Neurodegenerative Diseases and Exposure to Pesticides in the Elderly
Identifieur interne : 001361 ( Istex/Corpus ); précédent : 001360; suivant : 001362Neurodegenerative Diseases and Exposure to Pesticides in the Elderly
Auteurs : Isabelle Baldi ; Pierre Lebailly ; Brahim Mohammed-Brahim ; Luc Letenneur ; Jean-Franc Ois Dartigues ; Patrick BrochardSource :
- American Journal of Epidemiology [ 0002-9262 ] ; 2003-03-01.
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Abstract
The authors investigated the hypothesis that exposure to pesticides could be related to central nervous system disorders in a prospective cohort study of 1,507 French elderly (1992–1998). Lower cognitive performance was observed in subjects who had been occupationally exposed to pesticides. In men, the relative risks of developing Parkinson’s disease and Alzheimer’s disease for occupational exposure assessed by a job exposure matrix were 5.63 (95% confidence interval: 1.47, 21.58) and 2.39 (95% confidence interval: 1.02, 5.63), respectively, after confounding factors were taken into account. No association was found with having a primary job in agriculture or with environmental pesticide exposure, nor was an association found in women. These results suggest the presence of neurologic impairments in elderly persons who were exposed occupationally to pesticides.
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DOI: 10.1093/aje/kwf216
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ISTEX:DF17F05CDBBBE05AAB4433FBA8FF7E3895301C5DLe document en format XML
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France.</mods:affiliation></affiliation></author><author><name sortKey="Letenneur, Luc" sort="Letenneur, Luc" uniqKey="Letenneur L" first="Luc" last="Letenneur">Luc Letenneur</name><affiliation><mods:affiliation>INSERM U330, Université Victor Segalen Bordeaux 2, Bordeaux, France.</mods:affiliation></affiliation></author><author><name sortKey="Dartigues, Jean Franc Ois" sort="Dartigues, Jean Franc Ois" uniqKey="Dartigues J" first="Jean-Franc Ois" last="Dartigues">Jean-Franc Ois Dartigues</name><affiliation><mods:affiliation>INSERM U330, Université Victor Segalen Bordeaux 2, Bordeaux, France.</mods:affiliation></affiliation></author><author><name sortKey="Brochard, Patrick" sort="Brochard, Patrick" uniqKey="Brochard P" first="Patrick" last="Brochard">Patrick Brochard</name><affiliation><mods:affiliation>Laboratoire Santé Travail Environnement, Institut de Santé Publique d’Epidémiologie et de Développement, Université Victor Segalen Bordeaux 2, Bordeaux, France.</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">American Journal of Epidemiology</title><title level="j" type="abbrev">Am. 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Epidemiol.</title><idno type="ISSN">0002-9262</idno><idno type="eISSN">1476-6256</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2003-03-01">2003-03-01</date><biblScope unit="volume">157</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="409">409</biblScope><biblScope unit="page" to="414">414</biblScope></imprint><idno type="ISSN">0002-9262</idno></series><idno type="istex">DF17F05CDBBBE05AAB4433FBA8FF7E3895301C5D</idno><idno type="DOI">10.1093/aje/kwf216</idno><idno type="local">kwf216</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0002-9262</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abbreviations: CI, confidence interval; MMSE, Mini-Mental State Examination.</term><term>aged; Alzheimer disease; nervous system diseases; occupational exposure; Parkinson disease; pesticides</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The authors investigated the hypothesis that exposure to pesticides could be related to central nervous system disorders in a prospective cohort study of 1,507 French elderly (1992–1998). Lower cognitive performance was observed in subjects who had been occupationally exposed to pesticides. In men, the relative risks of developing Parkinson’s disease and Alzheimer’s disease for occupational exposure assessed by a job exposure matrix were 5.63 (95% confidence interval: 1.47, 21.58) and 2.39 (95% confidence interval: 1.02, 5.63), respectively, after confounding factors were taken into account. No association was found with having a primary job in agriculture or with environmental pesticide exposure, nor was an association found in women. These results suggest the presence of neurologic impairments in elderly persons who were exposed occupationally to pesticides.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>Isabelle Baldi</name><affiliations><json:string>Laboratoire Santé Travail Environnement, Institut de Santé Publique d’Epidémiologie et de Développement, Université Victor Segalen Bordeaux 2, Bordeaux, France.</json:string></affiliations></json:item><json:item><name>Pierre Lebailly</name><affiliations><json:string>Groupe Régional d’Etudes sur le Cancer, Centre François Baclesse, Université de Caen, Caen, France.</json:string></affiliations></json:item><json:item><name>Brahim Mohammed-Brahim</name><affiliations><json:string>Laboratoire Santé Travail Environnement, Institut de Santé Publique d’Epidémiologie et de Développement, Université Victor Segalen Bordeaux 2, Bordeaux, France.</json:string></affiliations></json:item><json:item><name>Luc Letenneur</name><affiliations><json:string>INSERM U330, Université Victor Segalen Bordeaux 2, Bordeaux, France.</json:string></affiliations></json:item><json:item><name>Jean-François Dartigues</name><affiliations><json:string>INSERM U330, Université Victor Segalen Bordeaux 2, Bordeaux, France.</json:string></affiliations></json:item><json:item><name>Patrick Brochard</name><affiliations><json:string>Laboratoire Santé Travail Environnement, Institut de Santé Publique d’Epidémiologie et de Développement, Université Victor Segalen Bordeaux 2, Bordeaux, France.</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>aged; Alzheimer disease; nervous system diseases; occupational exposure; Parkinson disease; pesticides</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Abbreviations: CI, confidence interval; MMSE, Mini-Mental State Examination.</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>research-article</json:string></originalGenre><abstract>The authors investigated the hypothesis that exposure to pesticides could be related to central nervous system disorders in a prospective cohort study of 1,507 French elderly (1992–1998). Lower cognitive performance was observed in subjects who had been occupationally exposed to pesticides. In men, the relative risks of developing Parkinson’s disease and Alzheimer’s disease for occupational exposure assessed by a job exposure matrix were 5.63 (95% confidence interval: 1.47, 21.58) and 2.39 (95% confidence interval: 1.02, 5.63), respectively, after confounding factors were taken into account. No association was found with having a primary job in agriculture or with environmental pesticide exposure, nor was an association found in women. These results suggest the presence of neurologic impairments in elderly persons who were exposed occupationally to pesticides.</abstract><qualityIndicators><score>6.797</score><pdfVersion>1.3</pdfVersion><pdfPageSize>612 x 792 pts (letter)</pdfPageSize><refBibsNative>false</refBibsNative><keywordCount>2</keywordCount><abstractCharCount>872</abstractCharCount><pdfWordCount>3309</pdfWordCount><pdfCharCount>22119</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>124</abstractWordCount></qualityIndicators><title>Neurodegenerative Diseases and Exposure to Pesticides in the Elderly</title><refBibs><json:item><author><json:item><name>D Lilienfeld</name></json:item><json:item><name>D Perl</name></json:item></author><host><volume>13</volume><pages><last>86</last><first>179</first></pages><author></author><title>Neuroepidemiology</title><publicationDate>1900</publicationDate></host><title>Projected neuro-degenerative disease mortality among minorities in the United 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J. Epidemiol.</title><idno type="pISSN">0002-9262</idno><idno type="eISSN">1476-6256</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2003-03-01"></date><biblScope unit="volume">157</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="409">409</biblScope><biblScope unit="page" to="414">414</biblScope></imprint></monogr><idno type="istex">DF17F05CDBBBE05AAB4433FBA8FF7E3895301C5D</idno><idno type="DOI">10.1093/aje/kwf216</idno><idno type="local">kwf216</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2003</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The authors investigated the hypothesis that exposure to pesticides could be related to central nervous system disorders in a prospective cohort study of 1,507 French elderly (1992–1998). Lower cognitive performance was observed in subjects who had been occupationally exposed to pesticides. In men, the relative risks of developing Parkinson’s disease and Alzheimer’s disease for occupational exposure assessed by a job exposure matrix were 5.63 (95% confidence interval: 1.47, 21.58) and 2.39 (95% confidence interval: 1.02, 5.63), respectively, after confounding factors were taken into account. No association was found with having a primary job in agriculture or with environmental pesticide exposure, nor was an association found in women. These results suggest the presence of neurologic impairments in elderly persons who were exposed occupationally to pesticides.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>KWD</head><item><term>aged; Alzheimer disease; nervous system diseases; occupational exposure; Parkinson disease; pesticides</term></item></list></keywords></textClass><textClass xml:lang="en"><keywords scheme="keyword"><list><head>ABR</head><item><term>Abbreviations: CI, confidence interval; MMSE, Mini-Mental State Examination.</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2003-03-01">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-12-22">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/DF17F05CDBBBE05AAB4433FBA8FF7E3895301C5D/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="US-ASCII"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article xml:lang="en" article-type="research-article"><front><journal-meta><journal-id journal-id-type="hwp">amjepid</journal-id><journal-id journal-id-type="nlm-ta">Am J Epidemiol</journal-id><journal-id journal-id-type="publisher-id">aje</journal-id><journal-title>American Journal of Epidemiology</journal-title><abbrev-journal-title abbrev-type="publisher">Am. J. Epidemiol.</abbrev-journal-title><issn pub-type="ppub">0002-9262</issn><issn pub-type="epub">1476-6256</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="other">kwf216</article-id><article-id pub-id-type="doi">10.1093/aje/kwf216</article-id><article-categories><subj-group subj-group-type="heading"><subject>ORIGINAL CONTRIBUTIONS</subject></subj-group></article-categories><title-group><article-title>Neurodegenerative Diseases and Exposure to Pesticides in the Elderly</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Baldi</surname><given-names>Isabelle</given-names></name><xref rid="CHDIBBFA">1</xref><xref rid="FN1"></xref></contrib><contrib contrib-type="author"><name><surname>Lebailly</surname><given-names>Pierre</given-names></name><xref rid="CHDBCGBI">2</xref></contrib><contrib contrib-type="author"><name><surname>Mohammed-Brahim</surname><given-names>Brahim</given-names></name><xref rid="CHDIBBFA">1</xref></contrib><contrib contrib-type="author"><name><surname>Letenneur</surname><given-names>Luc</given-names></name><xref rid="CHDEIFJD">3</xref></contrib><contrib contrib-type="author"><name><surname>Dartigues</surname><given-names>Jean-François</given-names></name><xref rid="CHDEIFJD">3</xref></contrib><contrib contrib-type="author"><name><surname>Brochard</surname><given-names>Patrick</given-names></name><xref rid="CHDIBBFA">1</xref></contrib><aff id="CHDIBBFA"><label>1</label> Laboratoire Santé Travail Environnement, Institut de Santé Publique d’Epidémiologie et de Développement, Université Victor Segalen Bordeaux 2, Bordeaux, France. </aff><aff id="CHDBCGBI"><label>2</label> Groupe Régional d’Etudes sur le Cancer, Centre François Baclesse, Université de Caen, Caen, France. </aff><aff id="CHDEIFJD"><label>3</label> INSERM U330, Université Victor Segalen Bordeaux 2, Bordeaux, France.</aff></contrib-group><pub-date pub-type="ppub"><day>01</day><month>03</month><year>2003</year></pub-date><volume>157</volume><issue>5</issue><fpage>409</fpage><lpage>414</lpage><permissions><copyright-year>2003</copyright-year></permissions><abstract xml:lang="en"><p>The authors investigated the hypothesis that exposure to pesticides could be related to central nervous system disorders in a prospective cohort study of 1,507 French elderly (1992–1998). Lower cognitive performance was observed in subjects who had been occupationally exposed to pesticides. In men, the relative risks of developing Parkinson’s disease and Alzheimer’s disease for occupational exposure assessed by a job exposure matrix were 5.63 (95% confidence interval: 1.47, 21.58) and 2.39 (95% confidence interval: 1.02, 5.63), respectively, after confounding factors were taken into account. No association was found with having a primary job in agriculture or with environmental pesticide exposure, nor was an association found in women. These results suggest the presence of neurologic impairments in elderly persons who were exposed occupationally to pesticides.</p></abstract><kwd-group kwd-group-type="KWD" xml:lang="en"><kwd>aged; Alzheimer disease; nervous system diseases; occupational exposure; Parkinson disease; pesticides</kwd></kwd-group><kwd-group kwd-group-type="ABR" xml:lang="en"><kwd>Abbreviations: CI, confidence interval; MMSE, Mini-Mental State Examination.</kwd></kwd-group><custom-meta-wrap><custom-meta><meta-name>hwp-legacy-fpage</meta-name><meta-value>409</meta-value></custom-meta><custom-meta><meta-name>hwp-legacy-dochead</meta-name><meta-value>Article</meta-value></custom-meta></custom-meta-wrap></article-meta><notes><p content-type="arthw-misc">Received for publication January 31, 2002; accepted for publication September 11, 2002.</p></notes></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Neurodegenerative Diseases and Exposure to Pesticides in the Elderly</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Neurodegenerative Diseases and Exposure to Pesticides in the Elderly</title></titleInfo><name type="personal"><namePart type="given">Isabelle</namePart><namePart type="family">Baldi</namePart><affiliation>Laboratoire Santé Travail Environnement, Institut de Santé Publique d’Epidémiologie et de Développement, Université Victor Segalen Bordeaux 2, Bordeaux, France.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Pierre</namePart><namePart type="family">Lebailly</namePart><affiliation>Groupe Régional d’Etudes sur le Cancer, Centre François Baclesse, Université de Caen, Caen, France.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Brahim</namePart><namePart type="family">Mohammed-Brahim</namePart><affiliation>Laboratoire Santé Travail Environnement, Institut de Santé Publique d’Epidémiologie et de Développement, Université Victor Segalen Bordeaux 2, Bordeaux, France.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Luc</namePart><namePart type="family">Letenneur</namePart><affiliation>INSERM U330, Université Victor Segalen Bordeaux 2, Bordeaux, France.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean-François</namePart><namePart type="family">Dartigues</namePart><affiliation>INSERM U330, Université Victor Segalen Bordeaux 2, Bordeaux, France.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Patrick</namePart><namePart type="family">Brochard</namePart><affiliation>Laboratoire Santé Travail Environnement, Institut de Santé Publique d’Epidémiologie et de Développement, Université Victor Segalen Bordeaux 2, Bordeaux, France.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><originInfo><publisher>Oxford University Press</publisher><dateIssued encoding="w3cdtf">2003-03-01</dateIssued><copyrightDate encoding="w3cdtf">2003</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">The authors investigated the hypothesis that exposure to pesticides could be related to central nervous system disorders in a prospective cohort study of 1,507 French elderly (1992–1998). 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