Histofluorescence analysis of several systems of catecholaminergic nerve fibres within the rat neostriatum revealed by either restricted lesions of the substantia nigra or γ-hydroxybutyrate
Identifieur interne : 002167 ( Istex/Curation ); précédent : 002166; suivant : 002168Histofluorescence analysis of several systems of catecholaminergic nerve fibres within the rat neostriatum revealed by either restricted lesions of the substantia nigra or γ-hydroxybutyrate
Auteurs : Michel Arluison ; France Javoy-Agid ; Claude Feuerstein [France] ; Michel Tauc ; Marie Conrath-Verrier ; Philippe MaillySource :
- Brain Research Bulletin [ 0361-9230 ] ; 1982.
Abstract
The glyoxylic acid fluorescence technique was applied to the study of catecholamine fibres in the caudate-putamen (neostriatum) of control and experimental adult rats. Cryostat or vibratome sectioning procedures were used; in the last case, either incubations of brain slices in γ-methyl-noradrenaline or pre-treatment of animals with γ-hydroxybutyrate were performed, in order to increase the intensity of fluorescence. In control animals and in the contralateral side of rats lesioned in the substantia nigra, the fluorescence of the dense plexus of dopamine nerver fibres appeared under the form of densely packed varicosities. However, some regions differed from the ordinary fluorescence of the neostriatum by their stronger intensity and more visible varicosities. They were located principally in the ventro-medial regions bordering either the nucleus accumbens, the dorsal nucleus interstitialis striae terminalis and the ventricle in the anterior part, or the amygdala, the globus pallidus and the ventricle in the posterior part. Moreover, islands of stronger fluorescence also were observed in the head of the caudate-putamen along the dorsal and lateral corpus callosum, as well as scattered in the central region. These particular neostriatal structures might correspond to a separate system of ascending dopamine nerve fibres. Therefore, restricted electrolytic lesions of the substantia nigra pars compacta were undertaken in order to study the morphology of the remaining Catecholaminergic fibres in the ipsilateral neostriatum. In largely denervated areas, different types of fluorescent axons were evident. Presumed noradrenergic nerve fibres characterized by a very coarse appearance and closed varicosities were rare. They contrasted markedly with numerous delicate fibres which might belong to several dopaminergic systems. Both first types exhibited long, clearly visible intervaricose segments and ovoid triangular varicosities. The second type, which was thicker and more strongly fluorescent, probably formed the islands observed in unlesioned striata. The third type had very closed, small spherical varicosities and poorly fluorescent intervaricose segments. Dopamine nerve fibres of the same morphology were described previously in the neocortex [43,44] and the possibility of a common origin for nerve fibres of the same type is discussed. When rats were treated with the anaesthetic γ-hydroxybutyrate, all the dopamine nerve fibres appeared to develop a strong fluorescence within the neostriatum, but more fluorescent islands were always visible. Additionally, some swollen fluorescent fibres were seen; these could be abnormal dopamine fibres whose metabolism had been pathologically altered by the drug.
Url:
DOI: 10.1016/0361-9230(82)90146-0
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :002169
Links to Exploration step
ISTEX:C6EED05FD190B8A7E21E920AE82D437B96F12874Curation
No country items
Michel Arluison<affiliation><mods:affiliation>Send reprint requests to Dr. Michel Arluison, Laboratoire de Cytologie, Université Pierre et Marie Curie, 7 quai Saint Bernard, 75005 Paris, France. This work has been supported by the “Direction des Recherches of Etudes Techniques” (D.R.E.T.) Grant 80/342.</mods:affiliation>
<wicri:noCountry code="subField">80/342.</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>Laboratoire de Médecine Expérimentale, Chu Pitié-Salpétrière, 91 Bd de l'Hopital, 75013 ParisFrance</mods:affiliation>
<wicri:noCountry code="subField">ParisFrance</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>Université Pierre et Marie Curie, Laboratoire de Cytologie, 7 quai Saint Bernard, 75005 Paris, ERA884, CNRS, ParisFrance</mods:affiliation>
<wicri:noCountry code="subField">ParisFrance</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>Université Pierre et Marie Curie, Laboratoire de Cytologie, 7 quai Saint Bernard, 75005 Paris, ERA884, CNRS, ParisFrance</mods:affiliation>
<wicri:noCountry code="subField">ParisFrance</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>Université Pierre et Marie Curie, Laboratoire de Cytologie, 7 quai Saint Bernard, 75005 Paris, ERA884, CNRS, ParisFrance</mods:affiliation>
<wicri:noCountry code="subField">ParisFrance</wicri:noCountry>
</affiliation>
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Histofluorescence analysis of several systems of catecholaminergic nerve fibres within the rat neostriatum revealed by either restricted lesions of the substantia nigra or γ-hydroxybutyrate</title>
<author><name sortKey="Arluison, Michel" sort="Arluison, Michel" uniqKey="Arluison M" first="Michel" last="Arluison">Michel Arluison</name>
<affiliation><mods:affiliation>Université Pierre et Marie Curie, Laboratoire de Cytologie, 7 quai Saint Bernard, 75005 Paris, ERA884, CNRS, ParisFrance</mods:affiliation>
<wicri:noCountry code="subField">ParisFrance</wicri:noCountry>
</affiliation>
<affiliation><mods:affiliation>Send reprint requests to Dr. Michel Arluison, Laboratoire de Cytologie, Université Pierre et Marie Curie, 7 quai Saint Bernard, 75005 Paris, France. This work has been supported by the “Direction des Recherches of Etudes Techniques” (D.R.E.T.) Grant 80/342.</mods:affiliation>
<wicri:noCountry code="subField">80/342.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Javoy Agid, France" sort="Javoy Agid, France" uniqKey="Javoy Agid F" first="France" last="Javoy-Agid">France Javoy-Agid</name>
<affiliation><mods:affiliation>Laboratoire de Médecine Expérimentale, Chu Pitié-Salpétrière, 91 Bd de l'Hopital, 75013 ParisFrance</mods:affiliation>
<wicri:noCountry code="subField">ParisFrance</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Feuerstein, Claude" sort="Feuerstein, Claude" uniqKey="Feuerstein C" first="Claude" last="Feuerstein">Claude Feuerstein</name>
<affiliation wicri:level="1"><mods:affiliation>Laboratoire de Neurophysiologie, Pavillon de Neurologie, Chu de Grenoble, BP 217 38043 Grenoble Cedex France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Neurophysiologie, Pavillon de Neurologie, Chu de Grenoble</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tauc, Michel" sort="Tauc, Michel" uniqKey="Tauc M" first="Michel" last="Tauc">Michel Tauc</name>
<affiliation><mods:affiliation>Université Pierre et Marie Curie, Laboratoire de Cytologie, 7 quai Saint Bernard, 75005 Paris, ERA884, CNRS, ParisFrance</mods:affiliation>
<wicri:noCountry code="subField">ParisFrance</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Conrath Verrier, Marie" sort="Conrath Verrier, Marie" uniqKey="Conrath Verrier M" first="Marie" last="Conrath-Verrier">Marie Conrath-Verrier</name>
<affiliation><mods:affiliation>Université Pierre et Marie Curie, Laboratoire de Cytologie, 7 quai Saint Bernard, 75005 Paris, ERA884, CNRS, ParisFrance</mods:affiliation>
<wicri:noCountry code="subField">ParisFrance</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mailly, Philippe" sort="Mailly, Philippe" uniqKey="Mailly P" first="Philippe" last="Mailly">Philippe Mailly</name>
<affiliation><mods:affiliation>Université Pierre et Marie Curie, Laboratoire de Cytologie, 7 quai Saint Bernard, 75005 Paris, ERA884, CNRS, ParisFrance</mods:affiliation>
<wicri:noCountry code="subField">ParisFrance</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:C6EED05FD190B8A7E21E920AE82D437B96F12874</idno>
<date when="1982" year="1982">1982</date>
<idno type="doi">10.1016/0361-9230(82)90146-0</idno>
<idno type="url">https://api.istex.fr/document/C6EED05FD190B8A7E21E920AE82D437B96F12874/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">002169</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002169</idno>
<idno type="wicri:Area/Istex/Curation">002167</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a">Histofluorescence analysis of several systems of catecholaminergic nerve fibres within the rat neostriatum revealed by either restricted lesions of the substantia nigra or γ-hydroxybutyrate</title>
<author><name sortKey="Arluison, Michel" sort="Arluison, Michel" uniqKey="Arluison M" first="Michel" last="Arluison">Michel Arluison</name>
<affiliation><mods:affiliation>Université Pierre et Marie Curie, Laboratoire de Cytologie, 7 quai Saint Bernard, 75005 Paris, ERA884, CNRS, ParisFrance</mods:affiliation>
</affiliation>
<affiliation><mods:affiliation>Send reprint requests to Dr. Michel Arluison, Laboratoire de Cytologie, Université Pierre et Marie Curie, 7 quai Saint Bernard, 75005 Paris, France. This work has been supported by the “Direction des Recherches of Etudes Techniques” (D.R.E.T.) Grant 80/342.</mods:affiliation>
<wicri:noCountry code="subField">80/342.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Javoy Agid, France" sort="Javoy Agid, France" uniqKey="Javoy Agid F" first="France" last="Javoy-Agid">France Javoy-Agid</name>
<affiliation><mods:affiliation>Laboratoire de Médecine Expérimentale, Chu Pitié-Salpétrière, 91 Bd de l'Hopital, 75013 ParisFrance</mods:affiliation>
<wicri:noCountry code="subField">ParisFrance</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Feuerstein, Claude" sort="Feuerstein, Claude" uniqKey="Feuerstein C" first="Claude" last="Feuerstein">Claude Feuerstein</name>
<affiliation wicri:level="1"><mods:affiliation>Laboratoire de Neurophysiologie, Pavillon de Neurologie, Chu de Grenoble, BP 217 38043 Grenoble Cedex France</mods:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Laboratoire de Neurophysiologie, Pavillon de Neurologie, Chu de Grenoble</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Tauc, Michel" sort="Tauc, Michel" uniqKey="Tauc M" first="Michel" last="Tauc">Michel Tauc</name>
<affiliation><mods:affiliation>Université Pierre et Marie Curie, Laboratoire de Cytologie, 7 quai Saint Bernard, 75005 Paris, ERA884, CNRS, ParisFrance</mods:affiliation>
<wicri:noCountry code="subField">ParisFrance</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Conrath Verrier, Marie" sort="Conrath Verrier, Marie" uniqKey="Conrath Verrier M" first="Marie" last="Conrath-Verrier">Marie Conrath-Verrier</name>
<affiliation><mods:affiliation>Université Pierre et Marie Curie, Laboratoire de Cytologie, 7 quai Saint Bernard, 75005 Paris, ERA884, CNRS, ParisFrance</mods:affiliation>
<wicri:noCountry code="subField">ParisFrance</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mailly, Philippe" sort="Mailly, Philippe" uniqKey="Mailly P" first="Philippe" last="Mailly">Philippe Mailly</name>
<affiliation><mods:affiliation>Université Pierre et Marie Curie, Laboratoire de Cytologie, 7 quai Saint Bernard, 75005 Paris, ERA884, CNRS, ParisFrance</mods:affiliation>
<wicri:noCountry code="subField">ParisFrance</wicri:noCountry>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Brain Research Bulletin</title>
<title level="j" type="abbrev">BRB</title>
<idno type="ISSN">0361-9230</idno>
<imprint><publisher>ELSEVIER</publisher>
<date type="published" when="1982">1982</date>
<biblScope unit="volume">9</biblScope>
<biblScope unit="issue">1–6</biblScope>
<biblScope unit="page" from="355">355</biblScope>
<biblScope unit="page" to="365">365</biblScope>
</imprint>
<idno type="ISSN">0361-9230</idno>
</series>
<idno type="istex">C6EED05FD190B8A7E21E920AE82D437B96F12874</idno>
<idno type="DOI">10.1016/0361-9230(82)90146-0</idno>
<idno type="PII">0361-9230(82)90146-0</idno>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0361-9230</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
<langUsage><language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The glyoxylic acid fluorescence technique was applied to the study of catecholamine fibres in the caudate-putamen (neostriatum) of control and experimental adult rats. Cryostat or vibratome sectioning procedures were used; in the last case, either incubations of brain slices in γ-methyl-noradrenaline or pre-treatment of animals with γ-hydroxybutyrate were performed, in order to increase the intensity of fluorescence. In control animals and in the contralateral side of rats lesioned in the substantia nigra, the fluorescence of the dense plexus of dopamine nerver fibres appeared under the form of densely packed varicosities. However, some regions differed from the ordinary fluorescence of the neostriatum by their stronger intensity and more visible varicosities. They were located principally in the ventro-medial regions bordering either the nucleus accumbens, the dorsal nucleus interstitialis striae terminalis and the ventricle in the anterior part, or the amygdala, the globus pallidus and the ventricle in the posterior part. Moreover, islands of stronger fluorescence also were observed in the head of the caudate-putamen along the dorsal and lateral corpus callosum, as well as scattered in the central region. These particular neostriatal structures might correspond to a separate system of ascending dopamine nerve fibres. Therefore, restricted electrolytic lesions of the substantia nigra pars compacta were undertaken in order to study the morphology of the remaining Catecholaminergic fibres in the ipsilateral neostriatum. In largely denervated areas, different types of fluorescent axons were evident. Presumed noradrenergic nerve fibres characterized by a very coarse appearance and closed varicosities were rare. They contrasted markedly with numerous delicate fibres which might belong to several dopaminergic systems. Both first types exhibited long, clearly visible intervaricose segments and ovoid triangular varicosities. The second type, which was thicker and more strongly fluorescent, probably formed the islands observed in unlesioned striata. The third type had very closed, small spherical varicosities and poorly fluorescent intervaricose segments. Dopamine nerve fibres of the same morphology were described previously in the neocortex [43,44] and the possibility of a common origin for nerve fibres of the same type is discussed. When rats were treated with the anaesthetic γ-hydroxybutyrate, all the dopamine nerve fibres appeared to develop a strong fluorescence within the neostriatum, but more fluorescent islands were always visible. Additionally, some swollen fluorescent fibres were seen; these could be abnormal dopamine fibres whose metabolism had been pathologically altered by the drug.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002167 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 002167 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Sante |area= ParkinsonFranceV1 |flux= Istex |étape= Curation |type= RBID |clé= ISTEX:C6EED05FD190B8A7E21E920AE82D437B96F12874 |texte= Histofluorescence analysis of several systems of catecholaminergic nerve fibres within the rat neostriatum revealed by either restricted lesions of the substantia nigra or γ-hydroxybutyrate }}
![]() | This area was generated with Dilib version V0.6.29. | ![]() |