie Alimentaire, Université Bordeaux I, 33405 Talence</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Talence</settlement></placeName><orgName type="university">Université Bordeaux I</orgName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Laboratoire de Toxicologie Alimentaire, Université Bordeaux I, Avenue des Facultés, F‐33405 Talence Cédex</wicri:regionArea><placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region><settlement type="city">Talence Cédex</settlement></placeName><orgName type="university">Université Bordeaux I</orgName></affiliation></author><author><name sortKey="Fukuhara, Morio" sort="Fukuhara, Morio" uniqKey="Fukuhara M" first="Morio" last="Fukuhara">Morio Fukuhara</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pharmaceutical Sciences, National Institute of Public Health, Minato‐Ku, Tokyo 108</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Ushio, Fusao" sort="Ushio, Fusao" uniqKey="Ushio F" first="Fusao" last="Ushio">Fusao Ushio</name><affiliation wicri:level="1"><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Nutrition, Tokyo Metropolitan Research Laboratory of Public Health, Shinjuku‐Ku, Tokyo 169</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Robertson, Larry W" sort="Robertson, Larry W" uniqKey="Robertson L" first="Larry W." last="Robertson">Larry W. Robertson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Kentucky</region></placeName><wicri:cityArea>Graduate Center for Toxicology, University of Kentucky, Lexington</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Biochemical Toxicology</title><title level="j" type="abbrev">J. Biochem. Toxicol.</title><idno type="ISSN">0887-2082</idno><idno type="eISSN">1522-7146</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Weinheim</pubPlace><date type="published" when="1994-10">1994-10</date><biblScope unit="volume">9</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="241">241</biblScope><biblScope unit="page" to="248">248</biblScope></imprint><idno type="ISSN">0887-2082</idno></series><idno type="istex">B008AF1592C7A972C513D27AEAFC4B06293EC1AE</idno><idno type="DOI">10.1002/jbt.2570090504</idno><idno type="ArticleID">JBT2570090504</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0887-2082</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>4′‐Trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl (CF3)</term><term>Cytochrome P‐450</term><term>Enzyme Induction</term><term>Hamster</term><term>Rat</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effects of a single injection (40 mg/kg) of 4′‐trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl (CF3) on hepatic cytochrome P‐450 monooxygenases were assessed in rat and syrian hamster. The CF3 treatment significantly increased the total amount of cytochrome P‐450 in both species. In rats, CF3 treatment caused marked increases in ethoxyresorufin O‐deethylase (EROD), arylhydrocarbon hydroxylase (AHH), and testosterone 7α‐hydroxylase activities but significantly reduced the activities of benzphetamine N‐demethylase (BzND), erythromycin N‐demethylase (ErND), testosterone 6β, 16α, and 16β‐hydroxylases, and formation of androstenedione. Administration of CF3 to hamsters strongly induced the activities of EROD, AHH, BzND, testosterone 15α, and 16α‐hydroxylases, and androstenedione production, whereas ErND, testosterone 6β, and 7α‐hydroxylases were decreased. Administration of CF3 to rats induced the CYP1A family proteins and CYP2A1, while CF3 reduced the level of CYP2B1, and, to a lesser extent, of CYP6β2. In hamsters, CF3 treatment significantly induced the CYP1A2, CYP2A1, CYP2A8, and CYP2B1 isozymes, whereas the CYP6β2 level was decreased. The ability of hepatic microsomes to activate aflatoxin B1 and benzo(a)pyrene was elevated by CF3 treatment in hamsters, while activation of aflatoxin B1 was decreased in microsomes from CF3‐treated rats. These results showed differences in the CF3‐induced pattern of rat and hamster cytochrome P‐450 monooxygenases.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004A29 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Curation/biblio.hfd -nk 004A29 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Main
|étape= Curation
|type= RBID
|clé= ISTEX:B008AF1592C7A972C513D27AEAFC4B06293EC1AE
|texte= Differential modulation of hepatic cytochrome P‐450 enzymes in rat and syrian hamster by 4′‐trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl
}}
| This area was generated with Dilib version V0.6.29. |  |