Relationships between striatal dopamine denervation and frontal executive tests in Parkinson's disease.
Identifieur interne : 000001 ( Ncbi/Merge ); précédent : 000000; suivant : 000002Relationships between striatal dopamine denervation and frontal executive tests in Parkinson's disease.
Auteurs : R M Marié [France] ; L. Barré ; B. Dupuy ; F. Viader ; G. Defer ; J C BaronSource :
- Neuroscience letters [ 0304-3940 ] ; 1999.
English descriptors
- KwdEn :
- Adult, Aged, Caudate Nucleus (physiopathology), Corpus Striatum (physiopathology), Dopamine (adverse effects), Dopamine Uptake Inhibitors (pharmacology), Female, Frontal Lobe (drug effects), Frontal Lobe (physiology), Humans, Male, Middle Aged, Neuropsychological Tests, Nomifensine (analogs & derivatives), Nomifensine (pharmacology), Parkinson Disease (physiopathology), Sympathectomy, Chemical (adverse effects), Tomography, Emission-Computed.
- MESH :
- chemical , adverse effects : Dopamine.
- chemical , analogs & derivatives : Nomifensine.
- chemical , pharmacology : Dopamine Uptake Inhibitors, Nomifensine.
- adverse effects : Sympathectomy, Chemical.
- drug effects : Frontal Lobe.
- physiology : Frontal Lobe.
- physiopathology : Caudate Nucleus, Corpus Striatum, Parkinson Disease.
- Adult, Aged, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Tomography, Emission-Computed.
Abstract
Indirect evidence from human and monkey investigations supports the idea that impaired frontal tasks in Parkinson's disease (PD) may result from striato-frontal disruption caused by dopamine (DA) denervation of the caudate nucleus. To directly investigate this hypothesis, we used PET with 11C-S-Nomifensine (11C-S-NMF), a sensitive marker of striatal DA denervation, in 10 non-demented PD patients in whom two frontal executive tests, the object alternation (OA) and the conditional associative learning (CAL) tasks, thought to reflect mainly set-shifting/inhibition and planning, respectively, were given. In addition, the central executive function of verbal working memory was assessed with the Brown Peterson paradigm (BPP). We found a highly significant correlation between right caudate 11C-S-NMF specific binding and OA performance, less significant and reverse-direction correlations between CAL performance and putamen 11C-S-NMF binding, and no significant correlation with BPP performance. Thus, caudate DA denervation may subtend poor set-shifting/inhibition process in PD. Our results also point to distinct and complex relationships between striatal DA and specific frontal tasks.
PubMed: 10025703
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Dupuy</name></author><author><name sortKey="Viader, F" sort="Viader, F" uniqKey="Viader F" first="F" last="Viader">F. Viader</name></author><author><name sortKey="Defer, G" sort="Defer, G" uniqKey="Defer G" first="G" last="Defer">G. 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Barré</name></author><author><name sortKey="Dupuy, B" sort="Dupuy, B" uniqKey="Dupuy B" first="B" last="Dupuy">B. Dupuy</name></author><author><name sortKey="Viader, F" sort="Viader, F" uniqKey="Viader F" first="F" last="Viader">F. Viader</name></author><author><name sortKey="Defer, G" sort="Defer, G" uniqKey="Defer G" first="G" last="Defer">G. Defer</name></author><author><name sortKey="Baron, J C" sort="Baron, J C" uniqKey="Baron J" first="J C" last="Baron">J C Baron</name></author></analytic><series><title level="j">Neuroscience letters</title><idno type="ISSN">0304-3940</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Caudate Nucleus (physiopathology)</term><term>Corpus Striatum (physiopathology)</term><term>Dopamine (adverse effects)</term><term>Dopamine Uptake Inhibitors (pharmacology)</term><term>Female</term><term>Frontal Lobe (drug effects)</term><term>Frontal Lobe (physiology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Nomifensine (analogs & derivatives)</term><term>Nomifensine (pharmacology)</term><term>Parkinson Disease (physiopathology)</term><term>Sympathectomy, Chemical (adverse effects)</term><term>Tomography, Emission-Computed</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Nomifensine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Dopamine Uptake Inhibitors</term><term>Nomifensine</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Sympathectomy, Chemical</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Frontal Lobe</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Frontal Lobe</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Caudate Nucleus</term><term>Corpus Striatum</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Tomography, Emission-Computed</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Indirect evidence from human and monkey investigations supports the idea that impaired frontal tasks in Parkinson's disease (PD) may result from striato-frontal disruption caused by dopamine (DA) denervation of the caudate nucleus. To directly investigate this hypothesis, we used PET with 11C-S-Nomifensine (11C-S-NMF), a sensitive marker of striatal DA denervation, in 10 non-demented PD patients in whom two frontal executive tests, the object alternation (OA) and the conditional associative learning (CAL) tasks, thought to reflect mainly set-shifting/inhibition and planning, respectively, were given. In addition, the central executive function of verbal working memory was assessed with the Brown Peterson paradigm (BPP). We found a highly significant correlation between right caudate 11C-S-NMF specific binding and OA performance, less significant and reverse-direction correlations between CAL performance and putamen 11C-S-NMF binding, and no significant correlation with BPP performance. Thus, caudate DA denervation may subtend poor set-shifting/inhibition process in PD. Our results also point to distinct and complex relationships between striatal DA and specific frontal tasks.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">10025703</PMID><DateCreated><Year>1999</Year><Month>06</Month><Day>18</Day></DateCreated><DateCompleted><Year>1999</Year><Month>06</Month><Day>18</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0304-3940</ISSN><JournalIssue CitedMedium="Print"><Volume>260</Volume><Issue>2</Issue><PubDate><Year>1999</Year><Month>Jan</Month><Day>29</Day></PubDate></JournalIssue><Title>Neuroscience letters</Title><ISOAbbreviation>Neurosci. Lett.</ISOAbbreviation></Journal><ArticleTitle>Relationships between striatal dopamine denervation and frontal executive tests in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>77-80</MedlinePgn></Pagination><Abstract><AbstractText>Indirect evidence from human and monkey investigations supports the idea that impaired frontal tasks in Parkinson's disease (PD) may result from striato-frontal disruption caused by dopamine (DA) denervation of the caudate nucleus. To directly investigate this hypothesis, we used PET with 11C-S-Nomifensine (11C-S-NMF), a sensitive marker of striatal DA denervation, in 10 non-demented PD patients in whom two frontal executive tests, the object alternation (OA) and the conditional associative learning (CAL) tasks, thought to reflect mainly set-shifting/inhibition and planning, respectively, were given. In addition, the central executive function of verbal working memory was assessed with the Brown Peterson paradigm (BPP). We found a highly significant correlation between right caudate 11C-S-NMF specific binding and OA performance, less significant and reverse-direction correlations between CAL performance and putamen 11C-S-NMF binding, and no significant correlation with BPP performance. Thus, caudate DA denervation may subtend poor set-shifting/inhibition process in PD. Our results also point to distinct and complex relationships between striatal DA and specific frontal tasks.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Marié</LastName><ForeName>R M</ForeName><Initials>RM</Initials><AffiliationInfo><Affiliation>INSERM U. 320, Cyceron, Services de Neurologie Vastel et Déjérine, CHU de Caen, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Barré</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Dupuy</LastName><ForeName>B</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Viader</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Defer</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Baron</LastName><ForeName>J C</ForeName><Initials>JC</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Ireland</Country><MedlineTA>Neurosci Lett</MedlineTA><NlmUniqueID>7600130</NlmUniqueID><ISSNLinking>0304-3940</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018765">Dopamine Uptake Inhibitors</NameOfSubstance></Chemical><Chemical><RegistryNumber>1LGS5JRP31</RegistryNumber><NameOfSubstance UI="D009627">Nomifensine</NameOfSubstance></Chemical><Chemical><RegistryNumber>VTD58H1Z2X</RegistryNumber><NameOfSubstance UI="D004298">Dopamine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002421" MajorTopicYN="N">Caudate Nucleus</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003342" MajorTopicYN="N">Corpus Striatum</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004298" MajorTopicYN="N">Dopamine</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018765" MajorTopicYN="N">Dopamine Uptake Inhibitors</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005625" MajorTopicYN="N">Frontal Lobe</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009483" MajorTopicYN="Y">Neuropsychological Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009627" MajorTopicYN="N">Nomifensine</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="N">analogs & derivatives</QualifierName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013563" MajorTopicYN="N">Sympathectomy, Chemical</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014055" MajorTopicYN="N">Tomography, Emission-Computed</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1999</Year><Month>2</Month><Day>20</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1999</Year><Month>2</Month><Day>20</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1999</Year><Month>2</Month><Day>20</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">10025703</ArticleId><ArticleId IdType="pii">S0304-3940(98)00928-8</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country></list><tree><noCountry><name sortKey="Baron, J C" sort="Baron, J C" uniqKey="Baron J" first="J C" last="Baron">J C Baron</name><name sortKey="Barre, L" sort="Barre, L" uniqKey="Barre L" first="L" last="Barré">L. Barré</name><name sortKey="Defer, G" sort="Defer, G" uniqKey="Defer G" first="G" last="Defer">G. Defer</name><name sortKey="Dupuy, B" sort="Dupuy, B" uniqKey="Dupuy B" first="B" last="Dupuy">B. Dupuy</name><name sortKey="Viader, F" sort="Viader, F" uniqKey="Viader F" first="F" last="Viader">F. Viader</name></noCountry><country name="France"><noRegion><name sortKey="Marie, R M" sort="Marie, R M" uniqKey="Marie R" first="R M" last="Marié">R M Marié</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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