ParkinsonFranceV1, Hal, Curation, bibRecord, 000350

Effects of GPi and STN inactivation on physiological, motor, cognitive and motivational processes in animal models of Parkinson's disease

Identifieur interne : 000350 ( Hal/Curation ); précédent : 000349; suivant : 000351

Effects of GPi and STN inactivation on physiological, motor, cognitive and motivational processes in animal models of Parkinson's disease

Auteurs : Christelle Baunez [France] ; Paolo Gubellini [France]

Source :

Progress in brain research [ 0079-6123 ] ; 2010.

RBID : Hal:hal-00848874

Abstract

Loss of the dopaminergic input to the striatum, characterizing Parkinson's disease, leads to the hyper-activity of two key nuclei of the basal ganglia (BG): the subthalamic nucleus (STN) and the internal segment of the globus pallidus (GPi). The anatomo-physiological organization of the BG and their output suggested that interfering with such hyper-activity could restore motor function and improve parkinsonism. Several animal models in rodents and primates, as well as clinical studies and neurosurgical treatments, have confirmed such hypothesis. This chapter will review the physiological and behavioural data obtained by inactivating the GPi or the STN by means of lesions, pharmacological approaches and deep brain stimulation. The consequences of these treatments will be examined at levels ranging from cellular to complex behavioural changes. Some of this experimental evidence suggested new and effective clinical treatments for PD, which are now routinely used worldwide. However, further studies are necessary to better understand the consequences of GPi and STN manipulation especially at the cognitive level in order to improve functional neurosurgical treatments for Parkinson's disease by minimizing risks of side-effects.

Url:

https://hal.archives-ouvertes.fr/hal-00848874

DOI: 10.1016/S0079-6123(10)83012-2

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000360

Links to Exploration step

Hal:hal-00848874

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of GPi and STN inactivation on physiological, motor, cognitive and motivational processes in animal models of Parkinson's disease</title>
<author><name sortKey="Baunez, Christelle" sort="Baunez, Christelle" uniqKey="Baunez C" first="Christelle" last="Baunez">Christelle Baunez</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-199398" status="VALID">  <idno type="RNSR">201220268H</idno>
  <orgName>Laboratoire de Neurosciences Cognitives</orgName>
  <orgName type="acronym">LNC</orgName>
  <date type="start">2012</date>
  <desc>    <address>      <addrLine>Pole 3 C Case C 3 Place Victor Hugo 13331 Marseille Cedex 3</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://lnc.univ-amu.fr/</ref>
  </desc>
  <listRelation>    <relation name="UMR7291" active="#struct-441569" type="direct"></relation>
    <relation name="UMR7291" active="#struct-198056" type="direct"></relation>
    <relation name="UMR6155" active="#struct-92823" type="direct"></relation>
  </listRelation>
<tutelles><tutelle name="UMR7291" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR7291" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"><idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR6155" active="#struct-92823" type="direct"><org type="institution" xml:id="struct-92823" status="OLD"><idno type="IdRef">026403781</idno>
<orgName>Université de Provence - Aix-Marseille 1</orgName>
<date type="end">2011-12-31</date>
<desc><address><addrLine>3, place Victor Hugo - 13331 Marseille Cedex 03</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-provence.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Gubellini, Paolo" sort="Gubellini, Paolo" uniqKey="Gubellini P" first="Paolo" last="Gubellini">Paolo Gubellini</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-199397" status="VALID">  <idno type="IdRef">149374186</idno>
  <idno type="RNSR">201220316K</idno>
  <orgName>Institut de Biologie du Développement de Marseille</orgName>
  <orgName type="acronym">IBDM</orgName>
  <date type="start">2012</date>
  <desc>    <address>      <addrLine>Case 907 - Parc Scientifique de Luminy 13288 Marseille Cedex 9</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ibdm.univ-mrs.fr</ref>
  </desc>
  <listRelation>    <relation name="UMR7288" active="#struct-303623" type="direct"></relation>
    <relation name="UMR7288" active="#struct-198056" type="direct"></relation>
    <relation name="UMR7288" active="#struct-441569" type="direct"></relation>
    <relation active="#struct-5033" type="direct"></relation>
  </listRelation>
<tutelles><tutelle name="UMR7288" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">  <idno type="IdRef">026388278</idno>
  <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
  <orgName type="acronym">INSERM</orgName>
  <desc>    <address>      <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.inserm.fr</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR7288" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"><idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7288" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-5033" type="direct"><org type="institution" xml:id="struct-5033" status="OLD">  <idno type="IdRef">026402882</idno>
  <orgName>Université de la Méditerranée - Aix-Marseille 2</orgName>
  <date type="start">1969</date>
  <date type="end">2011</date>
  <desc>    <address>      <addrLine>58, boulevard Charles Livon - 13284 Marseille cedex 07</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.univmed.fr/</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:hal-00848874</idno>
<idno type="halId">hal-00848874</idno>
<idno type="halUri">https://hal.archives-ouvertes.fr/hal-00848874</idno>
<idno type="url">https://hal.archives-ouvertes.fr/hal-00848874</idno>
<idno type="doi">10.1016/S0079-6123(10)83012-2</idno>
<date when="2010">2010</date>
<idno type="wicri:Area/Hal/Corpus">000360</idno>
<idno type="wicri:Area/Hal/Curation">000360</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Effects of GPi and STN inactivation on physiological, motor, cognitive and motivational processes in animal models of Parkinson's disease</title>
<author><name sortKey="Baunez, Christelle" sort="Baunez, Christelle" uniqKey="Baunez C" first="Christelle" last="Baunez">Christelle Baunez</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-199398" status="VALID">  <idno type="RNSR">201220268H</idno>
  <orgName>Laboratoire de Neurosciences Cognitives</orgName>
  <orgName type="acronym">LNC</orgName>
  <date type="start">2012</date>
  <desc>    <address>      <addrLine>Pole 3 C Case C 3 Place Victor Hugo 13331 Marseille Cedex 3</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://lnc.univ-amu.fr/</ref>
  </desc>
  <listRelation>    <relation name="UMR7291" active="#struct-441569" type="direct"></relation>
    <relation name="UMR7291" active="#struct-198056" type="direct"></relation>
    <relation name="UMR6155" active="#struct-92823" type="direct"></relation>
  </listRelation>
<tutelles><tutelle name="UMR7291" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR7291" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"><idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR6155" active="#struct-92823" type="direct"><org type="institution" xml:id="struct-92823" status="OLD"><idno type="IdRef">026403781</idno>
<orgName>Université de Provence - Aix-Marseille 1</orgName>
<date type="end">2011-12-31</date>
<desc><address><addrLine>3, place Victor Hugo - 13331 Marseille Cedex 03</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-provence.fr/</ref>
</desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Gubellini, Paolo" sort="Gubellini, Paolo" uniqKey="Gubellini P" first="Paolo" last="Gubellini">Paolo Gubellini</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-199397" status="VALID">  <idno type="IdRef">149374186</idno>
  <idno type="RNSR">201220316K</idno>
  <orgName>Institut de Biologie du Développement de Marseille</orgName>
  <orgName type="acronym">IBDM</orgName>
  <date type="start">2012</date>
  <desc>    <address>      <addrLine>Case 907 - Parc Scientifique de Luminy 13288 Marseille Cedex 9</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ibdm.univ-mrs.fr</ref>
  </desc>
  <listRelation>    <relation name="UMR7288" active="#struct-303623" type="direct"></relation>
    <relation name="UMR7288" active="#struct-198056" type="direct"></relation>
    <relation name="UMR7288" active="#struct-441569" type="direct"></relation>
    <relation active="#struct-5033" type="direct"></relation>
  </listRelation>
<tutelles><tutelle name="UMR7288" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">  <idno type="IdRef">026388278</idno>
  <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
  <orgName type="acronym">INSERM</orgName>
  <desc>    <address>      <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.inserm.fr</ref>
  </desc>
</org>
</tutelle>
<tutelle name="UMR7288" active="#struct-198056" type="direct"><org type="institution" xml:id="struct-198056" status="VALID"><idno type="IdRef">15863621X</idno>
<idno type="ISNI">0000 0001 2176 4817</idno>
<orgName>Aix Marseille Université</orgName>
<orgName type="acronym">AMU</orgName>
<date type="start">2012-01-01</date>
<desc><address><addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.univ-amu.fr/</ref>
</desc>
</org>
</tutelle>
<tutelle name="UMR7288" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID">  <idno type="IdRef">02636817X</idno>
  <idno type="ISNI">0000000122597504</idno>
  <orgName>Centre National de la Recherche Scientifique</orgName>
  <orgName type="acronym">CNRS</orgName>
  <date type="start">1939-10-19</date>
  <desc>    <address>      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cnrs.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-5033" type="direct"><org type="institution" xml:id="struct-5033" status="OLD">  <idno type="IdRef">026402882</idno>
  <orgName>Université de la Méditerranée - Aix-Marseille 2</orgName>
  <date type="start">1969</date>
  <date type="end">2011</date>
  <desc>    <address>      <addrLine>58, boulevard Charles Livon - 13284 Marseille cedex 07</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.univmed.fr/</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1016/S0079-6123(10)83012-2</idno>
<series><title level="j">Progress in brain research</title>
<idno type="ISSN">0079-6123</idno>
<imprint><date type="datePub">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Loss of the dopaminergic input to the striatum, characterizing Parkinson's disease, leads to the hyper-activity of two key nuclei of the basal ganglia (BG): the subthalamic nucleus (STN) and the internal segment of the globus pallidus (GPi). The anatomo-physiological organization of the BG and their output suggested that interfering with such hyper-activity could restore motor function and improve parkinsonism. Several animal models in rodents and primates, as well as clinical studies and neurosurgical treatments, have confirmed such hypothesis. This chapter will review the physiological and behavioural data obtained by inactivating the GPi or the STN by means of lesions, pharmacological approaches and deep brain stimulation. The consequences of these treatments will be examined at levels ranging from cellular to complex behavioural changes. Some of this experimental evidence suggested new and effective clinical treatments for PD, which are now routinely used worldwide. However, further studies are necessary to better understand the consequences of GPi and STN manipulation especially at the cognitive level in order to improve functional neurosurgical treatments for Parkinson's disease by minimizing risks of side-effects.</div>
</front>
</TEI>
<hal api="V3">          <titleStmt>            <title xml:lang="en">Effects of GPi and STN inactivation on physiological, motor, cognitive and motivational processes in animal models of Parkinson's disease</title>
            <author role="aut">              <persName>                <forename type="first">Christelle</forename>
                <surname>Baunez</surname>
              </persName>
              <idno type="halauthorid">608726</idno>
              <affiliation ref="#struct-199398"></affiliation>
            </author>
            <author role="aut">              <persName>                <forename type="first">Paolo</forename>
                <surname>Gubellini</surname>
              </persName>
              <idno type="halauthorid">410381</idno>
              <affiliation ref="#struct-199397"></affiliation>
            </author>
            <editor role="depositor">              <persName>                <forename>Lydia</forename>
                <surname>Nelsom</surname>
              </persName>
              <email type="md5">bba8ce8b7a76814561866cfe35712816</email>
              <email type="domain">univ-amu.fr</email>
            </editor>
          </titleStmt>
          <editionStmt>            <edition n="v1" type="current">              <date type="whenSubmitted">2013-07-29 14:21:48</date>
              <date type="whenModified">2016-10-14 16:31:52</date>
              <date type="whenReleased">2013-07-29 14:21:48</date>
              <date type="whenProduced">2010</date>
            </edition>
            <respStmt>              <resp>contributor</resp>
              <name key="112288">                <persName>                  <forename>Lydia</forename>
                  <surname>Nelsom</surname>
                </persName>
                <email type="md5">bba8ce8b7a76814561866cfe35712816</email>
                <email type="domain">univ-amu.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>            <distributor>CCSD</distributor>
            <idno type="halId">hal-00848874</idno>
            <idno type="halUri">https://hal.archives-ouvertes.fr/hal-00848874</idno>
            <idno type="halBibtex">baunez:hal-00848874</idno>
            <idno type="halRefHtml">Progress in brain research, Elsevier, 2010, Recent Advances in Parkinson’s Disease: Basic Research, 183, pp.235-258. <http://www.sciencedirect.com/science/article/pii/S0079612310830122>. <10.1016/S0079-6123(10)83012-2></idno>
            <idno type="halRef">Progress in brain research, Elsevier, 2010, Recent Advances in Parkinson’s Disease: Basic Research, 183, pp.235-258. <http://www.sciencedirect.com/science/article/pii/S0079612310830122>. <10.1016/S0079-6123(10)83012-2></idno>
          </publicationStmt>
          <seriesStmt>            <idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno>
            <idno type="stamp" n="UNIV-AMU">Aix Marseille Université</idno>
            <idno type="stamp" n="LNC">Laboratoire de Neurosciences Cognitives</idno>
          </seriesStmt>
          <notesStmt>            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>            <biblStruct>              <analytic>                <title xml:lang="en">Effects of GPi and STN inactivation on physiological, motor, cognitive and motivational processes in animal models of Parkinson's disease</title>
                <author role="aut">                  <persName>                    <forename type="first">Christelle</forename>
                    <surname>Baunez</surname>
                  </persName>
                  <idno type="halauthorid">608726</idno>
                  <affiliation ref="#struct-199398"></affiliation>
                </author>
                <author role="aut">                  <persName>                    <forename type="first">Paolo</forename>
                    <surname>Gubellini</surname>
                  </persName>
                  <idno type="halauthorid">410381</idno>
                  <affiliation ref="#struct-199397"></affiliation>
                </author>
              </analytic>
              <monogr>                <idno type="halJournalId" status="VALID">18247</idno>
                <idno type="issn">0079-6123</idno>
                <title level="j">Progress in brain research</title>
                <imprint>                  <publisher>Elsevier</publisher>
                  <biblScope unit="serie">Recent Advances in Parkinson’s Disease: Basic Research</biblScope>
                  <biblScope unit="volume">183</biblScope>
                  <biblScope unit="pp">235-258</biblScope>
                  <date type="datePub">2010</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/S0079-6123(10)83012-2</idno>
              <idno type="pubmed">20696323</idno>
              <ref type="publisher">http://www.sciencedirect.com/science/article/pii/S0079612310830122</ref>
            </biblStruct>
          </sourceDesc>
          <profileDesc>            <langUsage>              <language ident="en">English</language>
            </langUsage>
            <textClass>              <classCode scheme="mesh">Animals</classCode>
              <classCode scheme="mesh">Cognition</classCode>
              <classCode scheme="mesh">Motivation</classCode>
              <classCode scheme="mesh">Neural Pathways</classCode>
              <classCode scheme="mesh">Oxidopamine</classCode>
              <classCode scheme="mesh">Parkinson Disease</classCode>
              <classCode scheme="mesh">Rats</classCode>
              <classCode scheme="mesh">Subthalamic Nucleus</classCode>
              <classCode scheme="mesh">Disease Models, Animal</classCode>
              <classCode scheme="mesh">Electric Stimulation Therapy</classCode>
              <classCode scheme="mesh">Globus Pallidus</classCode>
              <classCode scheme="mesh">Humans</classCode>
              <classCode scheme="mesh">Models, Neurological</classCode>
              <classCode scheme="halDomain" n="sdv.bc">Life Sciences [q-bio]/Cellular Biology</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">Loss of the dopaminergic input to the striatum, characterizing Parkinson's disease, leads to the hyper-activity of two key nuclei of the basal ganglia (BG): the subthalamic nucleus (STN) and the internal segment of the globus pallidus (GPi). The anatomo-physiological organization of the BG and their output suggested that interfering with such hyper-activity could restore motor function and improve parkinsonism. Several animal models in rodents and primates, as well as clinical studies and neurosurgical treatments, have confirmed such hypothesis. This chapter will review the physiological and behavioural data obtained by inactivating the GPi or the STN by means of lesions, pharmacological approaches and deep brain stimulation. The consequences of these treatments will be examined at levels ranging from cellular to complex behavioural changes. Some of this experimental evidence suggested new and effective clinical treatments for PD, which are now routinely used worldwide. However, further studies are necessary to better understand the consequences of GPi and STN manipulation especially at the cognitive level in order to improve functional neurosurgical treatments for Parkinson's disease by minimizing risks of side-effects.</abstract>
          </profileDesc>
        </hal>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Hal/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000350 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Hal/Curation/biblio.hfd -nk 000350 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    ParkinsonFranceV1
   |flux=    Hal
   |étape=   Curation
   |type=    RBID
   |clé=     Hal:hal-00848874
   |texte=   Effects of GPi and STN inactivation on physiological, motor, cognitive and motivational processes in animal models of Parkinson's disease
}}

This area was generated with Dilib version V0.6.29.
Data generation: Wed May 17 19:46:39 2017. Site generation: Mon Mar 4 15:48:15 2024

	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

Effects of GPi and STN inactivation on physiological, motor, cognitive and motivational processes in animal models of Parkinson's disease

Effects of GPi and STN inactivation on physiological, motor, cognitive and motivational processes in animal models of Parkinson's disease

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri