Which factors predict cognitive decline in Parkinson's disease?
Identifieur interne : 004779 ( Main/Curation ); précédent : 004778; suivant : 004780Which factors predict cognitive decline in Parkinson's disease?
Auteurs : D. Caparros-Lefebvre [France] ; N. Pécheux [France] ; V. Petit [France] ; A. Duhamel [France] ; H. Petit [France]Source :
- Journal of Neurology, Neurosurgery & Psychiatry [ 0022-3050 ] ; 1995-01.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Activities of Daily Living, Age of Onset, Aged, Cognition Disorders (diagnosis), Cognition Disorders (etiology), Cognitive disorder, Depressive Disorder (etiology), Depressive Disorder (psychology), Educational Status, Human, Humans, Levodopa (therapeutic use), Middle Aged, Movement Disorders (etiology), Neuropsychological Tests, Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson disease, Prognosis, Risk factor, Severity of Illness Index, Task Performance and Analysis, Tremor (etiology).
- MESH :
- chemical , therapeutic use : Levodopa.
- complications : Parkinson Disease.
- diagnosis : Cognition Disorders.
- drug therapy : Parkinson Disease.
- etiology : Cognition Disorders, Depressive Disorder, Movement Disorders, Tremor.
- psychology : Depressive Disorder.
- Activities of Daily Living, Age of Onset, Aged, Educational Status, Humans, Middle Aged, Neuropsychological Tests, Prognosis, Severity of Illness Index, Task Performance and Analysis.
Abstract
The study assessed cognitive decline in non-demented, non-depressed patients with well defined Parkinson's disease and determined the predictive value for cognitive decline of different motor symptoms. Motor disability was measured with the Unified Parkinson's disease rating scale, impairment in activities of daily living, levodopa test, and long term clinical follow up. Neuropsychological evaluations included modified mini mental state, fluency, Wechsler logical memory, Wisconsin card sorting test, and the Montgomery and Asberg depression rating scale. Fifty three patients fulfilling clinical criteria for idiopathic Parkinson's disease were studied. Cognitive performance on initial testing was significantly correlated with education and disease duration but not with age at disease onset. Cognitive performance on retesting after three years of follow up was significantly reduced. This reduction was significantly greater in the late onset group, in patients with isolated dystonic dyskinesiae, and in patients with a lower percentage of motor improvement on levodopa. Cognitive decline in idiopathic Parkinson's disease may depend on both the prevalence of non-dopaminergic lesions and the topography of dopaminergic denervation. Predictive factors for cognitive decline, especially in executive tasks, relate more to non-dopaminergic than to dopaminergic lesions.
Url:
- https://api.istex.fr/document/2220D4EDDB54DBE63492497582798076F781B451/fulltext/pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1073268
DOI: 10.1136/jnnp.58.1.51
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Motor disability was measured with the Unified Parkinson's disease rating scale, impairment in activities of daily living, levodopa test, and long term clinical follow up. Neuropsychological evaluations included modified mini mental state, fluency, Wechsler logical memory, Wisconsin card sorting test, and the Montgomery and Asberg depression rating scale. Fifty three patients fulfilling clinical criteria for idiopathic Parkinson's disease were studied. Cognitive performance on initial testing was significantly correlated with education and disease duration but not with age at disease onset. Cognitive performance on retesting after three years of follow up was significantly reduced. This reduction was significantly greater in the late onset group, in patients with isolated dystonic dyskinesiae, and in patients with a lower percentage of motor improvement on levodopa. Cognitive decline in idiopathic Parkinson's disease may depend on both the prevalence of non-dopaminergic lesions and the topography of dopaminergic denervation. Predictive factors for cognitive decline, especially in executive tasks, relate more to non-dopaminergic than to dopaminergic lesions.</div></front></TEI><double idat="0022-3050:1995:Caparros Lefebvre D:which:factors:predict"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Which factors predict cognitive decline in Parkinson's disease ?</title><author><name sortKey="Caparros Lefebvre, D" sort="Caparros Lefebvre, D" uniqKey="Caparros Lefebvre D" first="D." last="Caparros-Lefebvre">D. Caparros-Lefebvre</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>CHU Lille, dep. neurology</s1><s2>59037 Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Pecheux, N" sort="Pecheux, N" uniqKey="Pecheux N" first="N." last="Pecheux">N. 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Petit</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">95-0145046</idno><date when="1995">1995</date><idno type="stanalyst">PASCAL 95-0145046 INIST</idno><idno type="RBID">Pascal:95-0145046</idno><idno type="wicri:Area/PascalFrancis/Corpus">001908</idno><idno type="wicri:Area/PascalFrancis/Curation">001739</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">001700</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">001700</idno><idno type="wicri:doubleKey">0022-3050:1995:Caparros Lefebvre D:which:factors:predict</idno><idno type="wicri:Area/Main/Merge">005181</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Which factors predict cognitive decline in Parkinson's disease ?</title><author><name sortKey="Caparros Lefebvre, D" sort="Caparros Lefebvre, D" uniqKey="Caparros Lefebvre D" first="D." last="Caparros-Lefebvre">D. Caparros-Lefebvre</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>CHU Lille, dep. neurology</s1><s2>59037 Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Pecheux, N" sort="Pecheux, N" uniqKey="Pecheux N" first="N." last="Pecheux">N. Pecheux</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>CHU Lille, dep. neurology</s1><s2>59037 Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Petit, V" sort="Petit, V" uniqKey="Petit V" first="V." last="Petit">V. Petit</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>CHU Lille, dep. neurology</s1><s2>59037 Lille</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Hauts-de-France</region><region type="old region" nuts="2">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Duhamel, A" sort="Duhamel, A" uniqKey="Duhamel A" first="A." last="Duhamel">A. Duhamel</name></author><author><name sortKey="Petit, H" sort="Petit, H" uniqKey="Petit H" first="H." last="Petit">H. Petit</name></author></analytic><series><title level="j" type="main">Journal of neurology, neurosurgery and psychiatry</title><title level="j" type="abbreviated">J. neurol. neurosurg. psychiatry</title><idno type="ISSN">0022-3050</idno><imprint><date when="1995">1995</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of neurology, neurosurgery and psychiatry</title><title level="j" type="abbreviated">J. neurol. neurosurg. psychiatry</title><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cognitive disorder</term><term>Human</term><term>Parkinson disease</term><term>Risk factor</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Trouble cognition</term><term>Facteur risque</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The study assessed cognitive decline in non-demented, non-depressed patients with well defined Parkinson's disease and determined the predictive value for cognitive decline of different motor symptoms. Motor disability was measured with the Unified Parkinson's disease rating scale, impairment in activities of daily living, levodopa test, and long term clinical follow up. Neuropsychological evaluations included modified mini mental state, fluency, Wechsler logical memory, Wisconsin card sorting test, and the Montgomery and Asberg depression rating scale. Fifty three patients fulfilling clinical criteria for idiopathic Parkinson's disease were studied. Cognitive performance on initial testing was significantly correlated with education and disease duration but not with age at disease onset. Cognitive performance on retesting after three years of follow up was significantly reduced. This reduction was significantly greater in the late onset group, in patients with isolated dystonic dyskinesiae, and in patients with a lower percentage of motor improvement on levodopa. Cognitive decline in idiopathic Parkinson's disease may depend on both the prevalence of non-dopaminergic lesions and the topography of dopaminergic denervation. Predictive factors for cognitive decline, especially in executive tasks, relate more to non-dopaminergic than to dopaminergic lesions</div></front></TEI></INIST><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Which factors predict cognitive decline in Parkinson's disease?</title><author><name sortKey="Caparros Lefebvre, D" sort="Caparros Lefebvre, D" uniqKey="Caparros Lefebvre D" first="D" last="Caparros-Lefebvre">D. Caparros-Lefebvre</name></author><author><name sortKey="Pecheux, N" sort="Pecheux, N" uniqKey="Pecheux N" first="N" last="Pécheux">N. Pécheux</name></author><author><name sortKey="Petit, V" sort="Petit, V" uniqKey="Petit V" first="V" last="Petit">V. 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Petit</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:2220D4EDDB54DBE63492497582798076F781B451</idno><date when="1995" year="1995">1995</date><idno type="doi">10.1136/jnnp.58.1.51</idno><idno type="url">https://api.istex.fr/document/2220D4EDDB54DBE63492497582798076F781B451/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001B76</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001B76</idno><idno type="wicri:Area/Istex/Curation">001B74</idno><idno type="wicri:Area/Istex/Checkpoint">001897</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001897</idno><idno type="wicri:doubleKey">0022-3050:1995:Caparros Lefebvre D:which:factors:predict</idno><idno type="wicri:Area/Main/Merge">005089</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Which factors predict cognitive decline in Parkinson's disease?</title><author><name sortKey="Caparros Lefebvre, D" sort="Caparros Lefebvre, D" uniqKey="Caparros Lefebvre D" first="D" last="Caparros-Lefebvre">D. Caparros-Lefebvre</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, CHU Lille</wicri:regionArea><wicri:noRegion>CHU Lille</wicri:noRegion><wicri:noRegion>CHU Lille</wicri:noRegion></affiliation></author><author><name sortKey="Pecheux, N" sort="Pecheux, N" uniqKey="Pecheux N" first="N" last="Pécheux">N. Pécheux</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, CHU Lille</wicri:regionArea><wicri:noRegion>CHU Lille</wicri:noRegion><wicri:noRegion>CHU Lille</wicri:noRegion></affiliation></author><author><name sortKey="Petit, V" sort="Petit, V" uniqKey="Petit V" first="V" last="Petit">V. Petit</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, CHU Lille</wicri:regionArea><wicri:noRegion>CHU Lille</wicri:noRegion><wicri:noRegion>CHU Lille</wicri:noRegion></affiliation></author><author><name sortKey="Duhamel, A" sort="Duhamel, A" uniqKey="Duhamel A" first="A" last="Duhamel">A. Duhamel</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, CHU Lille</wicri:regionArea><wicri:noRegion>CHU Lille</wicri:noRegion><wicri:noRegion>CHU Lille</wicri:noRegion></affiliation></author><author><name sortKey="Petit, H" sort="Petit, H" uniqKey="Petit H" first="H" last="Petit">H. Petit</name><affiliation wicri:level="1"><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, CHU Lille</wicri:regionArea><wicri:noRegion>CHU Lille</wicri:noRegion><wicri:noRegion>CHU Lille</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neurology, Neurosurgery & Psychiatry</title><title level="j" type="abbrev">J Neurol Neurosurg Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><publisher>BMJ Publishing Group Ltd</publisher><date type="published" when="1995-01">1995-01</date><biblScope unit="volume">58</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="51">51</biblScope></imprint><idno type="ISSN">0022-3050</idno></series><idno type="istex">2220D4EDDB54DBE63492497582798076F781B451</idno><idno type="DOI">10.1136/jnnp.58.1.51</idno><idno type="href">jnnp-58-51.pdf</idno><idno type="PMID">7823067</idno><idno type="local">jnnp;58/1/51</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-3050</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The study assessed cognitive decline in non-demented, non-depressed patients with well defined Parkinson's disease and determined the predictive value for cognitive decline of different motor symptoms. Motor disability was measured with the Unified Parkinson's disease rating scale, impairment in activities of daily living, levodopa test, and long term clinical follow up. Neuropsychological evaluations included modified mini mental state, fluency, Wechsler logical memory, Wisconsin card sorting test, and the Montgomery and Asberg depression rating scale. Fifty three patients fulfilling clinical criteria for idiopathic Parkinson's disease were studied. Cognitive performance on initial testing was significantly correlated with education and disease duration but not with age at disease onset. Cognitive performance on retesting after three years of follow up was significantly reduced. This reduction was significantly greater in the late onset group, in patients with isolated dystonic dyskinesiae, and in patients with a lower percentage of motor improvement on levodopa. Cognitive decline in idiopathic Parkinson's disease may depend on both the prevalence of non-dopaminergic lesions and the topography of dopaminergic denervation. Predictive factors for cognitive decline, especially in executive tasks, relate more to non-dopaminergic than to dopaminergic lesions.</div></front></TEI></ISTEX><PMC><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Which factors predict cognitive decline in Parkinson's disease?</title><author><name sortKey="Caparros Lefebvre, D" sort="Caparros Lefebvre, D" uniqKey="Caparros Lefebvre D" first="D" last="Caparros-Lefebvre">D. Caparros-Lefebvre</name></author><author><name sortKey="Pecheux, N" sort="Pecheux, N" uniqKey="Pecheux N" first="N" last="Pécheux">N. Pécheux</name></author><author><name sortKey="Petit, V" sort="Petit, V" uniqKey="Petit V" first="V" last="Petit">V. Petit</name></author><author><name sortKey="Duhamel, A" sort="Duhamel, A" uniqKey="Duhamel A" first="A" last="Duhamel">A. Duhamel</name></author><author><name sortKey="Petit, H" sort="Petit, H" uniqKey="Petit H" first="H" last="Petit">H. Petit</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">7823067</idno><idno type="pmc">1073268</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1073268</idno><idno type="RBID">PMC:1073268</idno><date when="1995">1995</date><idno type="wicri:Area/Pmc/Corpus">000285</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000285</idno><idno type="wicri:Area/Pmc/Curation">000283</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000283</idno><idno type="wicri:Area/Pmc/Checkpoint">000963</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000963</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">001651</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001651</idno><idno type="wicri:Area/PubMed/Curation">001610</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001610</idno><idno type="wicri:Area/PubMed/Checkpoint">001610</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001610</idno><idno type="wicri:Area/Ncbi/Merge">001C84</idno><idno type="wicri:Area/Ncbi/Curation">001C84</idno><idno type="wicri:Area/Ncbi/Checkpoint">001C84</idno><idno type="wicri:doubleKey">0022-3050:1995:Caparros Lefebvre D:which:factors:predict</idno><idno type="wicri:Area/Main/Merge">004F78</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Which factors predict cognitive decline in Parkinson's disease?</title><author><name sortKey="Caparros Lefebvre, D" sort="Caparros Lefebvre, D" uniqKey="Caparros Lefebvre D" first="D" last="Caparros-Lefebvre">D. Caparros-Lefebvre</name></author><author><name sortKey="Pecheux, N" sort="Pecheux, N" uniqKey="Pecheux N" first="N" last="Pécheux">N. Pécheux</name></author><author><name sortKey="Petit, V" sort="Petit, V" uniqKey="Petit V" first="V" last="Petit">V. Petit</name></author><author><name sortKey="Duhamel, A" sort="Duhamel, A" uniqKey="Duhamel A" first="A" last="Duhamel">A. Duhamel</name></author><author><name sortKey="Petit, H" sort="Petit, H" uniqKey="Petit H" first="H" last="Petit">H. Petit</name></author></analytic><series><title level="j">Journal of Neurology, Neurosurgery, and Psychiatry</title><idno type="ISSN">0022-3050</idno><idno type="eISSN">1468-330X</idno><imprint><date when="1995">1995</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activities of Daily Living</term><term>Age of Onset</term><term>Aged</term><term>Cognition Disorders (diagnosis)</term><term>Cognition Disorders (etiology)</term><term>Depressive Disorder (etiology)</term><term>Depressive Disorder (psychology)</term><term>Educational Status</term><term>Humans</term><term>Levodopa (therapeutic use)</term><term>Middle Aged</term><term>Movement Disorders (etiology)</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (drug therapy)</term><term>Prognosis</term><term>Severity of Illness Index</term><term>Task Performance and Analysis</term><term>Tremor (etiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term><term>Depressive Disorder</term><term>Movement Disorders</term><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Depressive Disorder</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Activities of Daily Living</term><term>Age of Onset</term><term>Aged</term><term>Educational Status</term><term>Humans</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Prognosis</term><term>Severity of Illness Index</term><term>Task Performance and Analysis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The study assessed cognitive decline in non-demented, non-depressed patients with well defined Parkinson's disease and determined the predictive value for cognitive decline of different motor symptoms. Motor disability was measured with the Unified Parkinson's disease rating scale, impairment in activities of daily living, levodopa test, and long term clinical follow up. Neuropsychological evaluations included modified mini mental state, fluency, Wechsler logical memory, Wisconsin card sorting test, and the Montgomery and Asberg depression rating scale. Fifty three patients fulfilling clinical criteria for idiopathic Parkinson's disease were studied. Cognitive performance on initial testing was significantly correlated with education and disease duration but not with age at disease onset. Cognitive performance on retesting after three years of follow up was significantly reduced. This reduction was significantly greater in the late onset group, in patients with isolated dystonic dyskinesiae, and in patients with a lower percentage of motor improvement on levodopa. Cognitive decline in idiopathic Parkinson's disease may depend on both the prevalence of non-dopaminergic lesions and the topography of dopaminergic denervation. Predictive factors for cognitive decline, especially in executive tasks, relate more to non-dopaminergic than to dopaminergic lesions.</p></div></front></TEI></PMC></double></record>Pour manipuler ce document sous Unix (Dilib)
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