ParkinsonFranceV1, Main, Curation, bibRecord, 003C74

Relationships between striatal dopamine denervation and frontal executive tests in Parkinson's disease

Identifieur interne : 003C74 ( Main/Curation ); précédent : 003C73; suivant : 003C75

Relationships between striatal dopamine denervation and frontal executive tests in Parkinson's disease

Auteurs : R. M Marié [France] ; L. Barré [France] ; B. Dupuy [France] ; F. Viader [France] ; G. Defer [France] ; J. C Baron [France]

Source :

Neuroscience Letters [ 0304-3940 ] ; 1999.

RBID : ISTEX:0F28EBDB916A3B4828DC6119C59DCA745B437B12

Descripteurs français

Pascal (Inist)
- Corps strié, Dopamine, Enervation, Homme, Mémoire travail, Parkinson maladie, Tomoscintigraphie.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Adult, Aged, Caudate Nucleus (physiopathology), Corpus Striatum (physiopathology), Corpus striatum, Denervation, Dopamine, Dopamine (adverse effects), Dopamine Uptake Inhibitors (pharmacology), Emission tomography, Female, Frontal Lobe (drug effects), Frontal Lobe (physiology), Human, Humans, Male, Middle Aged, Neuropsychological Tests, Nomifensine (analogs & derivatives), Nomifensine (pharmacology), Parkinson Disease (physiopathology), Parkinson disease, Sympathectomy, Chemical (adverse effects), Tomography, Emission-Computed, Working memory.
MESH :
- chemical , adverse effects : Dopamine.
- chemical , analogs & derivatives : Nomifensine.
- chemical , pharmacology : Dopamine Uptake Inhibitors, Nomifensine.
- adverse effects : Sympathectomy, Chemical.
- drug effects : Frontal Lobe.
- physiology : Frontal Lobe.
- physiopathology : Caudate Nucleus, Corpus Striatum, Parkinson Disease.
- Adult, Aged, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Tomography, Emission-Computed.

Abstract

Indirect evidence from human and monkey investigations supports the idea that impaired frontal tasks in Parkinson's disease (PD) may result from striato-frontal disruption caused by dopamine (DA) denervation of the caudate nucleus. To directly investigate this hypothesis, we used PET with 11C-S-Nomifensine (11C-S-NMF), a sensitive marker of striatal DA denervation, in 10 non-demented PD patients in whom two frontal executive tests, the object alternation (OA) and the conditional associative learning (CAL) tasks, thought to reflect mainly set-shifting/inhibition and planning, respectively, were given. In addition, the central executive function of verbal working memory was assessed with the Brown Peterson paradigm (BPP). We found a highly significant correlation between right caudate 11C-S-NMF specific binding and OA performance, less significant and reverse-direction correlations between CAL performance and putamen 11C-S-NMF binding, and no significant correlation with BPP performance. Thus, caudate DA denervation may subtend poor set-shifting/inhibition process in PD. Our results also point to distinct and complex relationships between striatal DA and specific frontal tasks.

Url:

https://api.istex.fr/document/0F28EBDB916A3B4828DC6119C59DCA745B437B12/fulltext/pdf

DOI: 10.1016/S0304-3940(98)00928-8

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Indirect evidence from human and monkey investigations supports the idea that impaired frontal tasks in Parkinson's disease (PD) may result from striato-frontal disruption caused by dopamine (DA) denervation of the caudate nucleus. To directly investigate this hypothesis, we used PET with 11C-S-Nomifensine (11C-S-NMF), a sensitive marker of striatal DA denervation, in 10 non-demented PD patients in whom two frontal executive tests, the object alternation (OA) and the conditional associative learning (CAL) tasks, thought to reflect mainly set-shifting/inhibition and planning, respectively, were given. In addition, the central executive function of verbal working memory was assessed with the Brown Peterson paradigm (BPP). We found a highly significant correlation between right caudate 11C-S-NMF specific binding and OA performance, less significant and reverse-direction correlations between CAL performance and putamen 11C-S-NMF binding, and no significant correlation with BPP performance. Thus, caudate DA denervation may subtend poor set-shifting/inhibition process in PD. Our results also point to distinct and complex relationships between striatal DA and specific frontal tasks.</div>
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<front><div type="abstract" xml:lang="en">Indirect evidence from human and monkey investigations supports the idea that impaired frontal tasks in Parkinson's disease (PD) may result from striato-frontal disruption caused by dopamine (DA) denervation of the caudate nucleus. To directly investigate this hypothesis, we used PET with <sup>11</sup>
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<front><div type="abstract" xml:lang="en">Indirect evidence from human and monkey investigations supports the idea that impaired frontal tasks in Parkinson's disease (PD) may result from striato-frontal disruption caused by dopamine (DA) denervation of the caudate nucleus. To directly investigate this hypothesis, we used PET with 11C-S-Nomifensine (11C-S-NMF), a sensitive marker of striatal DA denervation, in 10 non-demented PD patients in whom two frontal executive tests, the object alternation (OA) and the conditional associative learning (CAL) tasks, thought to reflect mainly set-shifting/inhibition and planning, respectively, were given. In addition, the central executive function of verbal working memory was assessed with the Brown Peterson paradigm (BPP). We found a highly significant correlation between right caudate 11C-S-NMF specific binding and OA performance, less significant and reverse-direction correlations between CAL performance and putamen 11C-S-NMF binding, and no significant correlation with BPP performance. Thus, caudate DA denervation may subtend poor set-shifting/inhibition process in PD. Our results also point to distinct and complex relationships between striatal DA and specific frontal tasks.</div>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Relationships between striatal dopamine denervation and frontal executive tests in Parkinson's disease

Relationships between striatal dopamine denervation and frontal executive tests in Parkinson's disease

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