Quantification of motor slowness in Parkinson's disease: Correlations between the tapping test and single joint ballistic movement parameters
Identifieur interne : 000497 ( Istex/Corpus ); précédent : 000496; suivant : 000498Quantification of motor slowness in Parkinson's disease: Correlations between the tapping test and single joint ballistic movement parameters
Auteurs : Thomas Boraud ; François Tison ; Christian GrossSource :
- Parkinsonism and Related Disorders [ 1353-8020 ] ; 1997.
Abstract
The tapping test is used routinely for the quantification of drug effects on motor slowness in Parkinson's disease (FD). This test has not been validated previously using reference methods measuring kinematic parameters of movement. We compared and correlated modifications of the tapping score induced by levodopa with that of kinematic parameters of a single joint ballistic movement in 10 PD patients. Results demonstrate that the modification of the tapping score correlates with the bradykinetic, but not the akinetic, component of motor slowness in PD. Also analyzed are the sensitivity and specificity of different thresholds of the increment of the tapping score for the detection of modifications in amplitude, velocity and acceleration. Using a tapping score threshold of positivity between 10 and 20% of increase, the sensitivity and specificity to detect significant modifications in velocity is 100%.
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DOI: 10.1016/S1353-8020(96)00039-9
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</json:item>
</author>
<host><volume>24</volume>
<pages><last>37</last>
<first>26</first>
</pages>
<issue>Suppl. 1</issue>
<author></author>
<title>Movement Disord.</title>
</host>
<title>Slowness of movement in Parkinson's disease</title>
</json:item>
<json:item><author><json:item><name>M. Hallett</name>
</json:item>
</author>
<host><volume>146</volume>
<pages><last>590</last>
<first>585</first>
</pages>
<author></author>
<title>Rev. Neurol. (Paris)</title>
</host>
<title>Clinical neurophysiology of akinesia</title>
</json:item>
<json:item><author><json:item><name>A. Baroni</name>
</json:item>
<json:item><name>F. Benuenuti</name>
</json:item>
<json:item><name>L. Fantini</name>
</json:item>
<json:item><name>T. Pantaleo</name>
</json:item>
<json:item><name>F. Urbani</name>
</json:item>
</author>
<host><volume>34</volume>
<pages><last>876</last>
<first>868</first>
</pages>
<author></author>
<title>Neurology</title>
</host>
<title>Human ballistic arm abduction movements: effects of levodopa treatment in Parkinson's disease</title>
</json:item>
<json:item><author><json:item><name>R.L. Watts</name>
</json:item>
<json:item><name>A.S. Mandir</name>
</json:item>
</author>
<host><pages><last>32</last>
<first>13</first>
</pages>
<author></author>
<title>The Scientific Basis for the Treatment of Parkinson's Disease</title>
</host>
<title>Quantitative methods of evaluating Parkinson's disease</title>
</json:item>
<json:item><author><json:item><name>E.B. Montgomery</name>
</json:item>
<json:item><name>D.S. Gorman</name>
</json:item>
<json:item><name>J. Nuessen</name>
</json:item>
</author>
<host><volume>41</volume>
<pages><last>1475</last>
<first>1469</first>
</pages>
<author></author>
<title>Neurology</title>
</host>
<title>Motor initiation versus execution in normal and Parkinson's disease subjects</title>
</json:item>
<json:item><author><json:item><name>E.B. Montgomery</name>
</json:item>
<json:item><name>J. Nuessen</name>
</json:item>
<json:item><name>D.S. Gorman</name>
</json:item>
</author>
<host><volume>41</volume>
<pages><last>1481</last>
<first>1476</first>
</pages>
<author></author>
<title>Neurology</title>
</host>
<title>Reaction time and movement velocity abnormalities in Parkinson's disease under different task conditions</title>
</json:item>
<json:item><author><json:item><name>G. Geminiani</name>
</json:item>
<json:item><name>B. Cesana</name>
</json:item>
<json:item><name>F. Tamma</name>
</json:item>
</author>
<host><volume>4</volume>
<pages><last>335</last>
<first>330</first>
</pages>
<author></author>
<title>Movement Disord.</title>
</host>
<title>Interobserver reliability between neurologists in training of Parkinson's disease rating scales. A multicenter study</title>
</json:item>
<json:item><author><json:item><name>M.A. Hely</name>
</json:item>
<json:item><name>T. Chey</name>
</json:item>
<json:item><name>A. Wilson</name>
</json:item>
</author>
<host><volume>4</volume>
<pages><last>472</last>
<first>466</first>
</pages>
<author></author>
<title>Movement Disord.</title>
</host>
<title>Reliability of the Columbia Scale for assessing signs of Parkinson's disease</title>
</json:item>
<json:item><author><json:item><name>D.F. Da Costa</name>
</json:item>
<json:item><name>R.J. Abbott</name>
</json:item>
<json:item><name>I.F. Pye</name>
</json:item>
<json:item><name>P.A.H. Millac</name>
</json:item>
</author>
<host><volume>54</volume>
<pages><last>872</last>
<first>870</first>
</pages>
<author></author>
<title>J. Neurol. Neurosurg. Psychiat.</title>
</host>
<title>The apomorphine test in Parkinsonian syndromes</title>
</json:item>
<json:item><author><json:item><name>T. Gasser</name>
</json:item>
<json:item><name>J. Schwartz</name>
</json:item>
<json:item><name>G. Arnold</name>
</json:item>
<json:item><name>C. Trenkwalder</name>
</json:item>
<json:item><name>W.H. Oertel</name>
</json:item>
</author>
<host><volume>49</volume>
<pages><last>1134</last>
<first>1131</first>
</pages>
<author></author>
<title>Arch. Neurol.</title>
</host>
<title>Apomorphine test for dopaminergic responsiveness in patients with previously untreated Parkinson's disease</title>
</json:item>
<json:item><author><json:item><name>U. Bonuccelli</name>
</json:item>
<json:item><name>P. Piccini</name>
</json:item>
<json:item><name>P. Del Dotto</name>
</json:item>
<json:item><name>G. Rossi</name>
</json:item>
<json:item><name>G.U. Corsim</name>
</json:item>
<json:item><name>A. Muratorio</name>
</json:item>
</author>
<host><volume>2</volume>
<pages><last>164</last>
<first>158</first>
</pages>
<author></author>
<title>Movement Disord.</title>
</host>
<title>Apomorphine test for dopaminergic responsiveness: a dose assessment study</title>
</json:item>
<json:item><author><json:item><name>J.G. Nutt</name>
</json:item>
<json:item><name>W.R. Woodward</name>
</json:item>
<json:item><name>J.H. Carter</name>
</json:item>
<json:item><name>S.T. Gancher</name>
</json:item>
</author>
<host><volume>49</volume>
<pages><last>1130</last>
<first>1123</first>
</pages>
<author></author>
<title>Arch. Neurol.</title>
</host>
<title>Effect of long-term therapy on the pharmacodynamics of levodopa. Relation to the On-Off phenomenon</title>
</json:item>
<json:item><author><json:item><name>N. Turjanski</name>
</json:item>
<json:item><name>W. Fernandez</name>
</json:item>
<json:item><name>A.L. Lees</name>
</json:item>
</author>
<host><volume>56</volume>
<pages><last>775</last>
<first>771</first>
</pages>
<author></author>
<title>J. Neurol. Neurosurg. Psychiat.</title>
</host>
<title>The effects of acute levodopa withdrawal on motor performance and dopaminergic receptor sensitivity in patients with Parkinson's disease</title>
</json:item>
<json:item><author><json:item><name>D. Doudet</name>
</json:item>
<json:item><name>C. Gross</name>
</json:item>
<json:item><name>P. Lebrun-Grandié</name>
</json:item>
<json:item><name>B. Bioulac</name>
</json:item>
</author>
<host><volume>335</volume>
<pages><last>199</last>
<first>194</first>
</pages>
<author></author>
<title>Brain Res.</title>
</host>
<title>MPTP primate model of Parkinson's disease: a mechanographic and electromyographic study</title>
</json:item>
<json:item><author><json:item><name>M. Sutter</name>
</json:item>
<json:item><name>C. Albani</name>
</json:item>
</author>
<host><volume>3</volume>
<pages><last>258</last>
<first>257</first>
</pages>
<author></author>
<title>New Trends Clin. Neuropharmacol.</title>
</host>
<title>Accuracy of tracking and tapping test in assessing effects of l-DOPA in Parkinsonian patients (abstract)</title>
</json:item>
</refBibs>
<genre><json:string>research-article</json:string>
</genre>
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<ce:textfn>Département de Neurologie, Hôpital Pellegrin, Bordeaux, France</ce:textfn>
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<ce:correspondence id="COR1"><ce:label>∗</ce:label>
<ce:text>Address correspondence to: T. Boraud, Laboratoire de Neurophysiologie, CNRS UMR 5543, Université de Bordeaux II, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France. Tel: (33) 557 57 15 51; Fax: (33) 556 90 14 21.</ce:text>
</ce:correspondence>
</ce:author-group>
<ce:date-received day="6" month="9" year="1996"></ce:date-received>
<ce:abstract><ce:section-title>Abstract</ce:section-title>
<ce:abstract-sec><ce:simple-para>The tapping test is used routinely for the quantification of drug effects on motor slowness in Parkinson's disease (FD). This test has not been validated previously using reference methods measuring kinematic parameters of movement. We compared and correlated modifications of the tapping score induced by levodopa with that of kinematic parameters of a single joint ballistic movement in 10 PD patients. Results demonstrate that the modification of the tapping score correlates with the bradykinetic, but not the akinetic, component of motor slowness in PD. Also analyzed are the sensitivity and specificity of different thresholds of the increment of the tapping score for the detection of modifications in amplitude, velocity and acceleration. Using a tapping score threshold of positivity between 10 and 20% of increase, the sensitivity and specificity to detect significant modifications in velocity is 100%.</ce:simple-para>
</ce:abstract-sec>
</ce:abstract>
<ce:keywords><ce:section-title>Keywords</ce:section-title>
<ce:keyword><ce:text>Parkinson's disease</ce:text>
</ce:keyword>
<ce:keyword><ce:text>Akinesia</ce:text>
</ce:keyword>
<ce:keyword><ce:text>bradykinesia</ce:text>
</ce:keyword>
</ce:keywords>
</head>
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<mods version="3.6"><titleInfo><title>Quantification of motor slowness in Parkinson's disease: Correlations between the tapping test and single joint ballistic movement parameters</title>
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<titleInfo type="alternative" contentType="CDATA"><title>Quantification of motor slowness in Parkinson's disease: Correlations between the tapping test and single joint ballistic movement parameters</title>
</titleInfo>
<name type="personal"><namePart type="given">Thomas</namePart>
<namePart type="family">Boraud</namePart>
<affiliation>Groupe Motricité, Laboratoire de Neurophysiologie, CNRS UMR 5543, Université de Bordeaux II, Bordeaux, France</affiliation>
<description>Address correspondence to: T. Boraud, Laboratoire de Neurophysiologie, CNRS UMR 5543, Université de Bordeaux II, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France. Tel: (33) 557 57 15 51; Fax: (33) 556 90 14 21.</description>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">François</namePart>
<namePart type="family">Tison</namePart>
<affiliation>Département de Neurologie, Hôpital Pellegrin, Bordeaux, France</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Christian</namePart>
<namePart type="family">Gross</namePart>
<affiliation>Groupe Motricité, Laboratoire de Neurophysiologie, CNRS UMR 5543, Université de Bordeaux II, Bordeaux, France</affiliation>
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<originInfo><publisher>ELSEVIER</publisher>
<dateIssued encoding="w3cdtf">1997</dateIssued>
<copyrightDate encoding="w3cdtf">1997</copyrightDate>
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<abstract lang="en">The tapping test is used routinely for the quantification of drug effects on motor slowness in Parkinson's disease (FD). This test has not been validated previously using reference methods measuring kinematic parameters of movement. We compared and correlated modifications of the tapping score induced by levodopa with that of kinematic parameters of a single joint ballistic movement in 10 PD patients. Results demonstrate that the modification of the tapping score correlates with the bradykinetic, but not the akinetic, component of motor slowness in PD. Also analyzed are the sensitivity and specificity of different thresholds of the increment of the tapping score for the detection of modifications in amplitude, velocity and acceleration. Using a tapping score threshold of positivity between 10 and 20% of increase, the sensitivity and specificity to detect significant modifications in velocity is 100%.</abstract>
<note type="content">Section title: Paper</note>
<subject><genre>Keywords</genre>
<topic>Parkinson's disease</topic>
<topic>Akinesia</topic>
<topic>bradykinesia</topic>
</subject>
<relatedItem type="host"><titleInfo><title>Parkinsonism and Related Disorders</title>
</titleInfo>
<titleInfo type="abbreviated"><title>PRD</title>
</titleInfo>
<genre type="journal">journal</genre>
<originInfo><dateIssued encoding="w3cdtf">199701</dateIssued>
</originInfo>
<identifier type="ISSN">1353-8020</identifier>
<identifier type="PII">S1353-8020(00)X0007-7</identifier>
<part><date>199701</date>
<detail type="volume"><number>3</number>
<caption>vol.</caption>
</detail>
<detail type="issue"><number>1</number>
<caption>no.</caption>
</detail>
<extent unit="issue pages"><start>1</start>
<end>63</end>
</extent>
<extent unit="pages"><start>47</start>
<end>50</end>
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<identifier type="istex">EFCC4E206F4739F24833F583295A3D28EA589D4D</identifier>
<identifier type="DOI">10.1016/S1353-8020(96)00039-9</identifier>
<identifier type="PII">S1353-8020(96)00039-9</identifier>
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