ParkinsonFranceV1, Main, Curation, bibRecord, 001304

Coordinated reset has sustained aftereffects in Parkinsonian monkeys

Identifieur interne : 001304 ( Main/Curation ); précédent : 001303; suivant : 001305

Coordinated reset has sustained aftereffects in Parkinsonian monkeys

Auteurs : Peter A. Tass [Allemagne] ; Li Qin [République populaire de Chine, Royaume-Uni] ; Christian Hauptmann [Allemagne] ; Sandra Dovero [France] ; Erwan Bezard [République populaire de Chine, Royaume-Uni, France] ; Thomas Boraud [France] ; Wassilios G. Meissner [France]

Source :

Annals of Neurology [ 0364-5134 ] ; 2012-11.

RBID : ISTEX:2D4DC45B620C9D00AA3ADA0D0E768886F58A5CD8

Descripteurs français

Pascal (Inist)
- Animal, Maladie de Parkinson, Pathologie du système nerveux, Singe.
Wicri :
- topic : Singe.

English descriptors

KwdEn :
- Animal, Monkey, Nervous system diseases, Parkinson disease.

Abstract

Coordinated reset neuromodulation consists of the application of consecutive brief high‐frequency pulse trains through the different contacts of the stimulation electrode. In theoretical studies, by achieving unlearning of abnormal connectivity between neurons, coordinated reset neuromodulation reduces pathological synchronization, a hallmark feature of Parkinson's disease pathophysiology. Here we show that coordinated reset neuromodulation of the subthalamic nucleus has both acute and sustained long‐lasting aftereffects on motor function in parkinsonian nonhuman primates. Long‐lasting aftereffects were not observed with classical deep brain stimulation. These observations encourage further development of coordinated reset neuromodulation for treating motor symptoms in Parkinson disease patients. ANN NEUROL 2012;72:816–820

Url:

https://api.istex.fr/document/2D4DC45B620C9D00AA3ADA0D0E768886F58A5CD8/fulltext/pdf

DOI: 10.1002/ana.23663

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ISTEX:2D4DC45B620C9D00AA3ADA0D0E768886F58A5CD8

Le document en format XML

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</placeName>
</affiliation>
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<sZ>5 aut.</sZ>
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<sZ>7 aut.</sZ>
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<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
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<sZ>6 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G." last="Meissner">Wassilios G. Meissner</name>
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<sZ>5 aut.</sZ>
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<sZ>7 aut.</sZ>
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</placeName>
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</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Centre de reference atrophie multisystématisée, CHU de Bordeaux</s1>
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<s3>FRA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Coordinated Reset Has Sustained Aftereffects in Parkinsonian Monkeys</title>
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<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
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<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
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</placeName>
</affiliation>
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<s3>DEU</s3>
<sZ>1 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
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</affiliation>
</author>
<author><name sortKey="Li Qin" sort="Li Qin" uniqKey="Li Qin" last="Li Qin">LI QIN</name>
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<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Motac Neuroscience</s1>
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<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Hauptmann, Christian" sort="Hauptmann, Christian" uniqKey="Hauptmann C" first="Christian" last="Hauptmann">Christian Hauptmann</name>
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<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Dovero, Sandra" sort="Dovero, Sandra" uniqKey="Dovero S" first="Sandra" last="Dovero">Sandra Dovero</name>
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<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
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<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>CNRS, Institut des Maladies Neurodégénératives, UMR 5293</s1>
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<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Institute of Laboratory Animal Sciences, China Academy of Medical Sciences</s1>
<s2>Beijing</s2>
<s3>CHN</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Motac Neuroscience</s1>
<s2>Manchester</s2>
<s3>GBR</s3>
<sZ>2 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Manchester</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Manchester</region>
</placeName>
</affiliation>
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<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>CNRS, Institut des Maladies Neurodégénératives, UMR 5293</s1>
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<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Service de Neurologie, CHU de Bordeaux</s1>
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<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Pessac</wicri:noRegion>
<wicri:noRegion>CHU de Bordeaux</wicri:noRegion>
<wicri:noRegion>Pessac</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Boraud, Thomas" sort="Boraud, Thomas" uniqKey="Boraud T" first="Thomas" last="Boraud">Thomas Boraud</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><inist:fA14 i1="06"><s1>CNRS, Institut des Maladies Neurodégénératives, UMR 5293</s1>
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<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Service de Neurologie, CHU de Bordeaux</s1>
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<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Pessac</wicri:noRegion>
<wicri:noRegion>CHU de Bordeaux</wicri:noRegion>
<wicri:noRegion>Pessac</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G." last="Meissner">Wassilios G. Meissner</name>
<affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
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<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Service de Neurologie, CHU de Bordeaux</s1>
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<s3>FRA</s3>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
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<wicri:noRegion>CHU de Bordeaux</wicri:noRegion>
<wicri:noRegion>Pessac</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Centre de reference atrophie multisystématisée, CHU de Bordeaux</s1>
<s2>Pessac</s2>
<s3>FRA</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Pessac</wicri:noRegion>
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<wicri:noRegion>Pessac</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Annals of neurology</title>
<title level="j" type="abbreviated">Ann. neurol.</title>
<idno type="ISSN">0364-5134</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Annals of neurology</title>
<title level="j" type="abbreviated">Ann. neurol.</title>
<idno type="ISSN">0364-5134</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term>
<term>Monkey</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du   système nerveux</term>
<term>Animal</term>
<term>Singe</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Singe</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">Coordinated reset neuromodulation consists of the application of consecutive brief high-frequency pulse trains through the different contacts of the stimulation electrode. In theoretical studies, by achieving unlearning of abnormal connectivity between neurons, coordinated reset neuromodulation reduces pathological synchronization, a hallmark feature of Parkinson's disease pathophysiology. Here we show that coordinated reset neuromodulation of the subthalamic nucleus has both acute and sustained long-lasting aftereffects on motor function in parkinsonian nonhuman primates. Long-lasting aftereffects were not observed with classical deep brain stimulation. These observations encourage further development of coordinated reset neuromodulation for treating motor symptoms in Parkinson disease patients.</div>
</front>
</TEI>
</INIST>
<ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Coordinated reset has sustained aftereffects in Parkinsonian monkeys</title>
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</author>
<author><name sortKey="Qin, Li" sort="Qin, Li" uniqKey="Qin L" first="Li" last="Qin">Li Qin</name>
</author>
<author><name sortKey="Hauptmann, Christian" sort="Hauptmann, Christian" uniqKey="Hauptmann C" first="Christian" last="Hauptmann">Christian Hauptmann</name>
</author>
<author><name sortKey="Dovero, Sandra" sort="Dovero, Sandra" uniqKey="Dovero S" first="Sandra" last="Dovero">Sandra Dovero</name>
</author>
<author><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name>
</author>
<author><name sortKey="Boraud, Thomas" sort="Boraud, Thomas" uniqKey="Boraud T" first="Thomas" last="Boraud">Thomas Boraud</name>
</author>
<author><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G." last="Meissner">Wassilios G. Meissner</name>
</author>
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<idno type="RBID">ISTEX:2D4DC45B620C9D00AA3ADA0D0E768886F58A5CD8</idno>
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<idno type="doi">10.1002/ana.23663</idno>
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<sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Coordinated reset has sustained aftereffects in Parkinsonian monkeys</title>
<author><name sortKey="Tass, Peter A" sort="Tass, Peter A" uniqKey="Tass P" first="Peter A." last="Tass">Peter A. Tass</name>
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<placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region>
<region type="district" nuts="2">District de Cologne</region>
<settlement type="city">Juliers</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division for Neuromodulation, Medical School, University of Cologne, Cologne</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Qin, Li" sort="Qin, Li" uniqKey="Qin L" first="Li" last="Qin">Li Qin</name>
<affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country>
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<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
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<region type="région" nuts="1">Grand Manchester</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hauptmann, Christian" sort="Hauptmann, Christian" uniqKey="Hauptmann C" first="Christian" last="Hauptmann">Christian Hauptmann</name>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Dovero, Sandra" sort="Dovero, Sandra" uniqKey="Dovero S" first="Sandra" last="Dovero">Sandra Dovero</name>
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<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
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<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bezard, Erwan" sort="Bezard, Erwan" uniqKey="Bezard E" first="Erwan" last="Bezard">Erwan Bezard</name>
<affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Institute of Laboratory Animal Sciences, China Academy of Medical Sciences, Beijing</wicri:regionArea>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Motac Neuroscience, Manchester</wicri:regionArea>
<placeName><settlement type="city">Manchester</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Manchester</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Service de Neurologie, CHU de Bordeaux, Pessac</wicri:regionArea>
<wicri:noRegion>Pessac</wicri:noRegion>
<wicri:noRegion>Pessac</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Boraud, Thomas" sort="Boraud, Thomas" uniqKey="Boraud T" first="Thomas" last="Boraud">Thomas Boraud</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Service de Neurologie, CHU de Bordeaux, Pessac</wicri:regionArea>
<wicri:noRegion>Pessac</wicri:noRegion>
<wicri:noRegion>Pessac</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Meissner, Wassilios G" sort="Meissner, Wassilios G" uniqKey="Meissner W" first="Wassilios G." last="Meissner">Wassilios G. Meissner</name>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>CNRS, Institut des Maladies Neurodégénératives, UMR 5293, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Service de Neurologie, CHU de Bordeaux, Pessac</wicri:regionArea>
<wicri:noRegion>Pessac</wicri:noRegion>
<wicri:noRegion>Pessac</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">France</country>
<wicri:regionArea>Centre de référence atrophie multisystématisée, CHU de Bordeaux, Pessac</wicri:regionArea>
<wicri:noRegion>Pessac</wicri:noRegion>
<wicri:noRegion>Pessac</wicri:noRegion>
</affiliation>
<affiliation wicri:level="3"><country xml:lang="fr">France</country>
<wicri:regionArea>Service de Neurologie, Hôpital du Haut‐Lévêque, CHU de Bordeaux, Avenue Magellan, 33604 Pessac cedex</wicri:regionArea>
<placeName><region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
<settlement type="city">Pessac</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Annals of Neurology</title>
<title level="j" type="abbrev">Ann Neurol.</title>
<idno type="ISSN">0364-5134</idno>
<idno type="eISSN">1531-8249</idno>
<imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher>
<pubPlace>Hoboken</pubPlace>
<date type="published" when="2012-11">2012-11</date>
<biblScope unit="volume">72</biblScope>
<biblScope unit="issue">5</biblScope>
<biblScope unit="page" from="816">816</biblScope>
<biblScope unit="page" to="820">820</biblScope>
</imprint>
<idno type="ISSN">0364-5134</idno>
</series>
<idno type="istex">2D4DC45B620C9D00AA3ADA0D0E768886F58A5CD8</idno>
<idno type="DOI">10.1002/ana.23663</idno>
<idno type="ArticleID">ANA23663</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0364-5134</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Coordinated reset neuromodulation consists of the application of consecutive brief high‐frequency pulse trains through the different contacts of the stimulation electrode. In theoretical studies, by achieving unlearning of abnormal connectivity between neurons, coordinated reset neuromodulation reduces pathological synchronization, a hallmark feature of Parkinson's disease pathophysiology. Here we show that coordinated reset neuromodulation of the subthalamic nucleus has both acute and sustained long‐lasting aftereffects on motor function in parkinsonian nonhuman primates. Long‐lasting aftereffects were not observed with classical deep brain stimulation. These observations encourage further development of coordinated reset neuromodulation for treating motor symptoms in Parkinson disease patients. ANN NEUROL 2012;72:816–820</div>
</front>
</TEI>
</ISTEX>
</double>
</record>

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	La maladie de Parkinson en France (serveur d'exploration)
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La maladie de Parkinson en France (serveur d'exploration)

Coordinated reset has sustained aftereffects in Parkinsonian monkeys

Coordinated reset has sustained aftereffects in Parkinsonian monkeys

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