Cerebrospinal fluid GABA and homocarnosine concentrations in patients with Friedreich's ataxia, Parkinson's disease, and Huntington's chorea
Identifieur interne : 000550 ( Istex/Curation ); précédent : 000549; suivant : 000551Cerebrospinal fluid GABA and homocarnosine concentrations in patients with Friedreich's ataxia, Parkinson's disease, and Huntington's chorea
Auteurs : A. M. Bonnet [France] ; A. M. Tell [France] ; P. J. Schechter [France] ; J. Grove [France] ; M. H. Saint-Hilaire [France] ; Y. De Smet [France] ; Y. Agid [France]Source :
- Movement Disorders [ 0885-3185 ] ; 1987.
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Abstract
Free and total γ‐aminobutyric acid (GABA) and homocarnosine concentrations were measured in the lumbar cerebrospinal fluid (CSF) of patients with Friedreich's ataxia, Huntington's chorea, and Parkinson's disease (with and without levodopa treatment), and compared with those determined in control subjects. Values found in Friedreich's ataxia or Parkinson's disease were not significantly different from those in controls. Unexpectedly, in Huntington patients, known to have a characteristic decrease in GABA and homocarinosine were significantly higher, whereas free GABA was not different from controls. These findings indicate that the measurement of CSF GABA and homocarnosine in patients with CNS degenerative diseases should be interpreted cautiously.
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DOI: 10.1002/mds.870020206
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="1987">1987</date><biblScope unit="volume">2</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="117">117</biblScope><biblScope unit="page" to="123">123</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">66F2876D6D1991ED6C2B9FA029DBAD69E93542BB</idno><idno type="DOI">10.1002/mds.870020206</idno><idno type="ArticleID">MDS870020206</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cerebrospinal fluid</term><term>Friedreich's ataxia</term><term>GABA</term><term>Homocarnosine</term><term>Huntington's chorea</term><term>Parkinson's disease</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Free and total γ‐aminobutyric acid (GABA) and homocarnosine concentrations were measured in the lumbar cerebrospinal fluid (CSF) of patients with Friedreich's ataxia, Huntington's chorea, and Parkinson's disease (with and without levodopa treatment), and compared with those determined in control subjects. Values found in Friedreich's ataxia or Parkinson's disease were not significantly different from those in controls. Unexpectedly, in Huntington patients, known to have a characteristic decrease in GABA and homocarinosine were significantly higher, whereas free GABA was not different from controls. These findings indicate that the measurement of CSF GABA and homocarnosine in patients with CNS degenerative diseases should be interpreted cautiously.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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