Neurodegenerative Diseases and Exposure to Pesticides in the Elderly
Identifieur interne : 000C82 ( Istex/Checkpoint ); précédent : 000C81; suivant : 000C83Neurodegenerative Diseases and Exposure to Pesticides in the Elderly
Auteurs : Isabelle Baldi [France] ; Pierre Lebailly [France] ; Brahim Mohammed-Brahim [France] ; Luc Letenneur [France] ; Jean-Franc Ois Dartigues [France] ; Patrick Brochard [France]Source :
- American Journal of Epidemiology [ 0002-9262 ] ; 2003-03-01.
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Abstract
The authors investigated the hypothesis that exposure to pesticides could be related to central nervous system disorders in a prospective cohort study of 1,507 French elderly (1992–1998). Lower cognitive performance was observed in subjects who had been occupationally exposed to pesticides. In men, the relative risks of developing Parkinson’s disease and Alzheimer’s disease for occupational exposure assessed by a job exposure matrix were 5.63 (95% confidence interval: 1.47, 21.58) and 2.39 (95% confidence interval: 1.02, 5.63), respectively, after confounding factors were taken into account. No association was found with having a primary job in agriculture or with environmental pesticide exposure, nor was an association found in women. These results suggest the presence of neurologic impairments in elderly persons who were exposed occupationally to pesticides.
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DOI: 10.1093/aje/kwf216
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Environnement, Institut de Santé Publique d’Epidémiologie et de Développement, Université Victor Segalen Bordeaux 2, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">American Journal of Epidemiology</title><title level="j" type="abbrev">Am. 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Epidemiol.</title><idno type="ISSN">0002-9262</idno><idno type="eISSN">1476-6256</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2003-03-01">2003-03-01</date><biblScope unit="volume">157</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="409">409</biblScope><biblScope unit="page" to="414">414</biblScope></imprint><idno type="ISSN">0002-9262</idno></series><idno type="istex">DF17F05CDBBBE05AAB4433FBA8FF7E3895301C5D</idno><idno type="DOI">10.1093/aje/kwf216</idno><idno type="local">kwf216</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0002-9262</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Abbreviations: CI, confidence interval; MMSE, Mini-Mental State Examination.</term><term>aged; Alzheimer disease; nervous system diseases; occupational exposure; Parkinson disease; pesticides</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The authors investigated the hypothesis that exposure to pesticides could be related to central nervous system disorders in a prospective cohort study of 1,507 French elderly (1992–1998). Lower cognitive performance was observed in subjects who had been occupationally exposed to pesticides. In men, the relative risks of developing Parkinson’s disease and Alzheimer’s disease for occupational exposure assessed by a job exposure matrix were 5.63 (95% confidence interval: 1.47, 21.58) and 2.39 (95% confidence interval: 1.02, 5.63), respectively, after confounding factors were taken into account. No association was found with having a primary job in agriculture or with environmental pesticide exposure, nor was an association found in women. 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