Integrating and Warehousing Liver Gene Expression Data and Related Biomedical Resources in GEDAW
Identifieur interne : 001F14 ( Istex/Corpus ); précédent : 001F13; suivant : 001F15Integrating and Warehousing Liver Gene Expression Data and Related Biomedical Resources in GEDAW
Auteurs : E. Guérin ; G. Marquet ; A. Burgun ; O. Loréal ; L. Berti-Equille ; U. Leser ; F. MoussouniSource :
- Lecture Notes in Computer Science [ 0302-9743 ] ; 2005.
Abstract
Abstract: Researchers at the medical research institute Inserm U522, specialized in the liver, use high throughput technologies to diagnose liver disease states. They seek to identify the set of dysregulated genes in different physiopathological situations, along with the molecular regulation mechanisms involved in the occurrence of these diseases, leading at mid-term to new diagnostic and therapeutic tools. To be able to resolve such a complex question, one has to consider both data generated on the genes by in-house transcriptome experiments and annotations extracted from the many publicly available heterogeneous resources in Biomedicine. This paper presents GEDAW, a gene expression data warehouse that has been developed to assist such discovery processes. The distinctive feature of GEDAW is that it systematically integrates gene information from a multitude of structured data sources. Data sources include: i) XML records of GENBANK to annotate gene sequence features, integrated using a schema mapping approach, ii) an inhouse relational database that stores detailed experimental data on the liver genes and is a permanent source for providing expression levels to the warehouse without unnecessary details on the experiments, and iii) a semi-structured data source called BioMeKE-XML that provides for each gene its nomenclature, its functional annotation according to Gene Ontology, and its medical annotation according to the UMLS. Because GEDAW is a liver gene expression data warehouse, we have paid more attention to the medical knowledge to be able to correlate biology mechanisms and medical knowledge with experimental data. The paper discusses the data sources and the transformation process that is applied to resolve syntactic and semantic conflicts between the source format and the GEDAW schema.
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DOI: 10.1007/11530084_14
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<front><div type="abstract" xml:lang="en">Abstract: Researchers at the medical research institute Inserm U522, specialized in the liver, use high throughput technologies to diagnose liver disease states. They seek to identify the set of dysregulated genes in different physiopathological situations, along with the molecular regulation mechanisms involved in the occurrence of these diseases, leading at mid-term to new diagnostic and therapeutic tools. To be able to resolve such a complex question, one has to consider both data generated on the genes by in-house transcriptome experiments and annotations extracted from the many publicly available heterogeneous resources in Biomedicine. This paper presents GEDAW, a gene expression data warehouse that has been developed to assist such discovery processes. The distinctive feature of GEDAW is that it systematically integrates gene information from a multitude of structured data sources. Data sources include: i) XML records of GENBANK to annotate gene sequence features, integrated using a schema mapping approach, ii) an inhouse relational database that stores detailed experimental data on the liver genes and is a permanent source for providing expression levels to the warehouse without unnecessary details on the experiments, and iii) a semi-structured data source called BioMeKE-XML that provides for each gene its nomenclature, its functional annotation according to Gene Ontology, and its medical annotation according to the UMLS. Because GEDAW is a liver gene expression data warehouse, we have paid more attention to the medical knowledge to be able to correlate biology mechanisms and medical knowledge with experimental data. The paper discusses the data sources and the transformation process that is applied to resolve syntactic and semantic conflicts between the source format and the GEDAW schema.</div>
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</json:item>
<json:item><name>G Vaysseix</name>
</json:item>
<json:item><name>E Barillot</name>
</json:item>
</author>
<host><volume>17</volume>
<pages><last>125</last>
<first>115</first>
</pages>
<issue>2</issue>
<author></author>
<title>Bioinformatics</title>
<publicationDate>2001</publicationDate>
</host>
<title>XML, bioinformatics and data integration</title>
<publicationDate>2001</publicationDate>
</json:item>
<json:item><host><author><json:item><name>V Babenko</name>
</json:item>
<json:item><name>B Brunk</name>
</json:item>
<json:item><name>J Crabtree</name>
</json:item>
<json:item><name>S Diskin</name>
</json:item>
<json:item><name>S Fischer</name>
</json:item>
<json:item><name>G Grant</name>
</json:item>
<json:item><name>Y Kondrahkin</name>
</json:item>
<json:item><name>L Li</name>
</json:item>
<json:item><name>J Liu</name>
</json:item>
<json:item><name>J Mazzarelli</name>
</json:item>
<json:item><name>D Pinney</name>
</json:item>
<json:item><name>A Pizarro</name>
</json:item>
<json:item><name>E Manduchi</name>
</json:item>
<json:item><name>S Mcweeney</name>
</json:item>
<json:item><name>J Schug</name>
</json:item>
<json:item><name>C Stoeckert</name>
</json:item>
</author>
<title>GUS The Genomics Unified Schema A Platform for Genomics Databases</title>
<publicationDate>2003</publicationDate>
</host>
</json:item>
<json:item><author><json:item><name>O Bodenreider</name>
</json:item>
</author>
<host><volume>32</volume>
<pages><last>70</last>
<first>267</first>
</pages>
<author></author>
<title>Nucleic Acids Res</title>
<publicationDate>2004-01-01</publicationDate>
</host>
<title>The Unified Medical Language System (UMLS): integrating biomedical terminology</title>
<publicationDate>2004-01-01</publicationDate>
</json:item>
<json:item><author><json:item><name>O Bodenreider</name>
</json:item>
<json:item><name>A Burgun</name>
</json:item>
</author>
<host><pages><last>31</last>
<first>327</first>
</pages>
<author></author>
<title>Medinfo</title>
<publicationDate>2004</publicationDate>
</host>
<title>Aligning Knowledge Sources in the UMLS: Methods, Quantitative Results, and Applications</title>
<publicationDate>2004</publicationDate>
</json:item>
<json:item><author><json:item><name>O Bodenreider</name>
</json:item>
<json:item><name>Ja Mitchell</name>
</json:item>
<json:item><name>At Mccray</name>
</json:item>
</author>
<host><pages><last>5</last>
<first>61</first>
</pages>
<author></author>
<title>Proc AMIA Symp</title>
<publicationDate>2002</publicationDate>
</host>
<title>Evaluation of the UMLS as a terminology and knowledge resource for biomedical informatics</title>
<publicationDate>2002</publicationDate>
</json:item>
<json:item><author><json:item><name>A Brazma</name>
</json:item>
<json:item><name>P Hingamp</name>
</json:item>
<json:item><name>J Quackenbush</name>
</json:item>
<json:item><name>G Sherlock</name>
</json:item>
<json:item><name>P Spellman</name>
</json:item>
<json:item><name>C Stoeckert</name>
</json:item>
<json:item><name>J Aach</name>
</json:item>
<json:item><name>W Ansorge</name>
</json:item>
<json:item><name>Ca Ball</name>
</json:item>
<json:item><name>Hc Causton</name>
</json:item>
<json:item><name>T Gaasterland</name>
</json:item>
<json:item><name>P Glenisson</name>
</json:item>
<json:item><name>Fc Holstege</name>
</json:item>
<json:item><name>If Kim</name>
</json:item>
<json:item><name>V Markowitz</name>
</json:item>
<json:item><name>Jc Matese</name>
</json:item>
<json:item><name>H Parkinson</name>
</json:item>
<json:item><name>A Robinson</name>
</json:item>
<json:item><name>U Sarkans</name>
</json:item>
<json:item><name>S Schulze-Kremer</name>
</json:item>
<json:item><name>J Stewart</name>
</json:item>
<json:item><name>R Taylor</name>
</json:item>
<json:item><name>J Vilo</name>
</json:item>
<json:item><name>M Vingron</name>
</json:item>
</author>
<host><volume>29</volume>
<pages><last>71</last>
<first>365</first>
</pages>
<issue>4</issue>
<author></author>
<title>Nat Genet</title>
<publicationDate>2001-12</publicationDate>
</host>
<title>Minimum information about a microarray experiment (MIAME)-toward standards for microarray data</title>
<publicationDate>2001-12</publicationDate>
</json:item>
<json:item><author><json:item><name>Benson,D A Karsch-Mizrachi</name>
</json:item>
<json:item><name>I </name>
</json:item>
<json:item><name>Lipman,D J Ostell</name>
</json:item>
<json:item><name>J </name>
</json:item>
<json:item><name>Wheeler,D L Genbank</name>
</json:item>
</author>
<host><volume>32</volume>
<pages><last>26</last>
<first>23</first>
</pages>
<author></author>
<title>Nucleic Acids Res</title>
<publicationDate>2004-01</publicationDate>
</host>
<publicationDate>2004-01</publicationDate>
</json:item>
<json:item><author><json:item><name>A Burgun</name>
</json:item>
<json:item><name>O Bodenreider</name>
</json:item>
<json:item><name>Le Duff</name>
</json:item>
<json:item><name>F Moussouni</name>
</json:item>
<json:item><name>F Loréal</name>
</json:item>
<json:item><name>O </name>
</json:item>
</author>
<host><pages><last>90</last>
<first>86</first>
</pages>
<author></author>
<title>Proc. AMIA 2002 Symp</title>
</host>
<title>Representation of roles in biomedical ontologies : a case study in functional genomics</title>
</json:item>
<json:item><author><json:item><name>M Cornell</name>
</json:item>
<json:item><name>Nw Paton</name>
</json:item>
<json:item><name>S Wu</name>
</json:item>
<json:item><name>Ca Goble</name>
</json:item>
<json:item><name>Cj Miller</name>
</json:item>
<json:item><name>P Kirby</name>
</json:item>
<json:item><name>K Eilbeck</name>
</json:item>
<json:item><name>A Brass</name>
</json:item>
<json:item><name>A Hayes</name>
</json:item>
<json:item><name>Sg Oliver</name>
</json:item>
</author>
<host><pages><last>22</last>
<first>15</first>
</pages>
<author></author>
<title>Proc. 2nd IEEE International Symposium on Bioinformatics and Bioengineering (BIBE)</title>
<publicationDate>2001</publicationDate>
</host>
<title>GIMS -a data warehouse for storage and analysis of genome sequence and functional data</title>
<publicationDate>2001</publicationDate>
</json:item>
<json:item><host><author><json:item><name>H.-H Do</name>
</json:item>
<json:item><name>E Rahm</name>
</json:item>
</author>
<title>Flexible Integration of Molecular-biological Annotation Data: The GenMapper Approach</title>
<publicationDate>2004</publicationDate>
</host>
</json:item>
<json:item><author><json:item><name>K Fellenberg</name>
</json:item>
<json:item><name>N,C Hauser</name>
</json:item>
<json:item><name>B Brors</name>
</json:item>
<json:item><name>Hoheisel,J D Vingron</name>
</json:item>
<json:item><name>M </name>
</json:item>
</author>
<host><volume>18</volume>
<pages><last>433</last>
<first>423</first>
</pages>
<author></author>
<title>Bioinformatics</title>
<publicationDate>2002-03</publicationDate>
</host>
<title>Microarray data warehouse allowing for inclusion of experiment annotations in statistical analysis</title>
<publicationDate>2002-03</publicationDate>
</json:item>
<json:item><author><json:item><name>E Guerin</name>
</json:item>
<json:item><name>G Marquet</name>
</json:item>
<json:item><name>F Moussouni</name>
</json:item>
<json:item><name>A Burgun</name>
</json:item>
<json:item><name>F Mougin</name>
</json:item>
<json:item><name>O Loréal</name>
</json:item>
</author>
<host><pages><last>60</last>
<first>59</first>
</pages>
<author></author>
<title>Proc. ECCB 2003</title>
</host>
<title>Deployment of heterogeneous ressources of genomic, biological and medical knowledge on the liver to build a datawarehouse</title>
</json:item>
<json:item><author><json:item><name>Ma Harris</name>
</json:item>
</author>
<host><volume>32</volume>
<pages><last>61</last>
<first>258</first>
</pages>
<author></author>
<title>Nucleic Acids Res</title>
<publicationDate>2004-01-01</publicationDate>
</host>
<title>Gene Ontology Consortium The Gene Ontology (GO) database and informatics resource</title>
<publicationDate>2004-01-01</publicationDate>
</json:item>
<json:item><author><json:item><name>V Kashyap</name>
</json:item>
<json:item><name>A Sheth</name>
</json:item>
</author>
<host><volume>5</volume>
<pages><last>304</last>
<first>276</first>
</pages>
<issue>4</issue>
<author></author>
<title>Int. J. Very Large Data Bases</title>
<publicationDate>1996</publicationDate>
</host>
<title>Schematic and semantic similarities between database objects: a context –based approach</title>
<publicationDate>1996</publicationDate>
</json:item>
<json:item><author><json:item><name>L Lakshmanan</name>
</json:item>
<json:item><name>F Sadri</name>
</json:item>
<json:item><name>I Subramanian</name>
</json:item>
</author>
<host><pages><last>100</last>
<first>81</first>
</pages>
<author></author>
<title>DOOD International Conference</title>
<publicationDate>1993</publicationDate>
</host>
<title>On the logical Foundation of Schema Integration and Evolution in Heterogeneous Database Systems</title>
<publicationDate>1993</publicationDate>
</json:item>
<json:item><author><json:item><name>Maurizio Lenzerini</name>
</json:item>
</author>
<host><author></author>
<title>Proc. of PODS</title>
<publicationDate>2002</publicationDate>
</host>
<title>Data integration: a theoretical perspective</title>
<publicationDate>2002</publicationDate>
</json:item>
<json:item><author><json:item><name>G Marquet</name>
</json:item>
<json:item><name>A Burgun</name>
</json:item>
<json:item><name>F Moussouni</name>
</json:item>
<json:item><name>E Guerin</name>
</json:item>
<json:item><name>Le Duff</name>
</json:item>
<json:item><name>F Loreal</name>
</json:item>
<json:item><name>O </name>
</json:item>
</author>
<host><volume>95</volume>
<pages><last>5</last>
<first>80</first>
</pages>
<author></author>
<title>Stud Health Technol Inform</title>
<publicationDate>2003</publicationDate>
</host>
<title>BioMeKE: an ontology-based biomedical knowledge extraction system devoted to transcriptome analysis</title>
<publicationDate>2003</publicationDate>
</json:item>
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</pages>
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</pages>
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<json:item><name>E Simon</name>
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<affiliation>University of Bern, Switzerland</affiliation>
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<editor><persName><forename type="first">C.</forename>
<surname>Pandu Rangan</surname>
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<affiliation>Indian Institute of Technology, Madras, India</affiliation>
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<editor><persName><forename type="first">Bernhard</forename>
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<editor><persName><forename type="first">Dough</forename>
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<editor><persName><forename type="first">Moshe</forename>
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<editor><persName><forename type="first">Louiqa</forename>
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<abstract xml:lang="en"><p>Abstract: Researchers at the medical research institute Inserm U522, specialized in the liver, use high throughput technologies to diagnose liver disease states. They seek to identify the set of dysregulated genes in different physiopathological situations, along with the molecular regulation mechanisms involved in the occurrence of these diseases, leading at mid-term to new diagnostic and therapeutic tools. To be able to resolve such a complex question, one has to consider both data generated on the genes by in-house transcriptome experiments and annotations extracted from the many publicly available heterogeneous resources in Biomedicine. This paper presents GEDAW, a gene expression data warehouse that has been developed to assist such discovery processes. The distinctive feature of GEDAW is that it systematically integrates gene information from a multitude of structured data sources. Data sources include: i) XML records of GENBANK to annotate gene sequence features, integrated using a schema mapping approach, ii) an inhouse relational database that stores detailed experimental data on the liver genes and is a permanent source for providing expression levels to the warehouse without unnecessary details on the experiments, and iii) a semi-structured data source called BioMeKE-XML that provides for each gene its nomenclature, its functional annotation according to Gene Ontology, and its medical annotation according to the UMLS. Because GEDAW is a liver gene expression data warehouse, we have paid more attention to the medical knowledge to be able to correlate biology mechanisms and medical knowledge with experimental data. The paper discusses the data sources and the transformation process that is applied to resolve syntactic and semantic conflicts between the source format and the GEDAW schema.</p>
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<ChapterTitle Language="En">Integrating and Warehousing Liver Gene Expression Data and Related Biomedical Resources in GEDAW</ChapterTitle>
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<Para>Researchers at the medical research institute Inserm U522, specialized in the liver, use high throughput technologies to diagnose liver disease states. They seek to identify the set of dysregulated genes in different physiopathological situations, along with the molecular regulation mechanisms involved in the occurrence of these diseases, leading at mid-term to new diagnostic and therapeutic tools. To be able to resolve such a complex question, one has to consider both data generated on the genes by in-house transcriptome experiments and annotations extracted from the many publicly available heterogeneous resources in Biomedicine. This paper presents GEDAW, a gene expression data warehouse that has been developed to assist such discovery processes. The distinctive feature of GEDAW is that it systematically integrates gene information from a multitude of structured data sources. Data sources include: i) XML records of GENBANK to annotate gene sequence features, integrated using a schema mapping approach, ii) an inhouse relational database that stores detailed experimental data on the liver genes and is a permanent source for providing expression levels to the warehouse without unnecessary details on the experiments, and iii) a semi-structured data source called BioMeKE-XML that provides for each gene its nomenclature, its functional annotation according to Gene Ontology, and its medical annotation according to the UMLS. Because GEDAW is a liver gene expression data warehouse, we have paid more attention to the medical knowledge to be able to correlate biology mechanisms and medical knowledge with experimental data. The paper discusses the data sources and the transformation process that is applied to resolve syntactic and semantic conflicts between the source format and the GEDAW schema.</Para>
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<abstract lang="en">Abstract: Researchers at the medical research institute Inserm U522, specialized in the liver, use high throughput technologies to diagnose liver disease states. They seek to identify the set of dysregulated genes in different physiopathological situations, along with the molecular regulation mechanisms involved in the occurrence of these diseases, leading at mid-term to new diagnostic and therapeutic tools. To be able to resolve such a complex question, one has to consider both data generated on the genes by in-house transcriptome experiments and annotations extracted from the many publicly available heterogeneous resources in Biomedicine. This paper presents GEDAW, a gene expression data warehouse that has been developed to assist such discovery processes. The distinctive feature of GEDAW is that it systematically integrates gene information from a multitude of structured data sources. Data sources include: i) XML records of GENBANK to annotate gene sequence features, integrated using a schema mapping approach, ii) an inhouse relational database that stores detailed experimental data on the liver genes and is a permanent source for providing expression levels to the warehouse without unnecessary details on the experiments, and iii) a semi-structured data source called BioMeKE-XML that provides for each gene its nomenclature, its functional annotation according to Gene Ontology, and its medical annotation according to the UMLS. Because GEDAW is a liver gene expression data warehouse, we have paid more attention to the medical knowledge to be able to correlate biology mechanisms and medical knowledge with experimental data. The paper discusses the data sources and the transformation process that is applied to resolve syntactic and semantic conflicts between the source format and the GEDAW schema.</abstract>
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