ParkinsonFranceV1, Main, Curation, bibRecord, 003B96

Dyskinesias and the subthalamic nucleus

Identifieur interne : 003B96 ( Main/Curation ); précédent : 003B95; suivant : 003B97

Dyskinesias and the subthalamic nucleus

Auteurs : A. L. Benabid [France] ; A. Benazzouz [France] ; P. Limousin [France] ; A. Koudsie [France] ; P. Krack [Allemagne] ; B. Piallat [France] ; P. Pollak [France]

Source :

Annals of neurology [ 0364-5134 ] ; 2000.

RBID : Pascal:00-0263304

Descripteurs français

Pascal (Inist)
- Parkinson maladie, Dyskinésie, Lévodopa, Antiparkinsonien, Stimulation instrumentale, Haute fréquence, Noyau sousthalamique, Traitement, Physiopathologie, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Animals, Antiparkinson agent, Dopamine Agents (adverse effects), Dyskinesia, Dyskinesia, Drug-Induced (physiopathology), High frequency, Human, Humans, Instrumental stimulation, Levodopa, Levodopa (adverse effects), Parkinson Disease (drug therapy), Parkinson disease, Pathophysiology, Subthalamic Nucleus (drug effects), Subthalamic Nucleus (physiopathology), Subthalamic nucleus, Treatment.
MESH :
- chemical , adverse effects : Dopamine Agents, Levodopa.
- drug effects : Subthalamic Nucleus.
- drug therapy : Parkinson Disease.
- physiopathology : Dyskinesia, Drug-Induced, Subthalamic Nucleus.
- Animals, Humans.

Abstract

Severe dyskinesias or ballism can occur following hemorrhagic events in the subthalamic nucleus (STN), and it has recently been established that the STN plays a major role in the pathophysiology of the motor dysfunction of Parkinson's disease (PD) and that STN inhibition improves parkinsonian dysfunction. Deep brain stimulation of the STN in PD patients is therefore currently being evaluated as a therapy. High-frequency stimulation of the STN in PD patients can induce intense dyskinesias that are similar to those induced by levodopa. These may occur with a variable latency and resemble all types of levodopa-induced dyskinesias (LIDs). They can be decreased by reducing the levodopa dosage, which is permitted by the antiparkinsonian effect of stimulating the STN. STN stimulation has been shown to improve all types of LIDs, with the most dramatic effect being that on off-period dystonia. The improvement in LIDs may relate to the decrease in drug dosage, while the off-period dystonia is likely improved by the simultaneous administration of levodopa and STN stimulation. It is thought that the STN is an important node in a network, which can produce dyskinesias when disturbed by a lesion, and is particularly sensitive for the induction of these abnormal movements.

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Le document en format XML

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<term>Dyskinesia, Drug-Induced (physiopathology)</term>
<term>High frequency</term>
<term>Human</term>
<term>Humans</term>
<term>Instrumental stimulation</term>
<term>Levodopa</term>
<term>Levodopa (adverse effects)</term>
<term>Parkinson Disease (drug therapy)</term>
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<term>Subthalamic Nucleus (physiopathology)</term>
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<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dyskinesia, Drug-Induced</term>
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<front><div type="abstract" xml:lang="en">Severe dyskinesias or ballism can occur following hemorrhagic events in the subthalamic nucleus (STN), and it has recently been established that the STN plays a major role in the pathophysiology of the motor dysfunction of Parkinson's disease (PD) and that STN inhibition improves parkinsonian dysfunction. Deep brain stimulation of the STN in PD patients is therefore currently being evaluated as a therapy. High-frequency stimulation of the STN in PD patients can induce intense dyskinesias that are similar to those induced by levodopa. These may occur with a variable latency and resemble all types of levodopa-induced dyskinesias (LIDs). They can be decreased by reducing the levodopa dosage, which is permitted by the antiparkinsonian effect of stimulating the STN. STN stimulation has been shown to improve all types of LIDs, with the most dramatic effect being that on off-period dystonia. The improvement in LIDs may relate to the decrease in drug dosage, while the off-period dystonia is likely improved by the simultaneous administration of levodopa and STN stimulation. It is thought that the STN is an important node in a network, which can produce dyskinesias when disturbed by a lesion, and is particularly sensitive for the induction of these abnormal movements.</div>
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<front><div type="abstract" xml:lang="en">Severe dyskinesias or ballism can occur following hemorrhagic events in the subthalamic nucleus (STN), and it has recently been established that the STN plays a major role in the pathophysiology of the motor dysfunction of Parkinson's disease (PD) and that STN inhibition improves parkinsonian dysfunction. Deep brain stimulation of the STN in PD patients is therefore currently being evaluated as a therapy. High-frequency stimulation of the STN in PD patients can induce intense dyskinesias that are similar to those induced by levodopa. These may occur with a variable latency and resemble all types of levodopa-induced dyskinesias (LIDs). They can be decreased by reducing the levodopa dosage, which is permitted by the antiparkinsonian effect of stimulating the STN. STN stimulation has been shown to improve all types of LIDs, with the most dramatic effect being that on off-period dystonia. The improvement in LIDs may relate to the decrease in drug dosage, while the off-period dystonia is likely improved by the simultaneous administration of levodopa and STN stimulation. It is thought that the STN is an important node in a network, which can produce dyskinesias when disturbed by a lesion, and is particularly sensitive for the induction of these abnormal movements.</div>
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<front><div type="abstract" xml:lang="en">Severe dyskinesias or ballism can occur following hemorrhagic events in the subthalamic nucleus (STN), and it has recently been established that the STN plays a major role in the pathophysiology of the motor dysfunction of Parkinson's disease (PD) and that STN inhibition improves parkinsonian dysfunction. Deep brain stimulation of the STN in PD patients is therefore currently being evaluated as a therapy. High-frequency stimulation of the STN in PD patients can induce intense dyskinesias that are similar to those induced by levodopa. These may occur with a variable latency and resemble all types of levodopa-induced dyskinesias (LIDs). They can be decreased by reducing the levodopa dosage, which is permitted by the antiparkinsonian effect of stimulating the STN. STN stimulation has been shown to improve all types of LIDs, with the most dramatic effect being that on off-period dystonia. The improvement in LIDs may relate to the decrease in drug dosage, while the off-period dystonia is likely improved by the simultaneous administration of levodopa and STN stimulation. It is thought that the STN is an important node in a network, which can produce dyskinesias when disturbed by a lesion, and is particularly sensitive for the induction of these abnormal movements.</div>
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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Dyskinesias and the subthalamic nucleus

Dyskinesias and the subthalamic nucleus

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