Brain Responses to Detection of Right or Left Somatic Targets are Symmetrical in Unilateral Parkinson's Disease: A Case Against the Concept of ‘Parkinsonian Neglect’
Identifieur interne : 002455 ( Istex/Corpus ); précédent : 002454; suivant : 002456Brain Responses to Detection of Right or Left Somatic Targets are Symmetrical in Unilateral Parkinson's Disease: A Case Against the Concept of ‘Parkinsonian Neglect’
Auteurs : L. García-Larrea ; E. Brousolle ; M. F. Gravejat ; G. Chazot ; F. MauguièreSource :
- Cortex [ 0010-9452 ] ; 1996.
Abstract
Signs of attentional dysfunction mimicking spatial neglect have been described both in humans with lateralised Parkinson's Disease (PD) and in animals with MPTP-related hemiparkinsonism. Such deficits have been attributed to dopamine loss in basal ganglia and cortical targets. However, in previous studies the existence of neglect was assumed from behavioural tests which needed a motor output, thus entailing interpretation ambiguities due to effects of directional hypokinesia. We recorded brain event-related potentials (ERPs) evoked by the presentation of target somatic stimuli to the affected and non-affected sides in 44 patients with unilateral or asymmetrical PD. The N2 and P3 ERP components were specifically analysed, since (a) they are triggered selectively by task-relevant, attended sensory stimuli; (b) their latency reflects stimulus evaluation time, independently from the execution of a motor response, and (c) they have proved to be abnormal in hemineglect syndromes due to focal brain lesions. Irrespective of the side (left or right) of motor symptom predominance there were no significant ERP differences to stimulation of the affected and non-affected limbs, nor was there any correlation between ERP latencies and the degree of dopaminerelated motor impairment. The P3 latency was abnormally delayed in 23% of the patients, but there was no trend for abnormalities to concentrate on the affected side. This study does not confirm the existence of a significant attentional impairment toward the affected limb in lateralised PD, and suggests that previous clinical evidence of ‘neglect’ behaviour in PD might be linked to directional hypokinesia, thus reflecting intentional, rather than attentional lateralised deficits.
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DOI: 10.1016/S0010-9452(96)80038-4
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Brain Responses to Detection of Right or Left Somatic Targets are Symmetrical in Unilateral Parkinson's Disease: A Case Against the Concept of ‘Parkinsonian Neglect’</title><author><name sortKey="Garcia Larrea, L" sort="Garcia Larrea, L" uniqKey="Garcia Larrea L" first="L." last="García-Larrea">L. García-Larrea</name><affiliation><mods:affiliation>Clinical Neurophysiology lab at the CERMEP, UPR 1880, VCB, Lyon, France</mods:affiliation></affiliation><affiliation><mods:affiliation>aLuis García-Larrea, CERMEP (Hôpital Neurologique), 59 Bd Pinel, 69003 Lyon, France.</mods:affiliation></affiliation></author><author><name sortKey="Brousolle, E" sort="Brousolle, E" uniqKey="Brousolle E" first="E." last="Brousolle">E. Brousolle</name><affiliation><mods:affiliation>Neurometabolic Unit, Neurological Hospital, Lyon, France</mods:affiliation></affiliation></author><author><name sortKey="Gravejat, M F" sort="Gravejat, M F" uniqKey="Gravejat M" first="M. F." last="Gravejat">M. F. Gravejat</name><affiliation><mods:affiliation>Clinical Psychology Unit, Antiquaille Hospital, Lyon, France</mods:affiliation></affiliation></author><author><name sortKey="Chazot, G" sort="Chazot, G" uniqKey="Chazot G" first="G." last="Chazot">G. Chazot</name><affiliation><mods:affiliation>Neurometabolic Unit, Neurological Hospital, Lyon, France</mods:affiliation></affiliation></author><author><name sortKey="Mauguiere, F" sort="Mauguiere, F" uniqKey="Mauguiere F" first="F." last="Mauguière">F. 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García-Larrea</name><affiliation><mods:affiliation>Clinical Neurophysiology lab at the CERMEP, UPR 1880, VCB, Lyon, France</mods:affiliation></affiliation><affiliation><mods:affiliation>aLuis García-Larrea, CERMEP (Hôpital Neurologique), 59 Bd Pinel, 69003 Lyon, France.</mods:affiliation></affiliation></author><author><name sortKey="Brousolle, E" sort="Brousolle, E" uniqKey="Brousolle E" first="E." last="Brousolle">E. Brousolle</name><affiliation><mods:affiliation>Neurometabolic Unit, Neurological Hospital, Lyon, France</mods:affiliation></affiliation></author><author><name sortKey="Gravejat, M F" sort="Gravejat, M F" uniqKey="Gravejat M" first="M. F." last="Gravejat">M. F. Gravejat</name><affiliation><mods:affiliation>Clinical Psychology Unit, Antiquaille Hospital, Lyon, France</mods:affiliation></affiliation></author><author><name sortKey="Chazot, G" sort="Chazot, G" uniqKey="Chazot G" first="G." last="Chazot">G. Chazot</name><affiliation><mods:affiliation>Neurometabolic Unit, Neurological Hospital, Lyon, France</mods:affiliation></affiliation></author><author><name sortKey="Mauguiere, F" sort="Mauguiere, F" uniqKey="Mauguiere F" first="F." last="Mauguière">F. Mauguière</name><affiliation><mods:affiliation>Clinical Neurophysiology lab at the CERMEP, UPR 1880, VCB, Lyon, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Cortex</title><title level="j" type="abbrev">CORTEX</title><idno type="ISSN">0010-9452</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1996">1996</date><biblScope unit="volume">32</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="679">679</biblScope><biblScope unit="page" to="691">691</biblScope></imprint><idno type="ISSN">0010-9452</idno></series><idno type="istex">F1368AD1863E9A23E453C61F00A44BA87B23FC74</idno><idno type="DOI">10.1016/S0010-9452(96)80038-4</idno><idno type="PII">S0010-9452(96)80038-4</idno><idno type="ArticleID">80038</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0010-9452</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Signs of attentional dysfunction mimicking spatial neglect have been described both in humans with lateralised Parkinson's Disease (PD) and in animals with MPTP-related hemiparkinsonism. Such deficits have been attributed to dopamine loss in basal ganglia and cortical targets. However, in previous studies the existence of neglect was assumed from behavioural tests which needed a motor output, thus entailing interpretation ambiguities due to effects of directional hypokinesia. We recorded brain event-related potentials (ERPs) evoked by the presentation of target somatic stimuli to the affected and non-affected sides in 44 patients with unilateral or asymmetrical PD. The N2 and P3 ERP components were specifically analysed, since (a) they are triggered selectively by task-relevant, attended sensory stimuli; (b) their latency reflects stimulus evaluation time, independently from the execution of a motor response, and (c) they have proved to be abnormal in hemineglect syndromes due to focal brain lesions. Irrespective of the side (left or right) of motor symptom predominance there were no significant ERP differences to stimulation of the affected and non-affected limbs, nor was there any correlation between ERP latencies and the degree of dopaminerelated motor impairment. The P3 latency was abnormally delayed in 23% of the patients, but there was no trend for abnormalities to concentrate on the affected side. This study does not confirm the existence of a significant attentional impairment toward the affected limb in lateralised PD, and suggests that previous clinical evidence of ‘neglect’ behaviour in PD might be linked to directional hypokinesia, thus reflecting intentional, rather than attentional lateralised deficits.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>L. García-Larrea</name><affiliations><json:string>Clinical Neurophysiology lab at the CERMEP, UPR 1880, VCB, Lyon, France</json:string><json:string>aLuis García-Larrea, CERMEP (Hôpital Neurologique), 59 Bd Pinel, 69003 Lyon, France.</json:string></affiliations></json:item><json:item><name>E. Brousolle</name><affiliations><json:string>Neurometabolic Unit, Neurological Hospital, Lyon, France</json:string></affiliations></json:item><json:item><name>M.F. Gravejat</name><affiliations><json:string>Clinical Psychology Unit, Antiquaille Hospital, Lyon, France</json:string></affiliations></json:item><json:item><name>G. Chazot</name><affiliations><json:string>Neurometabolic Unit, Neurological Hospital, Lyon, France</json:string></affiliations></json:item><json:item><name>F. 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We recorded brain event-related potentials (ERPs) evoked by the presentation of target somatic stimuli to the affected and non-affected sides in 44 patients with unilateral or asymmetrical PD. The N2 and P3 ERP components were specifically analysed, since (a) they are triggered selectively by task-relevant, attended sensory stimuli; (b) their latency reflects stimulus evaluation time, independently from the execution of a motor response, and (c) they have proved to be abnormal in hemineglect syndromes due to focal brain lesions. Irrespective of the side (left or right) of motor symptom predominance there were no significant ERP differences to stimulation of the affected and non-affected limbs, nor was there any correlation between ERP latencies and the degree of dopaminerelated motor impairment. The P3 latency was abnormally delayed in 23% of the patients, but there was no trend for abnormalities to concentrate on the affected side. This study does not confirm the existence of a significant attentional impairment toward the affected limb in lateralised PD, and suggests that previous clinical evidence of ‘neglect’ behaviour in PD might be linked to directional hypokinesia, thus reflecting intentional, rather than attentional lateralised deficits.</abstract><qualityIndicators><score>10</score><pdfVersion>1.7</pdfVersion><pdfPageSize>475.2 x 691.2 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1746</abstractCharCount><pdfWordCount>5635</pdfWordCount><pdfCharCount>36179</pdfCharCount><pdfPageCount>13</pdfPageCount><abstractWordCount>253</abstractWordCount></qualityIndicators><title>Brain Responses to Detection of Right or Left Somatic Targets are Symmetrical in Unilateral Parkinson's Disease: A Case Against the Concept of ‘Parkinsonian Neglect’</title><pii><json:string>S0010-9452(96)80038-4</json:string></pii><refBibs><json:item><author><json:item><name>B.W. 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Gancher</name></json:item></editor><pages><last>485</last><first>471</first></pages><language><json:string>unknown</json:string></language><title>Parkinson's Disease (Neurologic Clinics</title></serie><host><volume>32</volume><pii><json:string>S0010-9452(96)X8032-8</json:string></pii><pages><last>691</last><first>679</first></pages><issn><json:string>0010-9452</json:string></issn><issue>4</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><title>Cortex</title><publicationDate>1996</publicationDate></host><categories><wos><json:string>science</json:string><json:string>neurosciences</json:string><json:string>behavioral sciences</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>psychology & cognitive sciences</json:string><json:string>experimental psychology</json:string></scienceMetrix></categories><publicationDate>1996</publicationDate><copyrightDate>1996</copyrightDate><doi><json:string>10.1016/S0010-9452(96)80038-4</json:string></doi><id>F1368AD1863E9A23E453C61F00A44BA87B23FC74</id><score>0.18263055</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/F1368AD1863E9A23E453C61F00A44BA87B23FC74/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/F1368AD1863E9A23E453C61F00A44BA87B23FC74/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/F1368AD1863E9A23E453C61F00A44BA87B23FC74/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Brain Responses to Detection of Right or Left Somatic Targets are Symmetrical in Unilateral Parkinson's Disease: A Case Against the Concept of ‘Parkinsonian Neglect’</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>©1996 Mason S.p.A.</p></availability><date>1996</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Brain Responses to Detection of Right or Left Somatic Targets are Symmetrical in Unilateral Parkinson's Disease: A Case Against the Concept of ‘Parkinsonian Neglect’</title><author xml:id="author-1"><persName><forename type="first">L.</forename><surname>García-Larrea</surname></persName><affiliation>Clinical Neurophysiology lab at the CERMEP, UPR 1880, VCB, Lyon, France</affiliation><affiliation>aLuis García-Larrea, CERMEP (Hôpital Neurologique), 59 Bd Pinel, 69003 Lyon, France.</affiliation></author><author xml:id="author-2"><persName><forename type="first">E.</forename><surname>Brousolle</surname></persName><affiliation>Neurometabolic Unit, Neurological Hospital, Lyon, France</affiliation></author><author xml:id="author-3"><persName><forename type="first">M.F.</forename><surname>Gravejat</surname></persName><affiliation>Clinical Psychology Unit, Antiquaille Hospital, Lyon, France</affiliation></author><author xml:id="author-4"><persName><forename type="first">G.</forename><surname>Chazot</surname></persName><affiliation>Neurometabolic Unit, Neurological Hospital, Lyon, France</affiliation></author><author xml:id="author-5"><persName><forename type="first">F.</forename><surname>Mauguière</surname></persName><affiliation>Clinical Neurophysiology lab at the CERMEP, UPR 1880, VCB, Lyon, France</affiliation></author></analytic><monogr><title level="j">Cortex</title><title level="j" type="abbrev">CORTEX</title><idno type="pISSN">0010-9452</idno><idno type="PII">S0010-9452(96)X8032-8</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1996"></date><biblScope unit="volume">32</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="679">679</biblScope><biblScope unit="page" to="691">691</biblScope></imprint></monogr><idno type="istex">F1368AD1863E9A23E453C61F00A44BA87B23FC74</idno><idno type="DOI">10.1016/S0010-9452(96)80038-4</idno><idno type="PII">S0010-9452(96)80038-4</idno><idno type="ArticleID">80038</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1996</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Signs of attentional dysfunction mimicking spatial neglect have been described both in humans with lateralised Parkinson's Disease (PD) and in animals with MPTP-related hemiparkinsonism. Such deficits have been attributed to dopamine loss in basal ganglia and cortical targets. However, in previous studies the existence of neglect was assumed from behavioural tests which needed a motor output, thus entailing interpretation ambiguities due to effects of directional hypokinesia. We recorded brain event-related potentials (ERPs) evoked by the presentation of target somatic stimuli to the affected and non-affected sides in 44 patients with unilateral or asymmetrical PD. The N2 and P3 ERP components were specifically analysed, since (a) they are triggered selectively by task-relevant, attended sensory stimuli; (b) their latency reflects stimulus evaluation time, independently from the execution of a motor response, and (c) they have proved to be abnormal in hemineglect syndromes due to focal brain lesions. Irrespective of the side (left or right) of motor symptom predominance there were no significant ERP differences to stimulation of the affected and non-affected limbs, nor was there any correlation between ERP latencies and the degree of dopaminerelated motor impairment. The P3 latency was abnormally delayed in 23% of the patients, but there was no trend for abnormalities to concentrate on the affected side. This study does not confirm the existence of a significant attentional impairment toward the affected limb in lateralised PD, and suggests that previous clinical evidence of ‘neglect’ behaviour in PD might be linked to directional hypokinesia, thus reflecting intentional, rather than attentional lateralised deficits.</p></abstract></profileDesc><revisionDesc><change when="1996">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/F1368AD1863E9A23E453C61F00A44BA87B23FC74/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier doc found" wicri:toSee="Elsevier, no converted or simple article"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" </istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 5.2.0//EN//XML" URI="art520.dtd" name="istex:docType"></istex:docType><istex:document><article version="5.2" xml:lang="en" docsubtype="fla"><item-info><jid>CORTEX</jid><aid>80038</aid><ce:pii>S0010-9452(96)80038-4</ce:pii><ce:doi>10.1016/S0010-9452(96)80038-4</ce:doi><ce:copyright type="other" year="1996">Mason S.p.A.</ce:copyright><ce:copyright-line>1996 © Mason S.p.A.</ce:copyright-line></item-info><head><ce:title id="ttl005">Brain Responses to Detection of Right or Left Somatic Targets are Symmetrical in Unilateral Parkinson's Disease: A Case Against the Concept of ‘Parkinsonian Neglect’</ce:title><ce:author-group id="AUG005"><ce:author id="AUT005"><ce:given-name>L.</ce:given-name><ce:surname>García-Larrea</ce:surname><ce:cross-ref id="crr005" refid="aff1"><ce:sup>1</ce:sup></ce:cross-ref><ce:cross-ref id="crr010" refid="fn1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author id="AUT010"><ce:given-name>E.</ce:given-name><ce:surname>Brousolle</ce:surname><ce:cross-ref id="crr015" refid="aff2"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:author id="AUT015"><ce:given-name>M.F.</ce:given-name><ce:surname>Gravejat</ce:surname><ce:cross-ref id="crr020" refid="aff3"><ce:sup>3</ce:sup></ce:cross-ref></ce:author><ce:author id="AUT020"><ce:given-name>G.</ce:given-name><ce:surname>Chazot</ce:surname><ce:cross-ref id="crr025" refid="aff2"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:author id="AUT025"><ce:given-name>F.</ce:given-name><ce:surname>Mauguière</ce:surname><ce:cross-ref id="crr030" refid="aff1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="aff1"><ce:label>1</ce:label><ce:textfn>Clinical Neurophysiology lab at the CERMEP, UPR 1880, VCB, Lyon, France</ce:textfn><sa:affiliation><sa:organization>>Clinical Neurophysiology lab at the CERMEP</sa:organization><sa:city>Lyon</sa:city><sa:state>VCB</sa:state><sa:postal-code>UPR 1880</sa:postal-code><sa:country>France</sa:country></sa:affiliation></ce:affiliation><ce:affiliation id="aff2"><ce:label>2</ce:label><ce:textfn>Neurometabolic Unit, Neurological Hospital, Lyon, France</ce:textfn><sa:affiliation><sa:organization>Neurometabolic Unit, Neurological Hospital</sa:organization><sa:city>Lyon</sa:city><sa:country>France</sa:country></sa:affiliation></ce:affiliation><ce:affiliation id="aff3"><ce:label>3</ce:label><ce:textfn>Clinical Psychology Unit, Antiquaille Hospital, Lyon, France</ce:textfn><sa:affiliation><sa:organization>Clinical Psychology Unit, Antiquaille Hospital</sa:organization><sa:city>Lyon</sa:city><sa:country>France</sa:country></sa:affiliation></ce:affiliation><ce:footnote id="fn1"><ce:label>a</ce:label><ce:note-para id="ntp005">Luis García-Larrea, CERMEP (Hôpital Neurologique), 59 Bd Pinel, 69003 Lyon, France.</ce:note-para></ce:footnote></ce:author-group><ce:abstract id="ab1"><ce:section-title id="SET005">Abstract</ce:section-title><ce:abstract-sec id="abs005"><ce:simple-para id="SP0005">Signs of attentional dysfunction mimicking spatial neglect have been described both in humans with lateralised Parkinson's Disease (PD) and in animals with MPTP-related hemiparkinsonism. Such deficits have been attributed to dopamine loss in basal ganglia and cortical targets. However, in previous studies the existence of neglect was assumed from behavioural tests which needed a motor output, thus entailing interpretation ambiguities due to effects of directional hypokinesia. We recorded brain event-related potentials (ERPs) evoked by the presentation of target somatic stimuli to the affected and non-affected sides in 44 patients with unilateral or asymmetrical PD. The N2 and P3 ERP components were specifically analysed, since (a) they are triggered selectively by task-relevant, attended sensory stimuli; (b) their latency reflects stimulus evaluation time, independently from the execution of a motor response, and (c) they have proved to be abnormal in hemineglect syndromes due to focal brain lesions. Irrespective of the side (left or right) of motor symptom predominance there were no significant ERP differences to stimulation of the affected and non-affected limbs, nor was there any correlation between ERP latencies and the degree of dopaminerelated motor impairment. The P3 latency was abnormally delayed in 23% of the patients, but there was no trend for abnormalities to concentrate on the affected side. This study does not confirm the existence of a significant attentional impairment toward the affected limb in lateralised PD, and suggests that previous clinical evidence of ‘neglect’ behaviour in PD might be linked to directional hypokinesia, thus reflecting <ce:italic>intentional</ce:italic>, rather than attentional lateralised deficits.</ce:simple-para></ce:abstract-sec></ce:abstract></head><tail><ce:bibliography id="R0005"><ce:section-title id="SET010">References</ce:section-title><ce:bibliography-sec id="RS0005"><ce:bib-reference id="bib1"><ce:label>Abou-Khalil et al., 1987</ce:label><sb:reference 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lang="en"><title>Brain Responses to Detection of Right or Left Somatic Targets are Symmetrical in Unilateral Parkinson's Disease: A Case Against the Concept of ‘Parkinsonian Neglect’</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Brain Responses to Detection of Right or Left Somatic Targets are Symmetrical in Unilateral Parkinson's Disease: A Case Against the Concept of ‘Parkinsonian Neglect’</title></titleInfo><name type="personal"><namePart type="given">L.</namePart><namePart type="family">García-Larrea</namePart><affiliation>Clinical Neurophysiology lab at the CERMEP, UPR 1880, VCB, Lyon, France</affiliation><affiliation>aLuis García-Larrea, CERMEP (Hôpital Neurologique), 59 Bd Pinel, 69003 Lyon, France.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Brousolle</namePart><affiliation>Neurometabolic Unit, Neurological Hospital, Lyon, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.F.</namePart><namePart type="family">Gravejat</namePart><affiliation>Clinical Psychology Unit, Antiquaille Hospital, Lyon, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Chazot</namePart><affiliation>Neurometabolic Unit, Neurological Hospital, Lyon, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Mauguière</namePart><affiliation>Clinical Neurophysiology lab at the CERMEP, UPR 1880, VCB, Lyon, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1996</dateIssued><copyrightDate encoding="w3cdtf">1996</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Signs of attentional dysfunction mimicking spatial neglect have been described both in humans with lateralised Parkinson's Disease (PD) and in animals with MPTP-related hemiparkinsonism. Such deficits have been attributed to dopamine loss in basal ganglia and cortical targets. However, in previous studies the existence of neglect was assumed from behavioural tests which needed a motor output, thus entailing interpretation ambiguities due to effects of directional hypokinesia. We recorded brain event-related potentials (ERPs) evoked by the presentation of target somatic stimuli to the affected and non-affected sides in 44 patients with unilateral or asymmetrical PD. The N2 and P3 ERP components were specifically analysed, since (a) they are triggered selectively by task-relevant, attended sensory stimuli; (b) their latency reflects stimulus evaluation time, independently from the execution of a motor response, and (c) they have proved to be abnormal in hemineglect syndromes due to focal brain lesions. Irrespective of the side (left or right) of motor symptom predominance there were no significant ERP differences to stimulation of the affected and non-affected limbs, nor was there any correlation between ERP latencies and the degree of dopaminerelated motor impairment. The P3 latency was abnormally delayed in 23% of the patients, but there was no trend for abnormalities to concentrate on the affected side. This study does not confirm the existence of a significant attentional impairment toward the affected limb in lateralised PD, and suggests that previous clinical evidence of ‘neglect’ behaviour in PD might be linked to directional hypokinesia, thus reflecting intentional, rather than attentional lateralised deficits.</abstract><relatedItem type="host"><titleInfo><title>Cortex</title></titleInfo><titleInfo type="abbreviated"><title>CORTEX</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199612</dateIssued></originInfo><identifier type="ISSN">0010-9452</identifier><identifier type="PII">S0010-9452(96)X8032-8</identifier><part><date>199612</date><detail type="volume"><number>32</number><caption>vol.</caption></detail><detail type="issue"><number>4</number><caption>no.</caption></detail><extent unit="issue pages"><start>567</start><end>763</end></extent><extent unit="pages"><start>679</start><end>691</end></extent></part></relatedItem><identifier type="istex">F1368AD1863E9A23E453C61F00A44BA87B23FC74</identifier><identifier type="DOI">10.1016/S0010-9452(96)80038-4</identifier><identifier type="PII">S0010-9452(96)80038-4</identifier><identifier type="ArticleID">80038</identifier><accessCondition type="use and reproduction" contentType="copyright">©1996 Mason S.p.A.</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>Mason S.p.A., ©1996</recordOrigin></recordInfo></mods></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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