Two‐year follow‐up of subthalamic deep brain stimulation in Parkinson's disease
Identifieur interne : 001033 ( Istex/Curation ); précédent : 001032; suivant : 001034Two‐year follow‐up of subthalamic deep brain stimulation in Parkinson's disease
Auteurs : Jan Herzog [Allemagne] ; Jens Volkmann [Allemagne] ; Paul Krack [Allemagne, France] ; Florian Kopper [Allemagne] ; Monika Pötter [Allemagne] ; Delia Lorenz [Allemagne] ; Meike Steinbach [Allemagne] ; Stefan Klebe [Allemagne] ; Wolfgang Hamel [Allemagne] ; Bettina Schrader [Allemagne] ; Dieter Weinert [Allemagne] ; Dieter Müller [Allemagne] ; Hubertus M. Mehdorn [Allemagne] ; Günther Deuschl [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2003-11.
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Abstract
We studied 48 patients after bilateral subthalamic nucleus deep brain stimulation (STN‐DBS) who were evaluated 6 months after the surgical procedure using the Unified Parkinson's Disease Rating Scale (UPDRS) in a standardized levodopa test. Additional follow‐up was available in 32 patients after 12 months and in 20 patients after 24 months. At 6 months follow‐up, STN‐DBS reduced the UPDRS motor score by 50.9% compared to baseline. This improvement remained constant at 12 months with 57.5% and at 24 months with 57.3%. Relevant side effects after STN‐DBS included intraoperative subdural hematoma without neurological sequelae (n = 1), minor intracerebral bleeding with slight transient hemiparesis (n = 1), dislocation of impulse generator (n = 2), transient perioperative confusional symptoms (n = 7), psychotic symptoms (n = 2), depression (n = 5), hypomanic behaviour (n = 2), and transient manic psychosis (n = 1). One patient died because of heart failure during the first postoperative year. The current series demonstrates efficacy and safety of STN‐DBS beyond the first year after surgical procedure. Complications of STN‐DBS comprise a wide range of psychiatric adverse events which, however, were temporary. © 2003 Movement Disorder Society
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DOI: 10.1002/mds.10518
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last="Herzog">Jan Herzog</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel</wicri:regionArea></affiliation></author><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel</wicri:regionArea></affiliation></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Christian‐Albrechts 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Kiel</wicri:regionArea></affiliation></author><author><name sortKey="Steinbach, Meike" sort="Steinbach, Meike" uniqKey="Steinbach M" first="Meike" last="Steinbach">Meike Steinbach</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel</wicri:regionArea></affiliation></author><author><name sortKey="Klebe, Stefan" sort="Klebe, Stefan" uniqKey="Klebe S" first="Stefan" last="Klebe">Stefan Klebe</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel</wicri:regionArea></affiliation></author><author><name sortKey="Hamel, Wolfgang" sort="Hamel, Wolfgang" uniqKey="Hamel W" first="Wolfgang" last="Hamel">Wolfgang Hamel</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel</wicri:regionArea></affiliation></author><author><name sortKey="Schrader, Bettina" sort="Schrader, Bettina" uniqKey="Schrader B" first="Bettina" last="Schrader">Bettina Schrader</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel</wicri:regionArea></affiliation></author><author><name sortKey="Weinert, Dieter" sort="Weinert, Dieter" uniqKey="Weinert D" first="Dieter" last="Weinert">Dieter Weinert</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel</wicri:regionArea></affiliation></author><author><name sortKey="Muller, Dieter" sort="Muller, Dieter" uniqKey="Muller D" first="Dieter" last="Müller">Dieter Müller</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurosurgery, University of Hamburg, Hamburg, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurosurgery, University of Hamburg, Hamburg</wicri:regionArea></affiliation></author><author><name sortKey="Mehdorn, Hubertus M" sort="Mehdorn, Hubertus M" uniqKey="Mehdorn H" first="Hubertus M." last="Mehdorn">Hubertus M. Mehdorn</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel</wicri:regionArea></affiliation></author><author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Department of Neurology, Christian‐Albrechts University of Kiel, Niemannsweg 147, 24105 Kiel, Germany</mods:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Neurology, Christian‐Albrechts University of Kiel, Niemannsweg 147, 24105 Kiel</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2003-11">2003-11</date><biblScope unit="volume">18</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1332">1332</biblScope><biblScope unit="page" to="1337">1337</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">D960A89B118AE86962E899A6027E0B6931A65902</idno><idno type="DOI">10.1002/mds.10518</idno><idno type="ArticleID">MDS10518</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>deep brain stimulation</term><term>subthalamic nucleus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied 48 patients after bilateral subthalamic nucleus deep brain stimulation (STN‐DBS) who were evaluated 6 months after the surgical procedure using the Unified Parkinson's Disease Rating Scale (UPDRS) in a standardized levodopa test. Additional follow‐up was available in 32 patients after 12 months and in 20 patients after 24 months. At 6 months follow‐up, STN‐DBS reduced the UPDRS motor score by 50.9% compared to baseline. This improvement remained constant at 12 months with 57.5% and at 24 months with 57.3%. Relevant side effects after STN‐DBS included intraoperative subdural hematoma without neurological sequelae (n = 1), minor intracerebral bleeding with slight transient hemiparesis (n = 1), dislocation of impulse generator (n = 2), transient perioperative confusional symptoms (n = 7), psychotic symptoms (n = 2), depression (n = 5), hypomanic behaviour (n = 2), and transient manic psychosis (n = 1). One patient died because of heart failure during the first postoperative year. The current series demonstrates efficacy and safety of STN‐DBS beyond the first year after surgical procedure. Complications of STN‐DBS comprise a wide range of psychiatric adverse events which, however, were temporary. © 2003 Movement Disorder Society</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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