ParkinsonFranceV1, Hal, Curation, bibRecord, 000351

Effects of L-DOPA and STN-HFS dyskinesiogenic treatments on NR2B regulation in basal ganglia in the rat model of Parkinson's disease.

Identifieur interne : 000351 ( Hal/Curation ); précédent : 000350; suivant : 000352

Effects of L-DOPA and STN-HFS dyskinesiogenic treatments on NR2B regulation in basal ganglia in the rat model of Parkinson's disease.

Auteurs : Adrien Quintana [France] ; Véronique Sgambato-Faure [France] ; Marc Savasta [France]

Source :

Neurobiology of Disease [ 0969-9961 ] ; 2012-12.

RBID : Hal:inserm-00742517

Abstract

Dyskinesia is a major side effect of chronic levodopa (L-DOPA) administration, the reference treatment for Parkinson's disease (PD). High-frequency stimulation of the subthalamic nucleus (STN-HFS) alleviates parkinsonian motor symptoms and indirectly improves dyskinesia by decreasing L-DOPA requirement. However, inadequate stimulation can also trigger dyskinetic movements in PD patients and animal models. Here, we investigated the possible association between L-DOPA- and STN-HFS-induced dyskinesia and regulation of the NR2B subunit of NMDA receptors in the rodent model of PD. We subjected 6-OHDA-lesioned rats to HFS for 1h, at an intensity triggering forelimb dyskinesia. Other 6-OHDA-lesioned rats were treated with chronic high doses of L-DOPA for ten days, to induce abnormal involuntary movements. The 6-OHDA lesion regulated NR2B only in the SNr, where the activation of NR2B was observed (as assessed by phosphorylation of the Tyr(1472) residue). Both STN-HFS and L-DOPA dyskinesiogenic treatments induced NR2B activation in the STN and EP, but only L-DOPA triggered NR2B hyperphosphorylation in the striatum. Finally, the use of CP-101,606 exacerbated L-DOPA-induced motor behavior and associated NR2B hyperphosphorylation in the striatum, STN and EP. Thus, NR2B activation in basal ganglia structures is correlated with dyskinesia.

Url:

http://www.hal.inserm.fr/inserm-00742517

DOI: 10.1016/j.nbd.2012.06.009

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000361

Links to Exploration step

Hal:inserm-00742517

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of L-DOPA and STN-HFS dyskinesiogenic treatments on NR2B regulation in basal ganglia in the rat model of Parkinson's disease.</title>
<title xml:lang="en" type="sub">NR2B hyperphosphorylation driven by L-DOPA and STN-HFS</title>
<author><name sortKey="Quintana, Adrien" sort="Quintana, Adrien" uniqKey="Quintana A" first="Adrien" last="Quintana">Adrien Quintana</name>
<affiliation wicri:level="1"><hal:affiliation type="researchteam" xml:id="struct-391045" status="INCOMING">  <orgName>INSERM U836, équipe 10, Dynamique des réseaux neuronaux du mouvement</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-86972" type="direct"></relation>
    <relation active="#struct-51016" type="indirect"></relation>
    <relation name="DSV/IRTSV" active="#struct-300016" type="indirect"></relation>
    <relation active="#struct-300071" type="indirect"></relation>
    <relation name="U836" active="#struct-303623" type="indirect"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-86972" type="direct"><org type="laboratory" xml:id="struct-86972" status="VALID">  <orgName>Grenoble Institut des Neurosciences</orgName>
  <orgName type="acronym">GIN</orgName>
  <desc>    <address>      <addrLine>UJF - Site Santé La Tronche - BP 170 - 38042 Grenoble Cedex 9</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://neurosciences.ujf-grenoble.fr/</ref>
  </desc>
  <listRelation>    <relation active="#struct-51016" type="direct"></relation>
    <relation name="DSV/IRTSV" active="#struct-300016" type="direct"></relation>
    <relation active="#struct-300071" type="direct"></relation>
    <relation name="U836" active="#struct-303623" type="direct"></relation>
  </listRelation>
</org>
</tutelle>
<tutelle active="#struct-51016" type="indirect"><org type="institution" xml:id="struct-51016" status="OLD">  <idno type="IdRef">026404796</idno>
  <orgName>Université Joseph Fourier - Grenoble 1</orgName>
  <orgName type="acronym">UJF</orgName>
  <date type="end">2015-12-31</date>
  <desc>    <address>      <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ujf-grenoble.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="DSV/IRTSV" active="#struct-300016" type="indirect"><org type="institution" xml:id="struct-300016" status="VALID">  <orgName>Commissariat à l'énergie atomique et aux énergies alternatives</orgName>
  <orgName type="acronym">CEA</orgName>
  <desc>    <address>      <addrLine>Centre de SaclayCentre de GrenobleCentre de Cadaracheetc</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cea.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-300071" type="indirect"><org type="institution" xml:id="struct-300071" status="VALID">  <orgName>CHU Grenoble</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
<tutelle name="U836" active="#struct-303623" type="indirect"><org type="institution" xml:id="struct-303623" status="VALID">  <idno type="IdRef">026388278</idno>
  <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
  <orgName type="acronym">INSERM</orgName>
  <desc>    <address>      <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.inserm.fr</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Joseph Fourier</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Grenoble</orgName>
</affiliation>
</author>
<author><name sortKey="Sgambato Faure, Veronique" sort="Sgambato Faure, Veronique" uniqKey="Sgambato Faure V" first="Véronique" last="Sgambato-Faure">Véronique Sgambato-Faure</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-86972" status="VALID">  <orgName>Grenoble Institut des Neurosciences</orgName>
  <orgName type="acronym">GIN</orgName>
  <desc>    <address>      <addrLine>UJF - Site Santé La Tronche - BP 170 - 38042 Grenoble Cedex 9</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://neurosciences.ujf-grenoble.fr/</ref>
  </desc>
  <listRelation>    <relation active="#struct-51016" type="direct"></relation>
    <relation name="DSV/IRTSV" active="#struct-300016" type="direct"></relation>
    <relation active="#struct-300071" type="direct"></relation>
    <relation name="U836" active="#struct-303623" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-51016" type="direct"><org type="institution" xml:id="struct-51016" status="OLD">  <idno type="IdRef">026404796</idno>
  <orgName>Université Joseph Fourier - Grenoble 1</orgName>
  <orgName type="acronym">UJF</orgName>
  <date type="end">2015-12-31</date>
  <desc>    <address>      <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ujf-grenoble.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="DSV/IRTSV" active="#struct-300016" type="direct"><org type="institution" xml:id="struct-300016" status="VALID">  <orgName>Commissariat à l'énergie atomique et aux énergies alternatives</orgName>
  <orgName type="acronym">CEA</orgName>
  <desc>    <address>      <addrLine>Centre de SaclayCentre de GrenobleCentre de Cadaracheetc</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cea.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-300071" type="direct"><org type="institution" xml:id="struct-300071" status="VALID">  <orgName>CHU Grenoble</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
<tutelle name="U836" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">  <idno type="IdRef">026388278</idno>
  <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
  <orgName type="acronym">INSERM</orgName>
  <desc>    <address>      <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.inserm.fr</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Joseph Fourier</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Grenoble</orgName>
</affiliation>
</author>
<author><name sortKey="Savasta, Marc" sort="Savasta, Marc" uniqKey="Savasta M" first="Marc" last="Savasta">Marc Savasta</name>
<affiliation wicri:level="1"><hal:affiliation type="researchteam" xml:id="struct-391045" status="INCOMING">  <orgName>INSERM U836, équipe 10, Dynamique des réseaux neuronaux du mouvement</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-86972" type="direct"></relation>
    <relation active="#struct-51016" type="indirect"></relation>
    <relation name="DSV/IRTSV" active="#struct-300016" type="indirect"></relation>
    <relation active="#struct-300071" type="indirect"></relation>
    <relation name="U836" active="#struct-303623" type="indirect"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-86972" type="direct"><org type="laboratory" xml:id="struct-86972" status="VALID">  <orgName>Grenoble Institut des Neurosciences</orgName>
  <orgName type="acronym">GIN</orgName>
  <desc>    <address>      <addrLine>UJF - Site Santé La Tronche - BP 170 - 38042 Grenoble Cedex 9</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://neurosciences.ujf-grenoble.fr/</ref>
  </desc>
  <listRelation>    <relation active="#struct-51016" type="direct"></relation>
    <relation name="DSV/IRTSV" active="#struct-300016" type="direct"></relation>
    <relation active="#struct-300071" type="direct"></relation>
    <relation name="U836" active="#struct-303623" type="direct"></relation>
  </listRelation>
</org>
</tutelle>
<tutelle active="#struct-51016" type="indirect"><org type="institution" xml:id="struct-51016" status="OLD">  <idno type="IdRef">026404796</idno>
  <orgName>Université Joseph Fourier - Grenoble 1</orgName>
  <orgName type="acronym">UJF</orgName>
  <date type="end">2015-12-31</date>
  <desc>    <address>      <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ujf-grenoble.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="DSV/IRTSV" active="#struct-300016" type="indirect"><org type="institution" xml:id="struct-300016" status="VALID">  <orgName>Commissariat à l'énergie atomique et aux énergies alternatives</orgName>
  <orgName type="acronym">CEA</orgName>
  <desc>    <address>      <addrLine>Centre de SaclayCentre de GrenobleCentre de Cadaracheetc</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cea.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-300071" type="indirect"><org type="institution" xml:id="struct-300071" status="VALID">  <orgName>CHU Grenoble</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
<tutelle name="U836" active="#struct-303623" type="indirect"><org type="institution" xml:id="struct-303623" status="VALID">  <idno type="IdRef">026388278</idno>
  <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
  <orgName type="acronym">INSERM</orgName>
  <desc>    <address>      <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.inserm.fr</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Joseph Fourier</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Grenoble</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">HAL</idno>
<idno type="RBID">Hal:inserm-00742517</idno>
<idno type="halId">inserm-00742517</idno>
<idno type="halUri">http://www.hal.inserm.fr/inserm-00742517</idno>
<idno type="url">http://www.hal.inserm.fr/inserm-00742517</idno>
<idno type="doi">10.1016/j.nbd.2012.06.009</idno>
<date when="2012-12">2012-12</date>
<idno type="wicri:Area/Hal/Corpus">000361</idno>
<idno type="wicri:Area/Hal/Curation">000361</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Effects of L-DOPA and STN-HFS dyskinesiogenic treatments on NR2B regulation in basal ganglia in the rat model of Parkinson's disease.</title>
<title xml:lang="en" type="sub">NR2B hyperphosphorylation driven by L-DOPA and STN-HFS</title>
<author><name sortKey="Quintana, Adrien" sort="Quintana, Adrien" uniqKey="Quintana A" first="Adrien" last="Quintana">Adrien Quintana</name>
<affiliation wicri:level="1"><hal:affiliation type="researchteam" xml:id="struct-391045" status="INCOMING">  <orgName>INSERM U836, équipe 10, Dynamique des réseaux neuronaux du mouvement</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-86972" type="direct"></relation>
    <relation active="#struct-51016" type="indirect"></relation>
    <relation name="DSV/IRTSV" active="#struct-300016" type="indirect"></relation>
    <relation active="#struct-300071" type="indirect"></relation>
    <relation name="U836" active="#struct-303623" type="indirect"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-86972" type="direct"><org type="laboratory" xml:id="struct-86972" status="VALID">  <orgName>Grenoble Institut des Neurosciences</orgName>
  <orgName type="acronym">GIN</orgName>
  <desc>    <address>      <addrLine>UJF - Site Santé La Tronche - BP 170 - 38042 Grenoble Cedex 9</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://neurosciences.ujf-grenoble.fr/</ref>
  </desc>
  <listRelation>    <relation active="#struct-51016" type="direct"></relation>
    <relation name="DSV/IRTSV" active="#struct-300016" type="direct"></relation>
    <relation active="#struct-300071" type="direct"></relation>
    <relation name="U836" active="#struct-303623" type="direct"></relation>
  </listRelation>
</org>
</tutelle>
<tutelle active="#struct-51016" type="indirect"><org type="institution" xml:id="struct-51016" status="OLD">  <idno type="IdRef">026404796</idno>
  <orgName>Université Joseph Fourier - Grenoble 1</orgName>
  <orgName type="acronym">UJF</orgName>
  <date type="end">2015-12-31</date>
  <desc>    <address>      <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ujf-grenoble.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="DSV/IRTSV" active="#struct-300016" type="indirect"><org type="institution" xml:id="struct-300016" status="VALID">  <orgName>Commissariat à l'énergie atomique et aux énergies alternatives</orgName>
  <orgName type="acronym">CEA</orgName>
  <desc>    <address>      <addrLine>Centre de SaclayCentre de GrenobleCentre de Cadaracheetc</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cea.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-300071" type="indirect"><org type="institution" xml:id="struct-300071" status="VALID">  <orgName>CHU Grenoble</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
<tutelle name="U836" active="#struct-303623" type="indirect"><org type="institution" xml:id="struct-303623" status="VALID">  <idno type="IdRef">026388278</idno>
  <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
  <orgName type="acronym">INSERM</orgName>
  <desc>    <address>      <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.inserm.fr</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Joseph Fourier</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Grenoble</orgName>
</affiliation>
</author>
<author><name sortKey="Sgambato Faure, Veronique" sort="Sgambato Faure, Veronique" uniqKey="Sgambato Faure V" first="Véronique" last="Sgambato-Faure">Véronique Sgambato-Faure</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-86972" status="VALID">  <orgName>Grenoble Institut des Neurosciences</orgName>
  <orgName type="acronym">GIN</orgName>
  <desc>    <address>      <addrLine>UJF - Site Santé La Tronche - BP 170 - 38042 Grenoble Cedex 9</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://neurosciences.ujf-grenoble.fr/</ref>
  </desc>
  <listRelation>    <relation active="#struct-51016" type="direct"></relation>
    <relation name="DSV/IRTSV" active="#struct-300016" type="direct"></relation>
    <relation active="#struct-300071" type="direct"></relation>
    <relation name="U836" active="#struct-303623" type="direct"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-51016" type="direct"><org type="institution" xml:id="struct-51016" status="OLD">  <idno type="IdRef">026404796</idno>
  <orgName>Université Joseph Fourier - Grenoble 1</orgName>
  <orgName type="acronym">UJF</orgName>
  <date type="end">2015-12-31</date>
  <desc>    <address>      <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ujf-grenoble.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="DSV/IRTSV" active="#struct-300016" type="direct"><org type="institution" xml:id="struct-300016" status="VALID">  <orgName>Commissariat à l'énergie atomique et aux énergies alternatives</orgName>
  <orgName type="acronym">CEA</orgName>
  <desc>    <address>      <addrLine>Centre de SaclayCentre de GrenobleCentre de Cadaracheetc</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cea.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-300071" type="direct"><org type="institution" xml:id="struct-300071" status="VALID">  <orgName>CHU Grenoble</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
<tutelle name="U836" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID">  <idno type="IdRef">026388278</idno>
  <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
  <orgName type="acronym">INSERM</orgName>
  <desc>    <address>      <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.inserm.fr</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Joseph Fourier</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Grenoble</orgName>
</affiliation>
</author>
<author><name sortKey="Savasta, Marc" sort="Savasta, Marc" uniqKey="Savasta M" first="Marc" last="Savasta">Marc Savasta</name>
<affiliation wicri:level="1"><hal:affiliation type="researchteam" xml:id="struct-391045" status="INCOMING">  <orgName>INSERM U836, équipe 10, Dynamique des réseaux neuronaux du mouvement</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
  <listRelation>    <relation active="#struct-86972" type="direct"></relation>
    <relation active="#struct-51016" type="indirect"></relation>
    <relation name="DSV/IRTSV" active="#struct-300016" type="indirect"></relation>
    <relation active="#struct-300071" type="indirect"></relation>
    <relation name="U836" active="#struct-303623" type="indirect"></relation>
  </listRelation>
<tutelles><tutelle active="#struct-86972" type="direct"><org type="laboratory" xml:id="struct-86972" status="VALID">  <orgName>Grenoble Institut des Neurosciences</orgName>
  <orgName type="acronym">GIN</orgName>
  <desc>    <address>      <addrLine>UJF - Site Santé La Tronche - BP 170 - 38042 Grenoble Cedex 9</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://neurosciences.ujf-grenoble.fr/</ref>
  </desc>
  <listRelation>    <relation active="#struct-51016" type="direct"></relation>
    <relation name="DSV/IRTSV" active="#struct-300016" type="direct"></relation>
    <relation active="#struct-300071" type="direct"></relation>
    <relation name="U836" active="#struct-303623" type="direct"></relation>
  </listRelation>
</org>
</tutelle>
<tutelle active="#struct-51016" type="indirect"><org type="institution" xml:id="struct-51016" status="OLD">  <idno type="IdRef">026404796</idno>
  <orgName>Université Joseph Fourier - Grenoble 1</orgName>
  <orgName type="acronym">UJF</orgName>
  <date type="end">2015-12-31</date>
  <desc>    <address>      <addrLine>BP 53 - 38041 Grenoble Cedex 9</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.ujf-grenoble.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle name="DSV/IRTSV" active="#struct-300016" type="indirect"><org type="institution" xml:id="struct-300016" status="VALID">  <orgName>Commissariat à l'énergie atomique et aux énergies alternatives</orgName>
  <orgName type="acronym">CEA</orgName>
  <desc>    <address>      <addrLine>Centre de SaclayCentre de GrenobleCentre de Cadaracheetc</addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.cea.fr/</ref>
  </desc>
</org>
</tutelle>
<tutelle active="#struct-300071" type="indirect"><org type="institution" xml:id="struct-300071" status="VALID">  <orgName>CHU Grenoble</orgName>
  <desc>    <address>      <country key="FR"></country>
    </address>
  </desc>
</org>
</tutelle>
<tutelle name="U836" active="#struct-303623" type="indirect"><org type="institution" xml:id="struct-303623" status="VALID">  <idno type="IdRef">026388278</idno>
  <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
  <orgName type="acronym">INSERM</orgName>
  <desc>    <address>      <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
      <country key="FR"></country>
    </address>
    <ref type="url">http://www.inserm.fr</ref>
  </desc>
</org>
</tutelle>
</tutelles>
</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Grenoble</settlement>
<region type="region" nuts="2">Auvergne-Rhône-Alpes</region>
<region type="old region" nuts="2">Rhône-Alpes</region>
</placeName>
<orgName type="university">Université Joseph Fourier</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Grenoble</orgName>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1016/j.nbd.2012.06.009</idno>
<series><title level="j">Neurobiology of Disease</title>
<idno type="ISSN">0969-9961</idno>
<imprint><date type="datePub">2012-12</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Dyskinesia is a major side effect of chronic levodopa (L-DOPA) administration, the reference treatment for Parkinson's disease (PD). High-frequency stimulation of the subthalamic nucleus (STN-HFS) alleviates parkinsonian motor symptoms and indirectly improves dyskinesia by decreasing L-DOPA requirement. However, inadequate stimulation can also trigger dyskinetic movements in PD patients and animal models. Here, we investigated the possible association between L-DOPA- and STN-HFS-induced dyskinesia and regulation of the NR2B subunit of NMDA receptors in the rodent model of PD. We subjected 6-OHDA-lesioned rats to HFS for 1h, at an intensity triggering forelimb dyskinesia. Other 6-OHDA-lesioned rats were treated with chronic high doses of L-DOPA for ten days, to induce abnormal involuntary movements. The 6-OHDA lesion regulated NR2B only in the SNr, where the activation of NR2B was observed (as assessed by phosphorylation of the Tyr(1472) residue). Both STN-HFS and L-DOPA dyskinesiogenic treatments induced NR2B activation in the STN and EP, but only L-DOPA triggered NR2B hyperphosphorylation in the striatum. Finally, the use of CP-101,606 exacerbated L-DOPA-induced motor behavior and associated NR2B hyperphosphorylation in the striatum, STN and EP. Thus, NR2B activation in basal ganglia structures is correlated with dyskinesia.</div>
</front>
</TEI>
<hal api="V3">          <titleStmt>            <title xml:lang="en">Effects of L-DOPA and STN-HFS dyskinesiogenic treatments on NR2B regulation in basal ganglia in the rat model of Parkinson's disease.</title>
            <title xml:lang="en" type="sub">NR2B hyperphosphorylation driven by L-DOPA and STN-HFS</title>
            <author role="aut">              <persName>                <forename type="first">Adrien</forename>
                <surname>Quintana</surname>
              </persName>
              <idno type="halauthorid">687212</idno>
              <affiliation ref="#struct-391045"></affiliation>
            </author>
            <author role="crp">              <persName>                <forename type="first">Véronique</forename>
                <surname>Sgambato-Faure</surname>
              </persName>
              <email type="md5">33787b0c06f6dac6539af145ba5266ac</email>
              <email type="domain">isc.cnrs.fr</email>
              <idno type="halauthorid">773388</idno>
              <affiliation ref="#struct-86972"></affiliation>
            </author>
            <author role="crp">              <persName>                <forename type="first">Marc</forename>
                <surname>Savasta</surname>
              </persName>
              <email type="md5">17a3ed21e3dd17a996152da3d29e00bb</email>
              <email type="domain">ujf-grenoble.fr</email>
              <idno type="halauthorid">410373</idno>
              <affiliation ref="#struct-391045"></affiliation>
            </author>
            <editor role="depositor">              <persName>                <forename>Marc</forename>
                <surname>Savasta</surname>
              </persName>
              <email type="md5">17a3ed21e3dd17a996152da3d29e00bb</email>
              <email type="domain">ujf-grenoble.fr</email>
            </editor>
            <funder>Institut National de la Santé et de la Recherche Médicale; le Ministère de la Recherche et des Nouvelles Technologies; Région Rhône-Alpes (Cluster no.11); Association France Parkinson; Fondation NRJ-Institut de France.</funder>
          </titleStmt>
          <editionStmt>            <edition n="v1" type="current">              <date type="whenSubmitted">2012-10-16 15:23:36</date>
              <date type="whenModified">2014-10-13 15:43:25</date>
              <date type="whenReleased">2012-10-16 15:52:32</date>
              <date type="whenProduced">2012-12</date>
              <date type="whenEndEmbargoed">2012-10-16</date>
              <ref type="file" target="http://www.hal.inserm.fr/inserm-00742517/document">                <date notBefore="2012-10-16"></date>
              </ref>
              <ref type="file" subtype="author" n="1" target="http://www.hal.inserm.fr/inserm-00742517/file/Quintana_2012_DyskinesieParkinson_MA-1.pdf">                <date notBefore="2012-10-16"></date>
              </ref>
            </edition>
            <respStmt>              <resp>contributor</resp>
              <name key="140382">                <persName>                  <forename>Marc</forename>
                  <surname>Savasta</surname>
                </persName>
                <email type="md5">17a3ed21e3dd17a996152da3d29e00bb</email>
                <email type="domain">ujf-grenoble.fr</email>
              </name>
            </respStmt>
          </editionStmt>
          <publicationStmt>            <distributor>CCSD</distributor>
            <idno type="halId">inserm-00742517</idno>
            <idno type="halUri">http://www.hal.inserm.fr/inserm-00742517</idno>
            <idno type="halBibtex">quintana:inserm-00742517</idno>
            <idno type="halRefHtml">Neurobiology of Disease, Elsevier, 2012, 48 (3), pp.379-90. <10.1016/j.nbd.2012.06.009></idno>
            <idno type="halRef">Neurobiology of Disease, Elsevier, 2012, 48 (3), pp.379-90. <10.1016/j.nbd.2012.06.009></idno>
          </publicationStmt>
          <seriesStmt>            <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno>
            <idno type="stamp" n="CEA">CEA - Commissariat à l'énergie atomique</idno>
            <idno type="stamp" n="UNIV-GRENOBLE1" p="UGA">Université Joseph Fourier - Grenoble I</idno>
            <idno type="stamp" n="U836" p="INSERM">Grenoble Institut des Neurosciences</idno>
            <idno type="stamp" n="UGA">HAL Grenoble Alpes</idno>
          </seriesStmt>
          <notesStmt>            <note type="audience" n="2">International</note>
            <note type="popular" n="0">No</note>
            <note type="peer" n="1">Yes</note>
          </notesStmt>
          <sourceDesc>            <biblStruct>              <analytic>                <title xml:lang="en">Effects of L-DOPA and STN-HFS dyskinesiogenic treatments on NR2B regulation in basal ganglia in the rat model of Parkinson's disease.</title>
                <title xml:lang="en" type="sub">NR2B hyperphosphorylation driven by L-DOPA and STN-HFS</title>
                <author role="aut">                  <persName>                    <forename type="first">Adrien</forename>
                    <surname>Quintana</surname>
                  </persName>
                  <idno type="halauthorid">687212</idno>
                  <affiliation ref="#struct-391045"></affiliation>
                </author>
                <author role="crp">                  <persName>                    <forename type="first">Véronique</forename>
                    <surname>Sgambato-Faure</surname>
                  </persName>
                  <email type="md5">33787b0c06f6dac6539af145ba5266ac</email>
                  <email type="domain">isc.cnrs.fr</email>
                  <idno type="halauthorid">773388</idno>
                  <affiliation ref="#struct-86972"></affiliation>
                </author>
                <author role="crp">                  <persName>                    <forename type="first">Marc</forename>
                    <surname>Savasta</surname>
                  </persName>
                  <email type="md5">17a3ed21e3dd17a996152da3d29e00bb</email>
                  <email type="domain">ujf-grenoble.fr</email>
                  <idno type="halauthorid">410373</idno>
                  <affiliation ref="#struct-391045"></affiliation>
                </author>
              </analytic>
              <monogr>                <idno type="halJournalId" status="VALID">13277</idno>
                <idno type="issn">0969-9961</idno>
                <idno type="eissn">1095-953X</idno>
                <title level="j">Neurobiology of Disease</title>
                <imprint>                  <publisher>Elsevier</publisher>
                  <biblScope unit="volume">48</biblScope>
                  <biblScope unit="issue">3</biblScope>
                  <biblScope unit="pp">379-90</biblScope>
                  <date type="datePub">2012-12</date>
                  <date type="dateEpub">2012-06-30</date>
                </imprint>
              </monogr>
              <idno type="doi">10.1016/j.nbd.2012.06.009</idno>
              <idno type="pubmed">22759925</idno>
            </biblStruct>
          </sourceDesc>
          <profileDesc>            <langUsage>              <language ident="en">English</language>
            </langUsage>
            <textClass>              <classCode scheme="halDomain" n="sdv.neu">Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]</classCode>
              <classCode scheme="halDomain" n="sdv.mhep.phy">Life Sciences [q-bio]/Human health and pathology/Tissues and Organs [q-bio.TO]</classCode>
              <classCode scheme="halTypology" n="ART">Journal articles</classCode>
            </textClass>
            <abstract xml:lang="en">Dyskinesia is a major side effect of chronic levodopa (L-DOPA) administration, the reference treatment for Parkinson's disease (PD). High-frequency stimulation of the subthalamic nucleus (STN-HFS) alleviates parkinsonian motor symptoms and indirectly improves dyskinesia by decreasing L-DOPA requirement. However, inadequate stimulation can also trigger dyskinetic movements in PD patients and animal models. Here, we investigated the possible association between L-DOPA- and STN-HFS-induced dyskinesia and regulation of the NR2B subunit of NMDA receptors in the rodent model of PD. We subjected 6-OHDA-lesioned rats to HFS for 1h, at an intensity triggering forelimb dyskinesia. Other 6-OHDA-lesioned rats were treated with chronic high doses of L-DOPA for ten days, to induce abnormal involuntary movements. The 6-OHDA lesion regulated NR2B only in the SNr, where the activation of NR2B was observed (as assessed by phosphorylation of the Tyr(1472) residue). Both STN-HFS and L-DOPA dyskinesiogenic treatments induced NR2B activation in the STN and EP, but only L-DOPA triggered NR2B hyperphosphorylation in the striatum. Finally, the use of CP-101,606 exacerbated L-DOPA-induced motor behavior and associated NR2B hyperphosphorylation in the striatum, STN and EP. Thus, NR2B activation in basal ganglia structures is correlated with dyskinesia.</abstract>
          </profileDesc>
        </hal>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Hal/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000351 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Hal/Curation/biblio.hfd -nk 000351 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    ParkinsonFranceV1
   |flux=    Hal
   |étape=   Curation
   |type=    RBID
   |clé=     Hal:inserm-00742517
   |texte=   Effects of L-DOPA and STN-HFS dyskinesiogenic treatments on NR2B regulation in basal ganglia in the rat model of Parkinson's disease.
}}

This area was generated with Dilib version V0.6.29.
Data generation: Wed May 17 19:46:39 2017. Site generation: Mon Mar 4 15:48:15 2024

	La maladie de Parkinson en France (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson en France (serveur d'exploration)

Effects of L-DOPA and STN-HFS dyskinesiogenic treatments on NR2B regulation in basal ganglia in the rat model of Parkinson's disease.

Effects of L-DOPA and STN-HFS dyskinesiogenic treatments on NR2B regulation in basal ganglia in the rat model of Parkinson's disease.

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri