Mammalian-adaptive mutation NP-Q357K in Eurasian H1N1 Swine Influenza viruses determines the virulence phenotype in mice.
Identifieur interne : 000122 ( PubMed/Corpus ); précédent : 000121; suivant : 000123Mammalian-adaptive mutation NP-Q357K in Eurasian H1N1 Swine Influenza viruses determines the virulence phenotype in mice.
Auteurs : Wenfei Zhu ; Zhaomin Feng ; Yongkun Chen ; Lei Yang ; Jia Liu ; Xiyan Li ; Suli Liu ; Lijuan Zhou ; Hejiang Wei ; Rongbao Gao ; Dayan Wang ; Yuelong ShuSource :
- Emerging microbes & infections [ 2222-1751 ] ; 2019.
English descriptors
- KwdEn :
- Animals, China, Female, Genotype, Humans, Influenza A Virus, H1N1 Subtype (classification), Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (pathogenicity), Influenza A Virus, H1N1 Subtype (physiology), Influenza, Human (virology), Mice, Mice, Inbred C57BL, Mutation, Missense, Orthomyxoviridae Infections (veterinary), Orthomyxoviridae Infections (virology), Phylogeny, RNA-Binding Proteins (genetics), RNA-Binding Proteins (metabolism), Swine, Swine Diseases (virology), Viral Core Proteins (genetics), Viral Core Proteins (metabolism), Virulence, Virus Replication.
- MESH :
- chemical , genetics : RNA-Binding Proteins, Viral Core Proteins.
- chemical , metabolism : RNA-Binding Proteins, Viral Core Proteins.
- geographic : China.
- classification : Influenza A Virus, H1N1 Subtype.
- genetics : Influenza A Virus, H1N1 Subtype.
- pathogenicity : Influenza A Virus, H1N1 Subtype.
- physiology : Influenza A Virus, H1N1 Subtype.
- veterinary : Orthomyxoviridae Infections.
- virology : Influenza, Human, Orthomyxoviridae Infections, Swine Diseases.
- Animals, Female, Genotype, Humans, Mice, Mice, Inbred C57BL, Mutation, Missense, Phylogeny, Swine, Virulence, Virus Replication.
Abstract
It has recently been proposed that the Eurasian avian-like H1N1 (EA H1N1) swine influenza virus (SIV) is one of the most likely zoonotic viruses to cause the next influenza pandemic. Two main genotypes EA H1N1 viruses have been recognized to be infected humans in China. Our study finds that one of the genotypes JS1-like viruses are avirulent in mice. However, the other are HuN-like viruses and are virulent in mice. The molecular mechanism underlying this difference shows that the NP gene determines the virulence of the EA H1N1 viruses in mice. In addition, a single substitution, Q357K, in the NP protein of the EA H1N1 viruses alters the virulence phenotype. This substitution is a typical human signature marker, which is prevalent in human viruses but rarely detected in avian influenza viruses. The NP-Q357K substitution is readily to be occurred when avian influenza viruses circulate in pigs, and may facilitate their infection of humans and allow viruses also carrying NP-357K to circulate in humans. Our study demonstrates that the substitution Q357K in the NP protein plays a key role in the virulence phenotype of EA H1N1 SIVs, and provides important information for evaluating the pandemic risk of field influenza strains.
DOI: 10.1080/22221751.2019.1635873
PubMed: 31267843
Links to Exploration step
pubmed:31267843Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mammalian-adaptive mutation NP-Q357K in Eurasian H1N1 Swine Influenza viruses determines the virulence phenotype in mice.</title><author><name sortKey="Zhu, Wenfei" sort="Zhu, Wenfei" uniqKey="Zhu W" first="Wenfei" last="Zhu">Wenfei Zhu</name><affiliation><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Feng, Zhaomin" sort="Feng, Zhaomin" uniqKey="Feng Z" first="Zhaomin" last="Feng">Zhaomin Feng</name><affiliation><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Yongkun" sort="Chen, Yongkun" uniqKey="Chen Y" first="Yongkun" last="Chen">Yongkun Chen</name><affiliation><nlm:affiliation>c School of Public Health (Shenzhen) , Sun Yat-sen University , Guangdong , People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Lei" sort="Yang, Lei" uniqKey="Yang L" first="Lei" last="Yang">Lei Yang</name><affiliation><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Jia" sort="Liu, Jia" uniqKey="Liu J" first="Jia" last="Liu">Jia Liu</name><affiliation><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Xiyan" sort="Li, Xiyan" uniqKey="Li X" first="Xiyan" last="Li">Xiyan Li</name><affiliation><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Suli" sort="Liu, Suli" uniqKey="Liu S" first="Suli" last="Liu">Suli Liu</name><affiliation><nlm:affiliation>c School of Public Health (Shenzhen) , Sun Yat-sen University , Guangdong , People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhou, Lijuan" sort="Zhou, Lijuan" uniqKey="Zhou L" first="Lijuan" last="Zhou">Lijuan Zhou</name><affiliation><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Wei, Hejiang" sort="Wei, Hejiang" uniqKey="Wei H" first="Hejiang" last="Wei">Hejiang Wei</name><affiliation><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Gao, Rongbao" sort="Gao, Rongbao" uniqKey="Gao R" first="Rongbao" last="Gao">Rongbao Gao</name><affiliation><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Dayan" sort="Wang, Dayan" uniqKey="Wang D" first="Dayan" last="Wang">Dayan Wang</name><affiliation><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Shu, Yuelong" sort="Shu, Yuelong" uniqKey="Shu Y" first="Yuelong" last="Shu">Yuelong Shu</name><affiliation><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2019">2019</date><idno type="RBID">pubmed:31267843</idno><idno type="pmid">31267843</idno><idno type="doi">10.1080/22221751.2019.1635873</idno><idno type="wicri:Area/PubMed/Corpus">000122</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000122</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Mammalian-adaptive mutation NP-Q357K in Eurasian H1N1 Swine Influenza viruses determines the virulence phenotype in mice.</title><author><name sortKey="Zhu, Wenfei" sort="Zhu, Wenfei" uniqKey="Zhu W" first="Wenfei" last="Zhu">Wenfei Zhu</name><affiliation><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Feng, Zhaomin" sort="Feng, Zhaomin" uniqKey="Feng Z" first="Zhaomin" last="Feng">Zhaomin Feng</name><affiliation><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Chen, Yongkun" sort="Chen, Yongkun" uniqKey="Chen Y" first="Yongkun" last="Chen">Yongkun Chen</name><affiliation><nlm:affiliation>c School of Public Health (Shenzhen) , Sun Yat-sen University , Guangdong , People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Yang, Lei" sort="Yang, Lei" uniqKey="Yang L" first="Lei" last="Yang">Lei Yang</name><affiliation><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Jia" sort="Liu, Jia" uniqKey="Liu J" first="Jia" last="Liu">Jia Liu</name><affiliation><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Li, Xiyan" sort="Li, Xiyan" uniqKey="Li X" first="Xiyan" last="Li">Xiyan Li</name><affiliation><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Liu, Suli" sort="Liu, Suli" uniqKey="Liu S" first="Suli" last="Liu">Suli Liu</name><affiliation><nlm:affiliation>c School of Public Health (Shenzhen) , Sun Yat-sen University , Guangdong , People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Zhou, Lijuan" sort="Zhou, Lijuan" uniqKey="Zhou L" first="Lijuan" last="Zhou">Lijuan Zhou</name><affiliation><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Wei, Hejiang" sort="Wei, Hejiang" uniqKey="Wei H" first="Hejiang" last="Wei">Hejiang Wei</name><affiliation><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Gao, Rongbao" sort="Gao, Rongbao" uniqKey="Gao R" first="Rongbao" last="Gao">Rongbao Gao</name><affiliation><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Wang, Dayan" sort="Wang, Dayan" uniqKey="Wang D" first="Dayan" last="Wang">Dayan Wang</name><affiliation><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation></affiliation></author><author><name sortKey="Shu, Yuelong" sort="Shu, Yuelong" uniqKey="Shu Y" first="Yuelong" last="Shu">Yuelong Shu</name><affiliation><nlm:affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Emerging microbes & infections</title><idno type="eISSN">2222-1751</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>China</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Influenza A Virus, H1N1 Subtype (classification)</term><term>Influenza A Virus, H1N1 Subtype (genetics)</term><term>Influenza A Virus, H1N1 Subtype (pathogenicity)</term><term>Influenza A Virus, H1N1 Subtype (physiology)</term><term>Influenza, Human (virology)</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mutation, Missense</term><term>Orthomyxoviridae Infections (veterinary)</term><term>Orthomyxoviridae Infections (virology)</term><term>Phylogeny</term><term>RNA-Binding Proteins (genetics)</term><term>RNA-Binding Proteins (metabolism)</term><term>Swine</term><term>Swine Diseases (virology)</term><term>Viral Core Proteins (genetics)</term><term>Viral Core Proteins (metabolism)</term><term>Virulence</term><term>Virus Replication</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>RNA-Binding Proteins</term><term>Viral Core Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>RNA-Binding Proteins</term><term>Viral Core Proteins</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>China</term></keywords><keywords scheme="MESH" qualifier="classification" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term></keywords><keywords scheme="MESH" qualifier="veterinary" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term><term>Orthomyxoviridae Infections</term><term>Swine Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Female</term><term>Genotype</term><term>Humans</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Mutation, Missense</term><term>Phylogeny</term><term>Swine</term><term>Virulence</term><term>Virus Replication</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">It has recently been proposed that the Eurasian avian-like H1N1 (EA H1N1) swine influenza virus (SIV) is one of the most likely zoonotic viruses to cause the next influenza pandemic. Two main genotypes EA H1N1 viruses have been recognized to be infected humans in China. Our study finds that one of the genotypes JS1-like viruses are avirulent in mice. However, the other are HuN-like viruses and are virulent in mice. The molecular mechanism underlying this difference shows that the NP gene determines the virulence of the EA H1N1 viruses in mice. In addition, a single substitution, Q357K, in the NP protein of the EA H1N1 viruses alters the virulence phenotype. This substitution is a typical human signature marker, which is prevalent in human viruses but rarely detected in avian influenza viruses. The NP-Q357K substitution is readily to be occurred when avian influenza viruses circulate in pigs, and may facilitate their infection of humans and allow viruses also carrying NP-357K to circulate in humans. Our study demonstrates that the substitution Q357K in the NP protein plays a key role in the virulence phenotype of EA H1N1 SIVs, and provides important information for evaluating the pandemic risk of field influenza strains.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31267843</PMID><DateCompleted><Year>2019</Year><Month>11</Month><Day>08</Day></DateCompleted><DateRevised><Year>2020</Year><Month>02</Month><Day>25</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">2222-1751</ISSN><JournalIssue CitedMedium="Internet"><Volume>8</Volume><Issue>1</Issue><PubDate><Year>2019</Year></PubDate></JournalIssue><Title>Emerging microbes & infections</Title><ISOAbbreviation>Emerg Microbes Infect</ISOAbbreviation></Journal><ArticleTitle>Mammalian-adaptive mutation NP-Q357K in Eurasian H1N1 Swine Influenza viruses determines the virulence phenotype in mice.</ArticleTitle><Pagination><MedlinePgn>989-999</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1080/22221751.2019.1635873</ELocationID><Abstract><AbstractText>It has recently been proposed that the Eurasian avian-like H1N1 (EA H1N1) swine influenza virus (SIV) is one of the most likely zoonotic viruses to cause the next influenza pandemic. Two main genotypes EA H1N1 viruses have been recognized to be infected humans in China. Our study finds that one of the genotypes JS1-like viruses are avirulent in mice. However, the other are HuN-like viruses and are virulent in mice. The molecular mechanism underlying this difference shows that the NP gene determines the virulence of the EA H1N1 viruses in mice. In addition, a single substitution, Q357K, in the NP protein of the EA H1N1 viruses alters the virulence phenotype. This substitution is a typical human signature marker, which is prevalent in human viruses but rarely detected in avian influenza viruses. The NP-Q357K substitution is readily to be occurred when avian influenza viruses circulate in pigs, and may facilitate their infection of humans and allow viruses also carrying NP-357K to circulate in humans. Our study demonstrates that the substitution Q357K in the NP protein plays a key role in the virulence phenotype of EA H1N1 SIVs, and provides important information for evaluating the pandemic risk of field influenza strains.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zhu</LastName><ForeName>Wenfei</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Feng</LastName><ForeName>Zhaomin</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Yongkun</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>c School of Public Health (Shenzhen) , Sun Yat-sen University , Guangdong , People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Lei</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Jia</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Xiyan</ForeName><Initials>X</Initials><AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Suli</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>c School of Public Health (Shenzhen) , Sun Yat-sen University , Guangdong , People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Lijuan</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wei</LastName><ForeName>Hejiang</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gao</LastName><ForeName>Rongbao</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Dayan</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shu</LastName><ForeName>Yuelong</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>a National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases , Chinese Center for Disease Control and Prevention , Beijing , People's Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>b Key Laboratory for Medical Virology , National Health and Family Planning Commission , Beijing , People's Republic of China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>c School of Public Health (Shenzhen) , Sun Yat-sen University , Guangdong , People's Republic of 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MajorTopicYN="N" Type="Geographic">China</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005838" MajorTopicYN="N">Genotype</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D053118" MajorTopicYN="N">Influenza A Virus, H1N1 Subtype</DescriptorName><QualifierName UI="Q000145" MajorTopicYN="N">classification</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName><QualifierName UI="Q000821" MajorTopicYN="Y">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051379" 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