Cerebral neocortex modulation of immune functions
Identifieur interne : 000B22 ( Istex/Curation ); précédent : 000B21; suivant : 000B23Cerebral neocortex modulation of immune functions
Auteurs : P. J. Neveu [France]Source :
- Life Sciences [ 0024-3205 ] ; 1988.
Abstract
The immune system, classically considered as an auto regulated system, is known to be connected with the central nervous system (CNS). Several methodological approaches are usually used to elucidate the mechanisms whereby CNS and immune system can communicate. Stimulations or lesions of various hypothalamic areas modify some aspects of the immune responses. Likewise the cerebral neocortex appears to modulate immune responses. After unilateral lesions of the fronto-parietal cortex a balanced control of immune T cell responses can be demonstrated. Large lesions of the left cerebral cortex depressed whereas lesions of the right hemicortex enhanced, T cell immunity. Nevertheless when performing more restricted lesions, there is evidence that immunomodulatory functions of the cortex depends upon the various areas of the latter and that some connections between left and right cortex are involved in the modulation of the immune system. Furthermore different immunologic parameters appear not to be affected in the same way. However, many problems in regard to the immunomodulatory roles of the cerebral neocortex remain unsolved. The communication pathways between the cerebral neocortex and lymphocytes are not yet determined. It is not yet well known whether the cortical asymmetry in immunomodulation is related to other lateralized phenomena like behavior, cortex development or sympathetic innervation of lymphoid organs. Furthermore, as the CNS is highly specialized in mammals and especially in man, the asymmetry in the cerebral control of the immune responses should represent a phylogenetic advantage which has to be elucidated. This field of research will have an important bearing both on theoretical and clinical considerations.
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DOI: 10.1016/0024-3205(88)90490-0
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