Subthalamic nucleus stimulation and dysarthria in Parkinson’s disease: a PET study
Identifieur interne : 002456 ( Istex/Corpus ); précédent : 002455; suivant : 002457Subthalamic nucleus stimulation and dysarthria in Parkinson’s disease: a PET study
Auteurs : Serge Pinto ; Ste Phane Thobois ; Nicolas Costes ; Didier Le Bars ; Alim-Louis Benabid ; Emmanuel Broussolle ; Pierre Pollak ; Miche Le GentilSource :
- Brain [ 0006-8950 ] ; 2004-03.
English descriptors
- KwdEn :
- BA = Brodmann area; DLPFC = dorsolateral prefrontal cortex; MT = movement time; R = rest; rCBF = regional cerebral blood flow; RI = relative intensity; RT = reaction time; SA = silent articulation; SMA = supplementary motor area; SP = speech production; STN = subthalamic nucleus, Parkinson’s disease; subthalamic nucleus stimulation; speech production; [15O]H2O; PET.
Abstract
In Parkinson’s disease, functional imaging studies during limb motor tasks reveal cerebral activation abnormalities that can be reversed by subthalamic nucleus (STN) stimulation. The effect of STN stimulation on parkinsonian dysarthria has not, however, been investigated using PET. The aim of the present study was to evaluate the effect of STN stimulation on regional cerebral blood flow (rCBF) during speech production and silent articulation in patients with Parkinson’s disease. Ten Parkinson’s disease patients surgically implanted bilaterally in the STN and with significant improvement of their dysarthria induced by STN stimulation were included. Ten healthy control subjects also participated in this study. Control subjects performed six sessions of [15O]H2O–PET scanning corresponding to three duplicated conditions externally cued by an auditory signal. The conditions were: (i) rest; (ii) production of a short, simple sentence; and (iii) silent articulation of the same sentence. Parkinson’s disease patients carried out the six PET sessions twice, i.e., in the ON and OFF STN stimulation states. PET data analysis was performed using statistical parametric mapping (SPM99). In control subjects, speech production (SP) compared with rest was associated with increased rCBF bilaterally in the primary motor cortex (M1) corresponding to the orofacial somatotopy, the supplementary motor area (SMA), the associative auditory cortex and the cerebellar hemispheres. Silent articulation (SA) compared with rest induced a bilateral rCBF increase restricted to the orofacial M1 and cerebellar hemispheres. In Parkinson’s disease patients in the OFF stimulation condition, during both SP and SA there was a lack of activation in the right orofacial M1 and in the cerebellum, abnormal increased rCBF in the right superior premotor cortex, and overactivation of the SMA. There was also an abnormal, increased rCBF in the dorsolateral prefrontal cortex (DLPFC) only during SP and increased rCBF in the left insula only during SA. In Parkinson’s disease patients ON stimulation, for both SP and SA the activation pattern appeared similar to that in control subjects. In conclusion, our results suggest that parkinsonian dysarthria is associated with altered recruitment of the main motor cerebral regions (orofacial M1, cerebellum), and increased involvement of the premotor and prefrontal cortices (DLPFC, SMA, superior premotor cortex). These abnormal activations are different from those reported during hand motor tasks. They could be a compensatory mechanism, but might also arise directly as part of the pathophysiology of Parkinson’s disease. STN stimulation tends to reverse these abnormal activations, which is consistent with the observed improvement of Parkinson’s disease dysarthria.
Url:
DOI: 10.1093/brain/awh074
Links to Exploration step
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<front><div type="abstract" xml:lang="en">In Parkinson’s disease, functional imaging studies during limb motor tasks reveal cerebral activation abnormalities that can be reversed by subthalamic nucleus (STN) stimulation. The effect of STN stimulation on parkinsonian dysarthria has not, however, been investigated using PET. The aim of the present study was to evaluate the effect of STN stimulation on regional cerebral blood flow (rCBF) during speech production and silent articulation in patients with Parkinson’s disease. Ten Parkinson’s disease patients surgically implanted bilaterally in the STN and with significant improvement of their dysarthria induced by STN stimulation were included. Ten healthy control subjects also participated in this study. Control subjects performed six sessions of [15O]H2O–PET scanning corresponding to three duplicated conditions externally cued by an auditory signal. The conditions were: (i) rest; (ii) production of a short, simple sentence; and (iii) silent articulation of the same sentence. Parkinson’s disease patients carried out the six PET sessions twice, i.e., in the ON and OFF STN stimulation states. PET data analysis was performed using statistical parametric mapping (SPM99). In control subjects, speech production (SP) compared with rest was associated with increased rCBF bilaterally in the primary motor cortex (M1) corresponding to the orofacial somatotopy, the supplementary motor area (SMA), the associative auditory cortex and the cerebellar hemispheres. Silent articulation (SA) compared with rest induced a bilateral rCBF increase restricted to the orofacial M1 and cerebellar hemispheres. In Parkinson’s disease patients in the OFF stimulation condition, during both SP and SA there was a lack of activation in the right orofacial M1 and in the cerebellum, abnormal increased rCBF in the right superior premotor cortex, and overactivation of the SMA. There was also an abnormal, increased rCBF in the dorsolateral prefrontal cortex (DLPFC) only during SP and increased rCBF in the left insula only during SA. In Parkinson’s disease patients ON stimulation, for both SP and SA the activation pattern appeared similar to that in control subjects. In conclusion, our results suggest that parkinsonian dysarthria is associated with altered recruitment of the main motor cerebral regions (orofacial M1, cerebellum), and increased involvement of the premotor and prefrontal cortices (DLPFC, SMA, superior premotor cortex). These abnormal activations are different from those reported during hand motor tasks. They could be a compensatory mechanism, but might also arise directly as part of the pathophysiology of Parkinson’s disease. STN stimulation tends to reverse these abnormal activations, which is consistent with the observed improvement of Parkinson’s disease dysarthria.</div>
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<abstract>In Parkinson’s disease, functional imaging studies during limb motor tasks reveal cerebral activation abnormalities that can be reversed by subthalamic nucleus (STN) stimulation. The effect of STN stimulation on parkinsonian dysarthria has not, however, been investigated using PET. The aim of the present study was to evaluate the effect of STN stimulation on regional cerebral blood flow (rCBF) during speech production and silent articulation in patients with Parkinson’s disease. Ten Parkinson’s disease patients surgically implanted bilaterally in the STN and with significant improvement of their dysarthria induced by STN stimulation were included. Ten healthy control subjects also participated in this study. Control subjects performed six sessions of [15O]H2O–PET scanning corresponding to three duplicated conditions externally cued by an auditory signal. The conditions were: (i) rest; (ii) production of a short, simple sentence; and (iii) silent articulation of the same sentence. Parkinson’s disease patients carried out the six PET sessions twice, i.e., in the ON and OFF STN stimulation states. PET data analysis was performed using statistical parametric mapping (SPM99). In control subjects, speech production (SP) compared with rest was associated with increased rCBF bilaterally in the primary motor cortex (M1) corresponding to the orofacial somatotopy, the supplementary motor area (SMA), the associative auditory cortex and the cerebellar hemispheres. Silent articulation (SA) compared with rest induced a bilateral rCBF increase restricted to the orofacial M1 and cerebellar hemispheres. In Parkinson’s disease patients in the OFF stimulation condition, during both SP and SA there was a lack of activation in the right orofacial M1 and in the cerebellum, abnormal increased rCBF in the right superior premotor cortex, and overactivation of the SMA. There was also an abnormal, increased rCBF in the dorsolateral prefrontal cortex (DLPFC) only during SP and increased rCBF in the left insula only during SA. In Parkinson’s disease patients ON stimulation, for both SP and SA the activation pattern appeared similar to that in control subjects. In conclusion, our results suggest that parkinsonian dysarthria is associated with altered recruitment of the main motor cerebral regions (orofacial M1, cerebellum), and increased involvement of the premotor and prefrontal cortices (DLPFC, SMA, superior premotor cortex). These abnormal activations are different from those reported during hand motor tasks. They could be a compensatory mechanism, but might also arise directly as part of the pathophysiology of Parkinson’s disease. STN stimulation tends to reverse these abnormal activations, which is consistent with the observed improvement of Parkinson’s disease dysarthria.</abstract>
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<refBibs><json:item><author><json:item><name>H Ackermann</name>
</json:item>
<json:item><name>I Hertrich</name>
</json:item>
<json:item><name>I Daum</name>
</json:item>
<json:item><name>G Scharf</name>
</json:item>
<json:item><name>S Spieker</name>
</json:item>
</author>
<host><volume>12</volume>
<pages><last>27</last>
<first>1019</first>
</pages>
<author></author>
<title>Mov Disord</title>
<publicationDate>1997</publicationDate>
</host>
<title>Kinematic analysis of articulatory movements in central motor disorders</title>
<publicationDate>1997</publicationDate>
</json:item>
<json:item><author><json:item><name>H Ackermann</name>
</json:item>
<json:item><name>D Wildgruber</name>
</json:item>
<json:item><name>I Daum</name>
</json:item>
<json:item><name>W Grodd</name>
</json:item>
<json:item><name> 187±90</name>
</json:item>
<json:item><name>Sm Barlow</name>
</json:item>
<json:item><name>Jh Abbs</name>
</json:item>
</author>
<host><volume>247</volume>
<pages><last>21</last>
<first>616</first>
</pages>
<issue>336</issue>
<author></author>
<title>Neurosci Lett J Speech Hear Res Bates JF J Comp Neurol</title>
<publicationDate>1983</publicationDate>
</host>
<title>Does the cerebellum contribute to cognitive aspects of speech production? A functional magnetic resonance imaging (fMRI) study in humans Force transducers for the evaluation of labial, lingual, and mandibular motor impairments Prefrontal connections of medial motor areas in the rhesus monkey</title>
<publicationDate>1983</publicationDate>
</json:item>
<json:item><author><json:item><name>C Baumgartner</name>
</json:item>
<json:item><name>R Flint</name>
</json:item>
<json:item><name>I Tuxhorn</name>
</json:item>
<json:item><name>Van Ness</name>
</json:item>
<json:item><name>Pc Kosalko</name>
</json:item>
<json:item><name>J Olbrich</name>
</json:item>
<json:item><name>A </name>
</json:item>
</author>
<host><volume>46</volume>
<pages><last>14</last>
<first>508</first>
</pages>
<author></author>
<title>Neurology</title>
<publicationDate>1996</publicationDate>
</host>
<title>Supplementary motor area seizures: propagation pathways as studied with invasive recordings</title>
<publicationDate>1996</publicationDate>
</json:item>
<json:item><author><json:item><name>H Boecker</name>
</json:item>
<json:item><name>A Dagher</name>
</json:item>
<json:item><name>Ao Ceballos-Baumann</name>
</json:item>
<json:item><name>Re Passingham</name>
</json:item>
<json:item><name>M Samuel</name>
</json:item>
<json:item><name>Kj Friston</name>
</json:item>
</author>
<host><volume>79</volume>
<pages><last>80</last>
<first>1070</first>
</pages>
<author></author>
<title>J Neurophysiol</title>
<publicationDate>1998</publicationDate>
</host>
<title>Role of the human rostral supplementary motor area and the basal ganglia in motor sequence control: investigations with H2 15O PET</title>
<publicationDate>1998</publicationDate>
</json:item>
<json:item><author><json:item><name>Sy Bookheimer</name>
</json:item>
<json:item><name>Ta Zef®ro</name>
</json:item>
<json:item><name>Ta Blaxton</name>
</json:item>
<json:item><name>Pw Gaillard</name>
</json:item>
<json:item><name>Wh Theodore</name>
</json:item>
</author>
<host><volume>55</volume>
<pages><last>7</last>
<first>1151</first>
</pages>
<author></author>
<title>Neurology</title>
<publicationDate>2000</publicationDate>
</host>
<title>Activation of language cortex with automatic speech tasks</title>
<publicationDate>2000</publicationDate>
</json:item>
<json:item><author><json:item><name>Br Buchsbaum</name>
</json:item>
<json:item><name>G Hickok</name>
</json:item>
<json:item><name>C Humphries</name>
</json:item>
<json:item><name> 663±78</name>
</json:item>
<json:item><name>Mj Catalan</name>
</json:item>
<json:item><name>K Ishii</name>
</json:item>
<json:item><name>M Honda</name>
</json:item>
<json:item><name>A Samii</name>
</json:item>
<json:item><name>M Hallett</name>
</json:item>
<json:item><name> 483±95</name>
</json:item>
<json:item><name>Ao Ceballos-Baumann</name>
</json:item>
<json:item><name>H Boecker</name>
</json:item>
<json:item><name>P Bartenstein</name>
</json:item>
<json:item><name>I Von Falkenhayn</name>
</json:item>
<json:item><name>H Riescher</name>
</json:item>
<json:item><name>B Conrad</name>
</json:item>
</author>
<host><pages><last>75</last>
<first>451</first>
</pages>
<author></author>
<title>997±1003. Creutzfeldt O, Ojemann G, Lettich E. Neuronal activity in the human lateral temporal lobe. I. Responses to speech</title>
<publicationDate>1989</publicationDate>
</host>
<title>Role of left posterior superior temporal gyrus in phonological processing for speech perception and production A PET study of sequential ®nger movements of varying length in patients with Parkinson's disease A positron emission tomographic study of subthalamic nucleus stimulation in Parkinson disease: enhanced movement-related activity of motor-association cortex and decreased motor cortex resting activity</title>
<publicationDate>1989</publicationDate>
</json:item>
<json:item><author><json:item><name>De Nil</name>
</json:item>
<json:item><name>Lf Kroll</name>
</json:item>
<json:item><name>Rm Houle</name>
</json:item>
<json:item><name>S </name>
</json:item>
</author>
<host><volume>302</volume>
<pages><last>80</last>
<first>77</first>
</pages>
<author></author>
<title>Neurosci Lett</title>
<publicationDate>2001</publicationDate>
</host>
<title>Functional neuroimaging of cerebellar activation during single word reading and verb generation in stuttering and nonstuttering adults</title>
<publicationDate>2001</publicationDate>
</json:item>
<json:item><author><json:item><name>Mp Deiber</name>
</json:item>
<json:item><name>Re Passingham</name>
</json:item>
<json:item><name>Jg Colebatch</name>
</json:item>
<json:item><name>Kj Friston</name>
</json:item>
<json:item><name>Pd Nixon</name>
</json:item>
<json:item><name>Rs Frackowiak</name>
</json:item>
</author>
<host><volume>84</volume>
<pages><last>402</last>
<first>393</first>
</pages>
<issue>349</issue>
<author></author>
<title>Exp Brain Res Lancet</title>
<publicationDate>1991</publicationDate>
</host>
<title>Cortical areas and the selection of movement: a study with positron emission tomography Donnan GA, Darby DG, Saling MM. Identi®cation of brain region for coordinating speech articulation</title>
<publicationDate>1991</publicationDate>
</json:item>
<json:item><author><json:item><name>C Dromey</name>
</json:item>
<json:item><name>R Kumar</name>
</json:item>
<json:item><name>Ae Lang</name>
</json:item>
<json:item><name>Am Lozano</name>
</json:item>
</author>
<host><volume>15</volume>
<pages><last>8</last>
<first>1132</first>
</pages>
<author></author>
<title>Mov Disord</title>
<publicationDate>2000</publicationDate>
</host>
<title>An investigation of the effects of subthalamic nucleus stimulation on acoustic measures of voice</title>
<publicationDate>2000</publicationDate>
</json:item>
<json:item><author><json:item><name>Nf Dronkers</name>
</json:item>
</author>
<host><volume>384</volume>
<pages><last>61</last>
<first>159</first>
</pages>
<author></author>
<title>Nature</title>
<publicationDate>1996</publicationDate>
</host>
<title>A new brain region for coordinating speech articulation</title>
<publicationDate>1996</publicationDate>
</json:item>
<json:item><host><pages><last>64</last>
<first>153</first>
</pages>
<author><json:item><name>S Fahn</name>
</json:item>
<json:item><name>Rl Elton</name>
</json:item>
<json:item><name> Of</name>
</json:item>
<json:item><name> Updrs Development</name>
</json:item>
<json:item><name> Committee</name>
</json:item>
</author>
<title>Uni®ed Parkinson's Disease Rating Scale Recent developments in Parkinson's disease. Florham Park (NJ): MacMillan Health Care Information</title>
<publicationDate>1987</publicationDate>
</host>
</json:item>
<json:item><author><json:item><name>Pt Fox</name>
</json:item>
<json:item><name>Rj Ingham</name>
</json:item>
<json:item><name>Jc Ingham</name>
</json:item>
<json:item><name>Tb Hirsch</name>
</json:item>
<json:item><name>Jh Downs</name>
</json:item>
<json:item><name>C Martin</name>
</json:item>
</author>
<host><volume>382</volume>
<pages><last>66</last>
<first>3656</first>
</pages>
<issue>11</issue>
<author></author>
<title>Nature J Neurosci</title>
<publicationDate>1991</publicationDate>
</host>
<title>A PET study of the neural systems of stuttering Functional organization of human supplementary motor cortex studied by electrical stimulation</title>
<publicationDate>1991</publicationDate>
</json:item>
<json:item><author><json:item><name>Kj Friston</name>
</json:item>
<json:item><name>Ap Holmes</name>
</json:item>
<json:item><name>Kj Worsley</name>
</json:item>
<json:item><name>Jb Poline</name>
</json:item>
<json:item><name>Cd Frith</name>
</json:item>
<json:item><name>Rsj Frackowiak</name>
</json:item>
</author>
<host><volume>2</volume>
<pages><last>210</last>
<first>189</first>
</pages>
<author></author>
<title>Hum Brain Mapp</title>
<publicationDate>1995</publicationDate>
</host>
<title>Statistical parametric maps in functional imaging: a general linear approach</title>
<publicationDate>1995</publicationDate>
</json:item>
<json:item><author><json:item><name>M Gentil</name>
</json:item>
</author>
<host><pages><last>22</last>
<first>1</first>
</pages>
<author></author>
<title>Speech production and speech modelling</title>
<publicationDate>1990</publicationDate>
</host>
<title>Organization of the articulatory system: peripheral mechanisms and central coordination</title>
<publicationDate>1990</publicationDate>
</json:item>
<json:item><author><json:item><name>M Gentil</name>
</json:item>
<json:item><name>Cl Tournier</name>
</json:item>
<json:item><name>S Perrin</name>
</json:item>
<json:item><name>P Pollak</name>
</json:item>
</author>
<host><volume>22</volume>
<pages><last>74</last>
<first>1261</first>
</pages>
<author></author>
<title>Prog Neuro- Psychopharmacol Biol Psychiatry</title>
<publicationDate>1998</publicationDate>
</host>
<title>Effects of levodopa on ®nger and orofacial movements in Parkinson's disease</title>
<publicationDate>1998</publicationDate>
</json:item>
<json:item><author><json:item><name>M Gentil</name>
</json:item>
<json:item><name>P Garcia-Ruiz</name>
</json:item>
<json:item><name>P Pollak</name>
</json:item>
<json:item><name>Al Benabid</name>
</json:item>
</author>
<host><volume>67</volume>
<pages><last>33</last>
<first>329</first>
</pages>
<author></author>
<title>J Neurol Neurosurg Psychiatry</title>
<publicationDate>1999</publicationDate>
</host>
<title>Effect of stimulation of the subthalamic nucleus on oral control of patients with parkinsonism</title>
<publicationDate>1999</publicationDate>
</json:item>
<json:item><author><json:item><name>M Gentil</name>
</json:item>
<json:item><name>P Chauvin</name>
</json:item>
<json:item><name>S Pinto</name>
</json:item>
<json:item><name>P Pollak</name>
</json:item>
<json:item><name>Al Benabid</name>
</json:item>
</author>
<host><volume>78</volume>
<pages><last>40</last>
<first>233</first>
</pages>
<author></author>
<title>Brain Lang</title>
<publicationDate>2001</publicationDate>
</host>
<title>Effect of bilateral stimulation of the subthalamic nucleus on Parkinsonian voice</title>
<publicationDate>2001</publicationDate>
</json:item>
<json:item><author><json:item><name>M Gentil</name>
</json:item>
<json:item><name>S Pinto</name>
</json:item>
<json:item><name>P Pollak</name>
</json:item>
<json:item><name>A Benabid</name>
</json:item>
</author>
<host><volume>85</volume>
<pages><last>6</last>
<first>190</first>
</pages>
<author></author>
<title>Brain Lang</title>
<publicationDate>2003</publicationDate>
</host>
<title>Effect of bilateral stimulation of the subthalamic nucleus on parkinsonian dysarthria</title>
<publicationDate>2003</publicationDate>
</json:item>
<json:item><author><json:item><name>Wr Gibb</name>
</json:item>
<json:item><name>Aj Lees</name>
</json:item>
</author>
<host><volume>51</volume>
<pages><last>52</last>
<first>745</first>
</pages>
<author></author>
<title>J Neurol Neurosurg Psychiatry</title>
<publicationDate>1988</publicationDate>
</host>
<title>The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease</title>
<publicationDate>1988</publicationDate>
</json:item>
<json:item><author><json:item><name>C Gross</name>
</json:item>
<json:item><name>A Rougier</name>
</json:item>
<json:item><name>D Guehl</name>
</json:item>
<json:item><name>T Boraud</name>
</json:item>
<json:item><name>J Julien</name>
</json:item>
<json:item><name>B Bioulac</name>
</json:item>
</author>
<host><volume>87</volume>
<pages><last>8</last>
<first>491</first>
</pages>
<author></author>
<title>J Neurosurg</title>
<publicationDate>1997</publicationDate>
</host>
<title>Highfrequency stimulation of the globus pallidus internalis in Parkinson's disease: a study of seven cases</title>
<publicationDate>1997</publicationDate>
</json:item>
<json:item><author><json:item><name>B Haslinger</name>
</json:item>
<json:item><name>P Erhard</name>
</json:item>
<json:item><name>N Kampfe</name>
</json:item>
<json:item><name>H Boecker</name>
</json:item>
<json:item><name>E Rummeny</name>
</json:item>
<json:item><name>M Schwaiger</name>
</json:item>
</author>
<host><volume>124</volume>
<pages><last>70</last>
<first>558</first>
</pages>
<author></author>
<title>Brain</title>
<publicationDate>2001</publicationDate>
</host>
<title>Event-related functional magnetic resonance imaging in Parkinson's disease before and after levodopa</title>
<publicationDate>2001</publicationDate>
</json:item>
<json:item><author><json:item><name>G Hickok</name>
</json:item>
<json:item><name>P Erhard</name>
</json:item>
<json:item><name>J Kassubek</name>
</json:item>
<json:item><name>Ak Helms-Tillery</name>
</json:item>
<json:item><name>S Naeve-Velguth</name>
</json:item>
<json:item><name>Jp Strupp</name>
</json:item>
</author>
<host><volume>287</volume>
<pages><last>60</last>
<first>156</first>
</pages>
<author></author>
<title>Neurosci Lett</title>
<publicationDate>2000</publicationDate>
</host>
<title>A functional magnetic resonance imaging study of the role of left posterior superior temporal gyrus in speech production: implications for the explanation of conduction aphasia</title>
<publicationDate>2000</publicationDate>
</json:item>
<json:item><author><json:item><name>J Isnard</name>
</json:item>
<json:item><name>M Guenot</name>
</json:item>
<json:item><name>K Ostrowsky</name>
</json:item>
<json:item><name>M Sindou</name>
</json:item>
<json:item><name>F Mauguiere</name>
</json:item>
</author>
<host><volume>48</volume>
<pages><last>23</last>
<first>614</first>
</pages>
<author></author>
<title>Ann Neurol</title>
<publicationDate>2000</publicationDate>
</host>
<title>The role of the insular cortex in temporal lobe epilepsy</title>
<publicationDate>2000</publicationDate>
</json:item>
<json:item><author><json:item><name>Ih Jenkins</name>
</json:item>
<json:item><name>W Fernandez</name>
</json:item>
<json:item><name>Ed Playford</name>
</json:item>
<json:item><name>Aj Lees</name>
</json:item>
<json:item><name>Rs Frackowiak</name>
</json:item>
<json:item><name>Re Passingham</name>
</json:item>
</author>
<host><volume>32</volume>
<pages><last>57</last>
<first>749</first>
</pages>
<author></author>
<title>Ann Neurol</title>
<publicationDate>1992</publicationDate>
</host>
<title>Impaired activation of the supplementary motor area in Parkinson's disease is reversed when akinesia is treated with apomorphine</title>
<publicationDate>1992</publicationDate>
</json:item>
<json:item><author><json:item><name>Hl Klawans</name>
</json:item>
</author>
<host><volume>1</volume>
<pages><last>92</last>
<first>187</first>
</pages>
<author></author>
<title>Mov Disord</title>
<publicationDate>1986</publicationDate>
</host>
<title>Individual manifestations of Parkinson's disease after ten or more years of levodopa</title>
<publicationDate>1986</publicationDate>
</json:item>
<json:item><author><json:item><name>A Krainik</name>
</json:item>
<json:item><name>S Lehericy</name>
</json:item>
<json:item><name>H Duffau</name>
</json:item>
<json:item><name>L Capelle</name>
</json:item>
<json:item><name>H Chainay</name>
</json:item>
<json:item><name>P Cornu</name>
</json:item>
</author>
<host><volume>60</volume>
<pages><last>94</last>
<first>587</first>
</pages>
<author></author>
<title>Neurology</title>
<publicationDate>2003</publicationDate>
</host>
<title>Postoperative speech disorder after medial frontal surgery: role of the supplementary motor area</title>
<publicationDate>2003</publicationDate>
</json:item>
<json:item><author><json:item><name>Lv Laitinen</name>
</json:item>
<json:item><name>At Bergenheim</name>
</json:item>
<json:item><name>Mi,14±21 Hariz</name>
</json:item>
<json:item><name>P Limousin</name>
</json:item>
<json:item><name>P Pollak</name>
</json:item>
<json:item><name>A Benazzouz</name>
</json:item>
<json:item><name>D Hoffmann</name>
</json:item>
<json:item><name>Le Bas</name>
</json:item>
<json:item><name>Jf Broussolle</name>
</json:item>
<json:item><name>E </name>
</json:item>
</author>
<host><volume>58</volume>
<pages><last>5</last>
<first>91</first>
</pages>
<issue>345</issue>
<author></author>
<title>Stereotact Funct Neurosurg Lancet</title>
<publicationDate>1992</publicationDate>
</host>
<title>Ventroposterolateral pallidotomy can abolish all parkinsonian symptoms Effect of parkinsonian signs and symptoms of bilateral subthalamic nucleus stimulation</title>
<publicationDate>1992</publicationDate>
</json:item>
<json:item><author><json:item><name>P Limousin</name>
</json:item>
<json:item><name>J Greene</name>
</json:item>
<json:item><name>P Pollak</name>
</json:item>
<json:item><name>J Rothwell</name>
</json:item>
<json:item><name>Al Benabid</name>
</json:item>
<json:item><name>P Frackowiak R Limousin</name>
</json:item>
<json:item><name>P Krack</name>
</json:item>
<json:item><name>P Pollak</name>
</json:item>
<json:item><name>A Benazzouz</name>
</json:item>
<json:item><name>C Ardouin</name>
</json:item>
<json:item><name>D Hoffmann</name>
</json:item>
</author>
<host><volume>42</volume>
<pages><last>91</last>
<first>283</first>
</pages>
<issue>339</issue>
<author></author>
<title>Ann Neurol New Engl J Med</title>
<publicationDate>1997</publicationDate>
</host>
<title>Changes in cerebral activity pattern due to subthalamic nucleus or internal pallidum stimulation in Parkinson's disease Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease</title>
<publicationDate>1997</publicationDate>
</json:item>
<json:item><author><json:item><name>M Liotti</name>
</json:item>
<json:item><name>Lo Ramig</name>
</json:item>
<json:item><name>D Vogel</name>
</json:item>
<json:item><name>P New</name>
</json:item>
<json:item><name>Ci Cook</name>
</json:item>
<json:item><name>Rj Ingham</name>
</json:item>
</author>
<host><volume>60</volume>
<pages><last>40</last>
<first>432</first>
</pages>
<author></author>
<title>Neurology</title>
<publicationDate>2003</publicationDate>
</host>
<title>Hypophonia in Parkinson's disease: neural correlates of voice treatment revealed by PET</title>
<publicationDate>2003</publicationDate>
</json:item>
<json:item><author><json:item><name>M Lotze</name>
</json:item>
<json:item><name>G Seggewies</name>
</json:item>
<json:item><name>M Erb</name>
</json:item>
<json:item><name>W Grodd</name>
</json:item>
<json:item><name>N Birbaumer</name>
</json:item>
</author>
<host><volume>11</volume>
<pages><last>9</last>
<first>2985</first>
</pages>
<issue>11</issue>
<author></author>
<title>Neuroreport Curr Opin Neurobiol</title>
<publicationDate>2000</publicationDate>
</host>
<title>The representation of articulation in the primary sensorimotor cortex MacNeilage PF, Davis BL. Motor mechanisms in speech ontogeny: phylogenetic, neurobiological and linguistic implications</title>
<publicationDate>2000</publicationDate>
</json:item>
<json:item><author><json:item><name>Pk Mcguire</name>
</json:item>
<json:item><name>Da Silbersweig</name>
</json:item>
<json:item><name>Rm Murray</name>
</json:item>
<json:item><name>As David</name>
</json:item>
<json:item><name>Rs Frackowiak</name>
</json:item>
<json:item><name>Cd Frith</name>
</json:item>
</author>
<host><volume>26</volume>
<pages><last>38</last>
<first>29</first>
</pages>
<author></author>
<title>Psychol Med</title>
<publicationDate>1996</publicationDate>
</host>
<title>Functional anatomy of inner speech and auditory verbal imagery</title>
<publicationDate>1996</publicationDate>
</json:item>
<json:item><author><json:item><name>Ek Miller</name>
</json:item>
</author>
<host><volume>22</volume>
<pages><last>7</last>
<first>15</first>
</pages>
<author></author>
<title>Neuron</title>
<publicationDate>1999</publicationDate>
</host>
<title>The prefrontal cortex: complex neural properties for complex behavior</title>
<publicationDate>1999</publicationDate>
</json:item>
<json:item><author><json:item><name>A Mlcoch</name>
</json:item>
</author>
<host><pages><last>00</last>
<first>000</first>
</pages>
<author></author>
<title>Handbook of Parkinson's disease</title>
<publicationDate>1987</publicationDate>
</host>
<title>Diagnosis and treatment of parkinsonian dysarthria</title>
<publicationDate>1987</publicationDate>
</json:item>
<json:item><author><json:item><name>K Murphy</name>
</json:item>
<json:item><name>Dr Cor®eld</name>
</json:item>
<json:item><name>A Guz</name>
</json:item>
<json:item><name>Gr Fink</name>
</json:item>
<json:item><name>Rj Wise</name>
</json:item>
<json:item><name>J Harrison</name>
</json:item>
</author>
<host><volume>83</volume>
<pages><last>47</last>
<first>1438</first>
</pages>
<author></author>
<title>J Appl Physiol</title>
<publicationDate>1997</publicationDate>
</host>
<title>Cerebral areas associated with motor control of speech in humans</title>
<publicationDate>1997</publicationDate>
</json:item>
<json:item><author><json:item><name>Wj Mutch</name>
</json:item>
<json:item><name>A Strudwick</name>
</json:item>
<json:item><name>Sk Roy</name>
</json:item>
<json:item><name>Aw Downie</name>
</json:item>
<json:item><name> 675±7</name>
</json:item>
<json:item><name>B Okuda</name>
</json:item>
<json:item><name>K Kawabata</name>
</json:item>
<json:item><name>H Tachibana</name>
</json:item>
<json:item><name>M Sugita</name>
</json:item>
</author>
<host><volume>293</volume>
<pages><first>109</first>
</pages>
<issue>30</issue>
<author></author>
<title>Br Med J Stroke</title>
<publicationDate>1986</publicationDate>
</host>
<title>Parkinson's disease: disability, review, and management Cerebral blood ¯ow in pure dysarthria: role of frontal cortical hypoperfusion</title>
<publicationDate>1986</publicationDate>
</json:item>
<json:item><author><json:item><name>Am Owen</name>
</json:item>
<json:item><name>Jj Downes</name>
</json:item>
<json:item><name>Bj Sahakian</name>
</json:item>
<json:item><name>Ce Polkey</name>
</json:item>
<json:item><name>Tw Robbins</name>
</json:item>
</author>
<host><volume>28</volume>
<pages><last>34</last>
<first>1021</first>
</pages>
<author></author>
<title>Neuropsychologia</title>
<publicationDate>1990</publicationDate>
</host>
<title>Planning and spatial working memory following frontal lobe lesions in man</title>
<publicationDate>1990</publicationDate>
</json:item>
<json:item><host><author><json:item><name>W Pen®eld</name>
</json:item>
<json:item><name>T Rasmussen</name>
</json:item>
</author>
<title>The cerebral cortex of man</title>
<publicationDate>1950</publicationDate>
</host>
</json:item>
<json:item><author><json:item><name>Se Petersen</name>
</json:item>
<json:item><name>Pt Fox</name>
</json:item>
<json:item><name>Mi Posner</name>
</json:item>
<json:item><name>M Mintun</name>
</json:item>
<json:item><name>Me Raichle</name>
</json:item>
</author>
<host><volume>331</volume>
<pages><last>9</last>
<first>585</first>
</pages>
<author></author>
<title>Nature</title>
<publicationDate>1988</publicationDate>
</host>
<title>Positron emission tomographic studies of the cortical anatomy of single-word processing</title>
<publicationDate>1988</publicationDate>
</json:item>
<json:item><author><json:item><name>N Picard</name>
</json:item>
<json:item><name>Pl Strick</name>
</json:item>
</author>
<host><volume>6</volume>
<pages><last>53</last>
<first>342</first>
</pages>
<author></author>
<title>Cereb Cortex</title>
<publicationDate>1996</publicationDate>
</host>
<title>Motor areas of the medial wall: a review of their location and functional activation</title>
<publicationDate>1996</publicationDate>
</json:item>
<json:item><author><json:item><name>S Pinto</name>
</json:item>
<json:item><name>M Gentil</name>
</json:item>
<json:item><name>V Fraix</name>
</json:item>
<json:item><name>Al Benabid</name>
</json:item>
<json:item><name>P Pollak</name>
</json:item>
</author>
<host><volume>250</volume>
<pages><last>87</last>
<first>179</first>
</pages>
<author></author>
<title>J Neurol</title>
<publicationDate>2003</publicationDate>
</host>
<title>Bilateral subthalamic stimulation effects on oral force control in Parkinson's disease</title>
<publicationDate>2003</publicationDate>
</json:item>
<json:item><author><json:item><name>Ed Playford</name>
</json:item>
<json:item><name>Ih Jenkins</name>
</json:item>
<json:item><name>Re Passingham</name>
</json:item>
<json:item><name>J Nutt</name>
</json:item>
<json:item><name>Rs Frackowiak</name>
</json:item>
<json:item><name>Dj Brooks</name>
</json:item>
</author>
<host><volume>32</volume>
<pages><last>61</last>
<first>151</first>
</pages>
<author></author>
<title>Ann Neurol</title>
<publicationDate>1992</publicationDate>
</host>
<title>Impaired mesial frontal and putamen activation in Parkinson's disease: a positron emission tomography study</title>
<publicationDate>1992</publicationDate>
</json:item>
<json:item><author><json:item><name>Ed Playford</name>
</json:item>
<json:item><name>Ih Jenkins</name>
</json:item>
<json:item><name>Re Passingham</name>
</json:item>
<json:item><name>Rs Frackowiak</name>
</json:item>
<json:item><name>Dj Brooks</name>
</json:item>
</author>
<host><volume>60</volume>
<pages><last>31</last>
<first>919</first>
</pages>
<issue>119</issue>
<author></author>
<title>Adv Neurol Brain</title>
<publicationDate>1993</publicationDate>
</host>
<title>Impaired activation of frontal areas during movement in Parkinson's disease: a PET study Hearing and saying. The functional neuro-anatomy of auditory word processing</title>
<publicationDate>1993</publicationDate>
</json:item>
<json:item><author><json:item><name>Lo Ramig</name>
</json:item>
<json:item><name>Cm Bonitati</name>
</json:item>
<json:item><name>Jh Lemke</name>
</json:item>
<json:item><name>Y Horii</name>
</json:item>
</author>
<host><volume>2</volume>
<pages><last>209</last>
<first>191</first>
</pages>
<author></author>
<title>J Med Speech Lang Pathol</title>
<publicationDate>1994</publicationDate>
</host>
<title>Voice treatment for patients with Parkinson's disease. Development of an approach and preliminary ef®cacy data</title>
<publicationDate>1994</publicationDate>
</json:item>
<json:item><author><json:item><name>Lo Ramig</name>
</json:item>
<json:item><name>S Sapir</name>
</json:item>
<json:item><name>S Countryman</name>
</json:item>
<json:item><name>Aa Pawlas</name>
</json:item>
<json:item><name>O Brien</name>
</json:item>
<json:item><name>C Hoehn</name>
</json:item>
<json:item><name>M </name>
</json:item>
</author>
<host><volume>71</volume>
<pages><last>8</last>
<first>493</first>
</pages>
<issue>120</issue>
<author></author>
<title>J Neurol Neurosurg Psychiatry Brain</title>
<publicationDate>1997</publicationDate>
</host>
<title>Intensive voice treatment (LSVT) for patients with Parkinson's disease: a 2 year follow up The ipsilateral cerebellar hemisphere is overactive during hand movements in akinetic parkinsonian patients</title>
<publicationDate>1997</publicationDate>
</json:item>
<json:item><author><json:item><name>P Remy</name>
</json:item>
<json:item><name>M Zilbovicius</name>
</json:item>
<json:item><name>A Leroy-Willig</name>
</json:item>
<json:item><name>A Syrota</name>
</json:item>
<json:item><name>Y Samson</name>
</json:item>
</author>
<host><volume>36</volume>
<pages><last>26</last>
<first>19</first>
</pages>
<author></author>
<title>Ann Neurol</title>
<publicationDate>1994</publicationDate>
</host>
<title>Movementand task-related activations of motor cortical areas: a positron emission tomographic study</title>
<publicationDate>1994</publicationDate>
</json:item>
<json:item><author><json:item><name>A Riecker</name>
</json:item>
<json:item><name>D Wildgruber</name>
</json:item>
<json:item><name>W Grodd</name>
</json:item>
<json:item><name>H Ackermann</name>
</json:item>
</author>
<host><volume>8</volume>
<pages><last>23</last>
<first>417</first>
</pages>
<author></author>
<title>Neurocase</title>
<publicationDate>2002</publicationDate>
</host>
<title>Reorganization of speech production at the motor cortex and cerebellum following capsular infarction: a follow-up functional magnetic resonance imaging study</title>
<publicationDate>2002</publicationDate>
</json:item>
<json:item><author><json:item><name>Em Rouiller</name>
</json:item>
<json:item><name>F Liang</name>
</json:item>
<json:item><name>A Babalian</name>
</json:item>
<json:item><name>V Moret</name>
</json:item>
<json:item><name>M Wiesendanger</name>
</json:item>
</author>
<host><volume>345</volume>
<pages><last>213</last>
<first>185</first>
</pages>
<author></author>
<title>J Comp Neurol</title>
<publicationDate>1994</publicationDate>
</host>
<title>Cerebellothalamocortical and pallidothalamocortical projections to the primary and supplementary motor cortical areas: a multiple tracing study in macaque monkeys</title>
<publicationDate>1994</publicationDate>
</json:item>
<json:item><author><json:item><name>U Sabatini</name>
</json:item>
<json:item><name>K Boulanouar</name>
</json:item>
<json:item><name>N Fabre</name>
</json:item>
<json:item><name>F Martin</name>
</json:item>
<json:item><name>C Carel</name>
</json:item>
<json:item><name>C Colonnese</name>
</json:item>
</author>
<host><volume>123</volume>
<pages><last>403</last>
<first>394</first>
</pages>
<author></author>
<title>Brain</title>
<publicationDate>2000</publicationDate>
</host>
<title>Cortical motor reorganization in akinetic patients with Parkinson's disease: a functional MRI study</title>
<publicationDate>2000</publicationDate>
</json:item>
<json:item><author><json:item><name>St Sakai</name>
</json:item>
<json:item><name>I Stepniewska</name>
</json:item>
<json:item><name>Hx Qi</name>
</json:item>
<json:item><name>Jh Kaas</name>
</json:item>
</author>
<host><volume>417</volume>
<pages><last>80</last>
<first>164</first>
</pages>
<author></author>
<title>J Comp Neurol</title>
<publicationDate>2000</publicationDate>
</host>
<title>Pallidal and cerebellar afferents to pre-supplementary motor area thalamocortical neurons in the owl monkey: a multiple labeling study</title>
<publicationDate>2000</publicationDate>
</json:item>
<json:item><author><json:item><name>St Sakai</name>
</json:item>
<json:item><name>M Inase</name>
</json:item>
<json:item><name>J Tanji</name>
</json:item>
</author>
<host><volume>19</volume>
<pages><last>48</last>
<first>139</first>
</pages>
<author></author>
<title>Somatosens Mot Res</title>
<publicationDate>2002</publicationDate>
</host>
<title>The relationship between MI and SMA afferents and cerebellar and pallidal efferents in the macaque monkey</title>
<publicationDate>2002</publicationDate>
</json:item>
<json:item><author><json:item><name>M Samuel</name>
</json:item>
<json:item><name>Ao Ceballos-Baumann</name>
</json:item>
<json:item><name>J Blin</name>
</json:item>
<json:item><name>T Uema</name>
</json:item>
<json:item><name>H Boecker</name>
</json:item>
<json:item><name>Re Passingham</name>
</json:item>
</author>
<host><volume>120</volume>
<pages><last>76</last>
<first>963</first>
</pages>
<author></author>
<title>Brain</title>
<publicationDate>1997</publicationDate>
</host>
<title>Evidence for lateral premotor and parietal overactivity in Parkinson's disease during sequential and bimanual movements. A PET study</title>
<publicationDate>1997</publicationDate>
</json:item>
<json:item><author><json:item><name>R Schlosser</name>
</json:item>
<json:item><name>M Hutchinson</name>
</json:item>
<json:item><name>S Joseffer</name>
</json:item>
<json:item><name>H Rusinek</name>
</json:item>
<json:item><name>A Saarimaki</name>
</json:item>
<json:item><name>J Stevenson</name>
</json:item>
</author>
<host><volume>64</volume>
<pages><last>8</last>
<first>492</first>
</pages>
<author></author>
<title>J Neurol Neurosurg Psychiatry</title>
<publicationDate>1998</publicationDate>
</host>
<title>Functional magnetic resonance imaging of human brain activity in a verbal ¯uency task</title>
<publicationDate>1998</publicationDate>
</json:item>
<json:item><author><json:item><name>Gm Schulz</name>
</json:item>
<json:item><name>M Greer</name>
</json:item>
<json:item><name>W Friedman</name>
</json:item>
</author>
<host><volume>14</volume>
<pages><last>606</last>
<first>589</first>
</pages>
<author></author>
<title>J Voice</title>
<publicationDate>2000</publicationDate>
</host>
<title>Changes in vocal intensity in Parkinson's disease following pallidotomy surgery</title>
<publicationDate>2000</publicationDate>
</json:item>
<json:item><author><json:item><name>Oa Selnes</name>
</json:item>
<json:item><name>Hh Holcomb</name>
</json:item>
<json:item><name>B Gordon</name>
</json:item>
</author>
<host><volume>153</volume>
<pages><last>10</last>
<first>309</first>
</pages>
<author></author>
<title>Am J Psychiatry</title>
<publicationDate>1996</publicationDate>
</host>
<title>Images in neuroscience Progressive dysarthria: structural and brain correlations</title>
<publicationDate>1996</publicationDate>
</json:item>
<json:item><author><json:item><name>L Stewart</name>
</json:item>
<json:item><name>V Walsh</name>
</json:item>
<json:item><name>U Frith</name>
</json:item>
<json:item><name>Jc Rothwell</name>
</json:item>
</author>
<host><volume>13</volume>
<pages><last>8</last>
<first>472</first>
</pages>
<author></author>
<title>Neuroimage</title>
<publicationDate>2001</publicationDate>
</host>
<title>TMS produces two dissociable types of speech disruption</title>
<publicationDate>2001</publicationDate>
</json:item>
<json:item><author><json:item><name>A Stracciari</name>
</json:item>
<json:item><name>M Guarino</name>
</json:item>
<json:item><name>F Cirignotta</name>
</json:item>
<json:item><name>P Pazzaglia</name>
</json:item>
</author>
<host><pages><last>6</last>
<first>275</first>
</pages>
<author></author>
<title>Tournoux P. Co-planar stereotaxic atlas of the human brain</title>
<publicationDate>1988</publicationDate>
</host>
<title>Development of palilalia after stereotaxic thalamotomy in Parkinson's disease</title>
<publicationDate>1988</publicationDate>
</json:item>
<json:item><author><json:item><name>P Temperli</name>
</json:item>
<json:item><name>J Ghika</name>
</json:item>
<json:item><name>J-G Villemure</name>
</json:item>
<json:item><name>Pr Burkhard</name>
</json:item>
<json:item><name>J Bogousslavsky</name>
</json:item>
<json:item><name>Fjg Vingerhoets</name>
</json:item>
</author>
<host><volume>60</volume>
<pages><last>81</last>
<first>78</first>
</pages>
<author></author>
<title>Neurology</title>
<publicationDate>2003</publicationDate>
</host>
<title>How do parkinsonian signs return after discontinuation of subthalamic DBS</title>
<publicationDate>2003</publicationDate>
</json:item>
<json:item><author><json:item><name>S Thobois</name>
</json:item>
<json:item><name>P Dominey</name>
</json:item>
<json:item><name>J Decety</name>
</json:item>
<json:item><name>P Pollak</name>
</json:item>
<json:item><name>Mc Gregoire</name>
</json:item>
<json:item><name>E Broussolle</name>
</json:item>
</author>
<host><volume>11</volume>
<pages><last>9</last>
<first>785</first>
</pages>
<author></author>
<title>Neuroreport</title>
<publicationDate>2000</publicationDate>
</host>
<title>Overactivation of primary motor cortex is asymmetrical in hemiparkinsonian patients</title>
<publicationDate>2000</publicationDate>
</json:item>
<json:item><author><json:item><name>S Thobois</name>
</json:item>
<json:item><name>P Dominey</name>
</json:item>
<json:item><name>V Fraix</name>
</json:item>
<json:item><name>P Mertens</name>
</json:item>
<json:item><name>M Guenot</name>
</json:item>
<json:item><name>L Zimmer</name>
</json:item>
</author>
<host><volume>249</volume>
<pages><last>61</last>
<first>1057</first>
</pages>
<issue>353</issue>
<author></author>
<title>J Neurol Lancet</title>
<publicationDate>1999</publicationDate>
</host>
<title>Effects of subthalamic nucleus stimulation on actual and imagined movement in Parkinson's disease: a PET study Brain regions involved in articulation</title>
<publicationDate>1999</publicationDate>
</json:item>
</refBibs>
<genre><json:string>research-article</json:string>
</genre>
<host><volume>127</volume>
<publisherId><json:string>brainj</json:string>
</publisherId>
<pages><last>615</last>
<first>602</first>
</pages>
<issn><json:string>0006-8950</json:string>
</issn>
<issue>3</issue>
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<notesStmt><note>Correspondence to: Serge Pinto, PhD, Département de Neurologie, CHU de Grenoble, BP 217, 38043 Grenoble cedex 09, France E‐mail: serge_pinto@yahoo.fr</note>
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<author xml:id="author-1"><persName><forename type="first">Serge</forename>
<surname>Pinto</surname>
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<affiliation>INSERM U318, Grenoble,</affiliation>
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<author xml:id="author-2"><persName><forename type="first">Stéphane</forename>
<surname>Thobois</surname>
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<affiliation>Hôpital Neurologique Pierre Wertheimer,</affiliation>
<affiliation>Centre d’Exploration et de Recherche Médicales par Emission de Positrons (CERMEP), Lyon and</affiliation>
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<author xml:id="author-3"><persName><forename type="first">Nicolas</forename>
<surname>Costes</surname>
</persName>
<affiliation>Centre d’Exploration et de Recherche Médicales par Emission de Positrons (CERMEP), Lyon and</affiliation>
</author>
<author xml:id="author-4"><persName><forename type="first">Didier</forename>
<surname>Le Bars</surname>
</persName>
<affiliation>Centre d’Exploration et de Recherche Médicales par Emission de Positrons (CERMEP), Lyon and</affiliation>
</author>
<author xml:id="author-5"><persName><forename type="first">Alim‐Louis</forename>
<surname>Benabid</surname>
</persName>
<affiliation>INSERM U318, Grenoble,</affiliation>
</author>
<author xml:id="author-6"><persName><forename type="first">Emmanuel</forename>
<surname>Broussolle</surname>
</persName>
<affiliation>Hôpital Neurologique Pierre Wertheimer,</affiliation>
<affiliation>Centre d’Exploration et de Recherche Médicales par Emission de Positrons (CERMEP), Lyon and</affiliation>
</author>
<author xml:id="author-7"><persName><forename type="first">Pierre</forename>
<surname>Pollak</surname>
</persName>
<affiliation>INSERM U318, Grenoble,</affiliation>
<affiliation>Département de Neurologie, CHU de Grenoble, France</affiliation>
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<author xml:id="author-8"><persName><forename type="first">Michèle</forename>
<surname>Gentil</surname>
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<affiliation>INSERM U318, Grenoble,</affiliation>
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<monogr><title level="j">Brain</title>
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<abstract xml:lang="en"><p>In Parkinson’s disease, functional imaging studies during limb motor tasks reveal cerebral activation abnormalities that can be reversed by subthalamic nucleus (STN) stimulation. The effect of STN stimulation on parkinsonian dysarthria has not, however, been investigated using PET. The aim of the present study was to evaluate the effect of STN stimulation on regional cerebral blood flow (rCBF) during speech production and silent articulation in patients with Parkinson’s disease. Ten Parkinson’s disease patients surgically implanted bilaterally in the STN and with significant improvement of their dysarthria induced by STN stimulation were included. Ten healthy control subjects also participated in this study. Control subjects performed six sessions of [15O]H2O–PET scanning corresponding to three duplicated conditions externally cued by an auditory signal. The conditions were: (i) rest; (ii) production of a short, simple sentence; and (iii) silent articulation of the same sentence. Parkinson’s disease patients carried out the six PET sessions twice, i.e., in the ON and OFF STN stimulation states. PET data analysis was performed using statistical parametric mapping (SPM99). In control subjects, speech production (SP) compared with rest was associated with increased rCBF bilaterally in the primary motor cortex (M1) corresponding to the orofacial somatotopy, the supplementary motor area (SMA), the associative auditory cortex and the cerebellar hemispheres. Silent articulation (SA) compared with rest induced a bilateral rCBF increase restricted to the orofacial M1 and cerebellar hemispheres. In Parkinson’s disease patients in the OFF stimulation condition, during both SP and SA there was a lack of activation in the right orofacial M1 and in the cerebellum, abnormal increased rCBF in the right superior premotor cortex, and overactivation of the SMA. There was also an abnormal, increased rCBF in the dorsolateral prefrontal cortex (DLPFC) only during SP and increased rCBF in the left insula only during SA. In Parkinson’s disease patients ON stimulation, for both SP and SA the activation pattern appeared similar to that in control subjects. In conclusion, our results suggest that parkinsonian dysarthria is associated with altered recruitment of the main motor cerebral regions (orofacial M1, cerebellum), and increased involvement of the premotor and prefrontal cortices (DLPFC, SMA, superior premotor cortex). These abnormal activations are different from those reported during hand motor tasks. They could be a compensatory mechanism, but might also arise directly as part of the pathophysiology of Parkinson’s disease. STN stimulation tends to reverse these abnormal activations, which is consistent with the observed improvement of Parkinson’s disease dysarthria.</p>
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<item><term>BA = Brodmann area; DLPFC = dorsolateral prefrontal cortex; MT = movement time; R = rest; rCBF = regional cerebral blood flow; RI = relative intensity; RT = reaction time; SA = silent articulation; SMA = supplementary motor area; SP = speech production; STN = subthalamic nucleus</term>
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<contrib-group><contrib contrib-type="author"><name><surname>Pinto</surname>
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<given-names>Michèle</given-names>
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<xref rid="AWH074A1">1</xref>
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<aff id="AWH074A1"><label>1</label>
INSERM U318, Grenoble,</aff>
<aff id="AWH074A2"><label>2</label>
Hôpital Neurologique Pierre Wertheimer,</aff>
<aff id="AWH074A3"><label>3</label>
Centre d’Exploration et de Recherche Médicales par Emission de Positrons (CERMEP), Lyon and</aff>
<aff id="AWH074A4"><label>4</label>
Département de Neurologie, CHU de Grenoble, France</aff>
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<author-notes><corresp id="COR1"><label></label>
Correspondence to: Serge Pinto, PhD, Département de Neurologie, CHU de Grenoble, BP 217, 38043 Grenoble cedex 09, France E‐mail: <ext-link xlink:href="serge_pinto@yahoo.fr" ext-link-type="email">serge_pinto@yahoo.fr</ext-link>
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<pub-date pub-type="ppub"><month>03</month>
<year>2004</year>
</pub-date>
<volume>127</volume>
<issue>3</issue>
<fpage>602</fpage>
<lpage>615</lpage>
<history><date date-type="accepted"><day>30</day>
<month>10</month>
<year>2003</year>
</date>
<date date-type="received"><day>02</day>
<month>06</month>
<year>2003</year>
</date>
<date date-type="rev-recd"><day>15</day>
<month>10</month>
<year>2003</year>
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<copyright-statement>The Guarantors of Brain 2004</copyright-statement>
<copyright-year>2004</copyright-year>
<abstract xml:lang="en"><p>In Parkinson’s disease, functional imaging studies during limb motor tasks reveal cerebral activation abnormalities that can be reversed by subthalamic nucleus (STN) stimulation. The effect of STN stimulation on parkinsonian dysarthria has not, however, been investigated using PET. The aim of the present study was to evaluate the effect of STN stimulation on regional cerebral blood flow (rCBF) during speech production and silent articulation in patients with Parkinson’s disease. Ten Parkinson’s disease patients surgically implanted bilaterally in the STN and with significant improvement of their dysarthria induced by STN stimulation were included. Ten healthy control subjects also participated in this study. Control subjects performed six sessions of [<sup>15</sup>
O]H<sub>2</sub>
O–PET scanning corresponding to three duplicated conditions externally cued by an auditory signal. The conditions were: (i) rest; (ii) production of a short, simple sentence; and (iii) silent articulation of the same sentence. Parkinson’s disease patients carried out the six PET sessions twice, i.e., in the ON and OFF STN stimulation states. PET data analysis was performed using statistical parametric mapping (SPM99). In control subjects, speech production (SP) compared with rest was associated with increased rCBF bilaterally in the primary motor cortex (M1) corresponding to the orofacial somatotopy, the supplementary motor area (SMA), the associative auditory cortex and the cerebellar hemispheres. Silent articulation (SA) compared with rest induced a bilateral rCBF increase restricted to the orofacial M1 and cerebellar hemispheres. In Parkinson’s disease patients in the OFF stimulation condition, during both SP and SA there was a lack of activation in the right orofacial M1 and in the cerebellum, abnormal increased rCBF in the right superior premotor cortex, and overactivation of the SMA. There was also an abnormal, increased rCBF in the dorsolateral prefrontal cortex (DLPFC) only during SP and increased rCBF in the left insula only during SA. In Parkinson’s disease patients ON stimulation, for both SP and SA the activation pattern appeared similar to that in control subjects. In conclusion, our results suggest that parkinsonian dysarthria is associated with altered recruitment of the main motor cerebral regions (orofacial M1, cerebellum), and increased involvement of the premotor and prefrontal cortices (DLPFC, SMA, superior premotor cortex). These abnormal activations are different from those reported during hand motor tasks. They could be a compensatory mechanism, but might also arise directly as part of the pathophysiology of Parkinson’s disease. STN stimulation tends to reverse these abnormal activations, which is consistent with the observed improvement of Parkinson’s disease dysarthria. </p>
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<name type="personal"><namePart type="given">Nicolas</namePart>
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<name type="personal"><namePart type="given">Didier</namePart>
<namePart type="family">Le Bars</namePart>
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<name type="personal"><namePart type="given">Alim‐Louis</namePart>
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<name type="personal"><namePart type="given">Emmanuel</namePart>
<namePart type="family">Broussolle</namePart>
<affiliation>Hôpital Neurologique Pierre Wertheimer,</affiliation>
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<name type="personal"><namePart type="given">Pierre</namePart>
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<abstract lang="en">In Parkinson’s disease, functional imaging studies during limb motor tasks reveal cerebral activation abnormalities that can be reversed by subthalamic nucleus (STN) stimulation. The effect of STN stimulation on parkinsonian dysarthria has not, however, been investigated using PET. The aim of the present study was to evaluate the effect of STN stimulation on regional cerebral blood flow (rCBF) during speech production and silent articulation in patients with Parkinson’s disease. Ten Parkinson’s disease patients surgically implanted bilaterally in the STN and with significant improvement of their dysarthria induced by STN stimulation were included. Ten healthy control subjects also participated in this study. Control subjects performed six sessions of [15O]H2O–PET scanning corresponding to three duplicated conditions externally cued by an auditory signal. The conditions were: (i) rest; (ii) production of a short, simple sentence; and (iii) silent articulation of the same sentence. Parkinson’s disease patients carried out the six PET sessions twice, i.e., in the ON and OFF STN stimulation states. PET data analysis was performed using statistical parametric mapping (SPM99). In control subjects, speech production (SP) compared with rest was associated with increased rCBF bilaterally in the primary motor cortex (M1) corresponding to the orofacial somatotopy, the supplementary motor area (SMA), the associative auditory cortex and the cerebellar hemispheres. Silent articulation (SA) compared with rest induced a bilateral rCBF increase restricted to the orofacial M1 and cerebellar hemispheres. In Parkinson’s disease patients in the OFF stimulation condition, during both SP and SA there was a lack of activation in the right orofacial M1 and in the cerebellum, abnormal increased rCBF in the right superior premotor cortex, and overactivation of the SMA. There was also an abnormal, increased rCBF in the dorsolateral prefrontal cortex (DLPFC) only during SP and increased rCBF in the left insula only during SA. In Parkinson’s disease patients ON stimulation, for both SP and SA the activation pattern appeared similar to that in control subjects. In conclusion, our results suggest that parkinsonian dysarthria is associated with altered recruitment of the main motor cerebral regions (orofacial M1, cerebellum), and increased involvement of the premotor and prefrontal cortices (DLPFC, SMA, superior premotor cortex). These abnormal activations are different from those reported during hand motor tasks. They could be a compensatory mechanism, but might also arise directly as part of the pathophysiology of Parkinson’s disease. STN stimulation tends to reverse these abnormal activations, which is consistent with the observed improvement of Parkinson’s disease dysarthria.</abstract>
<note type="author-notes">Correspondence to: Serge Pinto, PhD, Département de Neurologie, CHU de Grenoble, BP 217, 38043 Grenoble cedex 09, France E‐mail: serge_pinto@yahoo.fr</note>
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