Integrating and Warehousing Liver Gene Expression Data and Related Biomedical Resources in GEDAW
Identifieur interne : 001F14 ( Istex/Corpus ); précédent : 001F13; suivant : 001F15Integrating and Warehousing Liver Gene Expression Data and Related Biomedical Resources in GEDAW
Auteurs : E. Guérin ; G. Marquet ; A. Burgun ; O. Loréal ; L. Berti-Equille ; U. Leser ; F. MoussouniSource :
- Lecture Notes in Computer Science [ 0302-9743 ] ; 2005.
Abstract
Abstract: Researchers at the medical research institute Inserm U522, specialized in the liver, use high throughput technologies to diagnose liver disease states. They seek to identify the set of dysregulated genes in different physiopathological situations, along with the molecular regulation mechanisms involved in the occurrence of these diseases, leading at mid-term to new diagnostic and therapeutic tools. To be able to resolve such a complex question, one has to consider both data generated on the genes by in-house transcriptome experiments and annotations extracted from the many publicly available heterogeneous resources in Biomedicine. This paper presents GEDAW, a gene expression data warehouse that has been developed to assist such discovery processes. The distinctive feature of GEDAW is that it systematically integrates gene information from a multitude of structured data sources. Data sources include: i) XML records of GENBANK to annotate gene sequence features, integrated using a schema mapping approach, ii) an inhouse relational database that stores detailed experimental data on the liver genes and is a permanent source for providing expression levels to the warehouse without unnecessary details on the experiments, and iii) a semi-structured data source called BioMeKE-XML that provides for each gene its nomenclature, its functional annotation according to Gene Ontology, and its medical annotation according to the UMLS. Because GEDAW is a liver gene expression data warehouse, we have paid more attention to the medical knowledge to be able to correlate biology mechanisms and medical knowledge with experimental data. The paper discusses the data sources and the transformation process that is applied to resolve syntactic and semantic conflicts between the source format and the GEDAW schema.
Url:
DOI: 10.1007/11530084_14
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Guérin</name><affiliation><mods:affiliation>INSERM U522 CHU Pontchaillou, 35033, Rennes, France</mods:affiliation></affiliation></author><author><name sortKey="Marquet, G" sort="Marquet, G" uniqKey="Marquet G" first="G." last="Marquet">G. Marquet</name><affiliation><mods:affiliation>Faculté de Médecine, EA 3888 LIM, 35043, Rennes, France</mods:affiliation></affiliation></author><author><name sortKey="Burgun, A" sort="Burgun, A" uniqKey="Burgun A" first="A." last="Burgun">A. Burgun</name><affiliation><mods:affiliation>Faculté de Médecine, EA 3888 LIM, 35043, Rennes, France</mods:affiliation></affiliation></author><author><name sortKey="Loreal, O" sort="Loreal, O" uniqKey="Loreal O" first="O." last="Loréal">O. Loréal</name><affiliation><mods:affiliation>INSERM U522 CHU Pontchaillou, 35033, Rennes, France</mods:affiliation></affiliation></author><author><name sortKey="Berti Equille, L" sort="Berti Equille, L" uniqKey="Berti Equille L" first="L." last="Berti-Equille">L. Berti-Equille</name><affiliation><mods:affiliation>IRISA, Campus Universitaire de Beaulieu, 35042, Rennes, France</mods:affiliation></affiliation></author><author><name sortKey="Leser, U" sort="Leser, U" uniqKey="Leser U" first="U." last="Leser">U. Leser</name><affiliation><mods:affiliation>Dep. for Computer Science, Humboldt-Universität, 10099, Berlin, Germany</mods:affiliation></affiliation></author><author><name sortKey="Moussouni, F" sort="Moussouni, F" uniqKey="Moussouni F" first="F." last="Moussouni">F. Moussouni</name><affiliation><mods:affiliation>INSERM U522 CHU Pontchaillou, 35033, Rennes, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="s">Lecture Notes in Computer Science</title><imprint><date>2005</date></imprint><idno type="ISSN">0302-9743</idno><idno type="eISSN">1611-3349</idno><idno type="ISSN">0302-9743</idno></series><idno type="istex">4D8E253D82035336D103059D8E6B3E5CC1BA13D2</idno><idno type="DOI">10.1007/11530084_14</idno><idno type="ChapterID">14</idno><idno type="ChapterID">Chap14</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0302-9743</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Researchers at the medical research institute Inserm U522, specialized in the liver, use high throughput technologies to diagnose liver disease states. They seek to identify the set of dysregulated genes in different physiopathological situations, along with the molecular regulation mechanisms involved in the occurrence of these diseases, leading at mid-term to new diagnostic and therapeutic tools. To be able to resolve such a complex question, one has to consider both data generated on the genes by in-house transcriptome experiments and annotations extracted from the many publicly available heterogeneous resources in Biomedicine. This paper presents GEDAW, a gene expression data warehouse that has been developed to assist such discovery processes. The distinctive feature of GEDAW is that it systematically integrates gene information from a multitude of structured data sources. Data sources include: i) XML records of GENBANK to annotate gene sequence features, integrated using a schema mapping approach, ii) an inhouse relational database that stores detailed experimental data on the liver genes and is a permanent source for providing expression levels to the warehouse without unnecessary details on the experiments, and iii) a semi-structured data source called BioMeKE-XML that provides for each gene its nomenclature, its functional annotation according to Gene Ontology, and its medical annotation according to the UMLS. Because GEDAW is a liver gene expression data warehouse, we have paid more attention to the medical knowledge to be able to correlate biology mechanisms and medical knowledge with experimental data. The paper discusses the data sources and the transformation process that is applied to resolve syntactic and semantic conflicts between the source format and the GEDAW schema.</div></front></TEI><istex><corpusName>springer</corpusName><author><json:item><name>E. Guérin</name><affiliations><json:string>INSERM U522 CHU Pontchaillou, 35033, Rennes, France</json:string></affiliations></json:item><json:item><name>G. Marquet</name><affiliations><json:string>Faculté de Médecine, EA 3888 LIM, 35043, Rennes, France</json:string></affiliations></json:item><json:item><name>A. Burgun</name><affiliations><json:string>Faculté de Médecine, EA 3888 LIM, 35043, Rennes, France</json:string></affiliations></json:item><json:item><name>O. Loréal</name><affiliations><json:string>INSERM U522 CHU Pontchaillou, 35033, Rennes, France</json:string></affiliations></json:item><json:item><name>L. Berti-Equille</name><affiliations><json:string>IRISA, Campus Universitaire de Beaulieu, 35042, Rennes, France</json:string></affiliations></json:item><json:item><name>U. Leser</name><affiliations><json:string>Dep. for Computer Science, Humboldt-Universität, 10099, Berlin, Germany</json:string></affiliations></json:item><json:item><name>F. Moussouni</name><affiliations><json:string>INSERM U522 CHU Pontchaillou, 35033, Rennes, France</json:string></affiliations></json:item></author><language><json:string>eng</json:string></language><originalGenre><json:string>OriginalPaper</json:string></originalGenre><abstract>Abstract: Researchers at the medical research institute Inserm U522, specialized in the liver, use high throughput technologies to diagnose liver disease states. They seek to identify the set of dysregulated genes in different physiopathological situations, along with the molecular regulation mechanisms involved in the occurrence of these diseases, leading at mid-term to new diagnostic and therapeutic tools. To be able to resolve such a complex question, one has to consider both data generated on the genes by in-house transcriptome experiments and annotations extracted from the many publicly available heterogeneous resources in Biomedicine. This paper presents GEDAW, a gene expression data warehouse that has been developed to assist such discovery processes. The distinctive feature of GEDAW is that it systematically integrates gene information from a multitude of structured data sources. Data sources include: i) XML records of GENBANK to annotate gene sequence features, integrated using a schema mapping approach, ii) an inhouse relational database that stores detailed experimental data on the liver genes and is a permanent source for providing expression levels to the warehouse without unnecessary details on the experiments, and iii) a semi-structured data source called BioMeKE-XML that provides for each gene its nomenclature, its functional annotation according to Gene Ontology, and its medical annotation according to the UMLS. Because GEDAW is a liver gene expression data warehouse, we have paid more attention to the medical knowledge to be able to correlate biology mechanisms and medical knowledge with experimental data. 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Barillot</name></json:item></author><host><volume>17</volume><pages><last>125</last><first>115</first></pages><issue>2</issue><author></author><title>Bioinformatics</title><publicationDate>2001</publicationDate></host><title>XML, bioinformatics and data integration</title><publicationDate>2001</publicationDate></json:item><json:item><host><author><json:item><name>V Babenko</name></json:item><json:item><name>B Brunk</name></json:item><json:item><name>J Crabtree</name></json:item><json:item><name>S Diskin</name></json:item><json:item><name>S Fischer</name></json:item><json:item><name>G Grant</name></json:item><json:item><name>Y Kondrahkin</name></json:item><json:item><name>L Li</name></json:item><json:item><name>J Liu</name></json:item><json:item><name>J Mazzarelli</name></json:item><json:item><name>D Pinney</name></json:item><json:item><name>A Pizarro</name></json:item><json:item><name>E Manduchi</name></json:item><json:item><name>S Mcweeney</name></json:item><json:item><name>J Schug</name></json:item><json:item><name>C Stoeckert</name></json:item></author><title>GUS The Genomics Unified Schema A Platform for Genomics Databases</title><publicationDate>2003</publicationDate></host></json:item><json:item><author><json:item><name>O Bodenreider</name></json:item></author><host><volume>32</volume><pages><last>70</last><first>267</first></pages><author></author><title>Nucleic Acids Res</title><publicationDate>2004-01-01</publicationDate></host><title>The Unified Medical Language System (UMLS): integrating biomedical terminology</title><publicationDate>2004-01-01</publicationDate></json:item><json:item><author><json:item><name>O Bodenreider</name></json:item><json:item><name>A Burgun</name></json:item></author><host><pages><last>31</last><first>327</first></pages><author></author><title>Medinfo</title><publicationDate>2004</publicationDate></host><title>Aligning Knowledge Sources in the UMLS: Methods, Quantitative Results, and Applications</title><publicationDate>2004</publicationDate></json:item><json:item><author><json:item><name>O Bodenreider</name></json:item><json:item><name>Ja Mitchell</name></json:item><json:item><name>At Mccray</name></json:item></author><host><pages><last>5</last><first>61</first></pages><author></author><title>Proc AMIA Symp</title><publicationDate>2002</publicationDate></host><title>Evaluation of the UMLS as a terminology and knowledge resource for biomedical informatics</title><publicationDate>2002</publicationDate></json:item><json:item><author><json:item><name>A Brazma</name></json:item><json:item><name>P Hingamp</name></json:item><json:item><name>J Quackenbush</name></json:item><json:item><name>G Sherlock</name></json:item><json:item><name>P Spellman</name></json:item><json:item><name>C Stoeckert</name></json:item><json:item><name>J Aach</name></json:item><json:item><name>W Ansorge</name></json:item><json:item><name>Ca Ball</name></json:item><json:item><name>Hc Causton</name></json:item><json:item><name>T Gaasterland</name></json:item><json:item><name>P Glenisson</name></json:item><json:item><name>Fc Holstege</name></json:item><json:item><name>If Kim</name></json:item><json:item><name>V Markowitz</name></json:item><json:item><name>Jc Matese</name></json:item><json:item><name>H Parkinson</name></json:item><json:item><name>A Robinson</name></json:item><json:item><name>U Sarkans</name></json:item><json:item><name>S Schulze-Kremer</name></json:item><json:item><name>J Stewart</name></json:item><json:item><name>R Taylor</name></json:item><json:item><name>J Vilo</name></json:item><json:item><name>M Vingron</name></json:item></author><host><volume>29</volume><pages><last>71</last><first>365</first></pages><issue>4</issue><author></author><title>Nat Genet</title><publicationDate>2001-12</publicationDate></host><title>Minimum information about a microarray experiment (MIAME)-toward standards for microarray data</title><publicationDate>2001-12</publicationDate></json:item><json:item><author><json:item><name>Benson,D A Karsch-Mizrachi</name></json:item><json:item><name>I </name></json:item><json:item><name>Lipman,D J Ostell</name></json:item><json:item><name>J </name></json:item><json:item><name>Wheeler,D L Genbank</name></json:item></author><host><volume>32</volume><pages><last>26</last><first>23</first></pages><author></author><title>Nucleic Acids Res</title><publicationDate>2004-01</publicationDate></host><publicationDate>2004-01</publicationDate></json:item><json:item><author><json:item><name>A Burgun</name></json:item><json:item><name>O Bodenreider</name></json:item><json:item><name>Le Duff</name></json:item><json:item><name>F Moussouni</name></json:item><json:item><name>F Loréal</name></json:item><json:item><name>O </name></json:item></author><host><pages><last>90</last><first>86</first></pages><author></author><title>Proc. AMIA 2002 Symp</title></host><title>Representation of roles in biomedical ontologies : a case study in functional genomics</title></json:item><json:item><author><json:item><name>M Cornell</name></json:item><json:item><name>Nw Paton</name></json:item><json:item><name>S Wu</name></json:item><json:item><name>Ca Goble</name></json:item><json:item><name>Cj Miller</name></json:item><json:item><name>P Kirby</name></json:item><json:item><name>K Eilbeck</name></json:item><json:item><name>A Brass</name></json:item><json:item><name>A Hayes</name></json:item><json:item><name>Sg Oliver</name></json:item></author><host><pages><last>22</last><first>15</first></pages><author></author><title>Proc. 2nd IEEE International Symposium on Bioinformatics and Bioengineering (BIBE)</title><publicationDate>2001</publicationDate></host><title>GIMS -a data warehouse for storage and analysis of genome sequence and functional data</title><publicationDate>2001</publicationDate></json:item><json:item><host><author><json:item><name>H.-H Do</name></json:item><json:item><name>E Rahm</name></json:item></author><title>Flexible Integration of Molecular-biological Annotation Data: The GenMapper Approach</title><publicationDate>2004</publicationDate></host></json:item><json:item><author><json:item><name>K Fellenberg</name></json:item><json:item><name>N,C Hauser</name></json:item><json:item><name>B Brors</name></json:item><json:item><name>Hoheisel,J D Vingron</name></json:item><json:item><name>M </name></json:item></author><host><volume>18</volume><pages><last>433</last><first>423</first></pages><author></author><title>Bioinformatics</title><publicationDate>2002-03</publicationDate></host><title>Microarray data warehouse allowing for inclusion of experiment annotations in statistical analysis</title><publicationDate>2002-03</publicationDate></json:item><json:item><author><json:item><name>E Guerin</name></json:item><json:item><name>G Marquet</name></json:item><json:item><name>F Moussouni</name></json:item><json:item><name>A Burgun</name></json:item><json:item><name>F Mougin</name></json:item><json:item><name>O Loréal</name></json:item></author><host><pages><last>60</last><first>59</first></pages><author></author><title>Proc. ECCB 2003</title></host><title>Deployment of heterogeneous ressources of genomic, biological and medical knowledge on the liver to build a datawarehouse</title></json:item><json:item><author><json:item><name>Ma Harris</name></json:item></author><host><volume>32</volume><pages><last>61</last><first>258</first></pages><author></author><title>Nucleic Acids Res</title><publicationDate>2004-01-01</publicationDate></host><title>Gene Ontology Consortium The Gene Ontology (GO) database and informatics resource</title><publicationDate>2004-01-01</publicationDate></json:item><json:item><author><json:item><name>V Kashyap</name></json:item><json:item><name>A Sheth</name></json:item></author><host><volume>5</volume><pages><last>304</last><first>276</first></pages><issue>4</issue><author></author><title>Int. J. Very Large Data Bases</title><publicationDate>1996</publicationDate></host><title>Schematic and semantic similarities between database objects: a context –based approach</title><publicationDate>1996</publicationDate></json:item><json:item><author><json:item><name>L Lakshmanan</name></json:item><json:item><name>F Sadri</name></json:item><json:item><name>I Subramanian</name></json:item></author><host><pages><last>100</last><first>81</first></pages><author></author><title>DOOD International Conference</title><publicationDate>1993</publicationDate></host><title>On the logical Foundation of Schema Integration and Evolution in Heterogeneous Database Systems</title><publicationDate>1993</publicationDate></json:item><json:item><author><json:item><name>Maurizio Lenzerini</name></json:item></author><host><author></author><title>Proc. of PODS</title><publicationDate>2002</publicationDate></host><title>Data integration: a theoretical perspective</title><publicationDate>2002</publicationDate></json:item><json:item><author><json:item><name>G Marquet</name></json:item><json:item><name>A Burgun</name></json:item><json:item><name>F Moussouni</name></json:item><json:item><name>E Guerin</name></json:item><json:item><name>Le Duff</name></json:item><json:item><name>F Loreal</name></json:item><json:item><name>O </name></json:item></author><host><volume>95</volume><pages><last>5</last><first>80</first></pages><author></author><title>Stud Health Technol Inform</title><publicationDate>2003</publicationDate></host><title>BioMeKE: an ontology-based biomedical knowledge extraction system devoted to transcriptome analysis</title><publicationDate>2003</publicationDate></json:item><json:item><author><json:item><name>Paton,N W </name></json:item><json:item><name>Khan,S A Hayes</name></json:item><json:item><name>A Moussouni</name></json:item><json:item><name>F Brass</name></json:item><json:item><name>A Eilbeck</name></json:item><json:item><name>K Goble</name></json:item><json:item><name>C,A </name></json:item><json:item><name>Hubbard,S J </name></json:item><json:item><name>Oliver,S G </name></json:item></author><host><volume>16</volume><pages><last>557</last><first>548</first></pages><author></author><title>Bioinformatics</title><publicationDate>2000-06</publicationDate></host><title>Conceptual modelling of genomic information</title><publicationDate>2000-06</publicationDate></json:item><json:item><author><json:item><name>S Povey</name></json:item><json:item><name>R Lovering</name></json:item><json:item><name>E Bruford</name></json:item><json:item><name>M Wright</name></json:item><json:item><name>M Lush</name></json:item><json:item><name>Wain,H </name></json:item></author><host><volume>109</volume><pages><last>80</last><first>678</first></pages><issue>6</issue><author></author><title>Hum Genet</title><publicationDate>2001</publicationDate></host><title>The HUGO Gene Nomenclature Committee (HGNC)</title><publicationDate>2001</publicationDate></json:item><json:item><author><json:item><name>O Tuason</name></json:item><json:item><name>L Chen</name></json:item><json:item><name>H Liu</name></json:item><json:item><name>Ja Blake</name></json:item><json:item><name>C Friedman</name></json:item></author><host><pages><last>49</last><first>238</first></pages><author></author><title>Pac Symp Biocomput</title><publicationDate>2004</publicationDate></host><title>Biological nomenclatures: a source of lexical knowledge and ambiguity</title><publicationDate>2004</publicationDate></json:item><json:item><author></author><host><volume>360</volume><pages><first>1019</first></pages><issue>9338</issue><author></author><title>MGED Microarray Gene Expression Data Lancet</title><publicationDate>2002-09-28</publicationDate></host><title>A guide to microarray experiments – an open letter to the scientific journals</title><publicationDate>2002-09-28</publicationDate></json:item><json:item><host><author><json:item><name>H Galhardas</name></json:item><json:item><name>D Florescu</name></json:item><json:item><name>D Sasha</name></json:item><json:item><name>E Simon</name></json:item><json:item><name>C,A Saita</name></json:item></author><title>Declarative Data Cleaning: Model, Language, and Algorithms</title><publicationDate>2001</publicationDate></host></json:item></refBibs><genre><json:string>conference</json:string></genre><serie><editor><json:item><name>David Hutchison</name><affiliations><json:string>Lancaster University, UK</json:string></affiliations></json:item><json:item><name>Takeo Kanade</name><affiliations><json:string>Carnegie Mellon University, Pittsburgh, PA, USA</json:string></affiliations></json:item><json:item><name>Josef Kittler</name><affiliations><json:string>University of Surrey, Guildford, UK</json:string></affiliations></json:item><json:item><name>Jon M. Kleinberg</name><affiliations><json:string>Cornell University, Ithaca, NY, USA</json:string></affiliations></json:item><json:item><name>Friedemann Mattern</name><affiliations><json:string>ETH Zurich, Switzerland</json:string></affiliations></json:item><json:item><name>John C. Mitchell</name><affiliations><json:string>Stanford University, CA, USA</json:string></affiliations></json:item><json:item><name>Moni Naor</name><affiliations><json:string>Weizmann Institute of Science, Rehovot, Israel</json:string></affiliations></json:item><json:item><name>Oscar Nierstrasz</name><affiliations><json:string>University of Bern, Switzerland</json:string></affiliations></json:item><json:item><name>C. Pandu Rangan</name><affiliations><json:string>Indian Institute of Technology, Madras, India</json:string></affiliations></json:item><json:item><name>Bernhard Steffen</name><affiliations><json:string>University of Dortmund, Germany</json:string></affiliations></json:item><json:item><name>Madhu Sudan</name><affiliations><json:string>Massachusetts Institute of Technology, MA, USA</json:string></affiliations></json:item><json:item><name>Demetri Terzopoulos</name><affiliations><json:string>New York University, NY, USA</json:string></affiliations></json:item><json:item><name>Dough Tygar</name><affiliations><json:string>University of California, Berkeley, CA, USA</json:string></affiliations></json:item><json:item><name>Moshe Y. Vardi</name><affiliations><json:string>Rice University, Houston, TX, USA</json:string></affiliations></json:item><json:item><name>Gerhard Weikum</name><affiliations><json:string>Max-Planck Institute of Computer Science, Saarbruecken, Germany</json:string></affiliations></json:item></editor><issn><json:string>0302-9743</json:string></issn><language><json:string>unknown</json:string></language><eissn><json:string>1611-3349</json:string></eissn><title>Lecture Notes in Computer Science</title><copyrightDate>2005</copyrightDate></serie><host><editor><json:item><name>Bertram Ludäscher</name><affiliations><json:string>Department of Computer Science, University of California, Davis,</json:string><json:string>E-mail: ludaesch@ucdavis.edu</json:string></affiliations></json:item><json:item><name>Louiqa Raschid</name><affiliations><json:string>University of Maryland, College Park, 20742, MD, USA</json:string><json:string>E-mail: louiqa@umiacs.umd.edu</json:string></affiliations></json:item></editor><subject><json:item><value>Computer Science</value></json:item><json:item><value>Computer Science</value></json:item><json:item><value>Information Storage and Retrieval</value></json:item><json:item><value>Health Informatics</value></json:item><json:item><value>Database Management</value></json:item><json:item><value>Information Systems Applications (incl.Internet)</value></json:item><json:item><value>Bioinformatics</value></json:item><json:item><value>Computer Appl. in Life Sciences</value></json:item></subject><isbn><json:string>978-3-540-27967-9</json:string></isbn><language><json:string>unknown</json:string></language><eissn><json:string>1611-3349</json:string></eissn><title>Data Integration in the Life Sciences</title><bookId><json:string>978-3-540-31879-8</json:string></bookId><volume>3615</volume><pages><last>174</last><first>158</first></pages><issn><json:string>0302-9743</json:string></issn><genre><json:string>book-series</json:string></genre><eisbn><json:string>978-3-540-31879-8</json:string></eisbn><copyrightDate>2005</copyrightDate><doi><json:string>10.1007/11530084</json:string></doi></host><publicationDate>2005</publicationDate><copyrightDate>2005</copyrightDate><doi><json:string>10.1007/11530084_14</json:string></doi><id>4D8E253D82035336D103059D8E6B3E5CC1BA13D2</id><score>0.18560672</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/4D8E253D82035336D103059D8E6B3E5CC1BA13D2/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/4D8E253D82035336D103059D8E6B3E5CC1BA13D2/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/4D8E253D82035336D103059D8E6B3E5CC1BA13D2/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Integrating and Warehousing Liver Gene Expression Data and Related Biomedical Resources in GEDAW</title><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Springer Berlin Heidelberg</publisher><pubPlace>Berlin, Heidelberg</pubPlace><availability><p>Springer-Verlag Berlin Heidelberg, 2005</p></availability><date>2005</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Integrating and Warehousing Liver Gene Expression Data and Related Biomedical Resources in GEDAW</title><author xml:id="author-1"><persName><forename type="first">E.</forename><surname>Guérin</surname></persName><affiliation>INSERM U522 CHU Pontchaillou, 35033, Rennes, France</affiliation></author><author xml:id="author-2"><persName><forename type="first">G.</forename><surname>Marquet</surname></persName><affiliation>Faculté de Médecine, EA 3888 LIM, 35043, Rennes, France</affiliation></author><author xml:id="author-3"><persName><forename type="first">A.</forename><surname>Burgun</surname></persName><affiliation>Faculté de Médecine, EA 3888 LIM, 35043, Rennes, France</affiliation></author><author xml:id="author-4"><persName><forename type="first">O.</forename><surname>Loréal</surname></persName><affiliation>INSERM U522 CHU Pontchaillou, 35033, Rennes, France</affiliation></author><author xml:id="author-5"><persName><forename type="first">L.</forename><surname>Berti-Equille</surname></persName><affiliation>IRISA, Campus Universitaire de Beaulieu, 35042, Rennes, France</affiliation></author><author xml:id="author-6"><persName><forename type="first">U.</forename><surname>Leser</surname></persName><affiliation>Dep. for Computer Science, Humboldt-Universität, 10099, Berlin, Germany</affiliation></author><author xml:id="author-7"><persName><forename type="first">F.</forename><surname>Moussouni</surname></persName><affiliation>INSERM U522 CHU Pontchaillou, 35033, Rennes, France</affiliation></author></analytic><monogr><title level="m">Data Integration in the Life Sciences</title><title level="m" type="sub">Second International Workshop, DILS 2005, San Diego, CA, USA, July 20-22, 2005. Proceedings</title><idno type="pISBN">978-3-540-27967-9</idno><idno type="eISBN">978-3-540-31879-8</idno><idno type="pISSN">0302-9743</idno><idno type="eISSN">1611-3349</idno><idno type="DOI">10.1007/11530084</idno><idno type="book-ID">978-3-540-31879-8</idno><idno type="book-title-ID">125479</idno><idno type="book-sequence-number">3615</idno><idno type="book-volume-number">3615</idno><idno type="book-chapter-count">35</idno><editor><persName><forename type="first">Bertram</forename><surname>Ludäscher</surname></persName><email>ludaesch@ucdavis.edu</email><affiliation>Department of Computer Science, University of California, Davis,</affiliation></editor><editor><persName><forename type="first">Louiqa</forename><surname>Raschid</surname></persName><email>louiqa@umiacs.umd.edu</email><affiliation>University of Maryland, College Park, 20742, MD, USA</affiliation></editor><imprint><publisher>Springer Berlin Heidelberg</publisher><pubPlace>Berlin, Heidelberg</pubPlace><date type="published" when="2005"></date><biblScope unit="volume">3615</biblScope><biblScope unit="page" from="158">158</biblScope><biblScope unit="page" to="174">174</biblScope></imprint></monogr><series><title level="s">Lecture Notes in Computer Science</title><editor><persName><forename type="first">David</forename><surname>Hutchison</surname></persName><affiliation>Lancaster University, UK</affiliation></editor><editor><persName><forename type="first">Takeo</forename><surname>Kanade</surname></persName><affiliation>Carnegie Mellon University, Pittsburgh, PA, USA</affiliation></editor><editor><persName><forename type="first">Josef</forename><surname>Kittler</surname></persName><affiliation>University of Surrey, Guildford, UK</affiliation></editor><editor><persName><forename type="first">Jon</forename><forename type="first">M.</forename><surname>Kleinberg</surname></persName><affiliation>Cornell University, Ithaca, NY, USA</affiliation></editor><editor><persName><forename type="first">Friedemann</forename><surname>Mattern</surname></persName><affiliation>ETH Zurich, Switzerland</affiliation></editor><editor><persName><forename type="first">John</forename><forename type="first">C.</forename><surname>Mitchell</surname></persName><affiliation>Stanford University, CA, USA</affiliation></editor><editor><persName><forename type="first">Moni</forename><surname>Naor</surname></persName><affiliation>Weizmann Institute of Science, Rehovot, Israel</affiliation></editor><editor><persName><forename type="first">Oscar</forename><surname>Nierstrasz</surname></persName><affiliation>University of Bern, Switzerland</affiliation></editor><editor><persName><forename type="first">C.</forename><surname>Pandu Rangan</surname></persName><affiliation>Indian Institute of Technology, Madras, India</affiliation></editor><editor><persName><forename type="first">Bernhard</forename><surname>Steffen</surname></persName><affiliation>University of Dortmund, Germany</affiliation></editor><editor><persName><forename type="first">Madhu</forename><surname>Sudan</surname></persName><affiliation>Massachusetts Institute of Technology, MA, USA</affiliation></editor><editor><persName><forename type="first">Demetri</forename><surname>Terzopoulos</surname></persName><affiliation>New York University, NY, USA</affiliation></editor><editor><persName><forename type="first">Dough</forename><surname>Tygar</surname></persName><affiliation>University of California, Berkeley, CA, USA</affiliation></editor><editor><persName><forename type="first">Moshe</forename><forename type="first">Y.</forename><surname>Vardi</surname></persName><affiliation>Rice University, Houston, TX, USA</affiliation></editor><editor><persName><forename type="first">Gerhard</forename><surname>Weikum</surname></persName><affiliation>Max-Planck Institute of Computer Science, Saarbruecken, Germany</affiliation></editor><biblScope><date>2005</date></biblScope><idno type="pISSN">0302-9743</idno><idno type="eISSN">1611-3349</idno><idno type="series-Id">558</idno></series><series><title level="s">Lecture Notes in Bioinformatics</title><editor><persName><forename type="first">David</forename><surname>Hutchison</surname></persName><affiliation>Lancaster University, UK</affiliation></editor><editor><persName><forename type="first">Takeo</forename><surname>Kanade</surname></persName><affiliation>Carnegie Mellon University, Pittsburgh, PA, USA</affiliation></editor><editor><persName><forename type="first">Josef</forename><surname>Kittler</surname></persName><affiliation>University of Surrey, Guildford, UK</affiliation></editor><editor><persName><forename type="first">Jon</forename><forename type="first">M.</forename><surname>Kleinberg</surname></persName><affiliation>Cornell University, Ithaca, NY, USA</affiliation></editor><editor><persName><forename type="first">Friedemann</forename><surname>Mattern</surname></persName><affiliation>ETH Zurich, Switzerland</affiliation></editor><editor><persName><forename type="first">John</forename><forename type="first">C.</forename><surname>Mitchell</surname></persName><affiliation>Stanford University, CA, USA</affiliation></editor><editor><persName><forename type="first">Moni</forename><surname>Naor</surname></persName><affiliation>Weizmann Institute of Science, Rehovot, Israel</affiliation></editor><editor><persName><forename type="first">Oscar</forename><surname>Nierstrasz</surname></persName><affiliation>University of Bern, Switzerland</affiliation></editor><editor><persName><forename type="first">C.</forename><surname>Pandu Rangan</surname></persName><affiliation>Indian Institute of Technology, Madras, India</affiliation></editor><editor><persName><forename type="first">Bernhard</forename><surname>Steffen</surname></persName><affiliation>University of Dortmund, Germany</affiliation></editor><editor><persName><forename type="first">Madhu</forename><surname>Sudan</surname></persName><affiliation>Massachusetts Institute of Technology, MA, USA</affiliation></editor><editor><persName><forename type="first">Demetri</forename><surname>Terzopoulos</surname></persName><affiliation>New York University, NY, USA</affiliation></editor><editor><persName><forename type="first">Dough</forename><surname>Tygar</surname></persName><affiliation>University of California, Berkeley, CA, USA</affiliation></editor><editor><persName><forename type="first">Moshe</forename><forename type="first">Y.</forename><surname>Vardi</surname></persName><affiliation>Rice University, Houston, TX, USA</affiliation></editor><editor><persName><forename type="first">Gerhard</forename><surname>Weikum</surname></persName><affiliation>Max-Planck Institute of Computer Science, Saarbruecken, Germany</affiliation></editor><editor><persName><forename type="first">Sorin</forename><surname>Istrail</surname></persName><affiliation>Celera Genomics, Applied Biosystems, Rockville, MD, USA</affiliation></editor><editor><persName><forename type="first">Pavel</forename><surname>Pevzner</surname></persName><affiliation>University of California, San Diego, CA, USA</affiliation></editor><editor><persName><forename type="first">Michael</forename><surname>Waterman</surname></persName><affiliation>University of Southern California, Los Angeles, CA, USA</affiliation></editor><editor><persName><forename type="first">Bertram</forename><surname>Ludäscher</surname></persName><email>ludaesch@ucdavis.edu</email><affiliation>Department of Computer Science, University of California, Davis,</affiliation></editor><editor><persName><forename type="first">Louiqa</forename><surname>Raschid</surname></persName><email>louiqa@umiacs.umd.edu</email><affiliation>University of Maryland, College Park, 20742, MD, USA</affiliation></editor><idno type="pISSN">0302-9743</idno><idno type="eISSN">1611-3349</idno><biblScope unit="seriesId">5381</biblScope></series><idno type="istex">4D8E253D82035336D103059D8E6B3E5CC1BA13D2</idno><idno type="DOI">10.1007/11530084_14</idno><idno type="ChapterID">14</idno><idno type="ChapterID">Chap14</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2005</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: Researchers at the medical research institute Inserm U522, specialized in the liver, use high throughput technologies to diagnose liver disease states. They seek to identify the set of dysregulated genes in different physiopathological situations, along with the molecular regulation mechanisms involved in the occurrence of these diseases, leading at mid-term to new diagnostic and therapeutic tools. To be able to resolve such a complex question, one has to consider both data generated on the genes by in-house transcriptome experiments and annotations extracted from the many publicly available heterogeneous resources in Biomedicine. This paper presents GEDAW, a gene expression data warehouse that has been developed to assist such discovery processes. The distinctive feature of GEDAW is that it systematically integrates gene information from a multitude of structured data sources. Data sources include: i) XML records of GENBANK to annotate gene sequence features, integrated using a schema mapping approach, ii) an inhouse relational database that stores detailed experimental data on the liver genes and is a permanent source for providing expression levels to the warehouse without unnecessary details on the experiments, and iii) a semi-structured data source called BioMeKE-XML that provides for each gene its nomenclature, its functional annotation according to Gene Ontology, and its medical annotation according to the UMLS. Because GEDAW is a liver gene expression data warehouse, we have paid more attention to the medical knowledge to be able to correlate biology mechanisms and medical knowledge with experimental data. The paper discusses the data sources and the transformation process that is applied to resolve syntactic and semantic conflicts between the source format and the GEDAW schema.</p></abstract><textClass><keywords scheme="Book-Subject-Collection"><list><label>SUCO11645</label><item><term>Computer Science</term></item></list></keywords></textClass><textClass><keywords scheme="Book-Subject-Group"><list><label>I</label><label>I18032</label><label>H28009</label><label>I18024</label><label>I18040</label><label>L15001</label><label>L17004</label><item><term>Computer Science</term></item><item><term>Information Storage and Retrieval</term></item><item><term>Health Informatics</term></item><item><term>Database Management</term></item><item><term>Information Systems Applications (incl.Internet)</term></item><item><term>Bioinformatics</term></item><item><term>Computer Appl. in Life Sciences</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2005">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-11-22">References added</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2017-01-21">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/4D8E253D82035336D103059D8E6B3E5CC1BA13D2/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Springer, Publisher found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType><istex:document><Publisher><PublisherInfo><PublisherName>Springer Berlin Heidelberg</PublisherName><PublisherLocation>Berlin, Heidelberg</PublisherLocation></PublisherInfo><Series><SeriesInfo SeriesType="Series" TocLevels="0"><SeriesID>558</SeriesID><SeriesPrintISSN>0302-9743</SeriesPrintISSN><SeriesElectronicISSN>1611-3349</SeriesElectronicISSN><SeriesTitle Language="En">Lecture Notes in Computer Science</SeriesTitle></SeriesInfo><SeriesHeader><EditorGroup><Editor AffiliationIDS="Aff1"><EditorName DisplayOrder="Western"><GivenName>David</GivenName><FamilyName>Hutchison</FamilyName></EditorName></Editor><Editor AffiliationIDS="Aff2"><EditorName DisplayOrder="Western"><GivenName>Takeo</GivenName><FamilyName>Kanade</FamilyName></EditorName></Editor><Editor AffiliationIDS="Aff3"><EditorName DisplayOrder="Western"><GivenName>Josef</GivenName><FamilyName>Kittler</FamilyName></EditorName></Editor><Editor AffiliationIDS="Aff4"><EditorName DisplayOrder="Western"><GivenName>Jon</GivenName><GivenName>M.</GivenName><FamilyName>Kleinberg</FamilyName></EditorName></Editor><Editor AffiliationIDS="Aff5"><EditorName 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University</OrgName><OrgAddress><City>Pittsburgh</City><State>PA</State><Country>USA</Country></OrgAddress></Affiliation><Affiliation ID="Aff3"><OrgName>University of Surrey</OrgName><OrgAddress><City>Guildford</City><Country>UK</Country></OrgAddress></Affiliation><Affiliation ID="Aff4"><OrgName>Cornell University</OrgName><OrgAddress><City>Ithaca</City><State>NY</State><Country>USA</Country></OrgAddress></Affiliation><Affiliation ID="Aff5"><OrgName>ETH Zurich</OrgName><OrgAddress><Country>Switzerland</Country></OrgAddress></Affiliation><Affiliation ID="Aff6"><OrgName>Stanford University</OrgName><OrgAddress><City>CA</City><Country>USA</Country></OrgAddress></Affiliation><Affiliation ID="Aff7"><OrgName>Weizmann Institute of Science</OrgName><OrgAddress><City>Rehovot</City><Country>Israel</Country></OrgAddress></Affiliation><Affiliation ID="Aff8"><OrgName>University of Bern</OrgName><OrgAddress><Country>Switzerland</Country></OrgAddress></Affiliation><Affiliation ID="Aff9"><OrgName>Indian Institute of Technology</OrgName><OrgAddress><City>Madras</City><Country>India</Country></OrgAddress></Affiliation><Affiliation ID="Aff10"><OrgName>University of Dortmund</OrgName><OrgAddress><Country>Germany</Country></OrgAddress></Affiliation><Affiliation ID="Aff11"><OrgName>Massachusetts Institute of Technology</OrgName><OrgAddress><City>MA</City><Country>USA</Country></OrgAddress></Affiliation><Affiliation ID="Aff12"><OrgName>New York University</OrgName><OrgAddress><City>NY</City><Country>USA</Country></OrgAddress></Affiliation><Affiliation ID="Aff13"><OrgName>University of California</OrgName><OrgAddress><City>Berkeley</City><State>CA</State><Country>USA</Country></OrgAddress></Affiliation><Affiliation ID="Aff14"><OrgName>Rice University</OrgName><OrgAddress><City>Houston</City><State>TX</State><Country>USA</Country></OrgAddress></Affiliation><Affiliation ID="Aff15"><OrgName>Max-Planck Institute of Computer 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Type="Secondary">Bioinformatics</BookSubject><BookSubject Code="L17004" Priority="6" Type="Secondary">Computer Appl. in Life Sciences</BookSubject><SubjectCollection Code="SUCO11645">Computer Science</SubjectCollection></BookSubjectGroup><BookContext><SeriesID>558</SeriesID><SubSeriesID>5381</SubSeriesID></BookContext></BookInfo><BookHeader><EditorGroup><Editor AffiliationIDS="Aff19"><EditorName DisplayOrder="Western"><GivenName>Bertram</GivenName><FamilyName>Ludäscher</FamilyName></EditorName><Contact><Email>ludaesch@ucdavis.edu</Email></Contact></Editor><Editor AffiliationIDS="Aff20"><EditorName DisplayOrder="Western"><GivenName>Louiqa</GivenName><FamilyName>Raschid</FamilyName></EditorName><Contact><Email>louiqa@umiacs.umd.edu</Email></Contact></Editor><Affiliation ID="Aff19"><OrgDivision>Department of Computer Science</OrgDivision><OrgName>University of California, Davis</OrgName><OrgAddress><Country> </Country></OrgAddress></Affiliation><Affiliation ID="Aff20"><OrgName>University of Maryland</OrgName><OrgAddress><Street>College Park</Street><Postcode>20742</Postcode><State>MD</State><Country>USA</Country></OrgAddress></Affiliation></EditorGroup></BookHeader><Part ID="Part4"><PartInfo TocLevels="0"><PartID>4</PartID><PartSequenceNumber>4</PartSequenceNumber><PartTitle>Data Integration I–IV</PartTitle><PartChapterCount>10</PartChapterCount><PartContext><SeriesID>558</SeriesID><BookTitle>Data Integration in the Life Sciences</BookTitle></PartContext></PartInfo><Chapter ID="Chap14" Language="En"><ChapterInfo ChapterType="OriginalPaper" ContainsESM="No" NumberingDepth="2" NumberingStyle="ContentOnly" TocLevels="0"><ChapterID>14</ChapterID><ChapterDOI>10.1007/11530084_14</ChapterDOI><ChapterSequenceNumber>14</ChapterSequenceNumber><ChapterTitle Language="En">Integrating and Warehousing Liver Gene Expression Data and Related Biomedical Resources in GEDAW</ChapterTitle><ChapterFirstPage>158</ChapterFirstPage><ChapterLastPage>174</ChapterLastPage><ChapterCopyright><CopyrightHolderName>Springer-Verlag Berlin Heidelberg</CopyrightHolderName><CopyrightYear>2005</CopyrightYear></ChapterCopyright><ChapterGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ChapterGrants><ChapterContext><SeriesID>558</SeriesID><PartID>4</PartID><BookID>978-3-540-31879-8</BookID><BookTitle>Data Integration in the Life Sciences</BookTitle></ChapterContext></ChapterInfo><ChapterHeader><AuthorGroup><Author AffiliationIDS="Aff21"><AuthorName DisplayOrder="Western"><GivenName>E.</GivenName><FamilyName>Guérin</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff22"><AuthorName DisplayOrder="Western"><GivenName>G.</GivenName><FamilyName>Marquet</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff22"><AuthorName DisplayOrder="Western"><GivenName>A.</GivenName><FamilyName>Burgun</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff21"><AuthorName DisplayOrder="Western"><GivenName>O.</GivenName><FamilyName>Loréal</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff23"><AuthorName DisplayOrder="Western"><GivenName>L.</GivenName><FamilyName>Berti-Equille</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff24"><AuthorName DisplayOrder="Western"><GivenName>U.</GivenName><FamilyName>Leser</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff21"><AuthorName DisplayOrder="Western"><GivenName>F.</GivenName><FamilyName>Moussouni</FamilyName></AuthorName></Author><Affiliation ID="Aff21"><OrgName>INSERM U522 CHU Pontchaillou</OrgName><OrgAddress><Postcode>35033</Postcode><City>Rennes</City><Country>France</Country></OrgAddress></Affiliation><Affiliation ID="Aff22"><OrgDivision>Faculté de Médecine</OrgDivision><OrgName>EA 3888 LIM</OrgName><OrgAddress><Postcode>35043</Postcode><City>Rennes</City><Country>France</Country></OrgAddress></Affiliation><Affiliation ID="Aff23"><OrgName>IRISA</OrgName><OrgAddress><Street>Campus Universitaire de Beaulieu</Street><Postcode>35042</Postcode><City>Rennes</City><Country>France</Country></OrgAddress></Affiliation><Affiliation ID="Aff24"><OrgDivision>Dep. for Computer Science</OrgDivision><OrgName>Humboldt-Universität</OrgName><OrgAddress><Postcode>10099</Postcode><City>Berlin</City><Country>Germany</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><Para>Researchers at the medical research institute Inserm U522, specialized in the liver, use high throughput technologies to diagnose liver disease states. They seek to identify the set of dysregulated genes in different physiopathological situations, along with the molecular regulation mechanisms involved in the occurrence of these diseases, leading at mid-term to new diagnostic and therapeutic tools. To be able to resolve such a complex question, one has to consider both data generated on the genes by in-house transcriptome experiments and annotations extracted from the many publicly available heterogeneous resources in Biomedicine. This paper presents GEDAW, a gene expression data warehouse that has been developed to assist such discovery processes. The distinctive feature of GEDAW is that it systematically integrates gene information from a multitude of structured data sources. Data sources include: i) XML records of GENBANK to annotate gene sequence features, integrated using a schema mapping approach, ii) an inhouse relational database that stores detailed experimental data on the liver genes and is a permanent source for providing expression levels to the warehouse without unnecessary details on the experiments, and iii) a semi-structured data source called BioMeKE-XML that provides for each gene its nomenclature, its functional annotation according to Gene Ontology, and its medical annotation according to the UMLS. Because GEDAW is a liver gene expression data warehouse, we have paid more attention to the medical knowledge to be able to correlate biology mechanisms and medical knowledge with experimental data. The paper discusses the data sources and the transformation process that is applied to resolve syntactic and semantic conflicts between the source format and the GEDAW schema.</Para></Abstract></ChapterHeader><NoBody></NoBody></Chapter></Part></Book></Series></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Integrating and Warehousing Liver Gene Expression Data and Related Biomedical Resources in GEDAW</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Integrating and Warehousing Liver Gene Expression Data and Related Biomedical Resources in GEDAW</title></titleInfo><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Guérin</namePart><affiliation>INSERM U522 CHU Pontchaillou, 35033, Rennes, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Marquet</namePart><affiliation>Faculté de Médecine, EA 3888 LIM, 35043, Rennes, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Burgun</namePart><affiliation>Faculté de Médecine, EA 3888 LIM, 35043, Rennes, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O.</namePart><namePart type="family">Loréal</namePart><affiliation>INSERM U522 CHU Pontchaillou, 35033, Rennes, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">L.</namePart><namePart type="family">Berti-Equille</namePart><affiliation>IRISA, Campus Universitaire de Beaulieu, 35042, Rennes, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U.</namePart><namePart type="family">Leser</namePart><affiliation>Dep. for Computer Science, Humboldt-Universität, 10099, Berlin, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Moussouni</namePart><affiliation>INSERM U522 CHU Pontchaillou, 35033, Rennes, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="conference" displayLabel="OriginalPaper"></genre><originInfo><publisher>Springer Berlin Heidelberg</publisher><place><placeTerm type="text">Berlin, Heidelberg</placeTerm></place><dateIssued encoding="w3cdtf">2005</dateIssued><copyrightDate encoding="w3cdtf">2005</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Abstract: Researchers at the medical research institute Inserm U522, specialized in the liver, use high throughput technologies to diagnose liver disease states. They seek to identify the set of dysregulated genes in different physiopathological situations, along with the molecular regulation mechanisms involved in the occurrence of these diseases, leading at mid-term to new diagnostic and therapeutic tools. To be able to resolve such a complex question, one has to consider both data generated on the genes by in-house transcriptome experiments and annotations extracted from the many publicly available heterogeneous resources in Biomedicine. This paper presents GEDAW, a gene expression data warehouse that has been developed to assist such discovery processes. The distinctive feature of GEDAW is that it systematically integrates gene information from a multitude of structured data sources. Data sources include: i) XML records of GENBANK to annotate gene sequence features, integrated using a schema mapping approach, ii) an inhouse relational database that stores detailed experimental data on the liver genes and is a permanent source for providing expression levels to the warehouse without unnecessary details on the experiments, and iii) a semi-structured data source called BioMeKE-XML that provides for each gene its nomenclature, its functional annotation according to Gene Ontology, and its medical annotation according to the UMLS. Because GEDAW is a liver gene expression data warehouse, we have paid more attention to the medical knowledge to be able to correlate biology mechanisms and medical knowledge with experimental data. The paper discusses the data sources and the transformation process that is applied to resolve syntactic and semantic conflicts between the source format and the GEDAW schema.</abstract><relatedItem type="host"><titleInfo><title>Data Integration in the Life Sciences</title><subTitle>Second International Workshop, DILS 2005, San Diego, CA, USA, July 20-22, 2005. Proceedings</subTitle></titleInfo><name type="personal"><namePart type="given">Bertram</namePart><namePart type="family">Ludäscher</namePart><affiliation>Department of Computer Science, University of California, Davis</affiliation><affiliation>E-mail: ludaesch@ucdavis.edu</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Louiqa</namePart><namePart type="family">Raschid</namePart><affiliation>University of Maryland, College Park, 20742, MD, USA</affiliation><affiliation>E-mail: louiqa@umiacs.umd.edu</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><genre type="book-series" displayLabel="Proceedings"></genre><originInfo><copyrightDate encoding="w3cdtf">2005</copyrightDate><issuance>monographic</issuance></originInfo><subject><genre>Book-Subject-Collection</genre><topic authority="SpringerSubjectCodes" authorityURI="SUCO11645">Computer Science</topic></subject><subject><genre>Book-Subject-Group</genre><topic authority="SpringerSubjectCodes" authorityURI="I">Computer Science</topic><topic authority="SpringerSubjectCodes" authorityURI="I18032">Information Storage and Retrieval</topic><topic authority="SpringerSubjectCodes" authorityURI="H28009">Health Informatics</topic><topic authority="SpringerSubjectCodes" authorityURI="I18024">Database Management</topic><topic authority="SpringerSubjectCodes" authorityURI="I18040">Information Systems Applications (incl.Internet)</topic><topic authority="SpringerSubjectCodes" authorityURI="L15001">Bioinformatics</topic><topic authority="SpringerSubjectCodes" authorityURI="L17004">Computer Appl. in Life Sciences</topic></subject><identifier type="DOI">10.1007/11530084</identifier><identifier type="ISBN">978-3-540-27967-9</identifier><identifier type="eISBN">978-3-540-31879-8</identifier><identifier type="ISSN">0302-9743</identifier><identifier type="eISSN">1611-3349</identifier><identifier type="BookTitleID">125479</identifier><identifier type="BookID">978-3-540-31879-8</identifier><identifier type="BookChapterCount">35</identifier><identifier type="BookVolumeNumber">3615</identifier><identifier type="BookSequenceNumber">3615</identifier><identifier type="PartChapterCount">10</identifier><part><date>2005</date><detail type="part"><title>Data Integration I–IV</title></detail><detail type="volume"><number>3615</number><caption>vol.</caption></detail><extent unit="pages"><start>158</start><end>174</end></extent></part><recordInfo><recordOrigin>Springer-Verlag Berlin Heidelberg, 2005</recordOrigin></recordInfo></relatedItem><relatedItem type="series"><titleInfo><title>Lecture Notes in Computer Science</title></titleInfo><name type="personal"><namePart type="given">David</namePart><namePart type="family">Hutchison</namePart><affiliation>Lancaster University, UK</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Takeo</namePart><namePart type="family">Kanade</namePart><affiliation>Carnegie Mellon University, Pittsburgh, PA, USA</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Josef</namePart><namePart type="family">Kittler</namePart><affiliation>University of Surrey, Guildford, UK</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Jon</namePart><namePart type="given">M.</namePart><namePart type="family">Kleinberg</namePart><affiliation>Cornell University, Ithaca, NY, USA</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Friedemann</namePart><namePart type="family">Mattern</namePart><affiliation>ETH Zurich, Switzerland</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">John</namePart><namePart type="given">C.</namePart><namePart type="family">Mitchell</namePart><affiliation>Stanford University, CA, USA</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Moni</namePart><namePart type="family">Naor</namePart><affiliation>Weizmann Institute of Science, Rehovot, Israel</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Oscar</namePart><namePart type="family">Nierstrasz</namePart><affiliation>University of Bern, Switzerland</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Pandu Rangan</namePart><affiliation>Indian Institute of Technology, Madras, India</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Bernhard</namePart><namePart type="family">Steffen</namePart><affiliation>University of Dortmund, Germany</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Madhu</namePart><namePart type="family">Sudan</namePart><affiliation>Massachusetts Institute of Technology, MA, USA</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Demetri</namePart><namePart type="family">Terzopoulos</namePart><affiliation>New York University, NY, USA</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Dough</namePart><namePart type="family">Tygar</namePart><affiliation>University of California, Berkeley, CA, USA</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Moshe</namePart><namePart type="given">Y.</namePart><namePart type="family">Vardi</namePart><affiliation>Rice University, Houston, TX, USA</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Gerhard</namePart><namePart type="family">Weikum</namePart><affiliation>Max-Planck Institute of Computer Science, Saarbruecken, Germany</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><originInfo><copyrightDate encoding="w3cdtf">2005</copyrightDate><issuance>serial</issuance></originInfo><relatedItem type="constituent"><titleInfo><title>Lecture Notes in Bioinformatics</title></titleInfo><name type="personal"><namePart type="given">David</namePart><namePart type="family">Hutchison</namePart><affiliation>Lancaster University, UK</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Takeo</namePart><namePart type="family">Kanade</namePart><affiliation>Carnegie Mellon University, Pittsburgh, PA, USA</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Josef</namePart><namePart type="family">Kittler</namePart><affiliation>University of Surrey, Guildford, UK</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Jon</namePart><namePart type="given">M.</namePart><namePart type="family">Kleinberg</namePart><affiliation>Cornell University, Ithaca, NY, USA</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Friedemann</namePart><namePart type="family">Mattern</namePart><affiliation>ETH Zurich, Switzerland</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">John</namePart><namePart type="given">C.</namePart><namePart type="family">Mitchell</namePart><affiliation>Stanford University, CA, USA</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Moni</namePart><namePart type="family">Naor</namePart><affiliation>Weizmann Institute of Science, Rehovot, Israel</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Oscar</namePart><namePart type="family">Nierstrasz</namePart><affiliation>University of Bern, Switzerland</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Pandu Rangan</namePart><affiliation>Indian Institute of Technology, Madras, India</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Bernhard</namePart><namePart type="family">Steffen</namePart><affiliation>University of Dortmund, Germany</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Madhu</namePart><namePart type="family">Sudan</namePart><affiliation>Massachusetts Institute of Technology, MA, USA</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Demetri</namePart><namePart type="family">Terzopoulos</namePart><affiliation>New York University, NY, USA</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Dough</namePart><namePart type="family">Tygar</namePart><affiliation>University of California, Berkeley, CA, USA</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Moshe</namePart><namePart type="given">Y.</namePart><namePart type="family">Vardi</namePart><affiliation>Rice University, Houston, TX, USA</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Gerhard</namePart><namePart 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type="family">Ludäscher</namePart><affiliation>Department of Computer Science, University of California, Davis</affiliation><affiliation>E-mail: ludaesch@ucdavis.edu</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><name type="personal"><namePart type="given">Louiqa</namePart><namePart type="family">Raschid</namePart><affiliation>University of Maryland, College Park, 20742, MD, USA</affiliation><affiliation>E-mail: louiqa@umiacs.umd.edu</affiliation><role><roleTerm type="text">editor</roleTerm></role></name><genre type="sub-series"></genre><identifier type="ISSN">0302-9743</identifier><identifier type="eISSN">1611-3349</identifier><identifier type="SubSeriesID">5381</identifier></relatedItem><identifier type="ISSN">0302-9743</identifier><identifier type="eISSN">1611-3349</identifier><identifier type="SeriesID">558</identifier><recordInfo><recordOrigin>Springer-Verlag Berlin Heidelberg, 2005</recordOrigin></recordInfo></relatedItem><identifier type="istex">4D8E253D82035336D103059D8E6B3E5CC1BA13D2</identifier><identifier type="DOI">10.1007/11530084_14</identifier><identifier type="ChapterID">14</identifier><identifier type="ChapterID">Chap14</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag Berlin Heidelberg, 2005</accessCondition><recordInfo><recordContentSource>SPRINGER</recordContentSource><recordOrigin>Springer-Verlag Berlin Heidelberg, 2005</recordOrigin></recordInfo></mods></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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