Differential modulation of hepatic cytochrome P‐450 enzymes in rat and syrian hamster by 4′‐trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl
Identifieur interne : 001442 ( Istex/Corpus ); précédent : 001441; suivant : 001443Differential modulation of hepatic cytochrome P‐450 enzymes in rat and syrian hamster by 4′‐trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl
Auteurs : Marie-Hélène Bani ; Marie-Hélène Narbonne ; Morio Fukuhara ; Fusao Ushio ; Larry W. RobertsonSource :
- Journal of Biochemical Toxicology [ 0887-2082 ] ; 1994-10.
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Abstract
The effects of a single injection (40 mg/kg) of 4′‐trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl (CF3) on hepatic cytochrome P‐450 monooxygenases were assessed in rat and syrian hamster. The CF3 treatment significantly increased the total amount of cytochrome P‐450 in both species. In rats, CF3 treatment caused marked increases in ethoxyresorufin O‐deethylase (EROD), arylhydrocarbon hydroxylase (AHH), and testosterone 7α‐hydroxylase activities but significantly reduced the activities of benzphetamine N‐demethylase (BzND), erythromycin N‐demethylase (ErND), testosterone 6β, 16α, and 16β‐hydroxylases, and formation of androstenedione. Administration of CF3 to hamsters strongly induced the activities of EROD, AHH, BzND, testosterone 15α, and 16α‐hydroxylases, and androstenedione production, whereas ErND, testosterone 6β, and 7α‐hydroxylases were decreased. Administration of CF3 to rats induced the CYP1A family proteins and CYP2A1, while CF3 reduced the level of CYP2B1, and, to a lesser extent, of CYP6β2. In hamsters, CF3 treatment significantly induced the CYP1A2, CYP2A1, CYP2A8, and CYP2B1 isozymes, whereas the CYP6β2 level was decreased. The ability of hepatic microsomes to activate aflatoxin B1 and benzo(a)pyrene was elevated by CF3 treatment in hamsters, while activation of aflatoxin B1 was decreased in microsomes from CF3‐treated rats. These results showed differences in the CF3‐induced pattern of rat and hamster cytochrome P‐450 monooxygenases.
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DOI: 10.1002/jbt.2570090504
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Differential modulation of hepatic cytochrome P‐450 enzymes in rat and syrian hamster by 4′‐trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl</title><author><name sortKey="Bani, Marie Elene" sort="Bani, Marie Elene" uniqKey="Bani M" first="Marie-Hélène" last="Bani">Marie-Hélène Bani</name><affiliation><mods:affiliation>Laboratoire de Toxicologie Alimentaire, Université Bordeaux I, 33405 Talence, France</mods:affiliation></affiliation></author><author><name sortKey="Narbonne, Marie Elene" sort="Narbonne, Marie Elene" uniqKey="Narbonne M" first="Marie-Hélène" last="Narbonne">Marie-Hélène Narbonne</name><affiliation><mods:affiliation>Laboratoire de Toxicologie Alimentaire, Université Bordeaux I, 33405 Talence, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Laboratoire de Toxicologie Alimentaire, Université Bordeaux I, Avenue des Facultés, F‐33405 Talence Cédex, France</mods:affiliation></affiliation></author><author><name sortKey="Fukuhara, Morio" sort="Fukuhara, Morio" uniqKey="Fukuhara M" first="Morio" last="Fukuhara">Morio Fukuhara</name><affiliation><mods:affiliation>Department of Pharmaceutical Sciences, National Institute of Public Health, Minato‐Ku, Tokyo 108, Japan</mods:affiliation></affiliation></author><author><name sortKey="Ushio, Fusao" sort="Ushio, Fusao" uniqKey="Ushio F" first="Fusao" last="Ushio">Fusao Ushio</name><affiliation><mods:affiliation>Department of Nutrition, Tokyo Metropolitan Research Laboratory of Public Health, Shinjuku‐Ku, Tokyo 169, Japan</mods:affiliation></affiliation></author><author><name sortKey="Robertson, Larry W" sort="Robertson, Larry W" uniqKey="Robertson L" first="Larry W." last="Robertson">Larry W. Robertson</name><affiliation><mods:affiliation>Graduate Center for Toxicology, University of Kentucky, Lexington, KY</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B008AF1592C7A972C513D27AEAFC4B06293EC1AE</idno><date when="1994" year="1994">1994</date><idno type="doi">10.1002/jbt.2570090504</idno><idno type="url">https://api.istex.fr/document/B008AF1592C7A972C513D27AEAFC4B06293EC1AE/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001442</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001442</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Differential modulation of hepatic cytochrome P‐450 enzymes in rat and syrian hamster by 4′‐trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl</title><author><name sortKey="Bani, Marie Elene" sort="Bani, Marie Elene" uniqKey="Bani M" first="Marie-Hélène" last="Bani">Marie-Hélène Bani</name><affiliation><mods:affiliation>Laboratoire de Toxicologie Alimentaire, Université Bordeaux I, 33405 Talence, France</mods:affiliation></affiliation></author><author><name sortKey="Narbonne, Marie Elene" sort="Narbonne, Marie Elene" uniqKey="Narbonne M" first="Marie-Hélène" last="Narbonne">Marie-Hélène Narbonne</name><affiliation><mods:affiliation>Laboratoire de Toxicologie Alimentaire, Université Bordeaux I, 33405 Talence, France</mods:affiliation></affiliation><affiliation><mods:affiliation>Laboratoire de Toxicologie Alimentaire, Université Bordeaux I, Avenue des Facultés, F‐33405 Talence Cédex, France</mods:affiliation></affiliation></author><author><name sortKey="Fukuhara, Morio" sort="Fukuhara, Morio" uniqKey="Fukuhara M" first="Morio" last="Fukuhara">Morio Fukuhara</name><affiliation><mods:affiliation>Department of Pharmaceutical Sciences, National Institute of Public Health, Minato‐Ku, Tokyo 108, Japan</mods:affiliation></affiliation></author><author><name sortKey="Ushio, Fusao" sort="Ushio, Fusao" uniqKey="Ushio F" first="Fusao" last="Ushio">Fusao Ushio</name><affiliation><mods:affiliation>Department of Nutrition, Tokyo Metropolitan Research Laboratory of Public Health, Shinjuku‐Ku, Tokyo 169, Japan</mods:affiliation></affiliation></author><author><name sortKey="Robertson, Larry W" sort="Robertson, Larry W" uniqKey="Robertson L" first="Larry W." last="Robertson">Larry W. Robertson</name><affiliation><mods:affiliation>Graduate Center for Toxicology, University of Kentucky, Lexington, KY</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Biochemical Toxicology</title><title level="j" type="abbrev">J. Biochem. Toxicol.</title><idno type="ISSN">0887-2082</idno><idno type="eISSN">1522-7146</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Weinheim</pubPlace><date type="published" when="1994-10">1994-10</date><biblScope unit="volume">9</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="241">241</biblScope><biblScope unit="page" to="248">248</biblScope></imprint><idno type="ISSN">0887-2082</idno></series><idno type="istex">B008AF1592C7A972C513D27AEAFC4B06293EC1AE</idno><idno type="DOI">10.1002/jbt.2570090504</idno><idno type="ArticleID">JBT2570090504</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0887-2082</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>4′‐Trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl (CF3)</term><term>Cytochrome P‐450</term><term>Enzyme Induction</term><term>Hamster</term><term>Rat</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effects of a single injection (40 mg/kg) of 4′‐trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl (CF3) on hepatic cytochrome P‐450 monooxygenases were assessed in rat and syrian hamster. The CF3 treatment significantly increased the total amount of cytochrome P‐450 in both species. In rats, CF3 treatment caused marked increases in ethoxyresorufin O‐deethylase (EROD), arylhydrocarbon hydroxylase (AHH), and testosterone 7α‐hydroxylase activities but significantly reduced the activities of benzphetamine N‐demethylase (BzND), erythromycin N‐demethylase (ErND), testosterone 6β, 16α, and 16β‐hydroxylases, and formation of androstenedione. Administration of CF3 to hamsters strongly induced the activities of EROD, AHH, BzND, testosterone 15α, and 16α‐hydroxylases, and androstenedione production, whereas ErND, testosterone 6β, and 7α‐hydroxylases were decreased. Administration of CF3 to rats induced the CYP1A family proteins and CYP2A1, while CF3 reduced the level of CYP2B1, and, to a lesser extent, of CYP6β2. In hamsters, CF3 treatment significantly induced the CYP1A2, CYP2A1, CYP2A8, and CYP2B1 isozymes, whereas the CYP6β2 level was decreased. The ability of hepatic microsomes to activate aflatoxin B1 and benzo(a)pyrene was elevated by CF3 treatment in hamsters, while activation of aflatoxin B1 was decreased in microsomes from CF3‐treated rats. These results showed differences in the CF3‐induced pattern of rat and hamster cytochrome P‐450 monooxygenases.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Marie‐Hélène Bani</name><affiliations><json:string>Laboratoire de Toxicologie Alimentaire, Université Bordeaux I, 33405 Talence, France</json:string></affiliations></json:item><json:item><name>Professor Narbonne</name><affiliations><json:string>Laboratoire de Toxicologie Alimentaire, Université Bordeaux I, 33405 Talence, France</json:string><json:string>Laboratoire de Toxicologie Alimentaire, Université Bordeaux I, Avenue des Facultés, F‐33405 Talence Cédex, France</json:string></affiliations></json:item><json:item><name>Morio Fukuhara</name><affiliations><json:string>Department of Pharmaceutical Sciences, National Institute of Public Health, Minato‐Ku, Tokyo 108, Japan</json:string></affiliations></json:item><json:item><name>Fusao Ushio</name><affiliations><json:string>Department of Nutrition, Tokyo Metropolitan Research Laboratory of Public Health, Shinjuku‐Ku, Tokyo 169, Japan</json:string></affiliations></json:item><json:item><name>Larry W. Robertson</name><affiliations><json:string>Graduate Center for Toxicology, University of Kentucky, Lexington, KY</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>4′‐Trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl (CF3)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Cytochrome P‐450</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Rat</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Hamster</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Enzyme Induction</value></json:item></subject><articleId><json:string>JBT2570090504</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>The effects of a single injection (40 mg/kg) of 4′‐trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl (CF3) on hepatic cytochrome P‐450 monooxygenases were assessed in rat and syrian hamster. The CF3 treatment significantly increased the total amount of cytochrome P‐450 in both species. In rats, CF3 treatment caused marked increases in ethoxyresorufin O‐deethylase (EROD), arylhydrocarbon hydroxylase (AHH), and testosterone 7α‐hydroxylase activities but significantly reduced the activities of benzphetamine N‐demethylase (BzND), erythromycin N‐demethylase (ErND), testosterone 6β, 16α, and 16β‐hydroxylases, and formation of androstenedione. Administration of CF3 to hamsters strongly induced the activities of EROD, AHH, BzND, testosterone 15α, and 16α‐hydroxylases, and androstenedione production, whereas ErND, testosterone 6β, and 7α‐hydroxylases were decreased. Administration of CF3 to rats induced the CYP1A family proteins and CYP2A1, while CF3 reduced the level of CYP2B1, and, to a lesser extent, of CYP6β2. In hamsters, CF3 treatment significantly induced the CYP1A2, CYP2A1, CYP2A8, and CYP2B1 isozymes, whereas the CYP6β2 level was decreased. The ability of hepatic microsomes to activate aflatoxin B1 and benzo(a)pyrene was elevated by CF3 treatment in hamsters, while activation of aflatoxin B1 was decreased in microsomes from CF3‐treated rats. These results showed differences in the CF3‐induced pattern of rat and hamster cytochrome P‐450 monooxygenases.</abstract><qualityIndicators><score>6.907</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 792 pts (letter)</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1469</abstractCharCount><pdfWordCount>4579</pdfWordCount><pdfCharCount>30173</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>194</abstractWordCount></qualityIndicators><title>Differential modulation of hepatic cytochrome P‐450 enzymes in rat and syrian hamster by 4′‐trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl</title><refBibs><json:item><author><json:item><name>F. P. Guengerich</name></json:item><json:item><name>G. A. Dannan</name></json:item><json:item><name>S. J. 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Biochem. Toxicol.</title><idno type="pISSN">0887-2082</idno><idno type="eISSN">1522-7146</idno><idno type="DOI">10.1002/(ISSN)1522-7146</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Weinheim</pubPlace><date type="published" when="1994-10"></date><biblScope unit="volume">9</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="241">241</biblScope><biblScope unit="page" to="248">248</biblScope></imprint></monogr><idno type="istex">B008AF1592C7A972C513D27AEAFC4B06293EC1AE</idno><idno type="DOI">10.1002/jbt.2570090504</idno><idno type="ArticleID">JBT2570090504</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1994</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The effects of a single injection (40 mg/kg) of 4′‐trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl (CF3) on hepatic cytochrome P‐450 monooxygenases were assessed in rat and syrian hamster. The CF3 treatment significantly increased the total amount of cytochrome P‐450 in both species. In rats, CF3 treatment caused marked increases in ethoxyresorufin O‐deethylase (EROD), arylhydrocarbon hydroxylase (AHH), and testosterone 7α‐hydroxylase activities but significantly reduced the activities of benzphetamine N‐demethylase (BzND), erythromycin N‐demethylase (ErND), testosterone 6β, 16α, and 16β‐hydroxylases, and formation of androstenedione. Administration of CF3 to hamsters strongly induced the activities of EROD, AHH, BzND, testosterone 15α, and 16α‐hydroxylases, and androstenedione production, whereas ErND, testosterone 6β, and 7α‐hydroxylases were decreased. Administration of CF3 to rats induced the CYP1A family proteins and CYP2A1, while CF3 reduced the level of CYP2B1, and, to a lesser extent, of CYP6β2. In hamsters, CF3 treatment significantly induced the CYP1A2, CYP2A1, CYP2A8, and CYP2B1 isozymes, whereas the CYP6β2 level was decreased. The ability of hepatic microsomes to activate aflatoxin B1 and benzo(a)pyrene was elevated by CF3 treatment in hamsters, while activation of aflatoxin B1 was decreased in microsomes from CF3‐treated rats. These results showed differences in the CF3‐induced pattern of rat and hamster cytochrome P‐450 monooxygenases.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>4′‐Trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl (CF3)</term></item><item><term>Cytochrome P‐450</term></item><item><term>Rat</term></item><item><term>Hamster</term></item><item><term>Enzyme Induction</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Article</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1994-02-23">Received</change><change when="1994-10">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/B008AF1592C7A972C513D27AEAFC4B06293EC1AE/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Weinheim</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1522-7146</doi><issn type="print">0887-2082</issn><issn type="electronic">1522-7146</issn><idGroup><id type="product" value="JBT"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="JOURNAL OF BIOCHEMICAL TOXICOLOGY">Journal of Biochemical Toxicology</title><title type="short">J. Biochem. Toxicol.</title></titleGroup></publicationMeta><publicationMeta level="part" position="50"><doi origin="wiley" registered="yes">10.1002/jbt.v9:5</doi><numberingGroup><numbering type="journalVolume" number="9">9</numbering><numbering type="journalIssue">5</numbering></numberingGroup><coverDate startDate="1994-10">October 1994</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="4" status="forIssue"><doi origin="wiley" registered="yes">10.1002/jbt.2570090504</doi><idGroup><id type="unit" value="JBT2570090504"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="articleCategory">Article</title><title type="tocHeading1">Articles</title></titleGroup><copyright ownership="publisher">Copyright © 1994 Wiley‐Liss, Inc., A Wiley Company</copyright><eventGroup><event type="manuscriptReceived" date="1994-02-23"></event><event type="firstOnline" date="2006-06-09"></event><event type="publishedOnlineFinalForm" date="2006-06-09"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-06"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-29"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-24"></event></eventGroup><numberingGroup><numbering type="pageFirst">241</numbering><numbering type="pageLast">248</numbering></numberingGroup><correspondenceTo>Laboratoire de Toxicologie Alimentaire, Université Bordeaux I, Avenue des Facultés, F‐33405 Talence Cédex, France</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JBT.JBT2570090504.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="57"></count></countGroup><titleGroup><title type="main" xml:lang="en">Differential modulation of hepatic cytochrome P‐450 enzymes in rat and syrian hamster by 4′‐trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl</title><title type="short" xml:lang="en">(CF3) ON RAT HAMSTER HEPATIC CYTOCHROME P‐450</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Marie‐Hélène</givenNames><familyName>Bani</familyName></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><honorifics>Professor</honorifics><givenNames>Jean‐Franco̧is</givenNames><familyName>Narbonne</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Morio</givenNames><familyName>Fukuhara</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af3"><personName><givenNames>Fusao</givenNames><familyName>Ushio</familyName></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af4"><personName><givenNames>Larry W.</givenNames><familyName>Robertson</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="FR" type="organization"><unparsedAffiliation>Laboratoire de Toxicologie Alimentaire, Université Bordeaux I, 33405 Talence, France</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="JP" type="organization"><unparsedAffiliation>Department of Pharmaceutical Sciences, National Institute of Public Health, Minato‐Ku, Tokyo 108, Japan</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="JP" type="organization"><unparsedAffiliation>Department of Nutrition, Tokyo Metropolitan Research Laboratory of Public Health, Shinjuku‐Ku, Tokyo 169, Japan</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="US" type="organization"><unparsedAffiliation>Graduate Center for Toxicology, University of Kentucky, Lexington, KY</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">4′‐Trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl (CF3)</keyword><keyword xml:id="kwd2">Cytochrome P‐450</keyword><keyword xml:id="kwd3">Rat</keyword><keyword xml:id="kwd4">Hamster</keyword><keyword xml:id="kwd5">Enzyme Induction</keyword></keywordGroup><fundingInfo><fundingAgency>Ministère de la Recherche et de l'Environnement (France)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Science and technology Agency of Japan (Japan)</fundingAgency></fundingInfo><fundingInfo><fundingAgency>NATO Collaborative Research Grant (Belgium)</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The effects of a single injection (40 mg/kg) of 4′‐trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl (CF3) on hepatic cytochrome P‐450 monooxygenases were assessed in rat and syrian hamster. The CF3 treatment significantly increased the total amount of cytochrome P‐450 in both species. In rats, CF3 treatment caused marked increases in ethoxyresorufin <i>O</i>‐deethylase (EROD), arylhydrocarbon hydroxylase (AHH), and testosterone 7α‐hydroxylase activities but significantly reduced the activities of benzphetamine <i>N</i>‐demethylase (BzND), erythromycin <i>N</i>‐demethylase (ErND), testosterone 6β, 16α, and 16β‐hydroxylases, and formation of androstenedione. Administration of CF3 to hamsters strongly induced the activities of EROD, AHH, BzND, testosterone 15α, and 16α‐hydroxylases, and androstenedione production, whereas ErND, testosterone 6β, and 7α‐hydroxylases were decreased. Administration of CF3 to rats induced the CYP1A family proteins and CYP2A1, while CF3 reduced the level of CYP2B1, and, to a lesser extent, of CYP6β2. In hamsters, CF3 treatment significantly induced the CYP1A2, CYP2A1, CYP2A8, and CYP2B1 isozymes, whereas the CYP6β2 level was decreased. The ability of hepatic microsomes to activate aflatoxin B1 and benzo(<i>a</i>)pyrene was elevated by CF3 treatment in hamsters, while activation of aflatoxin B1 was decreased in microsomes from CF3‐treated rats. These results showed differences in the CF3‐induced pattern of rat and hamster cytochrome P‐450 monooxygenases.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Differential modulation of hepatic cytochrome P‐450 enzymes in rat and syrian hamster by 4′‐trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>(CF3) ON RAT HAMSTER HEPATIC CYTOCHROME P‐450</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Differential modulation of hepatic cytochrome P‐450 enzymes in rat and syrian hamster by 4′‐trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl</title></titleInfo><name type="personal"><namePart type="given">Marie‐Hélène</namePart><namePart type="family">Bani</namePart><affiliation>Laboratoire de Toxicologie Alimentaire, Université Bordeaux I, 33405 Talence, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="termsOfAddress">Professor</namePart><namePart type="family">Narbonne</namePart><affiliation>Laboratoire de Toxicologie Alimentaire, Université Bordeaux I, 33405 Talence, France</affiliation><affiliation>Laboratoire de Toxicologie Alimentaire, Université Bordeaux I, Avenue des Facultés, F‐33405 Talence Cédex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Morio</namePart><namePart type="family">Fukuhara</namePart><affiliation>Department of Pharmaceutical Sciences, National Institute of Public Health, Minato‐Ku, Tokyo 108, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Fusao</namePart><namePart type="family">Ushio</namePart><affiliation>Department of Nutrition, Tokyo Metropolitan Research Laboratory of Public Health, Shinjuku‐Ku, Tokyo 169, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Larry W.</namePart><namePart type="family">Robertson</namePart><affiliation>Graduate Center for Toxicology, University of Kentucky, Lexington, KY</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Weinheim</placeTerm></place><dateIssued encoding="w3cdtf">1994-10</dateIssued><dateCaptured encoding="w3cdtf">1994-02-23</dateCaptured><copyrightDate encoding="w3cdtf">1994</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">2</extent><extent unit="references">57</extent></physicalDescription><abstract lang="en">The effects of a single injection (40 mg/kg) of 4′‐trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl (CF3) on hepatic cytochrome P‐450 monooxygenases were assessed in rat and syrian hamster. The CF3 treatment significantly increased the total amount of cytochrome P‐450 in both species. In rats, CF3 treatment caused marked increases in ethoxyresorufin O‐deethylase (EROD), arylhydrocarbon hydroxylase (AHH), and testosterone 7α‐hydroxylase activities but significantly reduced the activities of benzphetamine N‐demethylase (BzND), erythromycin N‐demethylase (ErND), testosterone 6β, 16α, and 16β‐hydroxylases, and formation of androstenedione. Administration of CF3 to hamsters strongly induced the activities of EROD, AHH, BzND, testosterone 15α, and 16α‐hydroxylases, and androstenedione production, whereas ErND, testosterone 6β, and 7α‐hydroxylases were decreased. Administration of CF3 to rats induced the CYP1A family proteins and CYP2A1, while CF3 reduced the level of CYP2B1, and, to a lesser extent, of CYP6β2. In hamsters, CF3 treatment significantly induced the CYP1A2, CYP2A1, CYP2A8, and CYP2B1 isozymes, whereas the CYP6β2 level was decreased. The ability of hepatic microsomes to activate aflatoxin B1 and benzo(a)pyrene was elevated by CF3 treatment in hamsters, while activation of aflatoxin B1 was decreased in microsomes from CF3‐treated rats. These results showed differences in the CF3‐induced pattern of rat and hamster cytochrome P‐450 monooxygenases.</abstract><note type="funding">Ministère de la Recherche et de l'Environnement (France)</note><note type="funding">Science and technology Agency of Japan (Japan)</note><note type="funding">NATO Collaborative Research Grant (Belgium)</note><subject lang="en"><genre>keywords</genre><topic>4′‐Trifluoromethyl‐2,3,4,5‐tetrachlorobiphenyl (CF3)</topic><topic>Cytochrome P‐450</topic><topic>Rat</topic><topic>Hamster</topic><topic>Enzyme Induction</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Biochemical Toxicology</title></titleInfo><titleInfo type="abbreviated"><title>J. Biochem. Toxicol.</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Article</topic></subject><identifier type="ISSN">0887-2082</identifier><identifier type="eISSN">1522-7146</identifier><identifier type="DOI">10.1002/(ISSN)1522-7146</identifier><identifier type="PublisherID">JBT</identifier><part><date>1994</date><detail type="volume"><caption>vol.</caption><number>9</number></detail><detail type="issue"><caption>no.</caption><number>5</number></detail><extent unit="pages"><start>241</start><end>248</end><total>8</total></extent></part></relatedItem><identifier type="istex">B008AF1592C7A972C513D27AEAFC4B06293EC1AE</identifier><identifier type="DOI">10.1002/jbt.2570090504</identifier><identifier type="ArticleID">JBT2570090504</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 1994 Wiley‐Liss, Inc., A Wiley Company</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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