Relationships between striatal dopamine denervation and frontal executive tests in Parkinson's disease.
Identifieur interne : 000001 ( Ncbi/Merge ); précédent : 000000; suivant : 000002Relationships between striatal dopamine denervation and frontal executive tests in Parkinson's disease.
Auteurs : R M Marié [France] ; L. Barré ; B. Dupuy ; F. Viader ; G. Defer ; J C BaronSource :
- Neuroscience letters [ 0304-3940 ] ; 1999.
English descriptors
- KwdEn :
- Adult, Aged, Caudate Nucleus (physiopathology), Corpus Striatum (physiopathology), Dopamine (adverse effects), Dopamine Uptake Inhibitors (pharmacology), Female, Frontal Lobe (drug effects), Frontal Lobe (physiology), Humans, Male, Middle Aged, Neuropsychological Tests, Nomifensine (analogs & derivatives), Nomifensine (pharmacology), Parkinson Disease (physiopathology), Sympathectomy, Chemical (adverse effects), Tomography, Emission-Computed.
- MESH :
- chemical , adverse effects : Dopamine.
- chemical , analogs & derivatives : Nomifensine.
- chemical , pharmacology : Dopamine Uptake Inhibitors, Nomifensine.
- adverse effects : Sympathectomy, Chemical.
- drug effects : Frontal Lobe.
- physiology : Frontal Lobe.
- physiopathology : Caudate Nucleus, Corpus Striatum, Parkinson Disease.
- Adult, Aged, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Tomography, Emission-Computed.
Abstract
Indirect evidence from human and monkey investigations supports the idea that impaired frontal tasks in Parkinson's disease (PD) may result from striato-frontal disruption caused by dopamine (DA) denervation of the caudate nucleus. To directly investigate this hypothesis, we used PET with 11C-S-Nomifensine (11C-S-NMF), a sensitive marker of striatal DA denervation, in 10 non-demented PD patients in whom two frontal executive tests, the object alternation (OA) and the conditional associative learning (CAL) tasks, thought to reflect mainly set-shifting/inhibition and planning, respectively, were given. In addition, the central executive function of verbal working memory was assessed with the Brown Peterson paradigm (BPP). We found a highly significant correlation between right caudate 11C-S-NMF specific binding and OA performance, less significant and reverse-direction correlations between CAL performance and putamen 11C-S-NMF binding, and no significant correlation with BPP performance. Thus, caudate DA denervation may subtend poor set-shifting/inhibition process in PD. Our results also point to distinct and complex relationships between striatal DA and specific frontal tasks.
PubMed: 10025703
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pubmed:10025703Le document en format XML
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<front><div type="abstract" xml:lang="en">Indirect evidence from human and monkey investigations supports the idea that impaired frontal tasks in Parkinson's disease (PD) may result from striato-frontal disruption caused by dopamine (DA) denervation of the caudate nucleus. To directly investigate this hypothesis, we used PET with 11C-S-Nomifensine (11C-S-NMF), a sensitive marker of striatal DA denervation, in 10 non-demented PD patients in whom two frontal executive tests, the object alternation (OA) and the conditional associative learning (CAL) tasks, thought to reflect mainly set-shifting/inhibition and planning, respectively, were given. In addition, the central executive function of verbal working memory was assessed with the Brown Peterson paradigm (BPP). We found a highly significant correlation between right caudate 11C-S-NMF specific binding and OA performance, less significant and reverse-direction correlations between CAL performance and putamen 11C-S-NMF binding, and no significant correlation with BPP performance. Thus, caudate DA denervation may subtend poor set-shifting/inhibition process in PD. Our results also point to distinct and complex relationships between striatal DA and specific frontal tasks.</div>
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<Abstract><AbstractText>Indirect evidence from human and monkey investigations supports the idea that impaired frontal tasks in Parkinson's disease (PD) may result from striato-frontal disruption caused by dopamine (DA) denervation of the caudate nucleus. To directly investigate this hypothesis, we used PET with 11C-S-Nomifensine (11C-S-NMF), a sensitive marker of striatal DA denervation, in 10 non-demented PD patients in whom two frontal executive tests, the object alternation (OA) and the conditional associative learning (CAL) tasks, thought to reflect mainly set-shifting/inhibition and planning, respectively, were given. In addition, the central executive function of verbal working memory was assessed with the Brown Peterson paradigm (BPP). We found a highly significant correlation between right caudate 11C-S-NMF specific binding and OA performance, less significant and reverse-direction correlations between CAL performance and putamen 11C-S-NMF binding, and no significant correlation with BPP performance. Thus, caudate DA denervation may subtend poor set-shifting/inhibition process in PD. Our results also point to distinct and complex relationships between striatal DA and specific frontal tasks.</AbstractText>
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