Electrophysiological study of the excitatory parafascicular projection to the subthalamic nucleus and evidence for ipsi- and contralateral controls
Identifieur interne : 001F13 ( Istex/Corpus ); précédent : 001F12; suivant : 001F14Electrophysiological study of the excitatory parafascicular projection to the subthalamic nucleus and evidence for ipsi- and contralateral controls
Auteurs : M. Mouroux ; O.-K. Hassani ; J. FégerSource :
- Neuroscience [ 0306-4522 ] ; 1995.
Abstract
Abstract: The activity of subthalamic neurons was recorded extracellularly in anaesthetized rats after stimulation, inhibition or lesioning of the parafascicular nucleus. Electrical stimulation of the parafascicular nucleus evoked a complex response with two excitatory phases. The first response was correlated with a monosynaptically-driven excitation via a parafascicular input to the subthalamic nucleus. Since the second phase was observed even when the early excitation was not recorded and was eliminated by lesion of the globus pallidus, we suggest that it is not generated by a mechanism intrinsic to the subthalamic nucleus and is due to a disinhibitory effect originating from the globus pallidus. Microinjection of carbachol into the parafascicular nucleus enhanced by 119% the discharge rate of the neurons in the ipsilateral subthalamic nucleus and that of muscimol decreased the discharge rate by 91%. Opposite changes, a decrease of the discharge rate of 49% after microinjection of carbachol and an increase of 47% after muscimol, occurred in the contralateral subthalamic nucleus. In contrast to the above results, the unilateral excitotoxic lesion of the parafascicular nucleus, performed one week before recording, decreased the discharge rate by 69% of the ipsilateral subthalamic nucleus neurons and by 34% that of the contralateral neurons.We suggest that the parafascicular input to the subthalamic nucleus is an excitatory pathway which can tonically drive the neuronal activity in this structure. The opposite changes recorded in the ipsi- and contralateral subthalamic nucleus during unilateral microinjection of excitatory or inhibitory drugs in the parafascicular nucleus emphasize the importance of this thalamic structure in the bilateral regulation of basal ganglia activity via the subthalamic nucleus.
Url:
DOI: 10.1016/0306-4522(95)00032-E
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Mouroux</name><affiliation><mods:affiliation>Laboratoire de Pharmacologie, Facultédes Sciences Pharmaceutiques et Biologiques, UniversitéR. Descartes, 4 avenue de l'Observatoire, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Hassani, O K" sort="Hassani, O K" uniqKey="Hassani O" first="O.-K." last="Hassani">O.-K. Hassani</name><affiliation><mods:affiliation>Laboratoire de Pharmacologie, Facultédes Sciences Pharmaceutiques et Biologiques, UniversitéR. Descartes, 4 avenue de l'Observatoire, Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Feger, J" sort="Feger, J" uniqKey="Feger J" first="J." last="Féger">J. Féger</name><affiliation><mods:affiliation>Laboratoire de Pharmacologie, Facultédes Sciences Pharmaceutiques et Biologiques, UniversitéR. 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Electrical stimulation of the parafascicular nucleus evoked a complex response with two excitatory phases. The first response was correlated with a monosynaptically-driven excitation via a parafascicular input to the subthalamic nucleus. Since the second phase was observed even when the early excitation was not recorded and was eliminated by lesion of the globus pallidus, we suggest that it is not generated by a mechanism intrinsic to the subthalamic nucleus and is due to a disinhibitory effect originating from the globus pallidus. Microinjection of carbachol into the parafascicular nucleus enhanced by 119% the discharge rate of the neurons in the ipsilateral subthalamic nucleus and that of muscimol decreased the discharge rate by 91%. Opposite changes, a decrease of the discharge rate of 49% after microinjection of carbachol and an increase of 47% after muscimol, occurred in the contralateral subthalamic nucleus. In contrast to the above results, the unilateral excitotoxic lesion of the parafascicular nucleus, performed one week before recording, decreased the discharge rate by 69% of the ipsilateral subthalamic nucleus neurons and by 34% that of the contralateral neurons.We suggest that the parafascicular input to the subthalamic nucleus is an excitatory pathway which can tonically drive the neuronal activity in this structure. The opposite changes recorded in the ipsi- and contralateral subthalamic nucleus during unilateral microinjection of excitatory or inhibitory drugs in the parafascicular nucleus emphasize the importance of this thalamic structure in the bilateral regulation of basal ganglia activity via the subthalamic nucleus.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>M. Mouroux</name><affiliations><json:string>Laboratoire de Pharmacologie, Facultédes Sciences Pharmaceutiques et Biologiques, UniversitéR. Descartes, 4 avenue de l'Observatoire, Paris, France</json:string></affiliations></json:item><json:item><name>O.-K. Hassani</name><affiliations><json:string>Laboratoire de Pharmacologie, Facultédes Sciences Pharmaceutiques et Biologiques, UniversitéR. Descartes, 4 avenue de l'Observatoire, Paris, France</json:string></affiliations></json:item><json:item><name>J. Féger</name><affiliations><json:string>Laboratoire de Pharmacologie, Facultédes Sciences Pharmaceutiques et Biologiques, UniversitéR. Descartes, 4 avenue de l'Observatoire, Paris, France</json:string></affiliations></json:item></author><articleId><json:string>9500032E</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: The activity of subthalamic neurons was recorded extracellularly in anaesthetized rats after stimulation, inhibition or lesioning of the parafascicular nucleus. Electrical stimulation of the parafascicular nucleus evoked a complex response with two excitatory phases. The first response was correlated with a monosynaptically-driven excitation via a parafascicular input to the subthalamic nucleus. Since the second phase was observed even when the early excitation was not recorded and was eliminated by lesion of the globus pallidus, we suggest that it is not generated by a mechanism intrinsic to the subthalamic nucleus and is due to a disinhibitory effect originating from the globus pallidus. Microinjection of carbachol into the parafascicular nucleus enhanced by 119% the discharge rate of the neurons in the ipsilateral subthalamic nucleus and that of muscimol decreased the discharge rate by 91%. Opposite changes, a decrease of the discharge rate of 49% after microinjection of carbachol and an increase of 47% after muscimol, occurred in the contralateral subthalamic nucleus. In contrast to the above results, the unilateral excitotoxic lesion of the parafascicular nucleus, performed one week before recording, decreased the discharge rate by 69% of the ipsilateral subthalamic nucleus neurons and by 34% that of the contralateral neurons.We suggest that the parafascicular input to the subthalamic nucleus is an excitatory pathway which can tonically drive the neuronal activity in this structure. The opposite changes recorded in the ipsi- and contralateral subthalamic nucleus during unilateral microinjection of excitatory or inhibitory drugs in the parafascicular nucleus emphasize the importance of this thalamic structure in the bilateral regulation of basal ganglia activity via the subthalamic nucleus.</abstract><qualityIndicators><score>8</score><pdfVersion>1.3</pdfVersion><pdfPageSize>540 x 771 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1835</abstractCharCount><pdfWordCount>6103</pdfWordCount><pdfCharCount>35569</pdfCharCount><pdfPageCount>9</pdfPageCount><abstractWordCount>264</abstractWordCount></qualityIndicators><title>Electrophysiological study of the excitatory parafascicular projection to the subthalamic nucleus and evidence for ipsi- and contralateral controls</title><pii><json:string>0306-4522(95)00032-E</json:string></pii><refBibs><json:item><author><json:item><name>R.L. Albin</name></json:item><json:item><name>A.B. Young</name></json:item><json:item><name>J.B. Penney</name></json:item></author><host><volume>12</volume><pages><last>375</last><first>366</first></pages><author></author><title>Trends Neurosci.</title></host><title>The functional anatomy of basal disorders</title></json:item><json:item><author><json:item><name>G.E. Alexander</name></json:item><json:item><name>M.D. Crutcher</name></json:item></author><host><volume>13</volume><pages><last>271</last><first>266</first></pages><author></author><title>Trends Neurosci.</title></host><title>Functional architecture of basal ganglia circuits: neural substrates of parallel processing</title></json:item><json:item><author><json:item><name>H.W. Berendse</name></json:item><json:item><name>H.J. Groenewegen</name></json:item></author><host><volume>299</volume><pages><last>228</last><first>187</first></pages><author></author><title>J. comp. Neurol.</title></host><title>Organization of the thalamostriatal projections in the rat, with special emphasis on the ventral striatum</title></json:item><json:item><author><json:item><name>H.W. Berendse</name></json:item><json:item><name>H.J. Groenewegen</name></json:item></author><host><pages><last>98</last><first>89</first></pages><author></author><title>The Basal Ganglia III</title></host><title>The connections of the medial part of the subthalamic nucleus in the rat: evidence for a parallel organization</title></json:item><json:item><author><json:item><name>R.F. Bolton</name></json:item><json:item><name>J. Cornwall</name></json:item><json:item><name>O.T. Phillipson</name></json:item></author><host><volume>6</volume><pages><last>111</last><first>101</first></pages><author></author><title>J. chem. Neuroanat.</title></host><title>Collateral axons of cholinergic pontine neurones projecting to midline, mediodorsal and parafascicular thalamic nuclei in the rat</title></json:item><json:item><author><json:item><name>B.S. Canteras</name></json:item><json:item><name>S.J. Shammah-Lagnado</name></json:item><json:item><name>B.A. Silva</name></json:item><json:item><name>J.A. Ricardo</name></json:item></author><host><volume>458</volume><pages><last>64</last><first>53</first></pages><author></author><title>Brain Res.</title></host><title>Somatosensory inputs to the subthalamic nucleus: a combined retrograde and anterograde horseradish peroxidase study in the rat</title></json:item><json:item><author><json:item><name>P. Cesaro</name></json:item><json:item><name>J. Nguyen-Legros</name></json:item><json:item><name>B. Berger</name></json:item><json:item><name>C. Alvarez</name></json:item><json:item><name>D. Albe-Fessard</name></json:item></author><host><volume>15</volume><pages><last>7</last><first>1</first></pages><author></author><title>Neurosci. Lett.</title></host><title>Double labelling of branched neurons in the central nervous system of the rat by retrograde axonal transport of horseradish peroxidase and iron dextran complex</title></json:item><json:item><author><json:item><name>P. Cesaro</name></json:item><json:item><name>J. Nguyen-Legros</name></json:item><json:item><name>B. Polin</name></json:item><json:item><name>S. Laplante</name></json:item></author><host><volume>325</volume><pages><last>37</last><first>29</first></pages><author></author><title>Brain Res.</title></host><title>Single intralaminar thalamic neurons project to cerebral cortex, striatum and nucleus reticularis thalami: A retrograde anatomical tracing study in the rat</title></json:item><json:item><author><json:item><name>A. Chéramy</name></json:item><json:item><name>M.-F. Chesselet</name></json:item><json:item><name>R. Romo</name></json:item><json:item><name>V. Leviel</name></json:item><json:item><name>J. Glowinski</name></json:item></author><host><volume>8</volume><pages><last>780</last><first>767</first></pages><author></author><title>Neuroscience</title></host><title>Effects of unilateral electrical stimulation of various thalamic nuclei on the release of dopamine from dendrites and nerve terminals of neurons of the two nigrostriatal dopaminergic pathways</title></json:item><json:item><author><json:item><name>J.M. Deniau</name></json:item><json:item><name>C. Hammond</name></json:item><json:item><name>G. Chevalier</name></json:item><json:item><name>J. Féger</name></json:item></author><host><volume>9</volume><pages><last>121</last><first>117</first></pages><author></author><title>Neurosci. Lett.</title></host><title>Evidence for branched subthalamic nucleus projections to substantia nigra, entopeduncular nucleus and globus pallidus</title></json:item><json:item><author><json:item><name>J. Féger</name></json:item><json:item><name>P. Robledo</name></json:item></author><host><volume>3</volume><pages><last>952</last><first>947</first></pages><author></author><title>Eur. J. Neurosci.</title></host><title>The effects of activation or inhibition of the subthalamic nucleus on the metabolic and electrophysiological activities within the pallidal complex and substantia nigra in the rat</title></json:item><json:item><author><json:item><name>J. Féger</name></json:item><json:item><name>M. Mouroux</name></json:item></author><host><volume>313</volume><pages><last>452</last><first>447</first></pages><author></author><title>C. r. hebd séanc. Acad. Sci., Paris</title></host><title>Mise enévidence de l'effet excitateur de l'efférence thalamo-subthalamique issue du noyau parafasciculaire</title></json:item><json:item><author><json:item><name>J. Féger</name></json:item><json:item><name>S. Mraovitch</name></json:item><json:item><name>M. Mouroux</name></json:item></author><host><volume>18</volume><pages><first>136</first></pages><author></author><title>Am. Neurosci. Abstract</title></host><title>The thalamic parafascicular projection to the subthalamic nucleus: a glutamatergic excitatory pathway</title></json:item><json:item><author><json:item><name>J. Féger</name></json:item><json:item><name>M. Bevan</name></json:item><json:item><name>A.R. Crossman</name></json:item></author><host><volume>60</volume><pages><last>132</last><first>125</first></pages><author></author><title>Neuroscience</title></host><title>The projections from the parafascicular thalamic nucleus to the subthalamic nucleus and the striatum arise from separate neuronal populations—a comparison with the corticostriatal and corticosubthalamic efferents in a retrograde fluorescent double-labelling study</title></json:item><json:item><author><json:item><name>K. Fujimoto</name></json:item><json:item><name>H. Kita</name></json:item></author><host><volume>609</volume><pages><last>192</last><first>185</first></pages><author></author><title>Brain Res.</title></host><title>Response characteristics of subthalamic neurons to the stimulation of the sensorimotor cortex in the rat</title></json:item><json:item><author><json:item><name>E. Gould</name></json:item><json:item><name>N.J. Woolf</name></json:item><json:item><name>L.L. Butcher</name></json:item></author><host><volume>28</volume><pages><last>623</last><first>611</first></pages><author></author><title>Neuroscience</title></host><title>Cholinergic projections to the substantia nigra from the pedunculopontine and laterodorsal tegmental nuclei</title></json:item><json:item><author><json:item><name>H.J. Groenewegen</name></json:item><json:item><name>H.W. Berendse</name></json:item></author><host><volume>17</volume><pages><last>57</last><first>52</first></pages><author></author><title>Trends Neurosci.</title></host><title>The specificity of the “nonspecific” midline and intralaminar thalamic nuclei</title></json:item><json:item><author><json:item><name>C. Hammond</name></json:item><json:item><name>J.M. Deniau</name></json:item><json:item><name>B. Rouzaire-Dubois</name></json:item><json:item><name>J. Féger</name></json:item></author><host><volume>9</volume><pages><last>176</last><first>171</first></pages><author></author><title>Neurosci. Lett.</title></host><title>Peripheral input to the rat subthalamic nucleus, an electrophysiological study</title></json:item><json:item><author><json:item><name>C. Hammond</name></json:item><json:item><name>B. Rouzaire-Dubois</name></json:item><json:item><name>J. Féger</name></json:item><json:item><name>A. Jackson</name></json:item><json:item><name>A.R. Crossman</name></json:item></author><host><volume>9</volume><pages><last>55</last><first>41</first></pages><author></author><title>Neuroscience</title></host><title>Anatomical and electrophysiological studies on the reciprocal projections between the subthalamic nucleus and the nucleus tegmenti pedonculopontinus in the rat nucleus</title></json:item><json:item><author><json:item><name>A.E. Kincaid</name></json:item><json:item><name>J.B. Penney</name></json:item><json:item><name>A.B. Young</name></json:item><json:item><name>S.W. Newman</name></json:item></author><host><volume>553</volume><pages><last>26</last><first>18</first></pages><author></author><title>Brain Res.</title></host><title>The globus pallidus receives a projection from the parafascicular nucleus in the rat</title></json:item><json:item><author><json:item><name>S.T. Kitai</name></json:item><json:item><name>J.M. Deniau</name></json:item></author><host><volume>211</volume><pages><last>415</last><first>411</first></pages><author></author><title>Brain Res.</title></host><title>Cortical inputs to the subthalamic nucleus: intracellular analysis</title></json:item><json:item><author><json:item><name>S.T. Kitai</name></json:item><json:item><name>H. Kita</name></json:item></author><host><pages><last>373</last><first>357</first></pages><author></author><title>The Basal Ganglia II, Structure and Function—Current Concepts</title></host><title>Anatomy and physiology of the subthalamic nucleus: a driving force of the basal ganglia</title></json:item><json:item><author><json:item><name>S.R. Lapper</name></json:item><json:item><name>J.P. Bolam</name></json:item></author><host><volume>51</volume><pages><last>545</last><first>533</first></pages><author></author><title>Neuroscience</title></host><title>Input from the frontal cortex and the parafascicular nucleus to cholinergic interneurons in the dorsal striatum of the rat</title></json:item><json:item><author><json:item><name>R. Llinas</name></json:item><json:item><name>Y. Yarom</name></json:item></author><host><volume>315</volume><pages><last>584</last><first>569</first></pages><author></author><title>J. Physiol.</title></host><title>Properties and distribution of ionic conductances generating electroresponsiveness of mammalian inferior olivary neurones in vitro</title></json:item><json:item><author><json:item><name>B.J. Losier</name></json:item><json:item><name>K. Semba</name></json:item></author><host><volume>604</volume><pages><last>52</last><first>41</first></pages><author></author><title>Brain Res.</title></host><title>Dual projections of single cholinergic and aminergic brainstem neurons to the thalamus and basal forebrain in the rat</title></json:item><json:item><author><json:item><name>D.A. McCormick</name></json:item></author><host><volume>39</volume><pages><last>388</last><first>337</first></pages><author></author><title>Prog. Neurobiol.</title></host><title>Neurotransmitter actions in the thalamus and cerebral cortex and their role in neuromodulation of thalamocortical activity</title></json:item><json:item><author><json:item><name>M.M. Mesulam</name></json:item><json:item><name>E.J. Mufson</name></json:item><json:item><name>B.H. Wainer</name></json:item><json:item><name>A.I. Levey</name></json:item></author><host><volume>10</volume><pages><last>1201</last><first>1185</first></pages><author></author><title>Neuroscience</title></host><title>Central cholinergic pathways in the rat: an overview based on an alternative nomenclature (Ch1–Ch6)</title></json:item><json:item><author><json:item><name>I. Mintz</name></json:item><json:item><name>C. Hammond</name></json:item><json:item><name>B. Guibert</name></json:item><json:item><name>V. Leviel</name></json:item></author><host><volume>376</volume><pages><last>408</last><first>406</first></pages><author></author><title>Brain Res.</title></host><title>Stimulation of the subthalamic nucleus enhances the release of dopamine in the rat substantia nigra</title></json:item><json:item><author><json:item><name>M. Mouroux</name></json:item><json:item><name>J. Féger</name></json:item></author><host><volume>4</volume><pages><last>615</last><first>613</first></pages><author></author><title>NeuroReport</title></host><title>Evidence that the parafascicular projection to the subthalamic nucleus is glutamatergic</title></json:item><json:item><author><json:item><name>S. Mraovitch</name></json:item><json:item><name>J. Féger</name></json:item><json:item><name>Y. Calando</name></json:item><json:item><name>J. Seylaz</name></json:item></author><host><pages><last>400</last><first>397</first></pages><author></author><title>Neurotransmission and Cerebrovascular Function</title></host><title>Cardiovascular and cerebrovascular alterations elicited by cholinergic stimulation of the centromedian-parafascicular complex in the rat</title></json:item><json:item><author><json:item><name>S. Mraovitch</name></json:item><json:item><name>Y. Calando</name></json:item><json:item><name>E. Pinard</name></json:item><json:item><name>W.J. Pearce</name></json:item><json:item><name>J. Seylaz</name></json:item></author><host><volume>49</volume><pages><last>466</last><first>451</first></pages><author></author><title>Neuroscience</title></host><title>Differential cerebrovascular and metabolic responses in specific neural systems elicited from the centromedian-parafascicular complex</title></json:item><json:item><author><json:item><name>D. Paré</name></json:item><json:item><name>Y. Smith</name></json:item><json:item><name>A. Parent</name></json:item><json:item><name>M. Steriade</name></json:item></author><host><volume>25</volume><pages><last>86</last><first>69</first></pages><author></author><title>Neuroscience</title></host><title>Projection of brainstem core cholinergic and non-cholinergic neurons of cat to intralaminar and reticular thalamic nuclei</title></json:item><json:item><host><author></author><title>The Rat Brain in Stereotaxic Coordinates</title></host></json:item><json:item><author><json:item><name>M.N. Perkins</name></json:item><json:item><name>T.W. Stone</name></json:item></author><host><volume>68</volume><pages><last>511</last><first>500</first></pages><author></author><title>Expl Neurol.</title></host><title>Subthalamic projections to the globus pallidus: an electrophysiological study in the rat</title></json:item><json:item><author><json:item><name>M.A. Raftery</name></json:item></author><host><author></author><title>Discussion in Neurosciences: Transduction of Neuronal Signals</title></host><serie><author></author><title>Discussion in Neurosciences: Transduction of Neuronal Signals</title></serie><title>Structural and functional aspects of the nicotinic acetylcholine receptor</title></json:item><json:item><author><json:item><name>V. Raos</name></json:item><json:item><name>M. Bentivoglio</name></json:item></author><host><volume>332</volume><pages><last>154</last><first>115</first></pages><author></author><title>J. comp. Neurol.</title></host><title>Crosstalk between the two sides of the thalamus through the reticular nucleus—a retrograde and anterograde tracing study in the rat</title></json:item><json:item><author><json:item><name>P. Robledo</name></json:item><json:item><name>I. Vezolle</name></json:item><json:item><name>J. Féger</name></json:item></author><host><volume>307</volume><pages><last>138</last><first>133</first></pages><author></author><title>C. r. hebd séanc. Acad. Sci., Paris</title></host><title>Mise enévidence d'un effet excitateur des efférences subthalamo-nigrales et subthalamo-pallidales chez le rat</title></json:item><json:item><author><json:item><name>P. Robledo</name></json:item><json:item><name>J. Féger</name></json:item></author><host><volume>518</volume><pages><last>54</last><first>47</first></pages><author></author><title>Brain Res.</title></host><title>Excitatory influence of rat subthalamic nucleus to substantia nigra pars reticulata and the pallidal complex: electrophysiological data</title></json:item><json:item><author><json:item><name>R. Romo</name></json:item><json:item><name>A. Chéramy</name></json:item><json:item><name>M. Desban</name></json:item><json:item><name>G. Godeheu</name></json:item><json:item><name>J. Glowinski</name></json:item></author><host><volume>11</volume><pages><last>680</last><first>671</first></pages><author></author><title>Brain Res. Bull.</title></host><title>GABA in the intralaminar thalamic nuclei modulates dopamine release from the two dopaminergic nigro-striatal pathways in the cat</title></json:item><json:item><author><json:item><name>B. Rouzaire-Dubois</name></json:item><json:item><name>C. Hammond</name></json:item><json:item><name>B. Hamon</name></json:item><json:item><name>J. Féger</name></json:item></author><host><volume>200</volume><pages><last>329</last><first>321</first></pages><author></author><title>Brain Res.</title></host><title>Pharmacological blockade of the globus pallidus-induced inhibitory responses of the subthalamic cells in the rat</title></json:item><json:item><author><json:item><name>B. Rouzaire-Dubois</name></json:item><json:item><name>E. Scarnati</name></json:item></author><host><volume>15</volume><pages><last>79</last><first>69</first></pages><author></author><title>Neuroscience</title></host><title>Bilateral corticosubthalamic nucleus projections: an electrophysiological study in rats with chronic cerebral lesions</title></json:item><json:item><author><json:item><name>B. Rouzaire-Dubois</name></json:item><json:item><name>E. Scarnati</name></json:item></author><host><volume>403</volume><pages><last>370</last><first>366</first></pages><author></author><title>Brain Res.</title></host><title>Increase in glutamate sensitivity of subthalamic neurons following bilateral decortication: a microiontophoretic study in the rat</title></json:item><json:item><author><json:item><name>B. Rouzaire-Dubois</name></json:item><json:item><name>E. Scarnati</name></json:item></author><host><volume>21</volume><pages><last>440</last><first>429</first></pages><author></author><title>Neuroscience</title></host><title>Pharmacological study of the cortical-induced excitation of subthalamic nucleus neurones in the rat: evidence for amino acids as putative neurotransmitters</title></json:item><json:item><author><json:item><name>K. Semba</name></json:item><json:item><name>P.B. Reiner</name></json:item><json:item><name>H.C. Fibiger</name></json:item></author><host><volume>38</volume><pages><last>654</last><first>643</first></pages><author></author><title>Neuroscience</title></host><title>Single cholinergic mesopontine tegmental neurons project to both the pontine reticular formation and the thalamus in the rat</title></json:item><json:item><author><json:item><name>T. Sugimoto</name></json:item><json:item><name>T. Hattori</name></json:item></author><host><volume>264</volume><pages><last>339</last><first>335</first></pages><author></author><title>Brain Res.</title></host><title>Confirmation of thalamosubthalamic projections by electron microscopic autoradiography</title></json:item><json:item><author><json:item><name>T. Sugimoto</name></json:item><json:item><name>T. Hattori</name></json:item><json:item><name>N. Mizuno</name></json:item><json:item><name>K. Itoh</name></json:item><json:item><name>M. Sato</name></json:item></author><host><volume>211</volume><pages><last>216</last><first>209</first></pages><author></author><title>J. comp. Neurol.</title></host><title>Direct projection from the centremédian-parafascicular complex to the subthalamic nucleus in the cat and rat</title></json:item><json:item><author><json:item><name>D. Van Der Kooy</name></json:item><json:item><name>T. Hattori</name></json:item></author><host><volume>192</volume><pages><last>790</last><first>751</first></pages><author></author><title>J. comp. Neurol.</title></host><title>Single subthalamic neurons project to both the globus pallidus and the substantia nigra in the rat</title></json:item><json:item><author><json:item><name>C.J. Wilson</name></json:item><json:item><name>J.T. Chang</name></json:item><json:item><name>S.T. Kitai</name></json:item></author><host><volume>51</volume><pages><last>226</last><first>217</first></pages><author></author><title>Expl Brain Res.</title></host><title>Origins of postsynaptic potentials evoked in spiny neostriatal neurons by thalamic stimulation in the rat</title></json:item><json:item><author><json:item><name>C.J. Wilson</name></json:item><json:item><name>H.T. Chang</name></json:item><json:item><name>S.T. Kitai</name></json:item></author><host><volume>10</volume><pages><last>519</last><first>508</first></pages><author></author><title>J. Neurosci.</title></host><title>Firing patterns and synaptic potentials of identified giant aspiny interneurons in the rat neostriatum</title></json:item><json:item><author><json:item><name>B.B. Wolfe</name></json:item></author><host><pages><last>150</last><first>125</first></pages><author></author><title>The Muscarinic Receptors</title></host><title>Subtypes of muscarinic cholinergic receptors: ligand binding, functional studies and cloning</title></json:item></refBibs><genre><json:string>research-article</json:string></genre><serie><volume>Vol 3</volume><pages><last>28</last><first>22</first></pages><language><json:string>unknown</json:string></language><title>Discussion in Neurosciences: Transduction of Neuronal Signals</title></serie><host><volume>67</volume><pii><json:string>S0306-4522(00)X0026-7</json:string></pii><pages><last>407</last><first>399</first></pages><issn><json:string>0306-4522</json:string></issn><issue>2</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><title>Neuroscience</title><publicationDate>1995</publicationDate></host><categories><wos><json:string>science</json:string><json:string>neurosciences</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>neurology & neurosurgery</json:string></scienceMetrix></categories><publicationDate>1995</publicationDate><copyrightDate>1995</copyrightDate><doi><json:string>10.1016/0306-4522(95)00032-E</json:string></doi><id>BC0FDA4EAAAF7B38ADF7D9B0262DD9B9F2075C4D</id><score>0.1131033</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/BC0FDA4EAAAF7B38ADF7D9B0262DD9B9F2075C4D/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/BC0FDA4EAAAF7B38ADF7D9B0262DD9B9F2075C4D/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/BC0FDA4EAAAF7B38ADF7D9B0262DD9B9F2075C4D/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Electrophysiological study of the excitatory parafascicular projection to the subthalamic nucleus and evidence for ipsi- and contralateral controls</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>©1995 IBRO</p></availability><date>1995</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Electrophysiological study of the excitatory parafascicular projection to the subthalamic nucleus and evidence for ipsi- and contralateral controls</title><author xml:id="author-1"><persName><forename type="first">M.</forename><surname>Mouroux</surname></persName><affiliation>To whom correspondence should be addressed.</affiliation><affiliation>Laboratoire de Pharmacologie, Facultédes Sciences Pharmaceutiques et Biologiques, UniversitéR. Descartes, 4 avenue de l'Observatoire, Paris, France</affiliation></author><author xml:id="author-2"><persName><forename type="first">O.-K.</forename><surname>Hassani</surname></persName><affiliation>Laboratoire de Pharmacologie, Facultédes Sciences Pharmaceutiques et Biologiques, UniversitéR. Descartes, 4 avenue de l'Observatoire, Paris, France</affiliation></author><author xml:id="author-3"><persName><forename type="first">J.</forename><surname>Féger</surname></persName><affiliation>Laboratoire de Pharmacologie, Facultédes Sciences Pharmaceutiques et Biologiques, UniversitéR. Descartes, 4 avenue de l'Observatoire, Paris, France</affiliation></author></analytic><monogr><title level="j">Neuroscience</title><title level="j" type="abbrev">NSC</title><idno type="pISSN">0306-4522</idno><idno type="PII">S0306-4522(00)X0026-7</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1995"></date><biblScope unit="volume">67</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="399">399</biblScope><biblScope unit="page" to="407">407</biblScope></imprint></monogr><idno type="istex">BC0FDA4EAAAF7B38ADF7D9B0262DD9B9F2075C4D</idno><idno type="DOI">10.1016/0306-4522(95)00032-E</idno><idno type="PII">0306-4522(95)00032-E</idno><idno type="ArticleID">9500032E</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1995</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: The activity of subthalamic neurons was recorded extracellularly in anaesthetized rats after stimulation, inhibition or lesioning of the parafascicular nucleus. Electrical stimulation of the parafascicular nucleus evoked a complex response with two excitatory phases. The first response was correlated with a monosynaptically-driven excitation via a parafascicular input to the subthalamic nucleus. Since the second phase was observed even when the early excitation was not recorded and was eliminated by lesion of the globus pallidus, we suggest that it is not generated by a mechanism intrinsic to the subthalamic nucleus and is due to a disinhibitory effect originating from the globus pallidus. Microinjection of carbachol into the parafascicular nucleus enhanced by 119% the discharge rate of the neurons in the ipsilateral subthalamic nucleus and that of muscimol decreased the discharge rate by 91%. Opposite changes, a decrease of the discharge rate of 49% after microinjection of carbachol and an increase of 47% after muscimol, occurred in the contralateral subthalamic nucleus. In contrast to the above results, the unilateral excitotoxic lesion of the parafascicular nucleus, performed one week before recording, decreased the discharge rate by 69% of the ipsilateral subthalamic nucleus neurons and by 34% that of the contralateral neurons.We suggest that the parafascicular input to the subthalamic nucleus is an excitatory pathway which can tonically drive the neuronal activity in this structure. The opposite changes recorded in the ipsi- and contralateral subthalamic nucleus during unilateral microinjection of excitatory or inhibitory drugs in the parafascicular nucleus emphasize the importance of this thalamic structure in the bilateral regulation of basal ganglia activity via the subthalamic nucleus.</p></abstract></profileDesc><revisionDesc><change when="1995">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/BC0FDA4EAAAF7B38ADF7D9B0262DD9B9F2075C4D/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier doc found" wicri:toSee="Elsevier, no converted or simple article"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 5.0.1//EN//XML" URI="art501.dtd" name="istex:docType"></istex:docType><istex:document><article version="5.0" xml:lang="en" docsubtype="fla"><item-info><jid>NSC</jid><aid>9500032E</aid><ce:pii>0306-4522(95)00032-E</ce:pii><ce:doi>10.1016/0306-4522(95)00032-E</ce:doi><ce:copyright type="unknown" year="1995">IBRO</ce:copyright></item-info><head><ce:title>Electrophysiological study of the excitatory parafascicular projection to the subthalamic nucleus and evidence for ipsi- and contralateral controls</ce:title><ce:author-group><ce:author><ce:given-name>M.</ce:given-name><ce:surname>Mouroux</ce:surname><ce:cross-ref refid="cor1"><ce:sup>*</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>O.-K.</ce:given-name><ce:surname>Hassani</ce:surname></ce:author><ce:author><ce:given-name>J.</ce:given-name><ce:surname>Féger</ce:surname></ce:author><ce:affiliation><ce:textfn>Laboratoire de Pharmacologie, Facultédes Sciences Pharmaceutiques et Biologiques, UniversitéR. Descartes, 4 avenue de l'Observatoire, Paris, France</ce:textfn></ce:affiliation><ce:correspondence id="cor1"><ce:label>*</ce:label><ce:text>To whom correspondence should be addressed.</ce:text></ce:correspondence></ce:author-group><ce:date-accepted day="5" month="1" year="1995"></ce:date-accepted><ce:abstract id="ab1" class="author" xml:lang="en"><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The activity of subthalamic neurons was recorded extracellularly in anaesthetized rats after stimulation, inhibition or lesioning of the parafascicular nucleus. Electrical stimulation of the parafascicular nucleus evoked a complex response with two excitatory phases. The first response was correlated with a monosynaptically-driven excitation via a parafascicular input to the subthalamic nucleus. Since the second phase was observed even when the early excitation was not recorded and was eliminated by lesion of the globus pallidus, we suggest that it is not generated by a mechanism intrinsic to the subthalamic nucleus and is due to a disinhibitory effect originating from the globus pallidus. Microinjection of carbachol into the parafascicular nucleus enhanced by 119% the discharge rate of the neurons in the ipsilateral subthalamic nucleus and that of muscimol decreased the discharge rate by 91%. Opposite changes, a decrease of the discharge rate of 49% after microinjection of carbachol and an increase of 47% after muscimol, occurred in the contralateral subthalamic nucleus. In contrast to the above results, the unilateral excitotoxic lesion of the parafascicular nucleus, performed one week before recording, decreased the discharge rate by 69% of the ipsilateral subthalamic nucleus neurons and by 34% that of the contralateral neurons.</ce:simple-para><ce:simple-para>We suggest that the parafascicular input to the subthalamic nucleus is an excitatory pathway which can tonically drive the neuronal activity in this structure. The opposite changes recorded in the ipsi- and contralateral subthalamic nucleus during unilateral microinjection of excitatory or inhibitory drugs in the parafascicular nucleus emphasize the importance of this thalamic structure in the bilateral regulation of basal ganglia activity via the subthalamic nucleus.</ce:simple-para></ce:abstract-sec></ce:abstract></head><tail><ce:bibliography><ce:section-title>Reference</ce:section-title><ce:bibliography-sec><ce:bib-reference id="bib1"><ce:label>1.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Albin</ce:surname><ce:given-name>R.L.</ce:given-name></sb:author><sb:author><ce:surname>Young</ce:surname><ce:given-name>A.B.</ce:given-name></sb:author><sb:author><ce:surname>Penney</ce:surname><ce:given-name>J.B.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>The functional anatomy of basal disorders</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Trends Neurosci.</sb:maintitle></sb:title><sb:volume-nr>12</sb:volume-nr></sb:series><sb:date>1989</sb:date></sb:issue><sb:pages><sb:first-page>366</sb:first-page><sb:last-page>375</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib2"><ce:label>2</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Alexander</ce:surname><ce:given-name>G.E.</ce:given-name></sb:author><sb:author><ce:surname>Crutcher</ce:surname><ce:given-name>M.D.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Functional architecture of basal ganglia circuits: neural substrates of parallel processing</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Trends Neurosci.</sb:maintitle></sb:title><sb:volume-nr>13</sb:volume-nr></sb:series><sb:date>1990</sb:date></sb:issue><sb:pages><sb:first-page>266</sb:first-page><sb:last-page>271</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib3"><ce:label>3.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Berendse</ce:surname><ce:given-name>H.W.</ce:given-name></sb:author><sb:author><ce:surname>Groenewegen</ce:surname><ce:given-name>H.J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Organization of the thalamostriatal projections in the rat, with special emphasis on the ventral striatum</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. comp. Neurol.</sb:maintitle></sb:title><sb:volume-nr>299</sb:volume-nr></sb:series><sb:date>1990</sb:date></sb:issue><sb:pages><sb:first-page>187</sb:first-page><sb:last-page>228</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib4"><ce:label>4.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Berendse</ce:surname><ce:given-name>H.W.</ce:given-name></sb:author><sb:author><ce:surname>Groenewegen</ce:surname><ce:given-name>H.J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>The connections of the medial part of the subthalamic nucleus in the rat: evidence for a parallel organization</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:editors><sb:editor><ce:surname>Bernardi</ce:surname><ce:given-name>G.</ce:given-name></sb:editor><sb:editor><ce:surname>Carpenter</ce:surname><ce:given-name>M.B.</ce:given-name></sb:editor><sb:editor><ce:surname>Chiara</ce:surname><ce:given-name>G.D.</ce:given-name></sb:editor><sb:editor><ce:surname>Morelli</ce:surname><ce:given-name>M.</ce:given-name></sb:editor><sb:editor><ce:surname>Stanzione</ce:surname><ce:given-name>P.</ce:given-name></sb:editor></sb:editors><sb:title><sb:maintitle>The Basal Ganglia III</sb:maintitle></sb:title><sb:date>1991</sb:date><sb:publisher><sb:name>Plenum Press</sb:name><sb:location>New York</sb:location></sb:publisher></sb:edited-book><sb:pages><sb:first-page>89</sb:first-page><sb:last-page>98</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib5"><ce:label>5.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Bolton</ce:surname><ce:given-name>R.F.</ce:given-name></sb:author><sb:author><ce:surname>Cornwall</ce:surname><ce:given-name>J.</ce:given-name></sb:author><sb:author><ce:surname>Phillipson</ce:surname><ce:given-name>O.T.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Collateral axons of cholinergic pontine neurones projecting to midline, mediodorsal and parafascicular thalamic nuclei in the rat</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. chem. Neuroanat.</sb:maintitle></sb:title><sb:volume-nr>6</sb:volume-nr></sb:series><sb:date>1993</sb:date></sb:issue><sb:pages><sb:first-page>101</sb:first-page><sb:last-page>111</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib6"><ce:label>6.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Canteras</ce:surname><ce:given-name>B.S.</ce:given-name></sb:author><sb:author><ce:surname>Shammah-Lagnado</ce:surname><ce:given-name>S.J.</ce:given-name></sb:author><sb:author><ce:surname>Silva</ce:surname><ce:given-name>B.A.</ce:given-name></sb:author><sb:author><ce:surname>Ricardo</ce:surname><ce:given-name>J.A.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Somatosensory inputs to the subthalamic nucleus: a combined retrograde and anterograde horseradish peroxidase study in the rat</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Brain Res.</sb:maintitle></sb:title><sb:volume-nr>458</sb:volume-nr></sb:series><sb:date>1988</sb:date></sb:issue><sb:pages><sb:first-page>53</sb:first-page><sb:last-page>64</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib7"><ce:label>7.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Cesaro</ce:surname><ce:given-name>P.</ce:given-name></sb:author><sb:author><ce:surname>Nguyen-Legros</ce:surname><ce:given-name>J.</ce:given-name></sb:author><sb:author><ce:surname>Berger</ce:surname><ce:given-name>B.</ce:given-name></sb:author><sb:author><ce:surname>Alvarez</ce:surname><ce:given-name>C.</ce:given-name></sb:author><sb:author><ce:surname>Albe-Fessard</ce:surname><ce:given-name>D.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Double labelling of branched neurons in the central nervous system of the rat by retrograde axonal transport of horseradish peroxidase and iron dextran complex</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neurosci. Lett.</sb:maintitle></sb:title><sb:volume-nr>15</sb:volume-nr></sb:series><sb:date>1979</sb:date></sb:issue><sb:pages><sb:first-page>1</sb:first-page><sb:last-page>7</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib8"><ce:label>8.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Cesaro</ce:surname><ce:given-name>P.</ce:given-name></sb:author><sb:author><ce:surname>Nguyen-Legros</ce:surname><ce:given-name>J.</ce:given-name></sb:author><sb:author><ce:surname>Polin</ce:surname><ce:given-name>B.</ce:given-name></sb:author><sb:author><ce:surname>Laplante</ce:surname><ce:given-name>S.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Single intralaminar thalamic neurons project to cerebral cortex, striatum and nucleus reticularis thalami: A retrograde anatomical tracing study in the rat</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Brain Res.</sb:maintitle></sb:title><sb:volume-nr>325</sb:volume-nr></sb:series><sb:date>1985</sb:date></sb:issue><sb:pages><sb:first-page>29</sb:first-page><sb:last-page>37</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib9"><ce:label>9.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Chéramy</ce:surname><ce:given-name>A.</ce:given-name></sb:author><sb:author><ce:surname>Chesselet</ce:surname><ce:given-name>M.-F.</ce:given-name></sb:author><sb:author><ce:surname>Romo</ce:surname><ce:given-name>R.</ce:given-name></sb:author><sb:author><ce:surname>Leviel</ce:surname><ce:given-name>V.</ce:given-name></sb:author><sb:author><ce:surname>Glowinski</ce:surname><ce:given-name>J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Effects of unilateral electrical stimulation of various thalamic nuclei on the release of dopamine from dendrites and nerve terminals of neurons of the two nigrostriatal dopaminergic pathways</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neuroscience</sb:maintitle></sb:title><sb:volume-nr>8</sb:volume-nr></sb:series><sb:date>1983</sb:date></sb:issue><sb:pages><sb:first-page>767</sb:first-page><sb:last-page>780</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib10"><ce:label>10.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Deniau</ce:surname><ce:given-name>J.M.</ce:given-name></sb:author><sb:author><ce:surname>Hammond</ce:surname><ce:given-name>C.</ce:given-name></sb:author><sb:author><ce:surname>Chevalier</ce:surname><ce:given-name>G.</ce:given-name></sb:author><sb:author><ce:surname>Féger</ce:surname><ce:given-name>J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Evidence for branched subthalamic nucleus projections to substantia nigra, entopeduncular nucleus and globus pallidus</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neurosci. Lett.</sb:maintitle></sb:title><sb:volume-nr>9</sb:volume-nr></sb:series><sb:date>1978</sb:date></sb:issue><sb:pages><sb:first-page>117</sb:first-page><sb:last-page>121</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib11"><ce:label>11.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Féger</ce:surname><ce:given-name>J.</ce:given-name></sb:author><sb:author><ce:surname>Robledo</ce:surname><ce:given-name>P.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>The effects of activation or inhibition of the subthalamic nucleus on the metabolic and electrophysiological activities within the pallidal complex and substantia nigra in the rat</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Eur. J. Neurosci.</sb:maintitle></sb:title><sb:volume-nr>3</sb:volume-nr></sb:series><sb:date>1991</sb:date></sb:issue><sb:pages><sb:first-page>947</sb:first-page><sb:last-page>952</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib12"><ce:label>12.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Féger</ce:surname><ce:given-name>J.</ce:given-name></sb:author><sb:author><ce:surname>Mouroux</ce:surname><ce:given-name>M.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Mise enévidence de l'effet excitateur de l'efférence thalamo-subthalamique issue du noyau parafasciculaire</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>C. r. hebd séanc. Acad. Sci., Paris</sb:maintitle></sb:title><sb:volume-nr>313</sb:volume-nr></sb:series><sb:date>1991</sb:date></sb:issue><sb:pages><sb:first-page>447</sb:first-page><sb:last-page>452</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib13"><ce:label>13.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Féger</ce:surname><ce:given-name>J.</ce:given-name></sb:author><sb:author><ce:surname>Mraovitch</ce:surname><ce:given-name>S.</ce:given-name></sb:author><sb:author><ce:surname>Mouroux</ce:surname><ce:given-name>M.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>The thalamic parafascicular projection to the subthalamic nucleus: a glutamatergic excitatory pathway</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Am. Neurosci. Abstract</sb:maintitle></sb:title><sb:volume-nr>18</sb:volume-nr></sb:series><sb:date>1992</sb:date></sb:issue><sb:pages><sb:first-page>136</sb:first-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib14"><ce:label>14.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Féger</ce:surname><ce:given-name>J.</ce:given-name></sb:author><sb:author><ce:surname>Bevan</ce:surname><ce:given-name>M.</ce:given-name></sb:author><sb:author><ce:surname>Crossman</ce:surname><ce:given-name>A.R.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>The projections from the parafascicular thalamic nucleus to the subthalamic nucleus and the striatum arise from separate neuronal populations—a comparison with the corticostriatal and corticosubthalamic efferents in a retrograde fluorescent double-labelling study</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neuroscience</sb:maintitle></sb:title><sb:volume-nr>60</sb:volume-nr></sb:series><sb:date>1994</sb:date></sb:issue><sb:pages><sb:first-page>125</sb:first-page><sb:last-page>132</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib15"><ce:label>15.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Fujimoto</ce:surname><ce:given-name>K.</ce:given-name></sb:author><sb:author><ce:surname>Kita</ce:surname><ce:given-name>H.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Response characteristics of subthalamic neurons to the stimulation of the sensorimotor cortex in the rat</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Brain Res.</sb:maintitle></sb:title><sb:volume-nr>609</sb:volume-nr></sb:series><sb:date>1993</sb:date></sb:issue><sb:pages><sb:first-page>185</sb:first-page><sb:last-page>192</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib16"><ce:label>16.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Gould</ce:surname><ce:given-name>E.</ce:given-name></sb:author><sb:author><ce:surname>Woolf</ce:surname><ce:given-name>N.J.</ce:given-name></sb:author><sb:author><ce:surname>Butcher</ce:surname><ce:given-name>L.L.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Cholinergic projections to the substantia nigra from the pedunculopontine and laterodorsal tegmental nuclei</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neuroscience</sb:maintitle></sb:title><sb:volume-nr>28</sb:volume-nr></sb:series><sb:date>1989</sb:date></sb:issue><sb:pages><sb:first-page>611</sb:first-page><sb:last-page>623</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib17"><ce:label>17.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Groenewegen</ce:surname><ce:given-name>H.J.</ce:given-name></sb:author><sb:author><ce:surname>Berendse</ce:surname><ce:given-name>H.W.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>The specificity of the “nonspecific” midline and intralaminar thalamic nuclei</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Trends Neurosci.</sb:maintitle></sb:title><sb:volume-nr>17</sb:volume-nr></sb:series><sb:date>1994</sb:date></sb:issue><sb:pages><sb:first-page>52</sb:first-page><sb:last-page>57</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib18"><ce:label>18.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Hammond</ce:surname><ce:given-name>C.</ce:given-name></sb:author><sb:author><ce:surname>Deniau</ce:surname><ce:given-name>J.M.</ce:given-name></sb:author><sb:author><ce:surname>Rouzaire-Dubois</ce:surname><ce:given-name>B.</ce:given-name></sb:author><sb:author><ce:surname>Féger</ce:surname><ce:given-name>J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Peripheral input to the rat subthalamic nucleus, an electrophysiological study</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neurosci. Lett.</sb:maintitle></sb:title><sb:volume-nr>9</sb:volume-nr></sb:series><sb:date>1978</sb:date></sb:issue><sb:pages><sb:first-page>171</sb:first-page><sb:last-page>176</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib19"><ce:label>19.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Hammond</ce:surname><ce:given-name>C.</ce:given-name></sb:author><sb:author><ce:surname>Rouzaire-Dubois</ce:surname><ce:given-name>B.</ce:given-name></sb:author><sb:author><ce:surname>Féger</ce:surname><ce:given-name>J.</ce:given-name></sb:author><sb:author><ce:surname>Jackson</ce:surname><ce:given-name>A.</ce:given-name></sb:author><sb:author><ce:surname>Crossman</ce:surname><ce:given-name>A.R.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Anatomical and electrophysiological studies on the reciprocal projections between the subthalamic nucleus and the nucleus tegmenti pedonculopontinus in the rat nucleus</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neuroscience</sb:maintitle></sb:title><sb:volume-nr>9</sb:volume-nr></sb:series><sb:date>1983</sb:date></sb:issue><sb:pages><sb:first-page>41</sb:first-page><sb:last-page>55</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib20"><ce:label>20.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Kincaid</ce:surname><ce:given-name>A.E.</ce:given-name></sb:author><sb:author><ce:surname>Penney</ce:surname><ce:given-name>J.B.</ce:given-name></sb:author><sb:author><ce:surname>Young</ce:surname><ce:given-name>A.B.</ce:given-name></sb:author><sb:author><ce:surname>Newman</ce:surname><ce:given-name>S.W.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>The globus pallidus receives a projection from the parafascicular nucleus in the rat</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Brain Res.</sb:maintitle></sb:title><sb:volume-nr>553</sb:volume-nr></sb:series><sb:date>1991</sb:date></sb:issue><sb:pages><sb:first-page>18</sb:first-page><sb:last-page>26</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib21"><ce:label>21.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Kitai</ce:surname><ce:given-name>S.T.</ce:given-name></sb:author><sb:author><ce:surname>Deniau</ce:surname><ce:given-name>J.M.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Cortical inputs to the subthalamic nucleus: intracellular analysis</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Brain Res.</sb:maintitle></sb:title><sb:volume-nr>211</sb:volume-nr></sb:series><sb:date>1981</sb:date></sb:issue><sb:pages><sb:first-page>411</sb:first-page><sb:last-page>415</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib22"><ce:label>22.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Kitai</ce:surname><ce:given-name>S.T.</ce:given-name></sb:author><sb:author><ce:surname>Kita</ce:surname><ce:given-name>H.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Anatomy and physiology of the subthalamic nucleus: a driving force of the basal ganglia</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:editors><sb:editor><ce:surname>Carpenter</ce:surname><ce:given-name>M.B.</ce:given-name></sb:editor><sb:editor><ce:surname>Jayaraman</ce:surname><ce:given-name>A.</ce:given-name></sb:editor></sb:editors><sb:title><sb:maintitle>The Basal Ganglia II, Structure and Function—Current Concepts</sb:maintitle></sb:title><sb:date>1987</sb:date><sb:publisher><sb:name>Plenum Press</sb:name><sb:location>New York</sb:location></sb:publisher></sb:edited-book><sb:pages><sb:first-page>357</sb:first-page><sb:last-page>373</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib23"><ce:label>23.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Lapper</ce:surname><ce:given-name>S.R.</ce:given-name></sb:author><sb:author><ce:surname>Bolam</ce:surname><ce:given-name>J.P.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Input from the frontal cortex and the parafascicular nucleus to cholinergic interneurons in the dorsal striatum of the rat</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neuroscience</sb:maintitle></sb:title><sb:volume-nr>51</sb:volume-nr></sb:series><sb:date>1992</sb:date></sb:issue><sb:pages><sb:first-page>533</sb:first-page><sb:last-page>545</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib24"><ce:label>24.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Llinas</ce:surname><ce:given-name>R.</ce:given-name></sb:author><sb:author><ce:surname>Yarom</ce:surname><ce:given-name>Y.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Properties and distribution of ionic conductances generating electroresponsiveness of mammalian inferior olivary neurones <ce:italic>in vitro</ce:italic></sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Physiol.</sb:maintitle></sb:title><sb:volume-nr>315</sb:volume-nr></sb:series><sb:date>1981</sb:date></sb:issue><sb:pages><sb:first-page>569</sb:first-page><sb:last-page>584</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib25"><ce:label>25.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Losier</ce:surname><ce:given-name>B.J.</ce:given-name></sb:author><sb:author><ce:surname>Semba</ce:surname><ce:given-name>K.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Dual projections of single cholinergic and aminergic brainstem neurons to the thalamus and basal forebrain in the rat</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Brain Res.</sb:maintitle></sb:title><sb:volume-nr>604</sb:volume-nr></sb:series><sb:date>1993</sb:date></sb:issue><sb:pages><sb:first-page>41</sb:first-page><sb:last-page>52</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib26"><ce:label>26.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>McCormick</ce:surname><ce:given-name>D.A.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Neurotransmitter actions in the thalamus and cerebral cortex and their role in neuromodulation of thalamocortical activity</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Prog. Neurobiol.</sb:maintitle></sb:title><sb:volume-nr>39</sb:volume-nr></sb:series><sb:date>1992</sb:date></sb:issue><sb:pages><sb:first-page>337</sb:first-page><sb:last-page>388</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib27"><ce:label>27.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Mesulam</ce:surname><ce:given-name>M.M.</ce:given-name></sb:author><sb:author><ce:surname>Mufson</ce:surname><ce:given-name>E.J.</ce:given-name></sb:author><sb:author><ce:surname>Wainer</ce:surname><ce:given-name>B.H.</ce:given-name></sb:author><sb:author><ce:surname>Levey</ce:surname><ce:given-name>A.I.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Central cholinergic pathways in the rat: an overview based on an alternative nomenclature (Ch1–Ch6)</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neuroscience</sb:maintitle></sb:title><sb:volume-nr>10</sb:volume-nr></sb:series><sb:date>1983</sb:date></sb:issue><sb:pages><sb:first-page>1185</sb:first-page><sb:last-page>1201</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib28"><ce:label>28.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Mintz</ce:surname><ce:given-name>I.</ce:given-name></sb:author><sb:author><ce:surname>Hammond</ce:surname><ce:given-name>C.</ce:given-name></sb:author><sb:author><ce:surname>Guibert</ce:surname><ce:given-name>B.</ce:given-name></sb:author><sb:author><ce:surname>Leviel</ce:surname><ce:given-name>V.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Stimulation of the subthalamic nucleus enhances the release of dopamine in the rat substantia nigra</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Brain Res.</sb:maintitle></sb:title><sb:volume-nr>376</sb:volume-nr></sb:series><sb:date>1986</sb:date></sb:issue><sb:pages><sb:first-page>406</sb:first-page><sb:last-page>408</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib29"><ce:label>29.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Mouroux</ce:surname><ce:given-name>M.</ce:given-name></sb:author><sb:author><ce:surname>Féger</ce:surname><ce:given-name>J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Evidence that the parafascicular projection to the subthalamic nucleus is glutamatergic</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>NeuroReport</sb:maintitle></sb:title><sb:volume-nr>4</sb:volume-nr></sb:series><sb:date>1993</sb:date></sb:issue><sb:pages><sb:first-page>613</sb:first-page><sb:last-page>615</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib30"><ce:label>30.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Mraovitch</ce:surname><ce:given-name>S.</ce:given-name></sb:author><sb:author><ce:surname>Féger</ce:surname><ce:given-name>J.</ce:given-name></sb:author><sb:author><ce:surname>Calando</ce:surname><ce:given-name>Y.</ce:given-name></sb:author><sb:author><ce:surname>Seylaz</ce:surname><ce:given-name>J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Cardiovascular and cerebrovascular alterations elicited by cholinergic stimulation of the centromedian-parafascicular complex in the rat</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:editors><sb:editor><ce:surname>MacKenzie</ce:surname><ce:given-name>E.T.</ce:given-name></sb:editor></sb:editors><sb:title><sb:maintitle>Neurotransmission and Cerebrovascular Function</sb:maintitle></sb:title><sb:date>1989</sb:date><sb:publisher><sb:name>Elsevier Science</sb:name><sb:location>Amsterdam</sb:location></sb:publisher></sb:edited-book><sb:pages><sb:first-page>397</sb:first-page><sb:last-page>400</sb:last-page></sb:pages></sb:host><sb:comment>J.S.a.</sb:comment></sb:reference></ce:bib-reference><ce:bib-reference id="bib31"><ce:label>31.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Mraovitch</ce:surname><ce:given-name>S.</ce:given-name></sb:author><sb:author><ce:surname>Calando</ce:surname><ce:given-name>Y.</ce:given-name></sb:author><sb:author><ce:surname>Pinard</ce:surname><ce:given-name>E.</ce:given-name></sb:author><sb:author><ce:surname>Pearce</ce:surname><ce:given-name>W.J.</ce:given-name></sb:author><sb:author><ce:surname>Seylaz</ce:surname><ce:given-name>J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Differential cerebrovascular and metabolic responses in specific neural systems elicited from the centromedian-parafascicular complex</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neuroscience</sb:maintitle></sb:title><sb:volume-nr>49</sb:volume-nr></sb:series><sb:date>1992</sb:date></sb:issue><sb:pages><sb:first-page>451</sb:first-page><sb:last-page>466</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib32"><ce:label>32.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Paré</ce:surname><ce:given-name>D.</ce:given-name></sb:author><sb:author><ce:surname>Smith</ce:surname><ce:given-name>Y.</ce:given-name></sb:author><sb:author><ce:surname>Parent</ce:surname><ce:given-name>A.</ce:given-name></sb:author><sb:author><ce:surname>Steriade</ce:surname><ce:given-name>M.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Projection of brainstem core cholinergic and non-cholinergic neurons of cat to intralaminar and reticular thalamic nuclei</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neuroscience</sb:maintitle></sb:title><sb:volume-nr>25</sb:volume-nr></sb:series><sb:date>1988</sb:date></sb:issue><sb:pages><sb:first-page>69</sb:first-page><sb:last-page>86</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib33"><ce:label>33.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Paxinos</ce:surname><ce:given-name>G.</ce:given-name></sb:author><sb:author><ce:surname>Watson</ce:surname><ce:given-name>C.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>The Rat Brain in Stereotaxic Coordinates</sb:maintitle></sb:title></sb:contribution><sb:host><sb:book><sb:date>1986</sb:date><sb:publisher><sb:name>Academic Press</sb:name><sb:location>Sydney</sb:location></sb:publisher></sb:book></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib34"><ce:label>34.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Perkins</ce:surname><ce:given-name>M.N.</ce:given-name></sb:author><sb:author><ce:surname>Stone</ce:surname><ce:given-name>T.W.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Subthalamic projections to the globus pallidus: an electrophysiological study in the rat</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Expl Neurol.</sb:maintitle></sb:title><sb:volume-nr>68</sb:volume-nr></sb:series><sb:date>1980</sb:date></sb:issue><sb:pages><sb:first-page>500</sb:first-page><sb:last-page>511</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib35"><ce:label>35.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Raftery</ce:surname><ce:given-name>M.A.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Structural and functional aspects of the nicotinic acetylcholine receptor</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:edition>5th edn</sb:edition><sb:book-series><sb:editors><sb:editor><ce:surname>Magistretti</ce:surname><ce:given-name>P.J.</ce:given-name></sb:editor><sb:editor><ce:surname>Morrison</ce:surname><ce:given-name>J.H.</ce:given-name></sb:editor><sb:editor><ce:surname>Reisine</ce:surname><ce:given-name>T.D.</ce:given-name></sb:editor></sb:editors><sb:series><sb:title><sb:maintitle>Discussion in Neurosciences: Transduction of Neuronal Signals</sb:maintitle></sb:title><sb:volume-nr>Vol 3</sb:volume-nr></sb:series></sb:book-series><sb:date>1986</sb:date></sb:edited-book><sb:pages><sb:first-page>22</sb:first-page><sb:last-page>28</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib36"><ce:label>36.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Raos</ce:surname><ce:given-name>V.</ce:given-name></sb:author><sb:author><ce:surname>Bentivoglio</ce:surname><ce:given-name>M.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Crosstalk between the two sides of the thalamus through the reticular nucleus—a retrograde and anterograde tracing study in the rat</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. comp. Neurol.</sb:maintitle></sb:title><sb:volume-nr>332</sb:volume-nr></sb:series><sb:date>1993</sb:date></sb:issue><sb:pages><sb:first-page>115</sb:first-page><sb:last-page>154</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib37"><ce:label>37.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Robledo</ce:surname><ce:given-name>P.</ce:given-name></sb:author><sb:author><ce:surname>Vezolle</ce:surname><ce:given-name>I.</ce:given-name></sb:author><sb:author><ce:surname>Féger</ce:surname><ce:given-name>J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Mise enévidence d'un effet excitateur des efférences subthalamo-nigrales et subthalamo-pallidales chez le rat</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>C. r. hebd séanc. Acad. Sci., Paris</sb:maintitle></sb:title><sb:volume-nr>307</sb:volume-nr></sb:series><sb:date>1988</sb:date></sb:issue><sb:pages><sb:first-page>133</sb:first-page><sb:last-page>138</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib38"><ce:label>38.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Robledo</ce:surname><ce:given-name>P.</ce:given-name></sb:author><sb:author><ce:surname>Féger</ce:surname><ce:given-name>J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Excitatory influence of rat subthalamic nucleus to substantia nigra pars reticulata and the pallidal complex: electrophysiological data</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Brain Res.</sb:maintitle></sb:title><sb:volume-nr>518</sb:volume-nr></sb:series><sb:date>1990</sb:date></sb:issue><sb:pages><sb:first-page>47</sb:first-page><sb:last-page>54</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib39"><ce:label>39.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Romo</ce:surname><ce:given-name>R.</ce:given-name></sb:author><sb:author><ce:surname>Chéramy</ce:surname><ce:given-name>A.</ce:given-name></sb:author><sb:author><ce:surname>Desban</ce:surname><ce:given-name>M.</ce:given-name></sb:author><sb:author><ce:surname>Godeheu</ce:surname><ce:given-name>G.</ce:given-name></sb:author><sb:author><ce:surname>Glowinski</ce:surname><ce:given-name>J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>GABA in the intralaminar thalamic nuclei modulates dopamine release from the two dopaminergic nigro-striatal pathways in the cat</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Brain Res. Bull.</sb:maintitle></sb:title><sb:volume-nr>11</sb:volume-nr></sb:series><sb:date>1983</sb:date></sb:issue><sb:pages><sb:first-page>671</sb:first-page><sb:last-page>680</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib40"><ce:label>40.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Rouzaire-Dubois</ce:surname><ce:given-name>B.</ce:given-name></sb:author><sb:author><ce:surname>Hammond</ce:surname><ce:given-name>C.</ce:given-name></sb:author><sb:author><ce:surname>Hamon</ce:surname><ce:given-name>B.</ce:given-name></sb:author><sb:author><ce:surname>Féger</ce:surname><ce:given-name>J.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Pharmacological blockade of the globus pallidus-induced inhibitory responses of the subthalamic cells in the rat</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Brain Res.</sb:maintitle></sb:title><sb:volume-nr>200</sb:volume-nr></sb:series><sb:date>1980</sb:date></sb:issue><sb:pages><sb:first-page>321</sb:first-page><sb:last-page>329</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib41"><ce:label>41.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Rouzaire-Dubois</ce:surname><ce:given-name>B.</ce:given-name></sb:author><sb:author><ce:surname>Scarnati</ce:surname><ce:given-name>E.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Bilateral corticosubthalamic nucleus projections: an electrophysiological study in rats with chronic cerebral lesions</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neuroscience</sb:maintitle></sb:title><sb:volume-nr>15</sb:volume-nr></sb:series><sb:date>1985</sb:date></sb:issue><sb:pages><sb:first-page>69</sb:first-page><sb:last-page>79</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib42"><ce:label>42.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Rouzaire-Dubois</ce:surname><ce:given-name>B.</ce:given-name></sb:author><sb:author><ce:surname>Scarnati</ce:surname><ce:given-name>E.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Increase in glutamate sensitivity of subthalamic neurons following bilateral decortication: a microiontophoretic study in the rat</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Brain Res.</sb:maintitle></sb:title><sb:volume-nr>403</sb:volume-nr></sb:series><sb:date>1987</sb:date></sb:issue><sb:pages><sb:first-page>366</sb:first-page><sb:last-page>370</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib43"><ce:label>43.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Rouzaire-Dubois</ce:surname><ce:given-name>B.</ce:given-name></sb:author><sb:author><ce:surname>Scarnati</ce:surname><ce:given-name>E.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Pharmacological study of the cortical-induced excitation of subthalamic nucleus neurones in the rat: evidence for amino acids as putative neurotransmitters</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neuroscience</sb:maintitle></sb:title><sb:volume-nr>21</sb:volume-nr></sb:series><sb:date>1987</sb:date></sb:issue><sb:pages><sb:first-page>429</sb:first-page><sb:last-page>440</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib44"><ce:label>44.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Semba</ce:surname><ce:given-name>K.</ce:given-name></sb:author><sb:author><ce:surname>Reiner</ce:surname><ce:given-name>P.B.</ce:given-name></sb:author><sb:author><ce:surname>Fibiger</ce:surname><ce:given-name>H.C.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Single cholinergic mesopontine tegmental neurons project to both the pontine reticular formation and the thalamus in the rat</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neuroscience</sb:maintitle></sb:title><sb:volume-nr>38</sb:volume-nr></sb:series><sb:date>1990</sb:date></sb:issue><sb:pages><sb:first-page>643</sb:first-page><sb:last-page>654</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib45"><ce:label>45.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Sugimoto</ce:surname><ce:given-name>T.</ce:given-name></sb:author><sb:author><ce:surname>Hattori</ce:surname><ce:given-name>T.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Confirmation of thalamosubthalamic projections by electron microscopic autoradiography</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Brain Res.</sb:maintitle></sb:title><sb:volume-nr>264</sb:volume-nr></sb:series><sb:date>1983</sb:date></sb:issue><sb:pages><sb:first-page>335</sb:first-page><sb:last-page>339</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib46"><ce:label>46.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Sugimoto</ce:surname><ce:given-name>T.</ce:given-name></sb:author><sb:author><ce:surname>Hattori</ce:surname><ce:given-name>T.</ce:given-name></sb:author><sb:author><ce:surname>Mizuno</ce:surname><ce:given-name>N.</ce:given-name></sb:author><sb:author><ce:surname>Itoh</ce:surname><ce:given-name>K.</ce:given-name></sb:author><sb:author><ce:surname>Sato</ce:surname><ce:given-name>M.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Direct projection from the centremédian-parafascicular complex to the subthalamic nucleus in the cat and rat</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. comp. Neurol.</sb:maintitle></sb:title><sb:volume-nr>211</sb:volume-nr></sb:series><sb:date>1983</sb:date></sb:issue><sb:pages><sb:first-page>209</sb:first-page><sb:last-page>216</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib47"><ce:label>47.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Van Der Kooy</ce:surname><ce:given-name>D.</ce:given-name></sb:author><sb:author><ce:surname>Hattori</ce:surname><ce:given-name>T.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Single subthalamic neurons project to both the globus pallidus and the substantia nigra in the rat</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. comp. Neurol.</sb:maintitle></sb:title><sb:volume-nr>192</sb:volume-nr></sb:series><sb:date>1980</sb:date></sb:issue><sb:pages><sb:first-page>751</sb:first-page><sb:last-page>790</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib48"><ce:label>48.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Wilson</ce:surname><ce:given-name>C.J.</ce:given-name></sb:author><sb:author><ce:surname>Chang</ce:surname><ce:given-name>J.T.</ce:given-name></sb:author><sb:author><ce:surname>Kitai</ce:surname><ce:given-name>S.T.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Origins of postsynaptic potentials evoked in spiny neostriatal neurons by thalamic stimulation in the rat</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Expl Brain Res.</sb:maintitle></sb:title><sb:volume-nr>51</sb:volume-nr></sb:series><sb:date>1983</sb:date></sb:issue><sb:pages><sb:first-page>217</sb:first-page><sb:last-page>226</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib49"><ce:label>49.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Wilson</ce:surname><ce:given-name>C.J.</ce:given-name></sb:author><sb:author><ce:surname>Chang</ce:surname><ce:given-name>H.T.</ce:given-name></sb:author><sb:author><ce:surname>Kitai</ce:surname><ce:given-name>S.T.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Firing patterns and synaptic potentials of identified giant aspiny interneurons in the rat neostriatum</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Neurosci.</sb:maintitle></sb:title><sb:volume-nr>10</sb:volume-nr></sb:series><sb:date>1990</sb:date></sb:issue><sb:pages><sb:first-page>508</sb:first-page><sb:last-page>519</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib50"><ce:label>50.</ce:label><sb:reference><sb:contribution><sb:authors><sb:author><ce:surname>Wolfe</ce:surname><ce:given-name>B.B.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Subtypes of muscarinic cholinergic receptors: ligand binding, functional studies and cloning</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:editors><sb:editor><ce:surname>Brown</ce:surname><ce:given-name>J.H.</ce:given-name></sb:editor></sb:editors><sb:title><sb:maintitle>The Muscarinic Receptors</sb:maintitle></sb:title><sb:date>1989</sb:date><sb:publisher><sb:name>Humana Press</sb:name><sb:location>Clifton, New Jersey</sb:location></sb:publisher></sb:edited-book><sb:pages><sb:first-page>125</sb:first-page><sb:last-page>150</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference></ce:bibliography-sec></ce:bibliography></tail></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Electrophysiological study of the excitatory parafascicular projection to the subthalamic nucleus and evidence for ipsi- and contralateral controls</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Electrophysiological study of the excitatory parafascicular projection to the subthalamic nucleus and evidence for ipsi- and contralateral controls</title></titleInfo><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Mouroux</namePart><affiliation>Laboratoire de Pharmacologie, Facultédes Sciences Pharmaceutiques et Biologiques, UniversitéR. Descartes, 4 avenue de l'Observatoire, Paris, France</affiliation><description>To whom correspondence should be addressed.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O.-K.</namePart><namePart type="family">Hassani</namePart><affiliation>Laboratoire de Pharmacologie, Facultédes Sciences Pharmaceutiques et Biologiques, UniversitéR. Descartes, 4 avenue de l'Observatoire, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Féger</namePart><affiliation>Laboratoire de Pharmacologie, Facultédes Sciences Pharmaceutiques et Biologiques, UniversitéR. Descartes, 4 avenue de l'Observatoire, Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1995</dateIssued><copyrightDate encoding="w3cdtf">1995</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Abstract: The activity of subthalamic neurons was recorded extracellularly in anaesthetized rats after stimulation, inhibition or lesioning of the parafascicular nucleus. Electrical stimulation of the parafascicular nucleus evoked a complex response with two excitatory phases. The first response was correlated with a monosynaptically-driven excitation via a parafascicular input to the subthalamic nucleus. Since the second phase was observed even when the early excitation was not recorded and was eliminated by lesion of the globus pallidus, we suggest that it is not generated by a mechanism intrinsic to the subthalamic nucleus and is due to a disinhibitory effect originating from the globus pallidus. Microinjection of carbachol into the parafascicular nucleus enhanced by 119% the discharge rate of the neurons in the ipsilateral subthalamic nucleus and that of muscimol decreased the discharge rate by 91%. Opposite changes, a decrease of the discharge rate of 49% after microinjection of carbachol and an increase of 47% after muscimol, occurred in the contralateral subthalamic nucleus. In contrast to the above results, the unilateral excitotoxic lesion of the parafascicular nucleus, performed one week before recording, decreased the discharge rate by 69% of the ipsilateral subthalamic nucleus neurons and by 34% that of the contralateral neurons.We suggest that the parafascicular input to the subthalamic nucleus is an excitatory pathway which can tonically drive the neuronal activity in this structure. The opposite changes recorded in the ipsi- and contralateral subthalamic nucleus during unilateral microinjection of excitatory or inhibitory drugs in the parafascicular nucleus emphasize the importance of this thalamic structure in the bilateral regulation of basal ganglia activity via the subthalamic nucleus.</abstract><relatedItem type="host"><titleInfo><title>Neuroscience</title></titleInfo><titleInfo type="abbreviated"><title>NSC</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199507</dateIssued></originInfo><identifier type="ISSN">0306-4522</identifier><identifier type="PII">S0306-4522(00)X0026-7</identifier><part><date>199507</date><detail type="volume"><number>67</number><caption>vol.</caption></detail><detail type="issue"><number>2</number><caption>no.</caption></detail><extent unit="issue pages"><start>263</start><end>524</end></extent><extent unit="pages"><start>399</start><end>407</end></extent></part></relatedItem><identifier type="istex">BC0FDA4EAAAF7B38ADF7D9B0262DD9B9F2075C4D</identifier><identifier type="DOI">10.1016/0306-4522(95)00032-E</identifier><identifier type="PII">0306-4522(95)00032-E</identifier><identifier type="ArticleID">9500032E</identifier><accessCondition type="use and reproduction" contentType="copyright">©1995 IBRO</accessCondition><recordInfo><recordContentSource>ELSEVIER</recordContentSource><recordOrigin>IBRO, ©1995</recordOrigin></recordInfo></mods></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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