ParkinsonFranceV1, Hal, Corpus, bibRecord, 000092

Anti-inflammatory actions of a taurine analogue; ethane β-sultam; in phagocytic cells; in vivo and in vitro

Identifieur interne : 000092 ( Hal/Corpus ); précédent : 000091; suivant : 000093

Anti-inflammatory actions of a taurine analogue; ethane β-sultam; in phagocytic cells; in vivo and in vitro

Auteurs : Roberta J. Ward ; Frederic Lallemand ; Philippe De Witte ; Robert R. Crichton ; Jacques Piette ; Keith Tipton ; Karl Hemmings ; Arnaud Pitard ; Mike Page ; Laura Della Corte ; Deanna Taylor ; David Dexter

Source :

Biochemical Pharmacology [ 0006-2952 ] ; 2011-02-21.

RBID : Hal:hal-00672299

English descriptors

mix :
- taurine: anti-inflammatory action: ethane-β sultam: nitric oxide: glutamate.

Abstract

The ability of a taurine prodrug, ethane β-sultam, to reduce cellular inflammation has been investigated, , in primary cultures of alveolar macrophages and an immortilised N9 microglial cell line and in an animal model of inflammation and control rats. Ethane β-sultam showed enhanced ability to reduce the inflammatory response in alveolar macrophages, as assayed by the lipopolysaccharide-stimulated-nitric oxide release, (LPS stimulated-NO), in comparison to taurine both (10nM, 50nM) and in vivo (0.15mmol/kg/day by gavage). In addition, ethane β-sultam, (50, 100 and 1000nM) significantly reduced LPS-stimulated glutamate release from N9 microglial cells to a greater extent than taurine. The anti-inflammatory response of taurine was shown to be mediated via stabilisation of IkBα. The use of a taurine prodrug as therapeutic agents, for the treatment of neurological conditions, such as Parkinson's and Alzheimer's disease and alcoholic brain damage, where activated phagocytic cells contribute to the pathogenesis, may be of great potential.

Url:

https://hal.archives-ouvertes.fr/hal-00672299

DOI: 10.1016/j.bcp.2010.12.030

Links to Exploration step

Hal:hal-00672299

Le document en format XML

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<front><div type="abstract" xml:lang="en">The ability of a taurine prodrug, ethane β-sultam, to reduce cellular inflammation has been investigated, , in primary cultures of alveolar macrophages and an immortilised N9 microglial cell line and in an animal model of inflammation and control rats. Ethane β-sultam showed enhanced ability to reduce the inflammatory response in alveolar macrophages, as assayed by the lipopolysaccharide-stimulated-nitric oxide release, (LPS stimulated-NO), in comparison to taurine both (10nM, 50nM) and in vivo (0.15mmol/kg/day by gavage). In addition, ethane β-sultam, (50, 100 and 1000nM) significantly reduced LPS-stimulated glutamate release from N9 microglial cells to a greater extent than taurine. The anti-inflammatory response of taurine was shown to be mediated via stabilisation of IkBα. The use of a taurine prodrug as therapeutic agents, for the treatment of neurological conditions, such as Parkinson's and Alzheimer's disease and alcoholic brain damage, where activated phagocytic cells contribute to the pathogenesis, may be of great potential.</div>
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                <author role="aut">                  <persName>                    <forename type="first">Roberta J</forename>
                    <surname>Ward</surname>
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                <author role="aut">                  <persName>                    <forename type="first">Arnaud</forename>
                    <surname>Pitard</surname>
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                <author role="aut">                  <persName>                    <forename type="first">Laura Della</forename>
                    <surname>Corte</surname>
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                <author role="aut">                  <persName>                    <forename type="first">Deanna</forename>
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                    <surname>Dexter</surname>
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                <title level="j">Biochemical Pharmacology</title>
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                  <biblScope unit="volume">81</biblScope>
                  <biblScope unit="issue">6</biblScope>
                  <biblScope unit="pp">743</biblScope>
                  <date type="datePub">2011-02-21</date>
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            <textClass>              <keywords scheme="author">                <term xml:lang="en">taurine: anti-inflammatory action: ethane-β sultam: nitric oxide: glutamate</term>
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            <abstract xml:lang="en">The ability of a taurine prodrug, ethane β-sultam, to reduce cellular inflammation has been investigated, , in primary cultures of alveolar macrophages and an immortilised N9 microglial cell line and in an animal model of inflammation and control rats. Ethane β-sultam showed enhanced ability to reduce the inflammatory response in alveolar macrophages, as assayed by the lipopolysaccharide-stimulated-nitric oxide release, (LPS stimulated-NO), in comparison to taurine both (10nM, 50nM) and in vivo (0.15mmol/kg/day by gavage). In addition, ethane β-sultam, (50, 100 and 1000nM) significantly reduced LPS-stimulated glutamate release from N9 microglial cells to a greater extent than taurine. The anti-inflammatory response of taurine was shown to be mediated via stabilisation of IkBα. The use of a taurine prodrug as therapeutic agents, for the treatment of neurological conditions, such as Parkinson's and Alzheimer's disease and alcoholic brain damage, where activated phagocytic cells contribute to the pathogenesis, may be of great potential.</abstract>
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	La maladie de Parkinson en France (serveur d'exploration)
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Anti-inflammatory actions of a taurine analogue; ethane β-sultam; in phagocytic cells; in vivo and in vitro

Anti-inflammatory actions of a taurine analogue; ethane β-sultam; in phagocytic cells; in vivo and in vitro

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