ParkinsonFranceV1, Main, Curation, bibRecord, 004778

“Pure” striatonigral degeneration and Parkinson's disease: A comparative clinical study

Identifieur interne : 004778 ( Main/Curation ); précédent : 004777; suivant : 004779

“Pure” striatonigral degeneration and Parkinson's disease: A comparative clinical study

Auteurs : Stéphane Gouider-Khouja [France] ; Marie Vidailhet [France] ; Anne-Marie Bonnet [France] ; Jacques Pichon [France] ; Yves Agid [France]

Source :

Movement Disorders [ 0885-3185 ] ; 1995-05.

RBID : ISTEX:CD6511E0BDA7CD4DB9469BEFE7DF451A79DA6892

English descriptors

KwdEn :
- Aged, Corpus Striatum (drug effects), Corpus Striatum (physiopathology), Diagnosis, Differential, Disability Evaluation, Female, Humans, Levodopa (therapeutic use), Male, Middle Aged, Nerve Degeneration (drug effects), Nerve Degeneration (physiology), Neurologic Examination (drug effects), Olivopontocerebellar Atrophies (diagnosis), Olivopontocerebellar Atrophies (physiopathology), Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Parkinson Disease, Secondary (diagnosis), Parkinson Disease, Secondary (physiopathology), Parkinson's disease, Striatonigral degeneration, Substantia Nigra (drug effects), Substantia Nigra (physiopathology).
MESH :
- chemical , therapeutic use : Levodopa.
- diagnosis : Olivopontocerebellar Atrophies, Parkinson Disease, Parkinson Disease, Secondary.
- drug effects : Corpus Striatum, Nerve Degeneration, Neurologic Examination, Substantia Nigra.
- physiology : Nerve Degeneration.
- physiopathology : Corpus Striatum, Olivopontocerebellar Atrophies, Parkinson Disease, Parkinson Disease, Secondary, Substantia Nigra.
- Aged, Diagnosis, Differential, Disability Evaluation, Female, Humans, Male, Middle Aged.

Abstract

Striatonigral degeneration (SND) is difficult to diagnose in vivo. The purpose of this study was to detect the best indicators for an early and reliable diagnosis of the disease. Eighteen patients clinically diagnosed as having SND were selected with rigorous inclusion criteria and compared to 18 patients with Parkinson's disease (PD) matched for age and disease duration. Apart from dysautonomia, the principal discriminant clinical features that distinguished SND from PD were the early appearance of the following symptoms and signs: (a) severe and atypical progressive parkinsonism characterized by bilateral bradykinesia and rigidity, slowness of gait, postural instability, and falls, and poor or absent response to adequate levodopa treatment; (b) increased tendon reflexes associated or not with frank pyramidal signs, severe dysarthria, and less consistently, dysphagia, stridor, antecollis, and stimulussensitive myoclonus, which, when present, are highly suggestive of the disease.

Url:

https://api.istex.fr/document/CD6511E0BDA7CD4DB9469BEFE7DF451A79DA6892/fulltext/pdf

DOI: 10.1002/mds.870100310

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ISTEX:CD6511E0BDA7CD4DB9469BEFE7DF451A79DA6892

Le document en format XML

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<front><div type="abstract" xml:lang="en">Striatonigral degeneration (SND) is difficult to diagnose in vivo. The purpose of this study was to detect the best indicators for an early and reliable diagnosis of the disease. Eighteen patients clinically diagnosed as having SND were selected with rigorous inclusion criteria and compared to 18 patients with Parkinson's disease (PD) matched for age and disease duration. Apart from dysautonomia, the principal discriminant clinical features that distinguished SND from PD were the early appearance of the following symptoms and signs: (a) severe and atypical progressive parkinsonism characterized by bilateral bradykinesia and rigidity, slowness of gait, postural instability, and falls, and poor or absent response to adequate levodopa treatment; (b) increased tendon reflexes associated or not with frank pyramidal signs, severe dysarthria, and less consistently, dysphagia, stridor, antecollis, and stimulussensitive myoclonus, which, when present, are highly suggestive of the disease.</div>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

“Pure” striatonigral degeneration and Parkinson's disease: A comparative clinical study

“Pure” striatonigral degeneration and Parkinson's disease: A comparative clinical study

Source :

English descriptors

Abstract

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