Basal ganglia dysfunction in OCD: subthalamic neuronal activity correlates with symptoms severity and predicts high-frequency stimulation efficacy
Identifieur interne : 001615 ( Main/Curation ); précédent : 001614; suivant : 001616Basal ganglia dysfunction in OCD: subthalamic neuronal activity correlates with symptoms severity and predicts high-frequency stimulation efficacy
Auteurs : M-L Welter [France] ; P. Burbaud [France] ; S. Fernandez-Vidal [France] ; E. Bardinet [France] ; J. Coste [France] ; B. Piallat [France] ; M. Borg [France] ; S. Besnard [France] ; P. Sauleau [France] ; B. Devaux [France] ; B. Pidoux [France] ; P. Chaynes [France] ; S. Tézenas Du Montcel [France] ; A. Bastian [France] ; N. Langbour [France] ; A. Teillant [France] ; W. Haynes [France] ; J. Yelnik [France] ; C. Karachi [France] ; L. Mallet [France]Source :
- Translational Psychiatry [ 2158-3188 ] ; 2011.
English descriptors
- KwdEn :
- Adult, Basal Ganglia (pathology), Basal Ganglia (physiopathology), Basal Ganglia (surgery), Deep Brain Stimulation (instrumentation), Deep Brain Stimulation (methods), Electrodes, Implanted, Humans, Neurons (pathology), Obsessive-Compulsive Disorder (pathology), Obsessive-Compulsive Disorder (physiopathology), Obsessive-Compulsive Disorder (therapy), Parkinson Disease (pathology), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Severity of Illness Index, Treatment Outcome.
- MESH :
- instrumentation : Deep Brain Stimulation.
- methods : Deep Brain Stimulation.
- pathology : Basal Ganglia, Neurons, Obsessive-Compulsive Disorder, Parkinson Disease.
- physiopathology : Basal Ganglia, Obsessive-Compulsive Disorder, Parkinson Disease.
- surgery : Basal Ganglia.
- therapy : Obsessive-Compulsive Disorder, Parkinson Disease.
- Adult, Electrodes, Implanted, Humans, Severity of Illness Index, Treatment Outcome.
- mix :
Abstract
Functional and connectivity changes in corticostriatal systems have been reported in the brains of patients with obsessive–compulsive disorder (OCD); however, the relationship between basal ganglia activity and OCD severity has never been adequately established. We recently showed that deep brain stimulation of the subthalamic nucleus (STN), a central basal ganglia nucleus, improves OCD. Here, single-unit subthalamic neuronal activity was analysed in 12 OCD patients, in relation to the severity of obsessions and compulsions and response to STN stimulation, and compared with that obtained in 12 patients with Parkinson's disease (PD). STN neurons in OCD patients had lower discharge frequency than those in PD patients, with a similar proportion of burst-type activity (69 vs 67%). Oscillatory activity was present in 46 and 68% of neurons in OCD and PD patients, respectively, predominantly in the low-frequency band (1–8 Hz). In OCD patients, the bursty and oscillatory subthalamic neuronal activity was mainly located in the associative–limbic part. Both OCD severity and clinical improvement following STN stimulation were related to the STN neuronal activity. In patients with the most severe OCD, STN neurons exhibited bursts with shorter duration and interburst interval, but higher intraburst frequency, and more oscillations in the low-frequency bands. In patients with best clinical outcome with STN stimulation, STN neurons displayed higher mean discharge, burst and intraburst frequencies, and lower interburst interval. These findings are consistent with the hypothesis of a dysfunction in the associative–limbic subdivision of the basal ganglia circuitry in OCD's pathophysiology.
Url:
DOI: 10.1038/tp.2011.5
PubMed: 22832400
PubMed Central: 3309476
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PMC:3309476Le document en format XML
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<country xml:lang="fr">France</country>
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<institution>Institut du Cerveau et de la Moelle épiniere (CRICM), Université Pierre et Marie Curie-Paris 6, UMR-S975</institution>
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<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Inserm, U975</institution>
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<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, UMR 7225</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris Centre d'Investigation Clinique</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
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</titleStmt>
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<date when="2011">2011</date>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Basal ganglia dysfunction in OCD: subthalamic neuronal activity correlates with symptoms severity and predicts high-frequency stimulation efficacy</title>
<author><name sortKey="Welter, M L" sort="Welter, M L" uniqKey="Welter M" first="M-L" last="Welter">M-L Welter</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Centre de Recherche de l</institution>
<institution>′</institution>
<institution>Institut du Cerveau et de la Moelle épiniere (CRICM), Université Pierre et Marie Curie-Paris 6, UMR-S975</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Inserm, U975</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, UMR 7225</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris Centre d'Investigation Clinique</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris</institution>
,<institution>Département de Neurologie, Bâtiment Paul Castaigne</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Burbaud, P" sort="Burbaud, P" uniqKey="Burbaud P" first="P" last="Burbaud">P. Burbaud</name>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Laboratoire Mouvement, Adaptation, Cognition, CNRS UMR 5227, Université Victor Segalen Bordeaux 2</institution>
, Bordeaux,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Service de Neurophysiologie, Hôpital Universitaire Pellegrin</institution>
, Bordeaux,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fernandez Vidal, S" sort="Fernandez Vidal, S" uniqKey="Fernandez Vidal S" first="S" last="Fernandez-Vidal">S. Fernandez-Vidal</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Centre de Recherche de l</institution>
<institution>′</institution>
<institution>Institut du Cerveau et de la Moelle épiniere (CRICM), Université Pierre et Marie Curie-Paris 6, UMR-S975</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Groupe Hospitalier Pitié-Salpêtrière, Centre de Neuroimagerie de Recherche (CENIR)</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bardinet, E" sort="Bardinet, E" uniqKey="Bardinet E" first="E" last="Bardinet">E. Bardinet</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Centre de Recherche de l</institution>
<institution>′</institution>
<institution>Institut du Cerveau et de la Moelle épiniere (CRICM), Université Pierre et Marie Curie-Paris 6, UMR-S975</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Groupe Hospitalier Pitié-Salpêtrière, Centre de Neuroimagerie de Recherche (CENIR)</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Coste, J" sort="Coste, J" uniqKey="Coste J" first="J" last="Coste">J. Coste</name>
<affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Service de Neurochirurgie A, CHU Clermont-Ferrand</institution>
, Clermont-Ferrand,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Piallat, B" sort="Piallat, B" uniqKey="Piallat B" first="B" last="Piallat">B. Piallat</name>
<affiliation wicri:level="1"><nlm:aff id="aff10"><institution>INSERM, U836, Grenoble Institute of Neuroscience</institution>
, Grenoble,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Borg, M" sort="Borg, M" uniqKey="Borg M" first="M" last="Borg">M. Borg</name>
<affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Service de Neurologie, CHU Nice</institution>
, Nice,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Besnard, S" sort="Besnard, S" uniqKey="Besnard S" first="S" last="Besnard">S. Besnard</name>
<affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Service de Neurophysiologie Clinique, CHU Poitiers</institution>
, Poitiers,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Sauleau, P" sort="Sauleau, P" uniqKey="Sauleau P" first="P" last="Sauleau">P. Sauleau</name>
<affiliation wicri:level="1"><nlm:aff id="aff13"><institution>Service de Neurophysiologie, CHU Rennes</institution>
, Rennes,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Devaux, B" sort="Devaux, B" uniqKey="Devaux B" first="B" last="Devaux">B. Devaux</name>
<affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Service de Neurochirurgie, Hôpital Sainte-Anne</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Pidoux, B" sort="Pidoux, B" uniqKey="Pidoux B" first="B" last="Pidoux">B. Pidoux</name>
<affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Service de Neurophysiologie Clinique</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chaynes, P" sort="Chaynes, P" uniqKey="Chaynes P" first="P" last="Chaynes">P. Chaynes</name>
<affiliation wicri:level="1"><nlm:aff id="aff16"><institution>Service de Neurochirurgie, CHU Toulouse</institution>
, Toulouse,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tezenas Du Montcel, S" sort="Tezenas Du Montcel, S" uniqKey="Tezenas Du Montcel S" first="S" last="Tézenas Du Montcel">S. Tézenas Du Montcel</name>
<affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Département de Biostatistiques et Information Médicale, ER4 (ex EA3974) Modélisation en Recherche Clinique</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Bastian, A" sort="Bastian, A" uniqKey="Bastian A" first="A" last="Bastian">A. Bastian</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Centre de Recherche de l</institution>
<institution>′</institution>
<institution>Institut du Cerveau et de la Moelle épiniere (CRICM), Université Pierre et Marie Curie-Paris 6, UMR-S975</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Inserm, U975</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, UMR 7225</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris Centre d'Investigation Clinique</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Langbour, N" sort="Langbour, N" uniqKey="Langbour N" first="N" last="Langbour">N. Langbour</name>
<affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Laboratoire Mouvement, Adaptation, Cognition, CNRS UMR 5227, Université Victor Segalen Bordeaux 2</institution>
, Bordeaux,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Teillant, A" sort="Teillant, A" uniqKey="Teillant A" first="A" last="Teillant">A. Teillant</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Centre de Recherche de l</institution>
<institution>′</institution>
<institution>Institut du Cerveau et de la Moelle épiniere (CRICM), Université Pierre et Marie Curie-Paris 6, UMR-S975</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Inserm, U975</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, UMR 7225</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris Centre d'Investigation Clinique</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Haynes, W" sort="Haynes, W" uniqKey="Haynes W" first="W" last="Haynes">W. Haynes</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Centre de Recherche de l</institution>
<institution>′</institution>
<institution>Institut du Cerveau et de la Moelle épiniere (CRICM), Université Pierre et Marie Curie-Paris 6, UMR-S975</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Inserm, U975</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, UMR 7225</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris Centre d'Investigation Clinique</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yelnik, J" sort="Yelnik, J" uniqKey="Yelnik J" first="J" last="Yelnik">J. Yelnik</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Centre de Recherche de l</institution>
<institution>′</institution>
<institution>Institut du Cerveau et de la Moelle épiniere (CRICM), Université Pierre et Marie Curie-Paris 6, UMR-S975</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Inserm, U975</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, UMR 7225</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris Centre d'Investigation Clinique</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Karachi, C" sort="Karachi, C" uniqKey="Karachi C" first="C" last="Karachi">C. Karachi</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Centre de Recherche de l</institution>
<institution>′</institution>
<institution>Institut du Cerveau et de la Moelle épiniere (CRICM), Université Pierre et Marie Curie-Paris 6, UMR-S975</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Inserm, U975</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, UMR 7225</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris Centre d'Investigation Clinique</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff18"><institution>Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, Service de Neurochirurgie</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mallet, L" sort="Mallet, L" uniqKey="Mallet L" first="L" last="Mallet">L. Mallet</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Centre de Recherche de l</institution>
<institution>′</institution>
<institution>Institut du Cerveau et de la Moelle épiniere (CRICM), Université Pierre et Marie Curie-Paris 6, UMR-S975</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Inserm, U975</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution>CNRS, UMR 7225</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris Centre d'Investigation Clinique</institution>
, Paris,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Translational Psychiatry</title>
<idno type="eISSN">2158-3188</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
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<term>Basal Ganglia (pathology)</term>
<term>Basal Ganglia (physiopathology)</term>
<term>Basal Ganglia (surgery)</term>
<term>Deep Brain Stimulation (instrumentation)</term>
<term>Deep Brain Stimulation (methods)</term>
<term>Electrodes, Implanted</term>
<term>Humans</term>
<term>Neurons (pathology)</term>
<term>Obsessive-Compulsive Disorder (pathology)</term>
<term>Obsessive-Compulsive Disorder (physiopathology)</term>
<term>Obsessive-Compulsive Disorder (therapy)</term>
<term>Parkinson Disease (pathology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinson Disease (therapy)</term>
<term>Severity of Illness Index</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Deep Brain Stimulation</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Basal Ganglia</term>
<term>Neurons</term>
<term>Obsessive-Compulsive Disorder</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Basal Ganglia</term>
<term>Obsessive-Compulsive Disorder</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Basal Ganglia</term>
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<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Obsessive-Compulsive Disorder</term>
<term>Parkinson Disease</term>
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<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Electrodes, Implanted</term>
<term>Humans</term>
<term>Severity of Illness Index</term>
<term>Treatment Outcome</term>
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<keywords scheme="mix" xml:lang="en"><term>Parkinson's disease</term>
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<front><div type="abstract" xml:lang="en"><p>Functional and connectivity changes in corticostriatal systems have been reported in the brains of patients with obsessive–compulsive disorder (OCD); however, the relationship between basal ganglia activity and OCD severity has never been adequately established. We recently showed that deep brain stimulation of the subthalamic nucleus (STN), a central basal ganglia nucleus, improves OCD. Here, single-unit subthalamic neuronal activity was analysed in 12 OCD patients, in relation to the severity of obsessions and compulsions and response to STN stimulation, and compared with that obtained in 12 patients with Parkinson's disease (PD). STN neurons in OCD patients had lower discharge frequency than those in PD patients, with a similar proportion of burst-type activity (69 vs 67%). Oscillatory activity was present in 46 and 68% of neurons in OCD and PD patients, respectively, predominantly in the low-frequency band (1–8 Hz). In OCD patients, the bursty and oscillatory subthalamic neuronal activity was mainly located in the associative–limbic part. Both OCD severity and clinical improvement following STN stimulation were related to the STN neuronal activity. In patients with the most severe OCD, STN neurons exhibited bursts with shorter duration and interburst interval, but higher intraburst frequency, and more oscillations in the low-frequency bands. In patients with best clinical outcome with STN stimulation, STN neurons displayed higher mean discharge, burst and intraburst frequencies, and lower interburst interval. These findings are consistent with the hypothesis of a dysfunction in the associative–limbic subdivision of the basal ganglia circuitry in OCD's pathophysiology.</p>
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