[Clinical characteristics and molecular epidemiology of the novel influenza A (H1N1) infection in children in Shanghai].
Identifieur interne : 000968 ( PubMed/Curation ); précédent : 000967; suivant : 000969[Clinical characteristics and molecular epidemiology of the novel influenza A (H1N1) infection in children in Shanghai].
Auteurs : Xiang-Shi Wang [République populaire de Chine] ; Jie-Hao Cai ; Wei-Lei Yao ; Yan-Ling Ge ; Qi-Rong Zhu ; Mei ZengSource :
- Zhonghua er ke za zhi = Chinese journal of pediatrics [ 0578-1310 ] ; 2013.
Descripteurs français
- KwdFr :
- Adolescent, Antiviraux (pharmacologie), Chine (épidémiologie), Données de séquences moléculaires, Enfant, Enfant d'âge préscolaire, Femelle, Grippe humaine (anatomopathologie), Grippe humaine (traitement médicamenteux), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains, Hémagglutinines virales (génétique), Mâle, Nourrisson, Oséltamivir (pharmacologie), Pandémies, Résistance virale aux médicaments, Sialidase (génétique), Sous-type H1N1 du virus de la grippe A (), Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (isolement et purification), Séquence d'acides aminés, Vaccins antiviraux (génétique), Vaccins antiviraux (immunologie), Épidémiologie moléculaire.
- MESH :
- anatomopathologie : Grippe humaine.
- génétique : Hémagglutinines virales, Sialidase, Sous-type H1N1 du virus de la grippe A, Vaccins antiviraux.
- immunologie : Vaccins antiviraux.
- isolement et purification : Sous-type H1N1 du virus de la grippe A.
- pharmacologie : Antiviraux, Oséltamivir.
- traitement médicamenteux : Grippe humaine.
- virologie : Grippe humaine.
- épidémiologie : Chine, Grippe humaine.
- Adolescent, Données de séquences moléculaires, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Mâle, Nourrisson, Pandémies, Résistance virale aux médicaments, Sous-type H1N1 du virus de la grippe A, Séquence d'acides aminés, Épidémiologie moléculaire.
- Wicri :
- geographic : République populaire de Chine.
English descriptors
- KwdEn :
- Adolescent, Amino Acid Sequence, Antiviral Agents (pharmacology), Child, Child, Preschool, China (epidemiology), Drug Resistance, Viral, Female, Hemagglutinins, Viral (genetics), Humans, Infant, Influenza A Virus, H1N1 Subtype (classification), Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (isolation & purification), Influenza, Human (drug therapy), Influenza, Human (epidemiology), Influenza, Human (pathology), Influenza, Human (virology), Male, Molecular Epidemiology, Molecular Sequence Data, Neuraminidase (genetics), Oseltamivir (pharmacology), Pandemics, Viral Vaccines (genetics), Viral Vaccines (immunology).
- MESH :
- chemical , genetics : Hemagglutinins, Viral, Neuraminidase, Viral Vaccines.
- chemical , immunology : Viral Vaccines.
- chemical , pharmacology : Antiviral Agents, Oseltamivir.
- geographic , epidemiology : China.
- classification : Influenza A Virus, H1N1 Subtype.
- drug therapy : Influenza, Human.
- epidemiology : Influenza, Human.
- genetics : Influenza A Virus, H1N1 Subtype.
- isolation & purification : Influenza A Virus, H1N1 Subtype.
- pathology : Influenza, Human.
- virology : Influenza, Human.
- Adolescent, Amino Acid Sequence, Child, Child, Preschool, Drug Resistance, Viral, Female, Humans, Infant, Male, Molecular Epidemiology, Molecular Sequence Data, Pandemics.
Abstract
To investigate the epidemiological features, genetic drift in the epitopes of hemagglutinin (HA) of the novel influenza A (H1N1) virus and oseltamivir-resistant variants characterized by H275Y and N295S mutations in children in Shanghai since the outbreak.
PubMed: 23941842
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(pharmacologie)</term><term>Pandémies</term><term>Résistance virale aux médicaments</term><term>Sialidase (génétique)</term><term>Sous-type H1N1 du virus de la grippe A ()</term><term>Sous-type H1N1 du virus de la grippe A (génétique)</term><term>Sous-type H1N1 du virus de la grippe A (isolement et purification)</term><term>Séquence d'acides aminés</term><term>Vaccins antiviraux (génétique)</term><term>Vaccins antiviraux (immunologie)</term><term>Épidémiologie moléculaire</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hemagglutinins, Viral</term><term>Neuraminidase</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Viral Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiviral Agents</term><term>Oseltamivir</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" 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Viral</term><term>Female</term><term>Humans</term><term>Infant</term><term>Male</term><term>Molecular Epidemiology</term><term>Molecular Sequence Data</term><term>Pandemics</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Données de séquences moléculaires</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Nourrisson</term><term>Pandémies</term><term>Résistance virale aux médicaments</term><term>Sous-type H1N1 du virus de la grippe A</term><term>Séquence d'acides aminés</term><term>Épidémiologie moléculaire</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To investigate the epidemiological features, genetic drift in the epitopes of hemagglutinin (HA) of the novel influenza A (H1N1) virus and oseltamivir-resistant variants characterized by H275Y and N295S mutations in children in Shanghai since the outbreak.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23941842</PMID><DateCompleted><Year>2014</Year><Month>04</Month><Day>07</Day></DateCompleted><DateRevised><Year>2016</Year><Month>06</Month><Day>07</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0578-1310</ISSN><JournalIssue CitedMedium="Print"><Volume>51</Volume><Issue>5</Issue><PubDate><Year>2013</Year><Month>May</Month></PubDate></JournalIssue><Title>Zhonghua er ke za zhi = Chinese journal of pediatrics</Title><ISOAbbreviation>Zhonghua Er Ke Za Zhi</ISOAbbreviation></Journal><ArticleTitle>[Clinical characteristics and molecular epidemiology of the novel influenza A (H1N1) infection in children in Shanghai].</ArticleTitle><Pagination><MedlinePgn>356-61</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">To investigate the epidemiological features, genetic drift in the epitopes of hemagglutinin (HA) of the novel influenza A (H1N1) virus and oseltamivir-resistant variants characterized by H275Y and N295S mutations in children in Shanghai since the outbreak.</AbstractText><AbstractText Label="METHOD" NlmCategory="METHODS">Between June 2009 and May 2012, a prospective surveillance study was carried out in Shanghainese children who attended the outpatient clinic of Children's Hospital of Fudan University for influenza-like illness. One-step real-time fluorescence quantitative RT-PCR was performed to detect seasonal influenza A and influenza B virus and the novel influenza A (H1N1) virus in the respiratory samples. Genetic drift from the vaccine strain in HA epitopes of the novel influenza H1N1 virus and the molecular markers associated with oseltamivir resistance in neuraminidase (NA) were analyzed.</AbstractText><AbstractText Label="RESULT" NlmCategory="RESULTS">Out of 3475 enrolled cases, the novel influenza A (H1N1) virus was confirmed virologically in 222 (6.4%) otherwise healthy children with 133 (59.9%) being boys and 89 (40.1%) girls. The median ages of children with the novel influenza A (H1N1) virus infection during the first wave from August 2009 to February 2010 and the second wave from December 2010 to February 2011 were 53.5 months and 32.0 months, respectively (Z = -4.601, P = 0.000); 119 (46.9%) had the close contact with persons suffering from fever or respiratory infection, of whom, 68 (57.1%) contacts were family members and 47 (39.5%) contacts were classmates. During the outbreak in 2009-2010 season, 66 (40.9%) were exposed to primary index cases, school students were the major exposure subjects, accounting for 50.0%. The nucleotide sequences of HA1 gene were highly homologous between the vaccine strain A/California/07/2009 and Shanghai circulating novel influenza A (H1N1) strains and only S83P mutation in epitope E of HA was detected inclusively in the circulating strains. The H275Y and N295S amino acid mutations associated with oseltamivir resistance were not found in the circulating novel influenza (H1N1) strains.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Two major waves of the novel influenza A (H1N1) outbreaks occurred in Shanghainese children during 2009-2011. Institutional children were the major affected individuals during the 2009 pandemic wave. Households and schools were the main sites of transmission among children during influenza pandemic. Influenza vaccination should be enhanced in children and their close family contacts. The novel influenza A (H1N1) virus in Shanghai has not undergone significant genetic changes. Oseltamivir is effective for the treatment of the novel influenza A (H1N1) virus.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Xiang-Shi</ForeName><Initials>XS</Initials><AffiliationInfo><Affiliation>Department of Infectious Diseases, Children's Hospital of Fudan University, Shanghai 201102, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cai</LastName><ForeName>Jie-Hao</ForeName><Initials>JH</Initials></Author><Author ValidYN="Y"><LastName>Yao</LastName><ForeName>Wei-Lei</ForeName><Initials>WL</Initials></Author><Author ValidYN="Y"><LastName>Ge</LastName><ForeName>Yan-Ling</ForeName><Initials>YL</Initials></Author><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Qi-Rong</ForeName><Initials>QR</Initials></Author><Author ValidYN="Y"><LastName>Zeng</LastName><ForeName>Mei</ForeName><Initials>M</Initials></Author></AuthorList><Language>chi</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>China</Country><MedlineTA>Zhonghua Er Ke Za Zhi</MedlineTA><NlmUniqueID>0417427</NlmUniqueID><ISSNLinking>0578-1310</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006389">Hemagglutinins, Viral</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D014765">Viral Vaccines</NameOfSubstance></Chemical><Chemical><RegistryNumber>20O93L6F9H</RegistryNumber><NameOfSubstance UI="D053139">Oseltamivir</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.2.1.18</RegistryNumber><NameOfSubstance UI="D009439">Neuraminidase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002681" MajorTopicYN="N" Type="Geographic">China</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D024882" MajorTopicYN="N">Drug Resistance, Viral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006389" MajorTopicYN="N">Hemagglutinins, Viral</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017720" MajorTopicYN="N">Molecular Epidemiology</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008969" MajorTopicYN="N">Molecular Sequence Data</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009439" MajorTopicYN="N">Neuraminidase</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053139" MajorTopicYN="N">Oseltamivir</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014765" MajorTopicYN="N">Viral Vaccines</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>8</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>8</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>4</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23941842</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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