In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis
Identifieur interne : 001619 ( Istex/Curation ); précédent : 001618; suivant : 001620In vivo protective effect of the lectin from Canavalia brasiliensis on BALB/c mice infected by Leishmania amazonensis
Auteurs : M. Barral-Netto [Brésil] ; R. L. Von Sohsten [Brésil] ; M. Teixeira [Brésil] ; W. L. Conrado Dos Santos [Brésil] ; M. L. Pompeu [Brésil] ; R. A. Moreira [Brésil] ; J. T. A. Oliveira [Brésil] ; B. S. Cavada [Brésil] ; E. Falcoff [France] ; A. Barral [Brésil]Source :
- Acta Tropica [ 0001-706X ] ; 1996.
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Abstract
In vivo administration of Canavalia brasiliensis lectin (at the time of infection, or maintained throughout the infection) reduced the lesions of highly susceptible BALB/c mice infected by Leishmania amazonensis. At the doses used C. brasiliensis lectin (ConBr) does not interfere with penetration or fate of Leishmania in the macrophages in vitro. Since Interferon-γ (IFN-γ) is the major macrophage activating factor, and considered a critical element in the successful immune response against leishmaniasis, we explored its participation in this phenomenon. ConBr either in vivo or in vitro induced IFN-γ production in normal or in leishmania-infected BALB/c mice. However we were unable to change the course of disease by in vivo IFN-γ administration (although IFN-γ preparations were effective in inducing a leishmanicidal effect in vitro on L. amazonensis-infected peritoneal macrophages). Additionally, IFN-γ neutralization with anti-IFN-γ monoclonal antibody did not alter the protection conferred by ConBr administration. These data show that lectin administration in vivo is protective in the otherwise unchecked L. amazonensis infection of BALB/c mice, and suggest that such effect is not mediated by IFN-γ.
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DOI: 10.1016/0001-706X(95)00120-4
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Cavada</name><affiliation wicri:level="1"><mods:affiliation>Departamentos de Patologia & Bioquimica, Universidade Federal do Ceará, Ceara, Brazil</mods:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Departamentos de Patologia & Bioquimica, Universidade Federal do Ceará, Ceara</wicri:regionArea></affiliation></author><author><name sortKey="Falcoff, E" sort="Falcoff, E" uniqKey="Falcoff E" first="E." last="Falcoff">E. Falcoff</name><affiliation wicri:level="1"><mods:affiliation>Institut Curie, Unité INSERM 196, Paris, France</mods:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Institut Curie, Unité INSERM 196, Paris</wicri:regionArea></affiliation></author><author><name sortKey="Barral, A" sort="Barral, A" uniqKey="Barral A" first="A." last="Barral">A. Barral</name><affiliation wicri:level="1"><mods:affiliation>Serviço de Imunologia, Hosp. Univ. Prof. Edgard Santos, Universidade Federal da Bahia, Bahia, Brazil</mods:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Serviço de Imunologia, Hosp. Univ. Prof. Edgard Santos, Universidade Federal da Bahia, Bahia</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Acta Tropica</title><title level="j" type="abbrev">ACTROP</title><idno type="ISSN">0001-706X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1996">1996</date><biblScope unit="volume">60</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="237">237</biblScope><biblScope unit="page" to="250">250</biblScope></imprint><idno type="ISSN">0001-706X</idno></series><idno type="istex">32EF19B1D2BDC6AD12A7CA2BDECB7F2D4794D9CD</idno><idno type="DOI">10.1016/0001-706X(95)00120-4</idno><idno type="PII">0001-706X(95)00120-4</idno><idno type="ArticleID">95001204</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0001-706X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Canavalia brasiliensis</term><term>Experimental leishmaniasis</term><term>Interferon-γ</term><term>Leishmania</term><term>Leishmania amazonensis</term><term>Leishmaniasis</term><term>Tegumentary leishmaniasis</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In vivo administration of Canavalia brasiliensis lectin (at the time of infection, or maintained throughout the infection) reduced the lesions of highly susceptible BALB/c mice infected by Leishmania amazonensis. At the doses used C. brasiliensis lectin (ConBr) does not interfere with penetration or fate of Leishmania in the macrophages in vitro. Since Interferon-γ (IFN-γ) is the major macrophage activating factor, and considered a critical element in the successful immune response against leishmaniasis, we explored its participation in this phenomenon. ConBr either in vivo or in vitro induced IFN-γ production in normal or in leishmania-infected BALB/c mice. However we were unable to change the course of disease by in vivo IFN-γ administration (although IFN-γ preparations were effective in inducing a leishmanicidal effect in vitro on L. amazonensis-infected peritoneal macrophages). Additionally, IFN-γ neutralization with anti-IFN-γ monoclonal antibody did not alter the protection conferred by ConBr administration. These data show that lectin administration in vivo is protective in the otherwise unchecked L. amazonensis infection of BALB/c mice, and suggest that such effect is not mediated by IFN-γ.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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