Two‐year follow‐up of subthalamic deep brain stimulation in Parkinson's disease
Identifieur interne : 001035 ( Istex/Corpus ); précédent : 001034; suivant : 001036Two‐year follow‐up of subthalamic deep brain stimulation in Parkinson's disease
Auteurs : Jan Herzog ; Jens Volkmann ; Paul Krack ; Florian Kopper ; Monika Pötter ; Delia Lorenz ; Meike Steinbach ; Stefan Klebe ; Wolfgang Hamel ; Bettina Schrader ; Dieter Weinert ; Dieter Müller ; Hubertus M. Mehdorn ; Günther DeuschlSource :
- Movement Disorders [ 0885-3185 ] ; 2003-11.
English descriptors
Abstract
We studied 48 patients after bilateral subthalamic nucleus deep brain stimulation (STN‐DBS) who were evaluated 6 months after the surgical procedure using the Unified Parkinson's Disease Rating Scale (UPDRS) in a standardized levodopa test. Additional follow‐up was available in 32 patients after 12 months and in 20 patients after 24 months. At 6 months follow‐up, STN‐DBS reduced the UPDRS motor score by 50.9% compared to baseline. This improvement remained constant at 12 months with 57.5% and at 24 months with 57.3%. Relevant side effects after STN‐DBS included intraoperative subdural hematoma without neurological sequelae (n = 1), minor intracerebral bleeding with slight transient hemiparesis (n = 1), dislocation of impulse generator (n = 2), transient perioperative confusional symptoms (n = 7), psychotic symptoms (n = 2), depression (n = 5), hypomanic behaviour (n = 2), and transient manic psychosis (n = 1). One patient died because of heart failure during the first postoperative year. The current series demonstrates efficacy and safety of STN‐DBS beyond the first year after surgical procedure. Complications of STN‐DBS comprise a wide range of psychiatric adverse events which, however, were temporary. © 2003 Movement Disorder Society
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DOI: 10.1002/mds.10518
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Two‐year follow‐up of subthalamic deep brain stimulation in Parkinson's disease</title><author><name sortKey="Herzog, Jan" sort="Herzog, Jan" uniqKey="Herzog J" first="Jan" last="Herzog">Jan Herzog</name><affiliation><mods:affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name><affiliation><mods:affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name><affiliation><mods:affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Current Address: Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Kopper, Florian" sort="Kopper, Florian" uniqKey="Kopper F" first="Florian" last="Kopper">Florian Kopper</name><affiliation><mods:affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Potter, Monika" sort="Potter, Monika" uniqKey="Potter M" first="Monika" last="Pötter">Monika Pötter</name><affiliation><mods:affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Lorenz, Delia" sort="Lorenz, Delia" uniqKey="Lorenz D" first="Delia" last="Lorenz">Delia Lorenz</name><affiliation><mods:affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Steinbach, Meike" sort="Steinbach, Meike" uniqKey="Steinbach M" first="Meike" last="Steinbach">Meike Steinbach</name><affiliation><mods:affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Klebe, Stefan" sort="Klebe, Stefan" uniqKey="Klebe S" first="Stefan" last="Klebe">Stefan Klebe</name><affiliation><mods:affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Hamel, Wolfgang" sort="Hamel, Wolfgang" uniqKey="Hamel W" first="Wolfgang" last="Hamel">Wolfgang Hamel</name><affiliation><mods:affiliation>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Schrader, Bettina" sort="Schrader, Bettina" uniqKey="Schrader B" first="Bettina" last="Schrader">Bettina Schrader</name><affiliation><mods:affiliation>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Weinert, Dieter" sort="Weinert, Dieter" uniqKey="Weinert D" first="Dieter" last="Weinert">Dieter Weinert</name><affiliation><mods:affiliation>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Muller, Dieter" sort="Muller, Dieter" uniqKey="Muller D" first="Dieter" last="Müller">Dieter Müller</name><affiliation><mods:affiliation>Department of Neurosurgery, University of Hamburg, Hamburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Mehdorn, Hubertus M" sort="Mehdorn, Hubertus M" uniqKey="Mehdorn H" first="Hubertus M." last="Mehdorn">Hubertus M. Mehdorn</name><affiliation><mods:affiliation>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name><affiliation><mods:affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Christian‐Albrechts University of Kiel, Niemannsweg 147, 24105 Kiel, Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:D960A89B118AE86962E899A6027E0B6931A65902</idno><date when="2003" year="2003">2003</date><idno type="doi">10.1002/mds.10518</idno><idno type="url">https://api.istex.fr/document/D960A89B118AE86962E899A6027E0B6931A65902/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001035</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001035</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Two‐year follow‐up of subthalamic deep brain stimulation in Parkinson's disease</title><author><name sortKey="Herzog, Jan" sort="Herzog, Jan" uniqKey="Herzog J" first="Jan" last="Herzog">Jan Herzog</name><affiliation><mods:affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name><affiliation><mods:affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Krack, Paul" sort="Krack, Paul" uniqKey="Krack P" first="Paul" last="Krack">Paul Krack</name><affiliation><mods:affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Current Address: Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, France</mods:affiliation></affiliation></author><author><name sortKey="Kopper, Florian" sort="Kopper, Florian" uniqKey="Kopper F" first="Florian" last="Kopper">Florian Kopper</name><affiliation><mods:affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Potter, Monika" sort="Potter, Monika" uniqKey="Potter M" first="Monika" last="Pötter">Monika Pötter</name><affiliation><mods:affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Lorenz, Delia" sort="Lorenz, Delia" uniqKey="Lorenz D" first="Delia" last="Lorenz">Delia Lorenz</name><affiliation><mods:affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Steinbach, Meike" sort="Steinbach, Meike" uniqKey="Steinbach M" first="Meike" last="Steinbach">Meike Steinbach</name><affiliation><mods:affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Klebe, Stefan" sort="Klebe, Stefan" uniqKey="Klebe S" first="Stefan" last="Klebe">Stefan Klebe</name><affiliation><mods:affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Hamel, Wolfgang" sort="Hamel, Wolfgang" uniqKey="Hamel W" first="Wolfgang" last="Hamel">Wolfgang Hamel</name><affiliation><mods:affiliation>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Schrader, Bettina" sort="Schrader, Bettina" uniqKey="Schrader B" first="Bettina" last="Schrader">Bettina Schrader</name><affiliation><mods:affiliation>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Weinert, Dieter" sort="Weinert, Dieter" uniqKey="Weinert D" first="Dieter" last="Weinert">Dieter Weinert</name><affiliation><mods:affiliation>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Muller, Dieter" sort="Muller, Dieter" uniqKey="Muller D" first="Dieter" last="Müller">Dieter Müller</name><affiliation><mods:affiliation>Department of Neurosurgery, University of Hamburg, Hamburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Mehdorn, Hubertus M" sort="Mehdorn, Hubertus M" uniqKey="Mehdorn H" first="Hubertus M." last="Mehdorn">Hubertus M. Mehdorn</name><affiliation><mods:affiliation>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation></affiliation></author><author><name sortKey="Deuschl, Gunther" sort="Deuschl, Gunther" uniqKey="Deuschl G" first="Günther" last="Deuschl">Günther Deuschl</name><affiliation><mods:affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Christian‐Albrechts University of Kiel, Niemannsweg 147, 24105 Kiel, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2003-11">2003-11</date><biblScope unit="volume">18</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1332">1332</biblScope><biblScope unit="page" to="1337">1337</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">D960A89B118AE86962E899A6027E0B6931A65902</idno><idno type="DOI">10.1002/mds.10518</idno><idno type="ArticleID">MDS10518</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>deep brain stimulation</term><term>subthalamic nucleus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We studied 48 patients after bilateral subthalamic nucleus deep brain stimulation (STN‐DBS) who were evaluated 6 months after the surgical procedure using the Unified Parkinson's Disease Rating Scale (UPDRS) in a standardized levodopa test. Additional follow‐up was available in 32 patients after 12 months and in 20 patients after 24 months. At 6 months follow‐up, STN‐DBS reduced the UPDRS motor score by 50.9% compared to baseline. This improvement remained constant at 12 months with 57.5% and at 24 months with 57.3%. Relevant side effects after STN‐DBS included intraoperative subdural hematoma without neurological sequelae (n = 1), minor intracerebral bleeding with slight transient hemiparesis (n = 1), dislocation of impulse generator (n = 2), transient perioperative confusional symptoms (n = 7), psychotic symptoms (n = 2), depression (n = 5), hypomanic behaviour (n = 2), and transient manic psychosis (n = 1). One patient died because of heart failure during the first postoperative year. The current series demonstrates efficacy and safety of STN‐DBS beyond the first year after surgical procedure. Complications of STN‐DBS comprise a wide range of psychiatric adverse events which, however, were temporary. © 2003 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Jan Herzog MD</name><affiliations><json:string>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</json:string></affiliations></json:item><json:item><name>Jens Volkmann MD, PhD</name><affiliations><json:string>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</json:string></affiliations></json:item><json:item><name>Paul Krack MD, PhD</name><affiliations><json:string>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</json:string><json:string>Current Address: Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, France</json:string></affiliations></json:item><json:item><name>Florian Kopper MD</name><affiliations><json:string>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</json:string></affiliations></json:item><json:item><name>Monika Pötter MD</name><affiliations><json:string>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</json:string></affiliations></json:item><json:item><name>Delia Lorenz MD</name><affiliations><json:string>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</json:string></affiliations></json:item><json:item><name>Meike Steinbach MD</name><affiliations><json:string>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</json:string></affiliations></json:item><json:item><name>Stefan Klebe MD</name><affiliations><json:string>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</json:string></affiliations></json:item><json:item><name>Wolfgang Hamel MD</name><affiliations><json:string>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</json:string></affiliations></json:item><json:item><name>Bettina Schrader MD</name><affiliations><json:string>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</json:string></affiliations></json:item><json:item><name>Dieter Weinert MD</name><affiliations><json:string>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</json:string></affiliations></json:item><json:item><name>Dieter Müller MD, PhD</name><affiliations><json:string>Department of Neurosurgery, University of Hamburg, Hamburg, Germany</json:string></affiliations></json:item><json:item><name>Hubertus M. Mehdorn MD, PhD</name><affiliations><json:string>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</json:string></affiliations></json:item><json:item><name>Günther Deuschl MD, PhD</name><affiliations><json:string>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</json:string><json:string>Department of Neurology, Christian‐Albrechts University of Kiel, Niemannsweg 147, 24105 Kiel, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>deep brain stimulation</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>subthalamic nucleus</value></json:item></subject><articleId><json:string>MDS10518</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>We studied 48 patients after bilateral subthalamic nucleus deep brain stimulation (STN‐DBS) who were evaluated 6 months after the surgical procedure using the Unified Parkinson's Disease Rating Scale (UPDRS) in a standardized levodopa test. Additional follow‐up was available in 32 patients after 12 months and in 20 patients after 24 months. At 6 months follow‐up, STN‐DBS reduced the UPDRS motor score by 50.9% compared to baseline. This improvement remained constant at 12 months with 57.5% and at 24 months with 57.3%. Relevant side effects after STN‐DBS included intraoperative subdural hematoma without neurological sequelae (n = 1), minor intracerebral bleeding with slight transient hemiparesis (n = 1), dislocation of impulse generator (n = 2), transient perioperative confusional symptoms (n = 7), psychotic symptoms (n = 2), depression (n = 5), hypomanic behaviour (n = 2), and transient manic psychosis (n = 1). One patient died because of heart failure during the first postoperative year. The current series demonstrates efficacy and safety of STN‐DBS beyond the first year after surgical procedure. Complications of STN‐DBS comprise a wide range of psychiatric adverse events which, however, were temporary. © 2003 Movement Disorder Society</abstract><qualityIndicators><score>6.349</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>1255</abstractCharCount><pdfWordCount>4081</pdfWordCount><pdfCharCount>25318</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>189</abstractWordCount></qualityIndicators><title>Two‐year follow‐up of subthalamic deep brain stimulation in Parkinson's disease</title><refBibs><json:item><author><json:item><name>A Hughes</name></json:item><json:item><name>S Daniel</name></json:item><json:item><name>L Kilford</name></json:item><json:item><name>A Lees</name></json:item></author><host><volume>55</volume><pages><last>184</last><first>181</first></pages><author></author><title>J Neurol Neurosurg Psychiatry</title></host><title>Accuracy of clinical diagnosis of idiopathic 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levodopa</title></json:item></refBibs><genre><json:string>article</json:string></genre><host><volume>18</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>6</total><last>1337</last><first>1332</first></pages><issn><json:string>0885-3185</json:string></issn><issue>11</issue><subject><json:item><value>Brief Report</value></json:item></subject><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><categories><wos><json:string>science</json:string><json:string>clinical neurology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>neurology & 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xml:id="author-3"><persName><forename type="first">Paul</forename><surname>Krack</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation><affiliation>Current Address: Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, France</affiliation></author><author xml:id="author-4"><persName><forename type="first">Florian</forename><surname>Kopper</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation></author><author xml:id="author-5"><persName><forename type="first">Monika</forename><surname>Pötter</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation></author><author xml:id="author-6"><persName><forename type="first">Delia</forename><surname>Lorenz</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation></author><author xml:id="author-7"><persName><forename type="first">Meike</forename><surname>Steinbach</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation></author><author xml:id="author-8"><persName><forename type="first">Stefan</forename><surname>Klebe</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation></author><author xml:id="author-9"><persName><forename type="first">Wolfgang</forename><surname>Hamel</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation></author><author xml:id="author-10"><persName><forename type="first">Bettina</forename><surname>Schrader</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation></author><author xml:id="author-11"><persName><forename type="first">Dieter</forename><surname>Weinert</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation></author><author xml:id="author-12"><persName><forename type="first">Dieter</forename><surname>Müller</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurosurgery, University of Hamburg, Hamburg, Germany</affiliation></author><author xml:id="author-13"><persName><forename type="first">Hubertus M.</forename><surname>Mehdorn</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation></author><author xml:id="author-14"><persName><forename type="first">Günther</forename><surname>Deuschl</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation><affiliation>Department of Neurology, Christian‐Albrechts University of Kiel, Niemannsweg 147, 24105 Kiel, Germany</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="sub">Official Journal of the Movement Disorder Society</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2003-11"></date><biblScope unit="volume">18</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1332">1332</biblScope><biblScope unit="page" to="1337">1337</biblScope></imprint></monogr><idno type="istex">D960A89B118AE86962E899A6027E0B6931A65902</idno><idno type="DOI">10.1002/mds.10518</idno><idno type="ArticleID">MDS10518</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2003</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>We studied 48 patients after bilateral subthalamic nucleus deep brain stimulation (STN‐DBS) who were evaluated 6 months after the surgical procedure using the Unified Parkinson's Disease Rating Scale (UPDRS) in a standardized levodopa test. Additional follow‐up was available in 32 patients after 12 months and in 20 patients after 24 months. At 6 months follow‐up, STN‐DBS reduced the UPDRS motor score by 50.9% compared to baseline. This improvement remained constant at 12 months with 57.5% and at 24 months with 57.3%. Relevant side effects after STN‐DBS included intraoperative subdural hematoma without neurological sequelae (n = 1), minor intracerebral bleeding with slight transient hemiparesis (n = 1), dislocation of impulse generator (n = 2), transient perioperative confusional symptoms (n = 7), psychotic symptoms (n = 2), depression (n = 5), hypomanic behaviour (n = 2), and transient manic psychosis (n = 1). One patient died because of heart failure during the first postoperative year. The current series demonstrates efficacy and safety of STN‐DBS beyond the first year after surgical procedure. 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href="file:MDS.MDS10518.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="4"></count><count type="referenceTotal" number="25"></count><count type="wordTotal" number="4675"></count></countGroup><titleGroup><title type="main" xml:lang="en">Two‐year follow‐up of subthalamic deep brain stimulation in Parkinson's disease</title><title type="short" xml:lang="en">STN–DBS: Two‐Year Follow‐Up</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Jan</givenNames><familyName>Herzog</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Jens</givenNames><familyName>Volkmann</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1" 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Additional follow‐up was available in 32 patients after 12 months and in 20 patients after 24 months. At 6 months follow‐up, STN‐DBS reduced the UPDRS motor score by 50.9% compared to baseline. This improvement remained constant at 12 months with 57.5% and at 24 months with 57.3%. Relevant side effects after STN‐DBS included intraoperative subdural hematoma without neurological sequelae (n = 1), minor intracerebral bleeding with slight transient hemiparesis (n = 1), dislocation of impulse generator (n = 2), transient perioperative confusional symptoms (n = 7), psychotic symptoms (n = 2), depression (n = 5), hypomanic behaviour (n = 2), and transient manic psychosis (n = 1). One patient died because of heart failure during the first postoperative year. The current series demonstrates efficacy and safety of STN‐DBS beyond the first year after surgical procedure. Complications of STN‐DBS comprise a wide range of psychiatric adverse events which, however, were temporary. © 2003 Movement Disorder Society</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Two‐year follow‐up of subthalamic deep brain stimulation in Parkinson's disease</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>STN–DBS: Two‐Year Follow‐Up</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Two‐year follow‐up of subthalamic deep brain stimulation in Parkinson's disease</title></titleInfo><name type="personal"><namePart type="given">Jan</namePart><namePart type="family">Herzog</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jens</namePart><namePart type="family">Volkmann</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Paul</namePart><namePart type="family">Krack</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation><affiliation>Current Address: Department of Clinical and Biological Neurosciences, Service de Neurologie, Centre Hospitalier Universitaire de Grenoble, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Florian</namePart><namePart type="family">Kopper</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Monika</namePart><namePart type="family">Pötter</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Delia</namePart><namePart type="family">Lorenz</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Meike</namePart><namePart type="family">Steinbach</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Stefan</namePart><namePart type="family">Klebe</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Wolfgang</namePart><namePart type="family">Hamel</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Bettina</namePart><namePart type="family">Schrader</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dieter</namePart><namePart type="family">Weinert</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dieter</namePart><namePart type="family">Müller</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurosurgery, University of Hamburg, Hamburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hubertus M.</namePart><namePart type="family">Mehdorn</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurosurgery, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Günther</namePart><namePart type="family">Deuschl</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, Christian‐Albrechts Universität Kiel, Kiel, Germany</affiliation><affiliation>Department of Neurology, Christian‐Albrechts University of Kiel, Niemannsweg 147, 24105 Kiel, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2003-11</dateIssued><dateCaptured encoding="w3cdtf">2002-11-26</dateCaptured><dateValid encoding="w3cdtf">2003-04-23</dateValid><copyrightDate encoding="w3cdtf">2003</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="tables">4</extent><extent unit="references">25</extent><extent unit="words">4675</extent></physicalDescription><abstract lang="en">We studied 48 patients after bilateral subthalamic nucleus deep brain stimulation (STN‐DBS) who were evaluated 6 months after the surgical procedure using the Unified Parkinson's Disease Rating Scale (UPDRS) in a standardized levodopa test. Additional follow‐up was available in 32 patients after 12 months and in 20 patients after 24 months. At 6 months follow‐up, STN‐DBS reduced the UPDRS motor score by 50.9% compared to baseline. This improvement remained constant at 12 months with 57.5% and at 24 months with 57.3%. Relevant side effects after STN‐DBS included intraoperative subdural hematoma without neurological sequelae (n = 1), minor intracerebral bleeding with slight transient hemiparesis (n = 1), dislocation of impulse generator (n = 2), transient perioperative confusional symptoms (n = 7), psychotic symptoms (n = 2), depression (n = 5), hypomanic behaviour (n = 2), and transient manic psychosis (n = 1). One patient died because of heart failure during the first postoperative year. The current series demonstrates efficacy and safety of STN‐DBS beyond the first year after surgical procedure. Complications of STN‐DBS comprise a wide range of psychiatric adverse events which, however, were temporary. © 2003 Movement Disorder Society</abstract><subject lang="en"><genre>keywords</genre><topic>deep brain stimulation</topic><topic>subthalamic nucleus</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title><subTitle>Official Journal of the Movement Disorder Society</subTitle></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2003</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><detail type="issue"><caption>no.</caption><number>11</number></detail><extent unit="pages"><start>1332</start><end>1337</end><total>6</total></extent></part></relatedItem><identifier type="istex">D960A89B118AE86962E899A6027E0B6931A65902</identifier><identifier type="DOI">10.1002/mds.10518</identifier><identifier type="ArticleID">MDS10518</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2003 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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