What treating Ebola means for pandemic influenza.
Identifieur interne : 000279 ( PubMed/Corpus ); précédent : 000278; suivant : 000280What treating Ebola means for pandemic influenza.
Auteurs : David S. FedsonSource :
- Journal of public health policy [ 1745-655X ] ; 2018.
English descriptors
- KwdEn :
- Angiotensin Receptor Antagonists (economics), Angiotensin Receptor Antagonists (therapeutic use), Clinical Trials as Topic, Drug Combinations, Drugs, Generic (economics), Drugs, Generic (supply & distribution), Drugs, Generic (therapeutic use), Global Health, Hemorrhagic Fever, Ebola (drug therapy), Hemorrhagic Fever, Ebola (epidemiology), Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors (economics), Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use), Influenza, Human (epidemiology), Influenza, Human (prevention & control), Molecular Targeted Therapy, Pandemics (prevention & control), Survival Analysis.
- MESH :
- chemical , economics : Angiotensin Receptor Antagonists, Drugs, Generic, Hydroxymethylglutaryl-CoA Reductase Inhibitors.
- chemical , supply & distribution : Drugs, Generic.
- chemical , therapeutic use : Angiotensin Receptor Antagonists, Drugs, Generic, Hydroxymethylglutaryl-CoA Reductase Inhibitors.
- drug therapy : Hemorrhagic Fever, Ebola.
- epidemiology : Hemorrhagic Fever, Ebola, Influenza, Human.
- prevention & control : Influenza, Human, Pandemics.
- Clinical Trials as Topic, Drug Combinations, Global Health, Humans, Molecular Targeted Therapy, Survival Analysis.
Abstract
Almost all new treatments being developed for the next influenza pandemic target the virus. During the Ebola crisis in West Africa, patients were treated with an inexpensive generic statin/angiotensin receptor blocker combination that appeared to greatly improve survival. These drugs target the host response, not the virus, and probably reverse endothelial dysfunction. Scientists and health officials have shown little interest in this idea. Yet, during the early months of the next pandemic, vaccines will be unavailable and treatment options will be limited. Physicians should be prepared to undertake clinical trials of widely available generic drugs to determine whether they improve survival in patients with seasonal influenza, other emerging virus diseases, and other forms of acute critical illness. Public health officials should give these studies their strong support. If successful, they will suggest a 'bottom up' approach to patient care that could be implemented worldwide on the first pandemic day.
DOI: 10.1057/s41271-018-0138-8
PubMed: 30013135
Links to Exploration step
pubmed:30013135Le document en format XML
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Fedson</name><affiliation><nlm:affiliation>, 57, chemin du Lavoir, 01630, Sergy Haut, France. davidsfedson@gmail.com.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:30013135</idno><idno type="pmid">30013135</idno><idno type="doi">10.1057/s41271-018-0138-8</idno><idno type="wicri:Area/PubMed/Corpus">000279</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000279</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">What treating Ebola means for pandemic influenza.</title><author><name sortKey="Fedson, David S" sort="Fedson, David S" uniqKey="Fedson D" first="David S" last="Fedson">David S. Fedson</name><affiliation><nlm:affiliation>, 57, chemin du Lavoir, 01630, Sergy Haut, France. davidsfedson@gmail.com.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Journal of public health policy</title><idno type="eISSN">1745-655X</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Angiotensin Receptor Antagonists (economics)</term><term>Angiotensin Receptor Antagonists (therapeutic use)</term><term>Clinical Trials as Topic</term><term>Drug Combinations</term><term>Drugs, Generic (economics)</term><term>Drugs, Generic (supply & distribution)</term><term>Drugs, Generic (therapeutic use)</term><term>Global Health</term><term>Hemorrhagic Fever, Ebola (drug therapy)</term><term>Hemorrhagic Fever, Ebola (epidemiology)</term><term>Humans</term><term>Hydroxymethylglutaryl-CoA Reductase Inhibitors (economics)</term><term>Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use)</term><term>Influenza, Human (epidemiology)</term><term>Influenza, Human (prevention & control)</term><term>Molecular Targeted Therapy</term><term>Pandemics (prevention & control)</term><term>Survival Analysis</term></keywords><keywords scheme="MESH" type="chemical" qualifier="economics" xml:lang="en"><term>Angiotensin Receptor Antagonists</term><term>Drugs, Generic</term><term>Hydroxymethylglutaryl-CoA Reductase Inhibitors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="supply & distribution" xml:lang="en"><term>Drugs, Generic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Angiotensin Receptor Antagonists</term><term>Drugs, Generic</term><term>Hydroxymethylglutaryl-CoA Reductase Inhibitors</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Hemorrhagic Fever, Ebola</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Hemorrhagic Fever, Ebola</term><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term><term>Pandemics</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Clinical Trials as Topic</term><term>Drug Combinations</term><term>Global Health</term><term>Humans</term><term>Molecular Targeted Therapy</term><term>Survival Analysis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Almost all new treatments being developed for the next influenza pandemic target the virus. During the Ebola crisis in West Africa, patients were treated with an inexpensive generic statin/angiotensin receptor blocker combination that appeared to greatly improve survival. These drugs target the host response, not the virus, and probably reverse endothelial dysfunction. Scientists and health officials have shown little interest in this idea. Yet, during the early months of the next pandemic, vaccines will be unavailable and treatment options will be limited. Physicians should be prepared to undertake clinical trials of widely available generic drugs to determine whether they improve survival in patients with seasonal influenza, other emerging virus diseases, and other forms of acute critical illness. Public health officials should give these studies their strong support. If successful, they will suggest a 'bottom up' approach to patient care that could be implemented worldwide on the first pandemic day.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30013135</PMID><DateCompleted><Year>2018</Year><Month>11</Month><Day>21</Day></DateCompleted><DateRevised><Year>2020</Year><Month>04</Month><Day>01</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1745-655X</ISSN><JournalIssue CitedMedium="Internet"><Volume>39</Volume><Issue>3</Issue><PubDate><Year>2018</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Journal of public health policy</Title><ISOAbbreviation>J Public Health Policy</ISOAbbreviation></Journal><ArticleTitle>What treating Ebola means for pandemic influenza.</ArticleTitle><Pagination><MedlinePgn>268-282</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1057/s41271-018-0138-8</ELocationID><Abstract><AbstractText>Almost all new treatments being developed for the next influenza pandemic target the virus. During the Ebola crisis in West Africa, patients were treated with an inexpensive generic statin/angiotensin receptor blocker combination that appeared to greatly improve survival. These drugs target the host response, not the virus, and probably reverse endothelial dysfunction. Scientists and health officials have shown little interest in this idea. Yet, during the early months of the next pandemic, vaccines will be unavailable and treatment options will be limited. Physicians should be prepared to undertake clinical trials of widely available generic drugs to determine whether they improve survival in patients with seasonal influenza, other emerging virus diseases, and other forms of acute critical illness. Public health officials should give these studies their strong support. If successful, they will suggest a 'bottom up' approach to patient care that could be implemented worldwide on the first pandemic day.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fedson</LastName><ForeName>David S</ForeName><Initials>DS</Initials><AffiliationInfo><Affiliation>, 57, chemin du Lavoir, 01630, Sergy Haut, France. davidsfedson@gmail.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>J Public Health Policy</MedlineTA><NlmUniqueID>8006508</NlmUniqueID><ISSNLinking>0197-5897</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D057911">Angiotensin Receptor Antagonists</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D004338">Drug Combinations</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016568">Drugs, Generic</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019161">Hydroxymethylglutaryl-CoA Reductase Inhibitors</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D057911" MajorTopicYN="N">Angiotensin Receptor Antagonists</DescriptorName><QualifierName UI="Q000191" MajorTopicYN="N">economics</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002986" MajorTopicYN="N">Clinical Trials as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004338" MajorTopicYN="N">Drug Combinations</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016568" MajorTopicYN="N">Drugs, Generic</DescriptorName><QualifierName UI="Q000191" MajorTopicYN="N">economics</QualifierName><QualifierName UI="Q000600" MajorTopicYN="N">supply & distribution</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014943" MajorTopicYN="N">Global Health</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019142" MajorTopicYN="N">Hemorrhagic Fever, Ebola</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019161" MajorTopicYN="N">Hydroxymethylglutaryl-CoA Reductase Inhibitors</DescriptorName><QualifierName UI="Q000191" MajorTopicYN="N">economics</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" 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