Mammalian-adaptive mutation NP-Q357K in Eurasian H1N1 Swine Influenza viruses determines the virulence phenotype in mice.
Identifieur interne : 000124 ( PubMed/Checkpoint ); précédent : 000123; suivant : 000125Mammalian-adaptive mutation NP-Q357K in Eurasian H1N1 Swine Influenza viruses determines the virulence phenotype in mice.
Auteurs : Wenfei Zhu [République populaire de Chine] ; Zhaomin Feng [République populaire de Chine] ; Yongkun Chen [République populaire de Chine] ; Lei Yang [République populaire de Chine] ; Jia Liu [République populaire de Chine] ; Xiyan Li [République populaire de Chine] ; Suli Liu [République populaire de Chine] ; Lijuan Zhou [République populaire de Chine] ; Hejiang Wei [République populaire de Chine] ; Rongbao Gao [République populaire de Chine] ; Dayan Wang [République populaire de Chine] ; Yuelong Shu [République populaire de Chine]Source :
- Emerging microbes & infections [ 2222-1751 ] ; 2019.
Descripteurs français
- KwdFr :
- Animaux, Chine, Femelle, Grippe humaine (virologie), Génotype, Humains, Infections à Orthomyxoviridae (médecine vétérinaire), Infections à Orthomyxoviridae (virologie), Maladies des porcs (virologie), Mutation faux-sens, Phylogénie, Protéines de liaison à l'ARN (génétique), Protéines de liaison à l'ARN (métabolisme), Protéines du core viral (génétique), Protéines du core viral (métabolisme), Réplication virale, Souris, Souris de lignée C57BL, Sous-type H1N1 du virus de la grippe A (), Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (pathogénicité), Sous-type H1N1 du virus de la grippe A (physiologie), Suidae, Virulence.
- MESH :
- génétique : Protéines de liaison à l'ARN, Protéines du core viral, Sous-type H1N1 du virus de la grippe A.
- médecine vétérinaire : Infections à Orthomyxoviridae.
- métabolisme : Protéines de liaison à l'ARN, Protéines du core viral.
- pathogénicité : Sous-type H1N1 du virus de la grippe A.
- physiologie : Sous-type H1N1 du virus de la grippe A.
- virologie : Grippe humaine, Infections à Orthomyxoviridae, Maladies des porcs.
- Animaux, Chine, Femelle, Génotype, Humains, Mutation faux-sens, Phylogénie, Réplication virale, Souris, Souris de lignée C57BL, Sous-type H1N1 du virus de la grippe A, Suidae, Virulence.
- Wicri :
- geographic : République populaire de Chine.
English descriptors
- KwdEn :
- Animals, China, Female, Genotype, Humans, Influenza A Virus, H1N1 Subtype (classification), Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (pathogenicity), Influenza A Virus, H1N1 Subtype (physiology), Influenza, Human (virology), Mice, Mice, Inbred C57BL, Mutation, Missense, Orthomyxoviridae Infections (veterinary), Orthomyxoviridae Infections (virology), Phylogeny, RNA-Binding Proteins (genetics), RNA-Binding Proteins (metabolism), Swine, Swine Diseases (virology), Viral Core Proteins (genetics), Viral Core Proteins (metabolism), Virulence, Virus Replication.
- MESH :
- chemical , genetics : RNA-Binding Proteins, Viral Core Proteins.
- chemical , metabolism : RNA-Binding Proteins, Viral Core Proteins.
- geographic : China.
- classification : Influenza A Virus, H1N1 Subtype.
- genetics : Influenza A Virus, H1N1 Subtype.
- pathogenicity : Influenza A Virus, H1N1 Subtype.
- physiology : Influenza A Virus, H1N1 Subtype.
- veterinary : Orthomyxoviridae Infections.
- virology : Influenza, Human, Orthomyxoviridae Infections, Swine Diseases.
- Animals, Female, Genotype, Humans, Mice, Mice, Inbred C57BL, Mutation, Missense, Phylogeny, Swine, Virulence, Virus Replication.
Abstract
It has recently been proposed that the Eurasian avian-like H1N1 (EA H1N1) swine influenza virus (SIV) is one of the most likely zoonotic viruses to cause the next influenza pandemic. Two main genotypes EA H1N1 viruses have been recognized to be infected humans in China. Our study finds that one of the genotypes JS1-like viruses are avirulent in mice. However, the other are HuN-like viruses and are virulent in mice. The molecular mechanism underlying this difference shows that the NP gene determines the virulence of the EA H1N1 viruses in mice. In addition, a single substitution, Q357K, in the NP protein of the EA H1N1 viruses alters the virulence phenotype. This substitution is a typical human signature marker, which is prevalent in human viruses but rarely detected in avian influenza viruses. The NP-Q357K substitution is readily to be occurred when avian influenza viruses circulate in pigs, and may facilitate their infection of humans and allow viruses also carrying NP-357K to circulate in humans. Our study demonstrates that the substitution Q357K in the NP protein plays a key role in the virulence phenotype of EA H1N1 SIVs, and provides important information for evaluating the pandemic risk of field influenza strains.
DOI: 10.1080/22221751.2019.1635873
PubMed: 31267843
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
pubmed:31267843Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mammalian-adaptive mutation NP-Q357K in Eurasian H1N1 Swine Influenza viruses determines the virulence phenotype in mice.</title>
<author><name sortKey="Zhu, Wenfei" sort="Zhu, Wenfei" uniqKey="Zhu W" first="Wenfei" last="Zhu">Wenfei Zhu</name>
<affiliation wicri:level="1"><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing </wicri:regionArea>
<wicri:noRegion>Beijing </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Feng, Zhaomin" sort="Feng, Zhaomin" uniqKey="Feng Z" first="Zhaomin" last="Feng">Zhaomin Feng</name>
<affiliation wicri:level="1"><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing </wicri:regionArea>
<wicri:noRegion>Beijing </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Yongkun" sort="Chen, Yongkun" uniqKey="Chen Y" first="Yongkun" last="Chen">Yongkun Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>c School of Public Health (Shenzhen) , Sun Yat-sen University , Guangdong , People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>c School of Public Health (Shenzhen) , Sun Yat-sen University , Guangdong </wicri:regionArea>
<wicri:noRegion>Guangdong </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Lei" sort="Yang, Lei" uniqKey="Yang L" first="Lei" last="Yang">Lei Yang</name>
<affiliation wicri:level="1"><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing </wicri:regionArea>
<wicri:noRegion>Beijing </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Jia" sort="Liu, Jia" uniqKey="Liu J" first="Jia" last="Liu">Jia Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing </wicri:regionArea>
<wicri:noRegion>Beijing </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Xiyan" sort="Li, Xiyan" uniqKey="Li X" first="Xiyan" last="Li">Xiyan Li</name>
<affiliation wicri:level="1"><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing </wicri:regionArea>
<wicri:noRegion>Beijing </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Suli" sort="Liu, Suli" uniqKey="Liu S" first="Suli" last="Liu">Suli Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>c School of Public Health (Shenzhen) , Sun Yat-sen University , Guangdong , People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>c School of Public Health (Shenzhen) , Sun Yat-sen University , Guangdong </wicri:regionArea>
<wicri:noRegion>Guangdong </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhou, Lijuan" sort="Zhou, Lijuan" uniqKey="Zhou L" first="Lijuan" last="Zhou">Lijuan Zhou</name>
<affiliation wicri:level="1"><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing </wicri:regionArea>
<wicri:noRegion>Beijing </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wei, Hejiang" sort="Wei, Hejiang" uniqKey="Wei H" first="Hejiang" last="Wei">Hejiang Wei</name>
<affiliation wicri:level="1"><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing </wicri:regionArea>
<wicri:noRegion>Beijing </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gao, Rongbao" sort="Gao, Rongbao" uniqKey="Gao R" first="Rongbao" last="Gao">Rongbao Gao</name>
<affiliation wicri:level="1"><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing </wicri:regionArea>
<wicri:noRegion>Beijing </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Dayan" sort="Wang, Dayan" uniqKey="Wang D" first="Dayan" last="Wang">Dayan Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing </wicri:regionArea>
<wicri:noRegion>Beijing </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shu, Yuelong" sort="Shu, Yuelong" uniqKey="Shu Y" first="Yuelong" last="Shu">Yuelong Shu</name>
<affiliation wicri:level="1"><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing </wicri:regionArea>
<wicri:noRegion>Beijing </wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2019">2019</date>
<idno type="RBID">pubmed:31267843</idno>
<idno type="pmid">31267843</idno>
<idno type="doi">10.1080/22221751.2019.1635873</idno>
<idno type="wicri:Area/PubMed/Corpus">000122</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000122</idno>
<idno type="wicri:Area/PubMed/Curation">000122</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000122</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000124</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000124</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Mammalian-adaptive mutation NP-Q357K in Eurasian H1N1 Swine Influenza viruses determines the virulence phenotype in mice.</title>
<author><name sortKey="Zhu, Wenfei" sort="Zhu, Wenfei" uniqKey="Zhu W" first="Wenfei" last="Zhu">Wenfei Zhu</name>
<affiliation wicri:level="1"><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing </wicri:regionArea>
<wicri:noRegion>Beijing </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Feng, Zhaomin" sort="Feng, Zhaomin" uniqKey="Feng Z" first="Zhaomin" last="Feng">Zhaomin Feng</name>
<affiliation wicri:level="1"><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing </wicri:regionArea>
<wicri:noRegion>Beijing </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Yongkun" sort="Chen, Yongkun" uniqKey="Chen Y" first="Yongkun" last="Chen">Yongkun Chen</name>
<affiliation wicri:level="1"><nlm:affiliation>c School of Public Health (Shenzhen) , Sun Yat-sen University , Guangdong , People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>c School of Public Health (Shenzhen) , Sun Yat-sen University , Guangdong </wicri:regionArea>
<wicri:noRegion>Guangdong </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yang, Lei" sort="Yang, Lei" uniqKey="Yang L" first="Lei" last="Yang">Lei Yang</name>
<affiliation wicri:level="1"><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing </wicri:regionArea>
<wicri:noRegion>Beijing </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Jia" sort="Liu, Jia" uniqKey="Liu J" first="Jia" last="Liu">Jia Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing </wicri:regionArea>
<wicri:noRegion>Beijing </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Li, Xiyan" sort="Li, Xiyan" uniqKey="Li X" first="Xiyan" last="Li">Xiyan Li</name>
<affiliation wicri:level="1"><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing </wicri:regionArea>
<wicri:noRegion>Beijing </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Suli" sort="Liu, Suli" uniqKey="Liu S" first="Suli" last="Liu">Suli Liu</name>
<affiliation wicri:level="1"><nlm:affiliation>c School of Public Health (Shenzhen) , Sun Yat-sen University , Guangdong , People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>c School of Public Health (Shenzhen) , Sun Yat-sen University , Guangdong </wicri:regionArea>
<wicri:noRegion>Guangdong </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhou, Lijuan" sort="Zhou, Lijuan" uniqKey="Zhou L" first="Lijuan" last="Zhou">Lijuan Zhou</name>
<affiliation wicri:level="1"><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing </wicri:regionArea>
<wicri:noRegion>Beijing </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wei, Hejiang" sort="Wei, Hejiang" uniqKey="Wei H" first="Hejiang" last="Wei">Hejiang Wei</name>
<affiliation wicri:level="1"><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing </wicri:regionArea>
<wicri:noRegion>Beijing </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gao, Rongbao" sort="Gao, Rongbao" uniqKey="Gao R" first="Rongbao" last="Gao">Rongbao Gao</name>
<affiliation wicri:level="1"><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing </wicri:regionArea>
<wicri:noRegion>Beijing </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Dayan" sort="Wang, Dayan" uniqKey="Wang D" first="Dayan" last="Wang">Dayan Wang</name>
<affiliation wicri:level="1"><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing </wicri:regionArea>
<wicri:noRegion>Beijing </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shu, Yuelong" sort="Shu, Yuelong" uniqKey="Shu Y" first="Yuelong" last="Shu">Yuelong Shu</name>
<affiliation wicri:level="1"><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing </wicri:regionArea>
<wicri:noRegion>Beijing </wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Emerging microbes & infections</title>
<idno type="eISSN">2222-1751</idno>
<imprint><date when="2019" type="published">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>China</term>
<term>Female</term>
<term>Genotype</term>
<term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype (classification)</term>
<term>Influenza A Virus, H1N1 Subtype (genetics)</term>
<term>Influenza A Virus, H1N1 Subtype (pathogenicity)</term>
<term>Influenza A Virus, H1N1 Subtype (physiology)</term>
<term>Influenza, Human (virology)</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mutation, Missense</term>
<term>Orthomyxoviridae Infections (veterinary)</term>
<term>Orthomyxoviridae Infections (virology)</term>
<term>Phylogeny</term>
<term>RNA-Binding Proteins (genetics)</term>
<term>RNA-Binding Proteins (metabolism)</term>
<term>Swine</term>
<term>Swine Diseases (virology)</term>
<term>Viral Core Proteins (genetics)</term>
<term>Viral Core Proteins (metabolism)</term>
<term>Virulence</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Chine</term>
<term>Femelle</term>
<term>Grippe humaine (virologie)</term>
<term>Génotype</term>
<term>Humains</term>
<term>Infections à Orthomyxoviridae (médecine vétérinaire)</term>
<term>Infections à Orthomyxoviridae (virologie)</term>
<term>Maladies des porcs (virologie)</term>
<term>Mutation faux-sens</term>
<term>Phylogénie</term>
<term>Protéines de liaison à l'ARN (génétique)</term>
<term>Protéines de liaison à l'ARN (métabolisme)</term>
<term>Protéines du core viral (génétique)</term>
<term>Protéines du core viral (métabolisme)</term>
<term>Réplication virale</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Sous-type H1N1 du virus de la grippe A ()</term>
<term>Sous-type H1N1 du virus de la grippe A (génétique)</term>
<term>Sous-type H1N1 du virus de la grippe A (pathogénicité)</term>
<term>Sous-type H1N1 du virus de la grippe A (physiologie)</term>
<term>Suidae</term>
<term>Virulence</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA-Binding Proteins</term>
<term>Viral Core Proteins</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>RNA-Binding Proteins</term>
<term>Viral Core Proteins</term>
</keywords>
<keywords scheme="MESH" type="geographic" xml:lang="en"><term>China</term>
</keywords>
<keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines de liaison à l'ARN</term>
<term>Protéines du core viral</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="médecine vétérinaire" xml:lang="fr"><term>Infections à Orthomyxoviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéines de liaison à l'ARN</term>
<term>Protéines du core viral</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
</keywords>
<keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Orthomyxoviridae Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term>
<term>Infections à Orthomyxoviridae</term>
<term>Maladies des porcs</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term>
<term>Orthomyxoviridae Infections</term>
<term>Swine Diseases</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Female</term>
<term>Genotype</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mutation, Missense</term>
<term>Phylogeny</term>
<term>Swine</term>
<term>Virulence</term>
<term>Virus Replication</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Chine</term>
<term>Femelle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Mutation faux-sens</term>
<term>Phylogénie</term>
<term>Réplication virale</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Suidae</term>
<term>Virulence</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>République populaire de Chine</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">It has recently been proposed that the Eurasian avian-like H1N1 (EA H1N1) swine influenza virus (SIV) is one of the most likely zoonotic viruses to cause the next influenza pandemic. Two main genotypes EA H1N1 viruses have been recognized to be infected humans in China. Our study finds that one of the genotypes JS1-like viruses are avirulent in mice. However, the other are HuN-like viruses and are virulent in mice. The molecular mechanism underlying this difference shows that the NP gene determines the virulence of the EA H1N1 viruses in mice. In addition, a single substitution, Q357K, in the NP protein of the EA H1N1 viruses alters the virulence phenotype. This substitution is a typical human signature marker, which is prevalent in human viruses but rarely detected in avian influenza viruses. The NP-Q357K substitution is readily to be occurred when avian influenza viruses circulate in pigs, and may facilitate their infection of humans and allow viruses also carrying NP-357K to circulate in humans. Our study demonstrates that the substitution Q357K in the NP protein plays a key role in the virulence phenotype of EA H1N1 SIVs, and provides important information for evaluating the pandemic risk of field influenza strains.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31267843</PMID>
<DateCompleted><Year>2019</Year>
<Month>11</Month>
<Day>08</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>02</Month>
<Day>25</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2222-1751</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>8</Volume>
<Issue>1</Issue>
<PubDate><Year>2019</Year>
</PubDate>
</JournalIssue>
<Title>Emerging microbes & infections</Title>
<ISOAbbreviation>Emerg Microbes Infect</ISOAbbreviation>
</Journal>
<ArticleTitle>Mammalian-adaptive mutation NP-Q357K in Eurasian H1N1 Swine Influenza viruses determines the virulence phenotype in mice.</ArticleTitle>
<Pagination><MedlinePgn>989-999</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1080/22221751.2019.1635873</ELocationID>
<Abstract><AbstractText>It has recently been proposed that the Eurasian avian-like H1N1 (EA H1N1) swine influenza virus (SIV) is one of the most likely zoonotic viruses to cause the next influenza pandemic. Two main genotypes EA H1N1 viruses have been recognized to be infected humans in China. Our study finds that one of the genotypes JS1-like viruses are avirulent in mice. However, the other are HuN-like viruses and are virulent in mice. The molecular mechanism underlying this difference shows that the NP gene determines the virulence of the EA H1N1 viruses in mice. In addition, a single substitution, Q357K, in the NP protein of the EA H1N1 viruses alters the virulence phenotype. This substitution is a typical human signature marker, which is prevalent in human viruses but rarely detected in avian influenza viruses. The NP-Q357K substitution is readily to be occurred when avian influenza viruses circulate in pigs, and may facilitate their infection of humans and allow viruses also carrying NP-357K to circulate in humans. Our study demonstrates that the substitution Q357K in the NP protein plays a key role in the virulence phenotype of EA H1N1 SIVs, and provides important information for evaluating the pandemic risk of field influenza strains.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhu</LastName>
<ForeName>Wenfei</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Feng</LastName>
<ForeName>Zhaomin</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Yongkun</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>c School of Public Health (Shenzhen) , Sun Yat-sen University , Guangdong , People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Lei</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Jia</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Xiyan</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Suli</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>c School of Public Health (Shenzhen) , Sun Yat-sen University , Guangdong , People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhou</LastName>
<ForeName>Lijuan</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wei</LastName>
<ForeName>Hejiang</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gao</LastName>
<ForeName>Rongbao</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Dayan</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shu</LastName>
<ForeName>Yuelong</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>c School of Public Health (Shenzhen) , Sun Yat-sen University , Guangdong , People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Emerg Microbes Infect</MedlineTA>
<NlmUniqueID>101594885</NlmUniqueID>
<ISSNLinking>2222-1751</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C048842">NP protein, Influenza A virus</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016601">RNA-Binding Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014758">Viral Core Proteins</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002681" MajorTopicYN="N" Type="Geographic">China</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName>
<QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020125" MajorTopicYN="Y">Mutation, Missense</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009976" MajorTopicYN="N">Orthomyxoviridae Infections</DescriptorName>
<QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016601" MajorTopicYN="N">RNA-Binding Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013552" MajorTopicYN="N">Swine</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013553" MajorTopicYN="N">Swine Diseases</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014758" MajorTopicYN="N">Viral Core Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014774" MajorTopicYN="N">Virulence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014779" MajorTopicYN="N">Virus Replication</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Eurasian avian-like H1N1 swine influenza viruses</Keyword>
<Keyword MajorTopicYN="N">NP gene</Keyword>
<Keyword MajorTopicYN="N">NP-K357Q</Keyword>
<Keyword MajorTopicYN="N">pandemic potential</Keyword>
<Keyword MajorTopicYN="N">pathogenicity</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2019</Year>
<Month>7</Month>
<Day>4</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2019</Year>
<Month>7</Month>
<Day>4</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2019</Year>
<Month>11</Month>
<Day>9</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">31267843</ArticleId>
<ArticleId IdType="doi">10.1080/22221751.2019.1635873</ArticleId>
<ArticleId IdType="pmc">PMC6609330</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>J Gen Virol. 2000 May;81(Pt 5):1283-91</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10769071</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Vet Microbiol. 2000 May 22;74(1-2):29-46</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10799776</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Rev Med Virol. 2000 Sep-Oct;10(5):337-48</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11015744</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2000 Nov;74(22):10807-10</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11044127</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2001 Sep 7;293(5536):1840-2</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11546875</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18590-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16339318</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2006 Dec 21;444(7122):1078-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17151603</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 2007 Jun 5;362(2):271-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17270230</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Vet Microbiol. 2007 Oct 6;124(3-4):193-201</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17512143</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virus Res. 2007 Sep;128(1-2):159-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17521765</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dis. 2007 Jul 15;196(2):258-65</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17570113</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2007 Oct;81(19):10292-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17652405</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2007 Oct 5;3(10):1414-21</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17922571</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2008 Feb 8;4(2):e11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18248089</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2009 Jan;5(1):e1000252</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19119420</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2009 May;83(10):5278-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19264775</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virus Res. 2009 Sep;144(1-2):123-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19393699</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Mol Genet Med. 2008 Nov 27;3(1):158-66</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19565018</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11709-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19597152</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2009 Nov;83(21):11102-15</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19692471</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 2010 May;91(Pt 5):1284-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20016035</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2009 Dec;5(12):e1000709</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20041223</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2010 May;84(9):4395-406</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20181719</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2010 Jun 18;328(5985):1529</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20558710</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2011 Jan;85(1):357-65</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20962098</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 2011 May 26;473(7348):519-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21614079</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Virol. 2013 Jan;158(1):39-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22935945</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2012 Dec 21;338(6114):1631-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23180774</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>MBio. 2012 Dec 26;4(1):e00467-12</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23269829</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Biol Evol. 2013 Apr;30(4):772-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23329690</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2013 Mar;9(3):e1003279</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23555271</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Biol Chem. 1990 Jul 5;265(19):11151-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">2358455</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2013 Jun 21;340(6139):1459-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">23641061</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2013 Oct;19(10):1709-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24050834</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Future Microbiol. 2013 Dec;8(12):1537-45</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24266354</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Bing Du Xue Bao. 2013 Sep;29(5):559-65</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24386847</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 2014 Sep;88(18):10864-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25008935</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Sci Rep. 2015 Sep 22;5:14170</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26391278</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):392-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26711995</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mol Biol Evol. 2016 Jul;33(7):1870-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27004904</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Emerg Infect Dis. 2016 Nov;22(11):1930-1936</Citation>
<ArticleIdList><ArticleId IdType="pubmed">27767007</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 1993 Mar;193(1):503-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8438586</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1993 Apr;67(4):1761-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">8445709</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Gen Virol. 1995 Apr;76 ( Pt 4):1009-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9049350</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Virol. 1998 Jul;72(7):5493-501</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9621005</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhu, Wenfei" sort="Zhu, Wenfei" uniqKey="Zhu W" first="Wenfei" last="Zhu">Wenfei Zhu</name>
</noRegion>
<name sortKey="Chen, Yongkun" sort="Chen, Yongkun" uniqKey="Chen Y" first="Yongkun" last="Chen">Yongkun Chen</name>
<name sortKey="Feng, Zhaomin" sort="Feng, Zhaomin" uniqKey="Feng Z" first="Zhaomin" last="Feng">Zhaomin Feng</name>
<name sortKey="Gao, Rongbao" sort="Gao, Rongbao" uniqKey="Gao R" first="Rongbao" last="Gao">Rongbao Gao</name>
<name sortKey="Li, Xiyan" sort="Li, Xiyan" uniqKey="Li X" first="Xiyan" last="Li">Xiyan Li</name>
<name sortKey="Liu, Jia" sort="Liu, Jia" uniqKey="Liu J" first="Jia" last="Liu">Jia Liu</name>
<name sortKey="Liu, Suli" sort="Liu, Suli" uniqKey="Liu S" first="Suli" last="Liu">Suli Liu</name>
<name sortKey="Shu, Yuelong" sort="Shu, Yuelong" uniqKey="Shu Y" first="Yuelong" last="Shu">Yuelong Shu</name>
<name sortKey="Wang, Dayan" sort="Wang, Dayan" uniqKey="Wang D" first="Dayan" last="Wang">Dayan Wang</name>
<name sortKey="Wei, Hejiang" sort="Wei, Hejiang" uniqKey="Wei H" first="Hejiang" last="Wei">Hejiang Wei</name>
<name sortKey="Yang, Lei" sort="Yang, Lei" uniqKey="Yang L" first="Lei" last="Yang">Lei Yang</name>
<name sortKey="Zhou, Lijuan" sort="Zhou, Lijuan" uniqKey="Zhou L" first="Lijuan" last="Zhou">Lijuan Zhou</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/PandemieGrippaleV1/Data/PubMed/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000124 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd -nk 000124 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= PandemieGrippaleV1 |flux= PubMed |étape= Checkpoint |type= RBID |clé= pubmed:31267843 |texte= Mammalian-adaptive mutation NP-Q357K in Eurasian H1N1 Swine Influenza viruses determines the virulence phenotype in mice. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i -Sk "pubmed:31267843" \ | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a PandemieGrippaleV1
![]() | This area was generated with Dilib version V0.6.34. | ![]() |