PandemieGrippaleV1, PubMed, Checkpoint, bibRecord, 000124

Mammalian-adaptive mutation NP-Q357K in Eurasian H1N1 Swine Influenza viruses determines the virulence phenotype in mice.

Identifieur interne : 000124 ( PubMed/Checkpoint ); précédent : 000123; suivant : 000125

Mammalian-adaptive mutation NP-Q357K in Eurasian H1N1 Swine Influenza viruses determines the virulence phenotype in mice.

Source :

Emerging microbes & infections [ 2222-1751 ] ; 2019.

RBID : pubmed:31267843

Descripteurs français

KwdFr :
- Animaux, Chine, Femelle, Grippe humaine (virologie), Génotype, Humains, Infections à Orthomyxoviridae (médecine vétérinaire), Infections à Orthomyxoviridae (virologie), Maladies des porcs (virologie), Mutation faux-sens, Phylogénie, Protéines de liaison à l'ARN (génétique), Protéines de liaison à l'ARN (métabolisme), Protéines du core viral (génétique), Protéines du core viral (métabolisme), Réplication virale, Souris, Souris de lignée C57BL, Sous-type H1N1 du virus de la grippe A (), Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (pathogénicité), Sous-type H1N1 du virus de la grippe A (physiologie), Suidae, Virulence.
MESH :
- génétique : Protéines de liaison à l'ARN, Protéines du core viral, Sous-type H1N1 du virus de la grippe A.
- médecine vétérinaire : Infections à Orthomyxoviridae.
- métabolisme : Protéines de liaison à l'ARN, Protéines du core viral.
- pathogénicité : Sous-type H1N1 du virus de la grippe A.
- physiologie : Sous-type H1N1 du virus de la grippe A.
- virologie : Grippe humaine, Infections à Orthomyxoviridae, Maladies des porcs.
- Animaux, Chine, Femelle, Génotype, Humains, Mutation faux-sens, Phylogénie, Réplication virale, Souris, Souris de lignée C57BL, Sous-type H1N1 du virus de la grippe A, Suidae, Virulence.
Wicri :
- geographic : République populaire de Chine.

English descriptors

KwdEn :
- Animals, China, Female, Genotype, Humans, Influenza A Virus, H1N1 Subtype (classification), Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (pathogenicity), Influenza A Virus, H1N1 Subtype (physiology), Influenza, Human (virology), Mice, Mice, Inbred C57BL, Mutation, Missense, Orthomyxoviridae Infections (veterinary), Orthomyxoviridae Infections (virology), Phylogeny, RNA-Binding Proteins (genetics), RNA-Binding Proteins (metabolism), Swine, Swine Diseases (virology), Viral Core Proteins (genetics), Viral Core Proteins (metabolism), Virulence, Virus Replication.
MESH :
- chemical , genetics : RNA-Binding Proteins, Viral Core Proteins.
- chemical , metabolism : RNA-Binding Proteins, Viral Core Proteins.
- geographic : China.
- classification : Influenza A Virus, H1N1 Subtype.
- genetics : Influenza A Virus, H1N1 Subtype.
- pathogenicity : Influenza A Virus, H1N1 Subtype.
- physiology : Influenza A Virus, H1N1 Subtype.
- veterinary : Orthomyxoviridae Infections.
- virology : Influenza, Human, Orthomyxoviridae Infections, Swine Diseases.
- Animals, Female, Genotype, Humans, Mice, Mice, Inbred C57BL, Mutation, Missense, Phylogeny, Swine, Virulence, Virus Replication.

Abstract

It has recently been proposed that the Eurasian avian-like H1N1 (EA H1N1) swine influenza virus (SIV) is one of the most likely zoonotic viruses to cause the next influenza pandemic. Two main genotypes EA H1N1 viruses have been recognized to be infected humans in China. Our study finds that one of the genotypes JS1-like viruses are avirulent in mice. However, the other are HuN-like viruses and are virulent in mice. The molecular mechanism underlying this difference shows that the NP gene determines the virulence of the EA H1N1 viruses in mice. In addition, a single substitution, Q357K, in the NP protein of the EA H1N1 viruses alters the virulence phenotype. This substitution is a typical human signature marker, which is prevalent in human viruses but rarely detected in avian influenza viruses. The NP-Q357K substitution is readily to be occurred when avian influenza viruses circulate in pigs, and may facilitate their infection of humans and allow viruses also carrying NP-357K to circulate in humans. Our study demonstrates that the substitution Q357K in the NP protein plays a key role in the virulence phenotype of EA H1N1 SIVs, and provides important information for evaluating the pandemic risk of field influenza strains.

DOI: 10.1080/22221751.2019.1635873
PubMed: 31267843

Affiliations:

République populaire de Chine

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Le document en format XML

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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing </wicri:regionArea>
<wicri:noRegion>Beijing </wicri:noRegion>
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<author><name sortKey="Feng, Zhaomin" sort="Feng, Zhaomin" uniqKey="Feng Z" first="Zhaomin" last="Feng">Zhaomin Feng</name>
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<wicri:regionArea>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing </wicri:regionArea>
<wicri:noRegion>Beijing </wicri:noRegion>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing </wicri:regionArea>
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<author><name sortKey="Li, Xiyan" sort="Li, Xiyan" uniqKey="Li X" first="Xiyan" last="Li">Xiyan Li</name>
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<country xml:lang="fr">République populaire de Chine</country>
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<author><name sortKey="Liu, Suli" sort="Liu, Suli" uniqKey="Liu S" first="Suli" last="Liu">Suli Liu</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>c School of Public Health (Shenzhen) , Sun Yat-sen University , Guangdong </wicri:regionArea>
<wicri:noRegion>Guangdong </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhou, Lijuan" sort="Zhou, Lijuan" uniqKey="Zhou L" first="Lijuan" last="Zhou">Lijuan Zhou</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing </wicri:regionArea>
<wicri:noRegion>Beijing </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wei, Hejiang" sort="Wei, Hejiang" uniqKey="Wei H" first="Hejiang" last="Wei">Hejiang Wei</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing </wicri:regionArea>
<wicri:noRegion>Beijing </wicri:noRegion>
</affiliation>
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<author><name sortKey="Gao, Rongbao" sort="Gao, Rongbao" uniqKey="Gao R" first="Rongbao" last="Gao">Rongbao Gao</name>
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<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing </wicri:regionArea>
<wicri:noRegion>Beijing </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Dayan" sort="Wang, Dayan" uniqKey="Wang D" first="Dayan" last="Wang">Dayan Wang</name>
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<wicri:noRegion>Beijing </wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shu, Yuelong" sort="Shu, Yuelong" uniqKey="Shu Y" first="Yuelong" last="Shu">Yuelong Shu</name>
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<term>Influenza A Virus, H1N1 Subtype (classification)</term>
<term>Influenza A Virus, H1N1 Subtype (genetics)</term>
<term>Influenza A Virus, H1N1 Subtype (pathogenicity)</term>
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<term>RNA-Binding Proteins (genetics)</term>
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<term>Swine</term>
<term>Swine Diseases (virology)</term>
<term>Viral Core Proteins (genetics)</term>
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<term>Virus Replication</term>
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<term>Humains</term>
<term>Infections à Orthomyxoviridae (médecine vétérinaire)</term>
<term>Infections à Orthomyxoviridae (virologie)</term>
<term>Maladies des porcs (virologie)</term>
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<term>Protéines de liaison à l'ARN (métabolisme)</term>
<term>Protéines du core viral (génétique)</term>
<term>Protéines du core viral (métabolisme)</term>
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<term>Sous-type H1N1 du virus de la grippe A (génétique)</term>
<term>Sous-type H1N1 du virus de la grippe A (pathogénicité)</term>
<term>Sous-type H1N1 du virus de la grippe A (physiologie)</term>
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<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term>
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<keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Sous-type H1N1 du virus de la grippe A</term>
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<term>Infections à Orthomyxoviridae</term>
<term>Maladies des porcs</term>
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<term>Orthomyxoviridae Infections</term>
<term>Swine Diseases</term>
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<term>Female</term>
<term>Genotype</term>
<term>Humans</term>
<term>Mice</term>
<term>Mice, Inbred C57BL</term>
<term>Mutation, Missense</term>
<term>Phylogeny</term>
<term>Swine</term>
<term>Virulence</term>
<term>Virus Replication</term>
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<term>Chine</term>
<term>Femelle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Mutation faux-sens</term>
<term>Phylogénie</term>
<term>Réplication virale</term>
<term>Souris</term>
<term>Souris de lignée C57BL</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Suidae</term>
<term>Virulence</term>
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<front><div type="abstract" xml:lang="en">It has recently been proposed that the Eurasian avian-like H1N1 (EA H1N1) swine influenza virus (SIV) is one of the most likely zoonotic viruses to cause the next influenza pandemic. Two main genotypes EA H1N1 viruses have been recognized to be infected humans in China. Our study finds that one of the genotypes JS1-like viruses are avirulent in mice. However, the other are HuN-like viruses and are virulent in mice. The molecular mechanism underlying this difference shows that the NP gene determines the virulence of the EA H1N1 viruses in mice. In addition, a single substitution, Q357K, in the NP protein of the EA H1N1 viruses alters the virulence phenotype. This substitution is a typical human signature marker, which is prevalent in human viruses but rarely detected in avian influenza viruses. The NP-Q357K substitution is readily to be occurred when avian influenza viruses circulate in pigs, and may facilitate their infection of humans and allow viruses also carrying NP-357K to circulate in humans. Our study demonstrates that the substitution Q357K in the NP protein plays a key role in the virulence phenotype of EA H1N1 SIVs, and provides important information for evaluating the pandemic risk of field influenza strains.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31267843</PMID>
<DateCompleted><Year>2019</Year>
<Month>11</Month>
<Day>08</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>02</Month>
<Day>25</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2222-1751</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>8</Volume>
<Issue>1</Issue>
<PubDate><Year>2019</Year>
</PubDate>
</JournalIssue>
<Title>Emerging microbes & infections</Title>
<ISOAbbreviation>Emerg Microbes Infect</ISOAbbreviation>
</Journal>
<ArticleTitle>Mammalian-adaptive mutation NP-Q357K in Eurasian H1N1 Swine Influenza viruses determines the virulence phenotype in mice.</ArticleTitle>
<Pagination><MedlinePgn>989-999</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1080/22221751.2019.1635873</ELocationID>
<Abstract><AbstractText>It has recently been proposed that the Eurasian avian-like H1N1 (EA H1N1) swine influenza virus (SIV) is one of the most likely zoonotic viruses to cause the next influenza pandemic. Two main genotypes EA H1N1 viruses have been recognized to be infected humans in China. Our study finds that one of the genotypes JS1-like viruses are avirulent in mice. However, the other are HuN-like viruses and are virulent in mice. The molecular mechanism underlying this difference shows that the NP gene determines the virulence of the EA H1N1 viruses in mice. In addition, a single substitution, Q357K, in the NP protein of the EA H1N1 viruses alters the virulence phenotype. This substitution is a typical human signature marker, which is prevalent in human viruses but rarely detected in avian influenza viruses. The NP-Q357K substitution is readily to be occurred when avian influenza viruses circulate in pigs, and may facilitate their infection of humans and allow viruses also carrying NP-357K to circulate in humans. Our study demonstrates that the substitution Q357K in the NP protein plays a key role in the virulence phenotype of EA H1N1 SIVs, and provides important information for evaluating the pandemic risk of field influenza strains.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhu</LastName>
<ForeName>Wenfei</ForeName>
<Initials>W</Initials>
<AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Feng</LastName>
<ForeName>Zhaomin</ForeName>
<Initials>Z</Initials>
<AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Chen</LastName>
<ForeName>Yongkun</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>c School of Public Health (Shenzhen) , Sun Yat-sen University , Guangdong , People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Yang</LastName>
<ForeName>Lei</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Jia</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Li</LastName>
<ForeName>Xiyan</ForeName>
<Initials>X</Initials>
<AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Liu</LastName>
<ForeName>Suli</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>c School of Public Health (Shenzhen) , Sun Yat-sen University , Guangdong , People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Zhou</LastName>
<ForeName>Lijuan</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wei</LastName>
<ForeName>Hejiang</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Gao</LastName>
<ForeName>Rongbao</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Wang</LastName>
<ForeName>Dayan</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Shu</LastName>
<ForeName>Yuelong</ForeName>
<Initials>Y</Initials>
<AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>c School of Public Health (Shenzhen) , Sun Yat-sen University , Guangdong , People's Republic of China.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Emerg Microbes Infect</MedlineTA>
<NlmUniqueID>101594885</NlmUniqueID>
<ISSNLinking>2222-1751</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C048842">NP protein, Influenza A virus</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016601">RNA-Binding Proteins</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D014758">Viral Core Proteins</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002681" MajorTopicYN="N" Type="Geographic">China</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName>
<QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName>
<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
<QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008810" MajorTopicYN="N">Mice, Inbred C57BL</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D020125" MajorTopicYN="Y">Mutation, Missense</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009976" MajorTopicYN="N">Orthomyxoviridae Infections</DescriptorName>
<QualifierName UI="Q000662" MajorTopicYN="Y">veterinary</QualifierName>
<QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016601" MajorTopicYN="N">RNA-Binding Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013552" MajorTopicYN="N">Swine</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013553" MajorTopicYN="N">Swine Diseases</DescriptorName>
<QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014758" MajorTopicYN="N">Viral Core Proteins</DescriptorName>
<QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014774" MajorTopicYN="N">Virulence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014779" MajorTopicYN="N">Virus Replication</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Eurasian avian-like H1N1 swine influenza viruses</Keyword>
<Keyword MajorTopicYN="N">NP gene</Keyword>
<Keyword MajorTopicYN="N">NP-K357Q</Keyword>
<Keyword MajorTopicYN="N">pandemic potential</Keyword>
<Keyword MajorTopicYN="N">pathogenicity</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2019</Year>
<Month>7</Month>
<Day>4</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="pubmed"><Year>2019</Year>
<Month>7</Month>
<Day>4</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="medline"><Year>2019</Year>
<Month>11</Month>
<Day>9</Day>
<Hour>6</Hour>
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<affiliations><list><country><li>République populaire de Chine</li>
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<tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhu, Wenfei" sort="Zhu, Wenfei" uniqKey="Zhu W" first="Wenfei" last="Zhu">Wenfei Zhu</name>
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<name sortKey="Liu, Jia" sort="Liu, Jia" uniqKey="Liu J" first="Jia" last="Liu">Jia Liu</name>
<name sortKey="Liu, Suli" sort="Liu, Suli" uniqKey="Liu S" first="Suli" last="Liu">Suli Liu</name>
<name sortKey="Shu, Yuelong" sort="Shu, Yuelong" uniqKey="Shu Y" first="Yuelong" last="Shu">Yuelong Shu</name>
<name sortKey="Wang, Dayan" sort="Wang, Dayan" uniqKey="Wang D" first="Dayan" last="Wang">Dayan Wang</name>
<name sortKey="Wei, Hejiang" sort="Wei, Hejiang" uniqKey="Wei H" first="Hejiang" last="Wei">Hejiang Wei</name>
<name sortKey="Yang, Lei" sort="Yang, Lei" uniqKey="Yang L" first="Lei" last="Yang">Lei Yang</name>
<name sortKey="Zhou, Lijuan" sort="Zhou, Lijuan" uniqKey="Zhou L" first="Lijuan" last="Zhou">Lijuan Zhou</name>
</country>
</tree>
</affiliations>
</record>

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HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000124 | SxmlIndent | more

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{{Explor lien
   |wiki=    Sante
   |area=    PandemieGrippaleV1
   |flux=    PubMed
   |étape=   Checkpoint
   |type=    RBID
   |clé=     pubmed:31267843
   |texte=   Mammalian-adaptive mutation NP-Q357K in Eurasian H1N1 Swine Influenza viruses determines the virulence phenotype in mice.
}}

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HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Checkpoint/RBID.i   -Sk "pubmed:31267843" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Checkpoint/biblio.hfd   \
       | NlmPubMed2Wicri -a PandemieGrippaleV1

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	Serveur d'exploration sur les pandémies grippales
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Serveur d'exploration sur les pandémies grippales

Mammalian-adaptive mutation NP-Q357K in Eurasian H1N1 Swine Influenza viruses determines the virulence phenotype in mice.

Mammalian-adaptive mutation NP-Q357K in Eurasian H1N1 Swine Influenza viruses determines the virulence phenotype in mice.

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