Advax delta inulin adjuvant overcomes immune immaturity in neonatal mice thereby allowing single–dose influenza vaccine protection
Identifieur interne : 000E28 ( Pmc/Curation ); précédent : 000E27; suivant : 000E29Advax delta inulin adjuvant overcomes immune immaturity in neonatal mice thereby allowing single–dose influenza vaccine protection
Auteurs : Yoshikazu Honda-Okubo [Australie] ; Chun Hao Ong [Australie] ; Nikolai Petrovsky [Australie]Source :
- Vaccine [ 0264-410X ] ; 2015.
Abstract
A single dose of Advax-adjuvanted influenza vaccine in 7-day-old pups protected against lethal influenza infection. Advax adjuvant enhanced both B-cell and T-cell memory in neonates. Influenza protection in Advax-immunized neonates was dependent on memory B-cells. Advax adjuvant confirmed to be safe and well tolerated in neonates.
Url:
DOI: 10.1016/j.vaccine.2015.07.051
PubMed: 26232344
PubMed Central: 4562881
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wicri:step="Curation">000E28</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Advax delta inulin adjuvant overcomes immune immaturity in neonatal mice thereby allowing single–dose influenza vaccine protection</title><author><name sortKey="Honda Okubo, Yoshikazu" sort="Honda Okubo, Yoshikazu" uniqKey="Honda Okubo Y" first="Yoshikazu" last="Honda-Okubo">Yoshikazu Honda-Okubo</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Vaxine Pty Ltd., Bedford Park, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Vaxine Pty Ltd., Bedford Park</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0010">Flinders Medical Centre, Adelaide 5042, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Flinders Medical Centre, Adelaide 5042</wicri:regionArea></affiliation></author><author><name sortKey="Ong, Chun Hao" sort="Ong, Chun Hao" uniqKey="Ong C" first="Chun Hao" last="Ong">Chun Hao Ong</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Vaxine Pty Ltd., Bedford Park, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Vaxine Pty Ltd., Bedford Park</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0010">Flinders Medical Centre, Adelaide 5042, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Flinders Medical Centre, Adelaide 5042</wicri:regionArea></affiliation></author><author><name sortKey="Petrovsky, Nikolai" sort="Petrovsky, Nikolai" uniqKey="Petrovsky N" first="Nikolai" last="Petrovsky">Nikolai Petrovsky</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Vaxine Pty Ltd., Bedford Park, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Vaxine Pty Ltd., Bedford Park</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0010">Flinders Medical Centre, Adelaide 5042, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Flinders Medical Centre, Adelaide 5042</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff0015">Department of Endocrinology, Flinders University, Adelaide 5042, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Endocrinology, Flinders University, Adelaide 5042</wicri:regionArea></affiliation></author></analytic><series><title level="j">Vaccine</title><idno type="ISSN">0264-410X</idno><idno type="eISSN">1873-2518</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">A single dose of Advax-adjuvanted influenza vaccine in 7-day-old pups protected against lethal influenza infection.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">Advax adjuvant enhanced both B-cell and T-cell memory in neonates.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">Influenza protection in Advax-immunized neonates was dependent on memory B-cells.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par0020">Advax adjuvant confirmed to be safe and well tolerated in neonates.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Wong, K K" uniqKey="Wong K">K.K. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Vaccine</journal-id><journal-id journal-id-type="iso-abbrev">Vaccine</journal-id><journal-title-group><journal-title>Vaccine</journal-title></journal-title-group><issn pub-type="ppub">0264-410X</issn><issn pub-type="epub">1873-2518</issn><publisher><publisher-name>Elsevier Ltd. Published by Elsevier Ltd.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26232344</article-id><article-id pub-id-type="pmc">4562881</article-id><article-id pub-id-type="publisher-id">S0264-410X(15)01012-9</article-id><article-id pub-id-type="doi">10.1016/j.vaccine.2015.07.051</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Advax delta inulin adjuvant overcomes immune immaturity in neonatal mice thereby allowing single–dose influenza vaccine protection</article-title></title-group><contrib-group><contrib contrib-type="author" id="aut0005"><name><surname>Honda-Okubo</surname><given-names>Yoshikazu</given-names></name><xref rid="aff0005" ref-type="aff">a</xref><xref rid="aff0010" ref-type="aff">b</xref></contrib><contrib contrib-type="author" id="aut0010"><name><surname>Ong</surname><given-names>Chun Hao</given-names></name><xref rid="aff0005" ref-type="aff">a</xref><xref rid="aff0010" ref-type="aff">b</xref></contrib><contrib contrib-type="author" id="aut0015"><name><surname>Petrovsky</surname><given-names>Nikolai</given-names></name><email>nikolai.petrovsky@flinders.edu.au</email><xref rid="aff0005" ref-type="aff">a</xref><xref rid="aff0010" ref-type="aff">b</xref><xref rid="aff0015" ref-type="aff">c</xref><xref rid="cor0005" ref-type="corresp">⁎</xref></contrib></contrib-group><aff id="aff0005"><label>a</label>Vaxine Pty Ltd., Bedford Park, Australia</aff><aff id="aff0010"><label>b</label>Flinders Medical Centre, Adelaide 5042, Australia</aff><aff id="aff0015"><label>c</label>Department of Endocrinology, Flinders University, Adelaide 5042, Australia</aff><author-notes><corresp id="cor0005"><label>⁎</label>Corresponding author at: Department of Diabetes and Endocrinology, Flinders Medical Centre, Adelaide 5042, SA, Australia. Tel.: +61 8 82044572; fax: +61 8 82045987. <email>nikolai.petrovsky@flinders.edu.au</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>29</day><month>7</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><day>11</day><month>9</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>29</day><month>7</month><year>2015</year></pub-date><volume>33</volume><issue>38</issue><fpage>4892</fpage><lpage>4900</lpage><history><date date-type="received"><day>19</day><month>3</month><year>2015</year></date><date date-type="rev-recd"><day>10</day><month>6</month><year>2015</year></date><date date-type="accepted"><day>17</day><month>7</month><year>2015</year></date></history><permissions><copyright-statement>Copyright © 2015 Elsevier Ltd. Published by Elsevier Ltd. All rights reserved.</copyright-statement><copyright-year>2015</copyright-year><copyright-holder>Elsevier Ltd</copyright-holder><license><license-p>Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.</license-p></license></permissions><abstract abstract-type="author-highlights" id="abs0005"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">A single dose of Advax-adjuvanted influenza vaccine in 7-day-old pups protected against lethal influenza infection.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">Advax adjuvant enhanced both B-cell and T-cell memory in neonates.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">Influenza protection in Advax-immunized neonates was dependent on memory B-cells.</p></list-item><list-item id="lsti0020"><label>•</label><p id="par0020">Advax adjuvant confirmed to be safe and well tolerated in neonates.</p></list-item></list></p></abstract><abstract id="abs0010"><p>Neonates are at high risk for influenza morbidity and mortality due to immune immaturity and lack of priming by prior influenza virus exposure. Inactivated influenza vaccines are ineffective in infants under six months and to provide protection in older children generally require two doses given a month apart. This leaves few options for rapid protection of infants, <italic>e.g.</italic> during an influenza pandemic. We investigated whether Advax™, a novel polysaccharide adjuvant based on delta inulin microparticles could help overcome neonatal immune hypo-responsiveness. We first tested whether it was possible to use Advax to obtain single-dose vaccine protection of neonatal pups against lethal influenza infection. Inactivated influenza A/H1N1 vaccine (iH1N1) combined with Advax™ adjuvant administered as a single subcutaneous immunization to 7-day-old mouse pups significantly enhanced serum influenza-specific IgM, IgG1, IgG2a and IgG2b levels and was associated with a 3–4 fold increase in the frequency of splenic influenza-specific IgM and IgG antibody secreting cells. Pups immunized with Advax had significantly higher splenocyte influenza-stimulated IFN-γ, IL-2, IL-4, and IL-10 production by CBA and a 3–10 fold higher frequency of IFN-γ, IL-2, IL-4 or IL-17 secreting T cells by ELISPOT. Immunization with iH1N1 + Advax induced robust protection of pups against virus challenge 3 weeks later, whereas pups immunized with iH1N1 antigen alone had no protection. Protection by Advax-adjuvanted iH1N1 was dependent on memory B cells rather than memory T cells, with no protection in neonatal μMT mice that are B-cell deficient. Hence, Advax adjuvant overcame neonatal immune hypo-responsiveness and enabled single-dose protection of pups against otherwise lethal influenza infection, thereby supporting ongoing development of Advax™ as a neonatal vaccine adjuvant.</p></abstract><kwd-group id="kwd0005"><title>Keywords</title><kwd>Vaccine</kwd><kwd>Neonate</kwd><kwd>Adjuvant</kwd><kwd>Influenza</kwd><kwd>Immunity</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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