Application of a new method based on conductivity measurements to determine the creaming stability of o/w emulsions
Identifieur interne : 001857 ( Istex/Corpus ); précédent : 001856; suivant : 001858Application of a new method based on conductivity measurements to determine the creaming stability of o/w emulsions
Auteurs : M. Bury ; J. Gerhards ; W. Erni ; A. StammSource :
- International Journal of Pharmaceutics [ 0378-5173 ] ; 1995.
Abstract
A kinetic model, based on equations used in biological population dynamics, is proposed to describe the creaming profile of oil-in-water emulsions at the top of a storage cell. The creaming profile itself is determined by conductivity measurements through the emulsion at different heights, and conversion of conductivities into volume fraction values of the dispersed phase in terms of dispersion dielectric theory. The reliability of the proposed model was successfully verified. This methodology (conductivity method and kinetic model) was applied to model emulsions, to analyze the most reliable test scheme for stability assessment (room temperature storage, temperature stress test, and low centrifugational stress test). The conductivity method is sensitive to small changes in the volume fraction of dispersed phase observed at room temperature. The creaming profile can then be analyzed with the kinetic model allowing extrapolations for long-term predictions and shortening the time needed for stability assessments. Additionally, an Arrhenius-type equation relating the creaming rate constants with the corresponding storage temperatures can principally be employed. With regard to centrifugation stress testing, if under centrifugation no creaming can be observed, it is normally correct to assume that the emulsion will be stable at normal gravitational condition. However, the reverse argument does not always apply.
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DOI: 10.1016/0378-5173(95)00075-T
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Bury</name><affiliation><mods:affiliation>Pharma Division Preclinical Research, F. Hoffmann-La Roche Ltd, CH-4002 Basel, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Gerhards, J" sort="Gerhards, J" uniqKey="Gerhards J" first="J." last="Gerhards">J. Gerhards</name><affiliation><mods:affiliation>Pharma Division Preclinical Research, F. Hoffmann-La Roche Ltd, CH-4002 Basel, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Erni, W" sort="Erni, W" uniqKey="Erni W" first="W." last="Erni">W. Erni</name><affiliation><mods:affiliation>Pharma Division Preclinical Research, F. Hoffmann-La Roche Ltd, CH-4002 Basel, Switzerland</mods:affiliation></affiliation></author><author><name sortKey="Stamm, A" sort="Stamm, A" uniqKey="Stamm A" first="A." last="Stamm">A. Stamm</name><affiliation><mods:affiliation>Laboratoire de Pharmacotechnie, UFR Pharmacie - ULP Strasbourg I, BP 24 Illkirch, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">International Journal of Pharmaceutics</title><title level="j" type="abbrev">IJP</title><idno type="ISSN">0378-5173</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1995">1995</date><biblScope unit="volume">124</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="183">183</biblScope><biblScope unit="page" to="194">194</biblScope></imprint><idno type="ISSN">0378-5173</idno></series><idno type="istex">6F50CDE698D07FBA4B3E681EB3AFDF502B3769AC</idno><idno type="DOI">10.1016/0378-5173(95)00075-T</idno><idno type="PII">0378-5173(95)00075-T</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0378-5173</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A kinetic model, based on equations used in biological population dynamics, is proposed to describe the creaming profile of oil-in-water emulsions at the top of a storage cell. The creaming profile itself is determined by conductivity measurements through the emulsion at different heights, and conversion of conductivities into volume fraction values of the dispersed phase in terms of dispersion dielectric theory. The reliability of the proposed model was successfully verified. This methodology (conductivity method and kinetic model) was applied to model emulsions, to analyze the most reliable test scheme for stability assessment (room temperature storage, temperature stress test, and low centrifugational stress test). The conductivity method is sensitive to small changes in the volume fraction of dispersed phase observed at room temperature. The creaming profile can then be analyzed with the kinetic model allowing extrapolations for long-term predictions and shortening the time needed for stability assessments. Additionally, an Arrhenius-type equation relating the creaming rate constants with the corresponding storage temperatures can principally be employed. With regard to centrifugation stress testing, if under centrifugation no creaming can be observed, it is normally correct to assume that the emulsion will be stable at normal gravitational condition. However, the reverse argument does not always apply.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>M. Bury</name><affiliations><json:string>Pharma Division Preclinical Research, F. Hoffmann-La Roche Ltd, CH-4002 Basel, Switzerland</json:string></affiliations></json:item><json:item><name>J. Gerhards</name><affiliations><json:string>Pharma Division Preclinical Research, F. Hoffmann-La Roche Ltd, CH-4002 Basel, Switzerland</json:string></affiliations></json:item><json:item><name>W. Erni</name><affiliations><json:string>Pharma Division Preclinical Research, F. Hoffmann-La Roche Ltd, CH-4002 Basel, Switzerland</json:string></affiliations></json:item><json:item><name>A. Stamm</name><affiliations><json:string>Laboratoire de Pharmacotechnie, UFR Pharmacie - ULP Strasbourg I, BP 24 Illkirch, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>o/w emulsion</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Creaming</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Conductivity measurement</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Kinetic model</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Testing program</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>A kinetic model, based on equations used in biological population dynamics, is proposed to describe the creaming profile of oil-in-water emulsions at the top of a storage cell. The creaming profile itself is determined by conductivity measurements through the emulsion at different heights, and conversion of conductivities into volume fraction values of the dispersed phase in terms of dispersion dielectric theory. The reliability of the proposed model was successfully verified. This methodology (conductivity method and kinetic model) was applied to model emulsions, to analyze the most reliable test scheme for stability assessment (room temperature storage, temperature stress test, and low centrifugational stress test). The conductivity method is sensitive to small changes in the volume fraction of dispersed phase observed at room temperature. The creaming profile can then be analyzed with the kinetic model allowing extrapolations for long-term predictions and shortening the time needed for stability assessments. Additionally, an Arrhenius-type equation relating the creaming rate constants with the corresponding storage temperatures can principally be employed. With regard to centrifugation stress testing, if under centrifugation no creaming can be observed, it is normally correct to assume that the emulsion will be stable at normal gravitational condition. However, the reverse argument does not always apply.</abstract><qualityIndicators><score>7.424</score><pdfVersion>1.2</pdfVersion><pdfPageSize>555 x 749 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>1430</abstractCharCount><pdfWordCount>5998</pdfWordCount><pdfCharCount>33456</pdfCharCount><pdfPageCount>12</pdfPageCount><abstractWordCount>202</abstractWordCount></qualityIndicators><title>Application of a new method based on conductivity measurements to determine the creaming stability of o/w emulsions</title><pii><json:string>0378-5173(95)00075-T</json:string></pii><refBibs><json:item><author><json:item><name>P. Becher</name></json:item></author><host><pages><first>423</first></pages><author></author></host><title>Emulsions: Theory and Practice</title></json:item><json:item><author><json:item><name>W. 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Hoffmann-La Roche Ltd, CH-4002 Basel, Switzerland</affiliation></author><author xml:id="author-2"><persName><forename type="first">J.</forename><surname>Gerhards</surname></persName><affiliation>Pharma Division Preclinical Research, F. Hoffmann-La Roche Ltd, CH-4002 Basel, Switzerland</affiliation></author><author xml:id="author-3"><persName><forename type="first">W.</forename><surname>Erni</surname></persName><affiliation>Pharma Division Preclinical Research, F. Hoffmann-La Roche Ltd, CH-4002 Basel, Switzerland</affiliation></author><author xml:id="author-4"><persName><forename type="first">A.</forename><surname>Stamm</surname></persName><affiliation>Laboratoire de Pharmacotechnie, UFR Pharmacie - ULP Strasbourg I, BP 24 Illkirch, France</affiliation></author></analytic><monogr><title level="j">International Journal of Pharmaceutics</title><title level="j" type="abbrev">IJP</title><idno type="pISSN">0378-5173</idno><idno type="PII">S0378-5173(00)X0017-8</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1995"></date><biblScope unit="volume">124</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="183">183</biblScope><biblScope unit="page" to="194">194</biblScope></imprint></monogr><idno type="istex">6F50CDE698D07FBA4B3E681EB3AFDF502B3769AC</idno><idno type="DOI">10.1016/0378-5173(95)00075-T</idno><idno type="PII">0378-5173(95)00075-T</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1995</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>A kinetic model, based on equations used in biological population dynamics, is proposed to describe the creaming profile of oil-in-water emulsions at the top of a storage cell. The creaming profile itself is determined by conductivity measurements through the emulsion at different heights, and conversion of conductivities into volume fraction values of the dispersed phase in terms of dispersion dielectric theory. The reliability of the proposed model was successfully verified. This methodology (conductivity method and kinetic model) was applied to model emulsions, to analyze the most reliable test scheme for stability assessment (room temperature storage, temperature stress test, and low centrifugational stress test). The conductivity method is sensitive to small changes in the volume fraction of dispersed phase observed at room temperature. The creaming profile can then be analyzed with the kinetic model allowing extrapolations for long-term predictions and shortening the time needed for stability assessments. Additionally, an Arrhenius-type equation relating the creaming rate constants with the corresponding storage temperatures can principally be employed. With regard to centrifugation stress testing, if under centrifugation no creaming can be observed, it is normally correct to assume that the emulsion will be stable at normal gravitational condition. However, the reverse argument does not always apply.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>o/w emulsion</term></item><item><term>Creaming</term></item><item><term>Conductivity measurement</term></item><item><term>Kinetic model</term></item><item><term>Testing program</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1995">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/6F50CDE698D07FBA4B3E681EB3AFDF502B3769AC/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>IJP</jid><aid>9500075T</aid><ce:pii>0378-5173(95)00075-T</ce:pii><ce:doi>10.1016/0378-5173(95)00075-T</ce:doi><ce:copyright type="unknown" year="1995"></ce:copyright></item-info><head><ce:dochead><ce:textfn>Research paper</ce:textfn></ce:dochead><ce:title>Application of a new method based on conductivity measurements to determine the creaming stability of o/w emulsions</ce:title><ce:author-group><ce:author><ce:given-name>M.</ce:given-name><ce:surname>Bury</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>J.</ce:given-name><ce:surname>Gerhards</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>W.</ce:given-name><ce:surname>Erni</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>a</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>A.</ce:given-name><ce:surname>Stamm</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>b</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Pharma Division Preclinical Research, F. Hoffmann-La Roche Ltd, CH-4002 Basel, Switzerland</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Laboratoire de Pharmacotechnie, UFR Pharmacie - ULP Strasbourg I, BP 24 Illkirch, France</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Corresponding author.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="11" month="11" year="1994"></ce:date-received><ce:date-accepted day="9" month="2" year="1995"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>A kinetic model, based on equations used in biological population dynamics, is proposed to describe the creaming profile of oil-in-water emulsions at the top of a storage cell. The creaming profile itself is determined by conductivity measurements through the emulsion at different heights, and conversion of conductivities into volume fraction values of the dispersed phase in terms of dispersion dielectric theory. The reliability of the proposed model was successfully verified. This methodology (conductivity method and kinetic model) was applied to model emulsions, to analyze the most reliable test scheme for stability assessment (room temperature storage, temperature stress test, and low centrifugational stress test). The conductivity method is sensitive to small changes in the volume fraction of dispersed phase observed at room temperature. The creaming profile can then be analyzed with the kinetic model allowing extrapolations for long-term predictions and shortening the time needed for stability assessments. Additionally, an Arrhenius-type equation relating the creaming rate constants with the corresponding storage temperatures can principally be employed. With regard to centrifugation stress testing, if under centrifugation no creaming can be observed, it is normally correct to assume that the emulsion will be stable at normal gravitational condition. However, the reverse argument does not always apply.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>o/w emulsion</ce:text></ce:keyword><ce:keyword><ce:text>Creaming</ce:text></ce:keyword><ce:keyword><ce:text>Conductivity measurement</ce:text></ce:keyword><ce:keyword><ce:text>Kinetic model</ce:text></ce:keyword><ce:keyword><ce:text>Testing program</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Application of a new method based on conductivity measurements to determine the creaming stability of o/w emulsions</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Application of a new method based on conductivity measurements to determine the creaming stability of o/w emulsions</title></titleInfo><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Bury</namePart><affiliation>Pharma Division Preclinical Research, F. Hoffmann-La Roche Ltd, CH-4002 Basel, Switzerland</affiliation><description>Corresponding author.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Gerhards</namePart><affiliation>Pharma Division Preclinical Research, F. Hoffmann-La Roche Ltd, CH-4002 Basel, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Erni</namePart><affiliation>Pharma Division Preclinical Research, F. Hoffmann-La Roche Ltd, CH-4002 Basel, Switzerland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Stamm</namePart><affiliation>Laboratoire de Pharmacotechnie, UFR Pharmacie - ULP Strasbourg I, BP 24 Illkirch, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1995</dateIssued><copyrightDate encoding="w3cdtf">1995</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">A kinetic model, based on equations used in biological population dynamics, is proposed to describe the creaming profile of oil-in-water emulsions at the top of a storage cell. The creaming profile itself is determined by conductivity measurements through the emulsion at different heights, and conversion of conductivities into volume fraction values of the dispersed phase in terms of dispersion dielectric theory. The reliability of the proposed model was successfully verified. This methodology (conductivity method and kinetic model) was applied to model emulsions, to analyze the most reliable test scheme for stability assessment (room temperature storage, temperature stress test, and low centrifugational stress test). The conductivity method is sensitive to small changes in the volume fraction of dispersed phase observed at room temperature. The creaming profile can then be analyzed with the kinetic model allowing extrapolations for long-term predictions and shortening the time needed for stability assessments. Additionally, an Arrhenius-type equation relating the creaming rate constants with the corresponding storage temperatures can principally be employed. With regard to centrifugation stress testing, if under centrifugation no creaming can be observed, it is normally correct to assume that the emulsion will be stable at normal gravitational condition. However, the reverse argument does not always apply.</abstract><note type="content">Section title: Research paper</note><subject><genre>Keywords</genre><topic>o/w emulsion</topic><topic>Creaming</topic><topic>Conductivity measurement</topic><topic>Kinetic model</topic><topic>Testing program</topic></subject><relatedItem type="host"><titleInfo><title>International Journal of Pharmaceutics</title></titleInfo><titleInfo type="abbreviated"><title>IJP</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">19951003</dateIssued></originInfo><identifier type="ISSN">0378-5173</identifier><identifier type="PII">S0378-5173(00)X0017-8</identifier><part><date>19951003</date><detail type="volume"><number>124</number><caption>vol.</caption></detail><detail type="issue"><number>2</number><caption>no.</caption></detail><extent unit="issue pages"><start>149</start><end>295</end></extent><extent unit="pages"><start>183</start><end>194</end></extent></part></relatedItem><identifier type="istex">6F50CDE698D07FBA4B3E681EB3AFDF502B3769AC</identifier><identifier type="DOI">10.1016/0378-5173(95)00075-T</identifier><identifier type="PII">0378-5173(95)00075-T</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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