Subthalamic nucleus modulates social and anxogenic-like behaviors.
Identifieur interne : 000968 ( Hal/Curation ); précédent : 000967; suivant : 000969Subthalamic nucleus modulates social and anxogenic-like behaviors.
Auteurs : Jean-Michel Reymann [France] ; Florian Naudet [France] ; Morgane Pihan [France] ; Stephan Saïkali [France] ; Bruno Laviolle [France] ; Danièle Bentué-Ferrer [France]Source :
- Behavioural Brain Research [ 0166-4328 ] ; 2013-06-06.
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Abstract
In Parkinson's disease, global social maladjustment and anxiety are frequent after subthalamic nucleus (STN) stimulation and are generally considered to be linked with sociofamilial alterations induced by the motor effects of stimulation. We hypothesized that the STN is per se involved in these changes and aimed to explore the role of STN in social and anxogenic-like behaviors using an animal model. Nineteen male Wistar rats with bilateral lesions of the STN were compared with 26 sham-lesioned rats by synchronizing an ethological approach based upon direct observation of social behaviors and a standardized approach, the elevated plus maze (EPM). Comparisons between groups were performed by a Mann-Whitney-Wilcoxon test. Lesioned rats showed impairments in their social (P=0.05) and aggressive behaviors with a diminution of attacking (P=0.04) and chasing (P=0.06). In the EPM, concerning the open arms, the percentage of distance, time, inactive time, and entry were significantly decreased in lesioned rats (P=0.02, P=0.01, P=0.04, and P=0.05). The time spent in non-protected head dips was also diminished in the lesioned rats (P=0.01). These results strongly implicate the STN in social behavior and anxogenic-like behavior. In human, as DBS induces changes in the underlying dynamics of the stimulated brain networks, it could create an abnormal brain state in which anxiety and social behavior are altered. These results highlight another level of complexity of the behavioral changes after stimulation.
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DOI: 10.1016/j.bbr.2013.05.059
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CS 46510 - 35065 Rennes cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-rennes1.fr/</ref> </desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Rennes</settlement><region type="region" nuts="2">Région Bretagne</region></placeName><orgName type="university">Université de Rennes 1</orgName><orgName type="institution" wicri:auto="newGroup">Université européenne de Bretagne</orgName></affiliation></author></analytic><idno type="DOI">10.1016/j.bbr.2013.05.059</idno><series><title level="j">Behavioural Brain Research</title><idno type="ISSN">0166-4328</idno><imprint><date type="datePub">2013-06-06</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Anxiety</term><term>Basal ganglia</term><term>EPM</term><term>Elevated Plus Maze</term><term>Lesion</term><term>PD</term><term>Parkinson's Disease</term><term>Rats</term><term>STN</term><term>Social behavior</term><term>SubThalamic Nucleus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In Parkinson's disease, global social maladjustment and anxiety are frequent after subthalamic nucleus (STN) stimulation and are generally considered to be linked with sociofamilial alterations induced by the motor effects of stimulation. We hypothesized that the STN is per se involved in these changes and aimed to explore the role of STN in social and anxogenic-like behaviors using an animal model. Nineteen male Wistar rats with bilateral lesions of the STN were compared with 26 sham-lesioned rats by synchronizing an ethological approach based upon direct observation of social behaviors and a standardized approach, the elevated plus maze (EPM). Comparisons between groups were performed by a Mann-Whitney-Wilcoxon test. Lesioned rats showed impairments in their social (P=0.05) and aggressive behaviors with a diminution of attacking (P=0.04) and chasing (P=0.06). In the EPM, concerning the open arms, the percentage of distance, time, inactive time, and entry were significantly decreased in lesioned rats (P=0.02, P=0.01, P=0.04, and P=0.05). The time spent in non-protected head dips was also diminished in the lesioned rats (P=0.01). These results strongly implicate the STN in social behavior and anxogenic-like behavior. In human, as DBS induces changes in the underlying dynamics of the stimulated brain networks, it could create an abnormal brain state in which anxiety and social behavior are altered. These results highlight another level of complexity of the behavioral changes after stimulation.</div></front></TEI><hal api="V3"> <titleStmt> <title xml:lang="en">Subthalamic nucleus modulates social and anxogenic-like behaviors.</title> <author role="aut"> <persName> <forename type="first">Jean-Michel</forename> <surname>Reymann</surname> </persName> <idno type="halauthorid">871314</idno> <affiliation ref="#struct-2610"></affiliation> <affiliation ref="#struct-227592"></affiliation> </author> <author role="crp"> <persName> <forename type="first">Florian</forename> <surname>Naudet</surname> </persName> <email type="md5">499d184571ebf264aa5f92f3b0d58443</email> <email type="domain">gmail.com</email> <idno type="halauthorid">871315</idno> <affiliation ref="#struct-2610"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Morgane</forename> <surname>Pihan</surname> </persName> <idno type="halauthorid">871316</idno> <affiliation ref="#struct-2610"></affiliation> <affiliation ref="#struct-227593"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Stephan</forename> <surname>Saïkali</surname> </persName> <idno type="halauthorid">379212</idno> <affiliation ref="#struct-227594"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Bruno</forename> <surname>Laviolle</surname> </persName> <idno type="halauthorid">108559</idno> <affiliation ref="#struct-400751"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Danièle</forename> <surname>Bentué-Ferrer</surname> </persName> <idno type="halauthorid">715978</idno> <affiliation ref="#struct-227592"></affiliation> </author> <editor role="depositor"> <persName> <forename>Laurent</forename> <surname>Jonchère</surname> </persName> <email type="md5">8503b29898396526c56d96d8ae07e3e5</email> <email type="domain">univ-rennes1.fr</email> </editor> <funder>Rennes 1 University UFR of Medicine</funder> </titleStmt> <editionStmt> <edition n="v1" type="current"> <date type="whenSubmitted">2013-07-17 16:39:10</date> <date type="whenModified">2016-10-20 14:11:20</date> <date type="whenReleased">2013-07-18 09:32:27</date> <date type="whenProduced">2013-06-06</date> <date type="whenEndEmbargoed">2013-07-17</date> <ref type="file" target="https://hal-univ-rennes1.archives-ouvertes.fr/hal-00845768/document"> <date notBefore="2013-07-17"></date> </ref> <ref type="file" subtype="author" n="1" target="https://hal-univ-rennes1.archives-ouvertes.fr/hal-00845768/file/BBR-accepted.pdf"> <date notBefore="2013-07-17"></date> </ref> </edition> <respStmt> <resp>contributor</resp> <name key="113861"> <persName> <forename>Laurent</forename> <surname>Jonchère</surname> </persName> <email type="md5">8503b29898396526c56d96d8ae07e3e5</email> <email type="domain">univ-rennes1.fr</email> </name> </respStmt> </editionStmt> <publicationStmt> <distributor>CCSD</distributor> <idno type="halId">hal-00845768</idno> <idno type="halUri">https://hal-univ-rennes1.archives-ouvertes.fr/hal-00845768</idno> <idno type="halBibtex">reymann:hal-00845768</idno> <idno type="halRefHtml">Behavioural Brain Research, Elsevier, 2013, 252C, pp.356-362. <10.1016/j.bbr.2013.05.059></idno> <idno type="halRef">Behavioural Brain Research, Elsevier, 2013, 252C, pp.356-362. <10.1016/j.bbr.2013.05.059></idno> </publicationStmt> <seriesStmt> <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno> <idno type="stamp" n="UNIV-RENNES1">Université de Rennes 1</idno> <idno type="stamp" n="CIC">CIC-Rennes</idno> <idno type="stamp" n="CIC203">CIC-1414</idno> <idno type="stamp" n="HL">Publications CHU - Rennes 1</idno> <idno type="stamp" n="BIOSIT">SFR Biosit - Biologie et Santé CNRS UMS 3480</idno> <idno type="stamp" n="UR1-UFR-SVE">UFR SVE Sciences de la vie et de l'environnement</idno> <idno type="stamp" n="STATS-UR1">Statistiques-HAL-UR1</idno> <idno type="stamp" n="UR1-HAL">Publications labos UR1 dans HAL-Rennes 1</idno> <idno type="stamp" n="UR1-SDV">UR1 - publications SDV</idno> </seriesStmt> <notesStmt> <note type="commentary">The sponsor had no role concerning: design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. There are no conflicts of interest regarding this paper.</note> <note type="audience" n="2">International</note> <note type="popular" n="0">No</note> <note type="peer" n="1">Yes</note> </notesStmt> <sourceDesc> <biblStruct> <analytic> <title xml:lang="en">Subthalamic nucleus modulates social and anxogenic-like behaviors.</title> <author role="aut"> <persName> <forename type="first">Jean-Michel</forename> <surname>Reymann</surname> </persName> <idno type="halauthorid">871314</idno> <affiliation ref="#struct-2610"></affiliation> <affiliation ref="#struct-227592"></affiliation> </author> <author role="crp"> <persName> <forename type="first">Florian</forename> <surname>Naudet</surname> </persName> <email type="md5">499d184571ebf264aa5f92f3b0d58443</email> <email type="domain">gmail.com</email> <idno type="halauthorid">871315</idno> <affiliation ref="#struct-2610"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Morgane</forename> <surname>Pihan</surname> </persName> <idno type="halauthorid">871316</idno> <affiliation ref="#struct-2610"></affiliation> <affiliation ref="#struct-227593"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Stephan</forename> <surname>Saïkali</surname> </persName> <idno type="halauthorid">379212</idno> <affiliation ref="#struct-227594"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Bruno</forename> <surname>Laviolle</surname> </persName> <idno type="halauthorid">108559</idno> <affiliation ref="#struct-400751"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Danièle</forename> <surname>Bentué-Ferrer</surname> </persName> <idno type="halauthorid">715978</idno> <affiliation ref="#struct-227592"></affiliation> </author> </analytic> <monogr> <idno type="halJournalId" status="VALID">11083</idno> <idno type="issn">0166-4328</idno> <title level="j">Behavioural Brain Research</title> <imprint> <publisher>Elsevier</publisher> <biblScope unit="volume">252C</biblScope> <biblScope unit="pp">356-362</biblScope> <date type="datePub">2013-06-06</date> <date type="dateEpub">2013-06-06</date> </imprint> </monogr> <idno type="pubmed">23748197</idno> <idno type="doi">10.1016/j.bbr.2013.05.059</idno> </biblStruct> </sourceDesc> <profileDesc> <langUsage> <language ident="en">English</language> </langUsage> <textClass> <keywords scheme="author"> <term xml:lang="en">Anxiety</term> <term xml:lang="en">Basal ganglia</term> <term xml:lang="en">EPM</term> <term xml:lang="en">Elevated Plus Maze</term> <term xml:lang="en">Lesion</term> <term xml:lang="en">PD</term> <term xml:lang="en">Parkinson's Disease</term> <term xml:lang="en">Rats</term> <term xml:lang="en">STN</term> <term xml:lang="en">Social behavior</term> <term xml:lang="en">SubThalamic Nucleus</term> </keywords> <classCode scheme="halDomain" n="sdv.neu.nb">Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology</classCode> <classCode scheme="halTypology" n="ART">Journal articles</classCode> </textClass> <abstract xml:lang="en">In Parkinson's disease, global social maladjustment and anxiety are frequent after subthalamic nucleus (STN) stimulation and are generally considered to be linked with sociofamilial alterations induced by the motor effects of stimulation. We hypothesized that the STN is per se involved in these changes and aimed to explore the role of STN in social and anxogenic-like behaviors using an animal model. Nineteen male Wistar rats with bilateral lesions of the STN were compared with 26 sham-lesioned rats by synchronizing an ethological approach based upon direct observation of social behaviors and a standardized approach, the elevated plus maze (EPM). Comparisons between groups were performed by a Mann-Whitney-Wilcoxon test. Lesioned rats showed impairments in their social (P=0.05) and aggressive behaviors with a diminution of attacking (P=0.04) and chasing (P=0.06). In the EPM, concerning the open arms, the percentage of distance, time, inactive time, and entry were significantly decreased in lesioned rats (P=0.02, P=0.01, P=0.04, and P=0.05). The time spent in non-protected head dips was also diminished in the lesioned rats (P=0.01). These results strongly implicate the STN in social behavior and anxogenic-like behavior. In human, as DBS induces changes in the underlying dynamics of the stimulated brain networks, it could create an abnormal brain state in which anxiety and social behavior are altered. These results highlight another level of complexity of the behavioral changes after stimulation.</abstract> </profileDesc> </hal></record>Pour manipuler ce document sous Unix (Dilib)
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