Modelling the emergence of influenza drug resistance: The roles of surface proteins, the immune response and antiviral mechanisms
Identifieur interne : 000C54 ( Pmc/Curation ); précédent : 000C53; suivant : 000C55Modelling the emergence of influenza drug resistance: The roles of surface proteins, the immune response and antiviral mechanisms
Auteurs : Hana M. Dobrovolny [États-Unis, Canada] ; Catherine A. A. Beauchemin [Canada, Japon]Source :
- PLoS ONE [ 1932-6203 ] ; 2017.
Abstract
The emergence of influenza drug resistance has become of particular interest as current planning for an influenza pandemic involves using massive amounts of antiviral drugs. We use semi-stochastic simulations to examine the emergence of drug resistant mutants during the course of a single infection within a patient in the presence and absence of antiviral therapy. We specifically examine three factors and their effect on the emergence of drug-resistant mutants: antiviral mechanism, the immune response, and surface proteins. We find that adamantanes, because they act at the start of the replication cycle to prevent infection, are less likely to produce drug-resistant mutants than NAIs, which act at the end of the replication cycle. A mismatch between surface proteins and internal RNA results in drug-resistant mutants being less likely to emerge, and emerging later in the infection because the mismatch gives antivirals a second chance to prevent propagation of the mutation. The immune response subdues slow growing infections, further reducing the probability that a drug resistant mutant will emerge and yield a drug-resistant infection. These findings improve our understanding of the factors that contribute to the emergence of drug resistance during the course of a single influenza infection.
Url:
DOI: 10.1371/journal.pone.0180582
PubMed: 28700622
PubMed Central: 5503263
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<front><div type="abstract" xml:lang="en"><p>The emergence of influenza drug resistance has become of particular interest as current planning for an influenza pandemic involves using massive amounts of antiviral drugs. We use semi-stochastic simulations to examine the emergence of drug resistant mutants during the course of a single infection within a patient in the presence and absence of antiviral therapy. We specifically examine three factors and their effect on the emergence of drug-resistant mutants: antiviral mechanism, the immune response, and surface proteins. We find that adamantanes, because they act at the start of the replication cycle to prevent infection, are less likely to produce drug-resistant mutants than NAIs, which act at the end of the replication cycle. A mismatch between surface proteins and internal RNA results in drug-resistant mutants being less likely to emerge, and emerging later in the infection because the mismatch gives antivirals a second chance to prevent propagation of the mutation. The immune response subdues slow growing infections, further reducing the probability that a drug resistant mutant will emerge and yield a drug-resistant infection. These findings improve our understanding of the factors that contribute to the emergence of drug resistance during the course of a single influenza infection.</p>
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<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Li, Tcm" uniqKey="Li T">TCM Li</name>
</author>
<author><name sortKey="Chan, Mcw" uniqKey="Chan M">MCW Chan</name>
</author>
<author><name sortKey="Lee, N" uniqKey="Lee N">N Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Abed, Y" uniqKey="Abed Y">Y Abed</name>
</author>
<author><name sortKey="Goyette, N" uniqKey="Goyette N">N Goyette</name>
</author>
<author><name sortKey="Boivin, G" uniqKey="Boivin G">G Boivin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jefferson, T" uniqKey="Jefferson T">T Jefferson</name>
</author>
<author><name sortKey="Demicheli, V" uniqKey="Demicheli V">V Demicheli</name>
</author>
<author><name sortKey="Rivetti, D" uniqKey="Rivetti D">D Rivetti</name>
</author>
<author><name sortKey="Jones, M" uniqKey="Jones M">M Jones</name>
</author>
<author><name sortKey="Pietrantonj, Cd" uniqKey="Pietrantonj C">CD Pietrantonj</name>
</author>
<author><name sortKey="Rivetti, A" uniqKey="Rivetti A">A Rivetti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bright, Ra" uniqKey="Bright R">RA Bright</name>
</author>
<author><name sortKey="Shay, Dk" uniqKey="Shay D">DK Shay</name>
</author>
<author><name sortKey="Shu, B" uniqKey="Shu B">B Shu</name>
</author>
<author><name sortKey="Cox, Nj" uniqKey="Cox N">NJ Cox</name>
</author>
<author><name sortKey="Klimov, Ai" uniqKey="Klimov A">AI Klimov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Abed, Y" uniqKey="Abed Y">Y Abed</name>
</author>
<author><name sortKey="Bourgault, Am" uniqKey="Bourgault A">AM Bourgault</name>
</author>
<author><name sortKey="Fenton, Rj" uniqKey="Fenton R">RJ Fenton</name>
</author>
<author><name sortKey="Morley, Pj" uniqKey="Morley P">PJ Morley</name>
</author>
<author><name sortKey="Gower, D" uniqKey="Gower D">D Gower</name>
</author>
<author><name sortKey="Owens, Ij" uniqKey="Owens I">IJ Owens</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gubareva, Lv" uniqKey="Gubareva L">LV Gubareva</name>
</author>
<author><name sortKey="Kaiser, L" uniqKey="Kaiser L">L Kaiser</name>
</author>
<author><name sortKey="Hayden, Fg" uniqKey="Hayden F">FG Hayden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jefferson, T" uniqKey="Jefferson T">T Jefferson</name>
</author>
<author><name sortKey="Jones, M" uniqKey="Jones M">M Jones</name>
</author>
<author><name sortKey="Doshi, P" uniqKey="Doshi P">P Doshi</name>
</author>
<author><name sortKey="Mar, Cd" uniqKey="Mar C">CD Mar</name>
</author>
<author><name sortKey="Dooley, L" uniqKey="Dooley L">L Dooley</name>
</author>
<author><name sortKey="Foxlee, R" uniqKey="Foxlee R">R Foxlee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hayden, Fg" uniqKey="Hayden F">FG Hayden</name>
</author>
<author><name sortKey="Treanor, Jj" uniqKey="Treanor J">JJ Treanor</name>
</author>
<author><name sortKey="Betts, Rf" uniqKey="Betts R">RF Betts</name>
</author>
<author><name sortKey="Lobo, M" uniqKey="Lobo M">M Lobo</name>
</author>
<author><name sortKey="Esinhart, Jd" uniqKey="Esinhart J">JD Esinhart</name>
</author>
<author><name sortKey="Hussey, Ek" uniqKey="Hussey E">EK Hussey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hayden, Fg" uniqKey="Hayden F">FG Hayden</name>
</author>
<author><name sortKey="Treanor, Jj" uniqKey="Treanor J">JJ Treanor</name>
</author>
<author><name sortKey="Fritz, Rs" uniqKey="Fritz R">RS Fritz</name>
</author>
<author><name sortKey="Lobo, M" uniqKey="Lobo M">M Lobo</name>
</author>
<author><name sortKey="Betts, Rf" uniqKey="Betts R">RF Betts</name>
</author>
<author><name sortKey="Miller, M" uniqKey="Miller M">M Miller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beauchemin, Caa" uniqKey="Beauchemin C">CAA Beauchemin</name>
</author>
<author><name sortKey="Mcsharry, Jj" uniqKey="Mcsharry J">JJ McSharry</name>
</author>
<author><name sortKey="Drusano, Gl" uniqKey="Drusano G">GL Drusano</name>
</author>
<author><name sortKey="Nguyen, Jt" uniqKey="Nguyen J">JT Nguyen</name>
</author>
<author><name sortKey="Went, Gt" uniqKey="Went G">GT Went</name>
</author>
<author><name sortKey="Ribeiro, Rm" uniqKey="Ribeiro R">RM Ribeiro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Belshe, Rb" uniqKey="Belshe R">RB Belshe</name>
</author>
<author><name sortKey="Smith, Mh" uniqKey="Smith M">MH Smith</name>
</author>
<author><name sortKey="Hall, Cb" uniqKey="Hall C">CB Hall</name>
</author>
<author><name sortKey="Betts, R" uniqKey="Betts R">R Betts</name>
</author>
<author><name sortKey="Hay, Aj" uniqKey="Hay A">AJ Hay</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brown, An" uniqKey="Brown A">AN Brown</name>
</author>
<author><name sortKey="Mcsharry, Jj" uniqKey="Mcsharry J">JJ McSharry</name>
</author>
<author><name sortKey="Weng, Q" uniqKey="Weng Q">Q Weng</name>
</author>
<author><name sortKey="Driebe, Em" uniqKey="Driebe E">EM Driebe</name>
</author>
<author><name sortKey="Engelthaler, Dm" uniqKey="Engelthaler D">DM Engelthaler</name>
</author>
<author><name sortKey="Sheff, K" uniqKey="Sheff K">K Sheff</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cheng, Pkc" uniqKey="Cheng P">PKC Cheng</name>
</author>
<author><name sortKey="Leung, Twc" uniqKey="Leung T">TWC Leung</name>
</author>
<author><name sortKey="Ho, Ecm" uniqKey="Ho E">ECM Ho</name>
</author>
<author><name sortKey="Leung, Pck" uniqKey="Leung P">PCK Leung</name>
</author>
<author><name sortKey="Ng, Ayy" uniqKey="Ng A">AYY Ng</name>
</author>
<author><name sortKey="Lai, Myy" uniqKey="Lai M">MYY Lai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baz, M" uniqKey="Baz M">M Baz</name>
</author>
<author><name sortKey="Abed, Y" uniqKey="Abed Y">Y Abed</name>
</author>
<author><name sortKey="Mcdonald, J" uniqKey="Mcdonald J">J McDonald</name>
</author>
<author><name sortKey="Boivin, G" uniqKey="Boivin G">G Boivin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dharan, Nj" uniqKey="Dharan N">NJ Dharan</name>
</author>
<author><name sortKey="Gubareva, Lv" uniqKey="Gubareva L">LV Gubareva</name>
</author>
<author><name sortKey="Meyer, Jj" uniqKey="Meyer J">JJ Meyer</name>
</author>
<author><name sortKey="Okomo Adhiambo, M" uniqKey="Okomo Adhiambo M">M Okomo-Adhiambo</name>
</author>
<author><name sortKey="Mcclinton, Rc" uniqKey="Mcclinton R">RC McClinton</name>
</author>
<author><name sortKey="Marshall, Sa" uniqKey="Marshall S">SA Marshall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zaraket, H" uniqKey="Zaraket H">H Zaraket</name>
</author>
<author><name sortKey="Saito, R" uniqKey="Saito R">R Saito</name>
</author>
<author><name sortKey="Suzuki, Y" uniqKey="Suzuki Y">Y Suzuki</name>
</author>
<author><name sortKey="Baranovich, T" uniqKey="Baranovich T">T Baranovich</name>
</author>
<author><name sortKey="Dapat, C" uniqKey="Dapat C">C Dapat</name>
</author>
<author><name sortKey="Caperig Dapat, I" uniqKey="Caperig Dapat I">I Caperig-Dapat</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Itoh, Y" uniqKey="Itoh Y">Y Itoh</name>
</author>
<author><name sortKey="Shinya, K" uniqKey="Shinya K">K Shinya</name>
</author>
<author><name sortKey="Kiso, M" uniqKey="Kiso M">M Kiso</name>
</author>
<author><name sortKey="Watanabe, T" uniqKey="Watanabe T">T Watanabe</name>
</author>
<author><name sortKey="Sakoda, Y" uniqKey="Sakoda Y">Y Sakoda</name>
</author>
<author><name sortKey="Hatta, M" uniqKey="Hatta M">M Hatta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gubareva, Lv" uniqKey="Gubareva L">LV Gubareva</name>
</author>
<author><name sortKey="Kaiser, L" uniqKey="Kaiser L">L Kaiser</name>
</author>
<author><name sortKey="Matrosovich, Mn" uniqKey="Matrosovich M">MN Matrosovich</name>
</author>
<author><name sortKey="Soo Hoo, Y" uniqKey="Soo Hoo Y">Y Soo-Hoo</name>
</author>
<author><name sortKey="Hayden, Fg" uniqKey="Hayden F">FG Hayden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gubareva, Lv" uniqKey="Gubareva L">LV Gubareva</name>
</author>
<author><name sortKey="Bethell, R" uniqKey="Bethell R">R Bethell</name>
</author>
<author><name sortKey="Hart, Gj" uniqKey="Hart G">GJ Hart</name>
</author>
<author><name sortKey="Murti, Kg" uniqKey="Murti K">KG Murti</name>
</author>
<author><name sortKey="Penn, Cr" uniqKey="Penn C">CR Penn</name>
</author>
<author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Mz" uniqKey="Wang M">MZ Wang</name>
</author>
<author><name sortKey="Tai, Cy" uniqKey="Tai C">CY Tai</name>
</author>
<author><name sortKey="Mendel, Db" uniqKey="Mendel D">DB Mendel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pinilla, Lt" uniqKey="Pinilla L">LT Pinilla</name>
</author>
<author><name sortKey="Holder, Bp" uniqKey="Holder B">BP Holder</name>
</author>
<author><name sortKey="Abed, Y" uniqKey="Abed Y">Y Abed</name>
</author>
<author><name sortKey="Boivin, G" uniqKey="Boivin G">G Boivin</name>
</author>
<author><name sortKey="Beauchemin, Caa" uniqKey="Beauchemin C">CAA Beauchemin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Holder, Bp" uniqKey="Holder B">BP Holder</name>
</author>
<author><name sortKey="Simon, P" uniqKey="Simon P">P Simon</name>
</author>
<author><name sortKey="Liao, Le" uniqKey="Liao L">LE Liao</name>
</author>
<author><name sortKey="Abed, Y" uniqKey="Abed Y">Y Abed</name>
</author>
<author><name sortKey="Bouhy, X" uniqKey="Bouhy X">X Bouhy</name>
</author>
<author><name sortKey="Beauchemin, Caa" uniqKey="Beauchemin C">CAA Beauchemin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wong, Dd" uniqKey="Wong D">DD Wong</name>
</author>
<author><name sortKey="Choy, Kt" uniqKey="Choy K">KT Choy</name>
</author>
<author><name sortKey="Chan, Rwy" uniqKey="Chan R">RWY Chan</name>
</author>
<author><name sortKey="Sia, Sf" uniqKey="Sia S">SF Sia</name>
</author>
<author><name sortKey="Chiu, Hp" uniqKey="Chiu H">HP Chiu</name>
</author>
<author><name sortKey="Cheung, Pph" uniqKey="Cheung P">PPH Cheung</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brookes, Dw" uniqKey="Brookes D">DW Brookes</name>
</author>
<author><name sortKey="Miah, S" uniqKey="Miah S">S Miah</name>
</author>
<author><name sortKey="Lackenby, A" uniqKey="Lackenby A">A Lackenby</name>
</author>
<author><name sortKey="Hartgroves, L" uniqKey="Hartgroves L">L Hartgroves</name>
</author>
<author><name sortKey="Barclay, Ws" uniqKey="Barclay W">WS Barclay</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Herlocher, Ml" uniqKey="Herlocher M">ML Herlocher</name>
</author>
<author><name sortKey="Truscon, R" uniqKey="Truscon R">R Truscon</name>
</author>
<author><name sortKey="Elias, S" uniqKey="Elias S">S Elias</name>
</author>
<author><name sortKey="Yen, Hl" uniqKey="Yen H">HL Yen</name>
</author>
<author><name sortKey="Roberts, Na" uniqKey="Roberts N">NA Roberts</name>
</author>
<author><name sortKey="Ohmit, Se" uniqKey="Ohmit S">SE Ohmit</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ives, Jal" uniqKey="Ives J">JAL Ives</name>
</author>
<author><name sortKey="Carr, Ja" uniqKey="Carr J">JA Carr</name>
</author>
<author><name sortKey="Mendel, Db" uniqKey="Mendel D">DB Mendel</name>
</author>
<author><name sortKey="Tai, Cy" uniqKey="Tai C">CY Tai</name>
</author>
<author><name sortKey="Lambdin, R" uniqKey="Lambdin R">R Lambdin</name>
</author>
<author><name sortKey="Kelly, L" uniqKey="Kelly L">L Kelly</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Govorkova, E" uniqKey="Govorkova E">E Govorkova</name>
</author>
<author><name sortKey="Ilyushina, N" uniqKey="Ilyushina N">N Ilyushina</name>
</author>
<author><name sortKey="Marathe, Bm" uniqKey="Marathe B">BM Marathe</name>
</author>
<author><name sortKey="Mcclaren, Jl" uniqKey="Mcclaren J">JL McClaren</name>
</author>
<author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alexander, Me" uniqKey="Alexander M">ME Alexander</name>
</author>
<author><name sortKey="Bowman, Cs" uniqKey="Bowman C">CS Bowman</name>
</author>
<author><name sortKey="Feng, Z" uniqKey="Feng Z">Z Feng</name>
</author>
<author><name sortKey="Gardam, M" uniqKey="Gardam M">M Gardam</name>
</author>
<author><name sortKey="Moghadas, Sm" uniqKey="Moghadas S">SM Moghadas</name>
</author>
<author><name sortKey="Rost, G" uniqKey="Rost G">G Rost</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Debarre, F" uniqKey="Debarre F">F Debarre</name>
</author>
<author><name sortKey="Bonhoeffer, S" uniqKey="Bonhoeffer S">S Bonhoeffer</name>
</author>
<author><name sortKey="Regoes, Rr" uniqKey="Regoes R">RR Regoes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ferguson, Nm" uniqKey="Ferguson N">NM Ferguson</name>
</author>
<author><name sortKey="Mallett, S" uniqKey="Mallett S">S Mallett</name>
</author>
<author><name sortKey="Jackson, H" uniqKey="Jackson H">H Jackson</name>
</author>
<author><name sortKey="Roberts, N" uniqKey="Roberts N">N Roberts</name>
</author>
<author><name sortKey="Ward, P" uniqKey="Ward P">P Ward</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moghadas, Sm" uniqKey="Moghadas S">SM Moghadas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xu, Y" uniqKey="Xu Y">Y Xu</name>
</author>
<author><name sortKey="Allen, Ljs" uniqKey="Allen L">LJS Allen</name>
</author>
<author><name sortKey="Perelson, As" uniqKey="Perelson A">AS Perelson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Handel, A" uniqKey="Handel A">A Handel</name>
</author>
<author><name sortKey="Longini, Im" uniqKey="Longini I">IM Longini</name>
</author>
<author><name sortKey="Antia, R" uniqKey="Antia R">R Antia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chao, Dl" uniqKey="Chao D">DL Chao</name>
</author>
<author><name sortKey="Bloom, Jd" uniqKey="Bloom J">JD Bloom</name>
</author>
<author><name sortKey="Kochin, Bf" uniqKey="Kochin B">BF Kochin</name>
</author>
<author><name sortKey="Antia, R" uniqKey="Antia R">R Antia</name>
</author>
<author><name sortKey="Ira M Longini, J" uniqKey="Ira M Longini J">J Ira M Longini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Robinson, M" uniqKey="Robinson M">M Robinson</name>
</author>
<author><name sortKey="Stilianakis, N" uniqKey="Stilianakis N">N Stilianakis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Althouse, Bm" uniqKey="Althouse B">BM Althouse</name>
</author>
<author><name sortKey="Patterson Lomba, O" uniqKey="Patterson Lomba O">O Patterson-Lomba</name>
</author>
<author><name sortKey="Goerg, Gm" uniqKey="Goerg G">GM Goerg</name>
</author>
<author><name sortKey="Hebert Dufresne, L" uniqKey="Hebert Dufresne L">L Hebert-Dufresne</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xiao, Y" uniqKey="Xiao Y">Y Xiao</name>
</author>
<author><name sortKey="Brauer, F" uniqKey="Brauer F">F Brauer</name>
</author>
<author><name sortKey="Moghadas, S" uniqKey="Moghadas S">S Moghadas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Handel, A" uniqKey="Handel A">A Handel</name>
</author>
<author><name sortKey="Jr, Iml" uniqKey="Jr I">IML Jr</name>
</author>
<author><name sortKey="Antia, R" uniqKey="Antia R">R Antia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Paradis, Eg" uniqKey="Paradis E">EG Paradis</name>
</author>
<author><name sortKey="Pinilla, Lt" uniqKey="Pinilla L">LT Pinilla</name>
</author>
<author><name sortKey="Holder, Bp" uniqKey="Holder B">BP Holder</name>
</author>
<author><name sortKey="Abed, Y" uniqKey="Abed Y">Y Abed</name>
</author>
<author><name sortKey="Boivin, G" uniqKey="Boivin G">G Boivin</name>
</author>
<author><name sortKey="Beauchemin, Caa" uniqKey="Beauchemin C">CAA Beauchemin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Butler, J" uniqKey="Butler J">J Butler</name>
</author>
<author><name sortKey="Hooper, Ka" uniqKey="Hooper K">KA Hooper</name>
</author>
<author><name sortKey="Petrie, S" uniqKey="Petrie S">S Petrie</name>
</author>
<author><name sortKey="Lee, R" uniqKey="Lee R">R Lee</name>
</author>
<author><name sortKey="Maurer Stroh, S" uniqKey="Maurer Stroh S">S Maurer-Stroh</name>
</author>
<author><name sortKey="Reh, L" uniqKey="Reh L">L Reh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Petrie, Sm" uniqKey="Petrie S">SM Petrie</name>
</author>
<author><name sortKey="Butler, J" uniqKey="Butler J">J Butler</name>
</author>
<author><name sortKey="Barr, Ig" uniqKey="Barr I">IG Barr</name>
</author>
<author><name sortKey="Mcvernon, J" uniqKey="Mcvernon J">J McVernon</name>
</author>
<author><name sortKey="Hurt, Ac" uniqKey="Hurt A">AC Hurt</name>
</author>
<author><name sortKey="Mccaw, Jm" uniqKey="Mccaw J">JM McCaw</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Canini, L" uniqKey="Canini L">L Canini</name>
</author>
<author><name sortKey="Conway, Jm" uniqKey="Conway J">JM Conway</name>
</author>
<author><name sortKey="Perelson, As" uniqKey="Perelson A">AS Perelson</name>
</author>
<author><name sortKey="Carrat, F" uniqKey="Carrat F">F Carrat</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Perelson, As" uniqKey="Perelson A">AS Perelson</name>
</author>
<author><name sortKey="Rong, L" uniqKey="Rong L">L Rong</name>
</author>
<author><name sortKey="Hayden, Fg" uniqKey="Hayden F">FG Hayden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hur, Ky" uniqKey="Hur K">KY Hur</name>
</author>
<author><name sortKey="Moon, Jy" uniqKey="Moon J">JY Moon</name>
</author>
<author><name sortKey="Kim, Sh" uniqKey="Kim S">SH Kim</name>
</author>
<author><name sortKey="Yoo, Jy" uniqKey="Yoo J">JY Yoo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Drake, Jw" uniqKey="Drake J">JW Drake</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hay, Aj" uniqKey="Hay A">AJ Hay</name>
</author>
<author><name sortKey="Richman, Dd" uniqKey="Richman D">DD Richman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hayden, Fg" uniqKey="Hayden F">FG Hayden</name>
</author>
<author><name sortKey="Richman, Dd" uniqKey="Richman D">DD Richman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baccam, P" uniqKey="Baccam P">P Baccam</name>
</author>
<author><name sortKey="Beauchemin, C" uniqKey="Beauchemin C">C Beauchemin</name>
</author>
<author><name sortKey="Macken, Ca" uniqKey="Macken C">CA Macken</name>
</author>
<author><name sortKey="Hayden, Fg" uniqKey="Hayden F">FG Hayden</name>
</author>
<author><name sortKey="Perelson, As" uniqKey="Perelson A">AS Perelson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Crystal, Rg" uniqKey="Crystal R">RG Crystal</name>
</author>
<author><name sortKey="West, Jb" uniqKey="West J">JB West</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sheu, Tg" uniqKey="Sheu T">TG Sheu</name>
</author>
<author><name sortKey="Deyde, Vm" uniqKey="Deyde V">VM Deyde</name>
</author>
<author><name sortKey="Okomo Adhiambo, M" uniqKey="Okomo Adhiambo M">M Okomo-Adhiambo</name>
</author>
<author><name sortKey="Garten, Rj" uniqKey="Garten R">RJ Garten</name>
</author>
<author><name sortKey="Xu, X" uniqKey="Xu X">X Xu</name>
</author>
<author><name sortKey="Bright, Ra" uniqKey="Bright R">RA Bright</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Abed, Y" uniqKey="Abed Y">Y Abed</name>
</author>
<author><name sortKey="Baz, M" uniqKey="Baz M">M Baz</name>
</author>
<author><name sortKey="Boivin, G" uniqKey="Boivin G">G Boivin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yen, Hl" uniqKey="Yen H">HL Yen</name>
</author>
<author><name sortKey="Herlocher, Lm" uniqKey="Herlocher L">LM Herlocher</name>
</author>
<author><name sortKey="Hoffmann, E" uniqKey="Hoffmann E">E Hoffmann</name>
</author>
<author><name sortKey="Matrosovich, Mn" uniqKey="Matrosovich M">MN Matrosovich</name>
</author>
<author><name sortKey="Monto, As" uniqKey="Monto A">AS Monto</name>
</author>
<author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, Hl" uniqKey="Wu H">HL Wu</name>
</author>
<author><name sortKey="Huang, Yx" uniqKey="Huang Y">YX Huang</name>
</author>
<author><name sortKey="Dykes, C" uniqKey="Dykes C">C Dykes</name>
</author>
<author><name sortKey="Liu, Dc" uniqKey="Liu D">DC Liu</name>
</author>
<author><name sortKey="Ma, Jm" uniqKey="Ma J">JM Ma</name>
</author>
<author><name sortKey="Perelson, As" uniqKey="Perelson A">AS Perelson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wargo, Ar" uniqKey="Wargo A">AR Wargo</name>
</author>
<author><name sortKey="Kurath, G" uniqKey="Kurath G">G Kurath</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rodriguez Boulan, E" uniqKey="Rodriguez Boulan E">E Rodriguez-Boulan</name>
</author>
<author><name sortKey="Paskiet, Kt" uniqKey="Paskiet K">KT Paskiet</name>
</author>
<author><name sortKey="Salas, Pji" uniqKey="Salas P">PJI Salas</name>
</author>
<author><name sortKey="Bard, E" uniqKey="Bard E">E Bard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Copeland, C" uniqKey="Copeland C">C Copeland</name>
</author>
<author><name sortKey="Doms, Rw" uniqKey="Doms R">RW Doms</name>
</author>
<author><name sortKey="Bolzau, Em" uniqKey="Bolzau E">EM Bolzau</name>
</author>
<author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
<author><name sortKey="Helenius, A" uniqKey="Helenius A">A Helenius</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kundu, A" uniqKey="Kundu A">A Kundu</name>
</author>
<author><name sortKey="Nayak, D" uniqKey="Nayak D">D Nayak</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Daniels, Pu" uniqKey="Daniels P">PU Daniels</name>
</author>
<author><name sortKey="Edwardson, Jm" uniqKey="Edwardson J">JM Edwardson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hughey, P" uniqKey="Hughey P">P Hughey</name>
</author>
<author><name sortKey="Compans, R" uniqKey="Compans R">R Compans</name>
</author>
<author><name sortKey="Zebedee, S" uniqKey="Zebedee S">S Zebedee</name>
</author>
<author><name sortKey="Lamb, R" uniqKey="Lamb R">R Lamb</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Enami, M" uniqKey="Enami M">M Enami</name>
</author>
<author><name sortKey="Fukuda, R" uniqKey="Fukuda R">R Fukuda</name>
</author>
<author><name sortKey="Ishihama, A" uniqKey="Ishihama A">A Ishihama</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vester, D" uniqKey="Vester D">D Vester</name>
</author>
<author><name sortKey="Lagoda, A" uniqKey="Lagoda A">A Lagoda</name>
</author>
<author><name sortKey="Hoffmann, D" uniqKey="Hoffmann D">D Hoffmann</name>
</author>
<author><name sortKey="Seitz, C" uniqKey="Seitz C">C Seitz</name>
</author>
<author><name sortKey="Heldt, S" uniqKey="Heldt S">S Heldt</name>
</author>
<author><name sortKey="Bettenbrock, K" uniqKey="Bettenbrock K">K Bettenbrock</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tamura, S" uniqKey="Tamura S">S Tamura</name>
</author>
<author><name sortKey="Kurata, T" uniqKey="Kurata T">T Kurata</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dobrovolny, Hm" uniqKey="Dobrovolny H">HM Dobrovolny</name>
</author>
<author><name sortKey="Reddy, Mb" uniqKey="Reddy M">MB Reddy</name>
</author>
<author><name sortKey="Kamal, Ma" uniqKey="Kamal M">MA Kamal</name>
</author>
<author><name sortKey="Rayner, Cr" uniqKey="Rayner C">CR Rayner</name>
</author>
<author><name sortKey="Beauchemin, Caa" uniqKey="Beauchemin C">CAA Beauchemin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Atkinson, K" uniqKey="Atkinson K">K Atkinson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dobrovolny, Hm" uniqKey="Dobrovolny H">HM Dobrovolny</name>
</author>
<author><name sortKey="Baron, Mj" uniqKey="Baron M">MJ Baron</name>
</author>
<author><name sortKey="Gieschke, R" uniqKey="Gieschke R">R Gieschke</name>
</author>
<author><name sortKey="Davies, Be" uniqKey="Davies B">BE Davies</name>
</author>
<author><name sortKey="Jumbe, Nl" uniqKey="Jumbe N">NL Jumbe</name>
</author>
<author><name sortKey="Beauchemin, Caa" uniqKey="Beauchemin C">CAA Beauchemin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baranovich, T" uniqKey="Baranovich T">T Baranovich</name>
</author>
<author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name>
</author>
<author><name sortKey="Govorkova, Ea" uniqKey="Govorkova E">EA Govorkova</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Simon, P" uniqKey="Simon P">P Simon</name>
</author>
<author><name sortKey="Holder, Bp" uniqKey="Holder B">BP Holder</name>
</author>
<author><name sortKey="Bouhy, X" uniqKey="Bouhy X">X Bouhy</name>
</author>
<author><name sortKey="Abed, Y" uniqKey="Abed Y">Y Abed</name>
</author>
<author><name sortKey="Beauchemin, Caa" uniqKey="Beauchemin C">CAA Beauchemin</name>
</author>
<author><name sortKey="Boivin, G" uniqKey="Boivin G">G Boivin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bourret, V" uniqKey="Bourret V">V Bourret</name>
</author>
<author><name sortKey="Croville, G" uniqKey="Croville G">G Croville</name>
</author>
<author><name sortKey="Mansuy, Jm" uniqKey="Mansuy J">JM Mansuy</name>
</author>
<author><name sortKey="Mengelle, C" uniqKey="Mengelle C">C Mengelle</name>
</author>
<author><name sortKey="Mariette, J" uniqKey="Mariette J">J Mariette</name>
</author>
<author><name sortKey="Klopp, C" uniqKey="Klopp C">C Klopp</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wutzler, P" uniqKey="Wutzler P">P Wutzler</name>
</author>
<author><name sortKey="Ehlers, M" uniqKey="Ehlers M">M Ehlers</name>
</author>
<author><name sortKey="Farber, I" uniqKey="Farber I">I Farber</name>
</author>
<author><name sortKey="Fock, R" uniqKey="Fock R">R Fock</name>
</author>
<author><name sortKey="Gillissen, A" uniqKey="Gillissen A">A Gillissen</name>
</author>
<author><name sortKey="Heckler, R" uniqKey="Heckler R">R Heckler</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schunemann, Hj" uniqKey="Schunemann H">HJ Schunemann</name>
</author>
<author><name sortKey="Hill, Sr" uniqKey="Hill S">SR Hill</name>
</author>
<author><name sortKey="Kakad, M" uniqKey="Kakad M">M Kakad</name>
</author>
<author><name sortKey="Bellamy, R" uniqKey="Bellamy R">R Bellamy</name>
</author>
<author><name sortKey="Uyeki, Tm" uniqKey="Uyeki T">TM Uyeki</name>
</author>
<author><name sortKey="Hayden, Fg" uniqKey="Hayden F">FG Hayden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boianelli, A" uniqKey="Boianelli A">A Boianelli</name>
</author>
<author><name sortKey="Sharma Chawla, N" uniqKey="Sharma Chawla N">N Sharma-Chawla</name>
</author>
<author><name sortKey="Bruder, D" uniqKey="Bruder D">D Bruder</name>
</author>
<author><name sortKey="Hernandez Vargas, Ea" uniqKey="Hernandez Vargas E">EA Hernandez-Vargas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, X" uniqKey="Zhao X">X Zhao</name>
</author>
<author><name sortKey="Jie, Y" uniqKey="Jie Y">Y Jie</name>
</author>
<author><name sortKey="Rosenberg, Mr" uniqKey="Rosenberg M">MR Rosenberg</name>
</author>
<author><name sortKey="Wan, J" uniqKey="Wan J">J Wan</name>
</author>
<author><name sortKey="Zeng, S" uniqKey="Zeng S">S Zeng</name>
</author>
<author><name sortKey="Cui, W" uniqKey="Cui W">W Cui</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Morrison, D" uniqKey="Morrison D">D Morrison</name>
</author>
<author><name sortKey="Roy, S" uniqKey="Roy S">S Roy</name>
</author>
<author><name sortKey="Rayner, C" uniqKey="Rayner C">C Rayner</name>
</author>
<author><name sortKey="Amer, A" uniqKey="Amer A">A Amer</name>
</author>
<author><name sortKey="Howard, D" uniqKey="Howard D">D Howard</name>
</author>
<author><name sortKey="Smith, Jr" uniqKey="Smith J">JR Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hamelin, Me" uniqKey="Hamelin M">ME Hamelin</name>
</author>
<author><name sortKey="Baz, M" uniqKey="Baz M">M Baz</name>
</author>
<author><name sortKey="Bouhy, X" uniqKey="Bouhy X">X Bouhy</name>
</author>
<author><name sortKey="Beaulieu, E" uniqKey="Beaulieu E">E Beaulieu</name>
</author>
<author><name sortKey="Dube, K" uniqKey="Dube K">K Dube</name>
</author>
<author><name sortKey="Mallett, C" uniqKey="Mallett C">C Mallett</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seibert, C" uniqKey="Seibert C">C Seibert</name>
</author>
<author><name sortKey="Kaminski, M" uniqKey="Kaminski M">M Kaminski</name>
</author>
<author><name sortKey="Philipp, J" uniqKey="Philipp J">J Philipp</name>
</author>
<author><name sortKey="Rubbenstroth, D" uniqKey="Rubbenstroth D">D Rubbenstroth</name>
</author>
<author><name sortKey="Albrecht, Ra" uniqKey="Albrecht R">RA Albrecht</name>
</author>
<author><name sortKey="Schwalm, F" uniqKey="Schwalm F">F Schwalm</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hurt, Ac" uniqKey="Hurt A">AC Hurt</name>
</author>
<author><name sortKey="Nor, Ss" uniqKey="Nor S">SS Nor’e</name>
</author>
<author><name sortKey="Mccaw, Jm" uniqKey="Mccaw J">JM McCaw</name>
</author>
<author><name sortKey="Fryer, Hr" uniqKey="Fryer H">HR Fryer</name>
</author>
<author><name sortKey="Mosse, J" uniqKey="Mosse J">J Mosse</name>
</author>
<author><name sortKey="Mclean, Ar" uniqKey="Mclean A">AR McLean</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pizzorno, A" uniqKey="Pizzorno A">A Pizzorno</name>
</author>
<author><name sortKey="Abed, Y" uniqKey="Abed Y">Y Abed</name>
</author>
<author><name sortKey="Bouhy, X" uniqKey="Bouhy X">X Bouhy</name>
</author>
<author><name sortKey="Beaulieu, E" uniqKey="Beaulieu E">E Beaulieu</name>
</author>
<author><name sortKey="Mallett, C" uniqKey="Mallett C">C Mallett</name>
</author>
<author><name sortKey="Russell, R" uniqKey="Russell R">R Russell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Abed, Y" uniqKey="Abed Y">Y Abed</name>
</author>
<author><name sortKey="Goyette, N" uniqKey="Goyette N">N Goyette</name>
</author>
<author><name sortKey="Boivin, G" uniqKey="Boivin G">G Boivin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Samji, T" uniqKey="Samji T">T Samji</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nayak, Dp" uniqKey="Nayak D">DP Nayak</name>
</author>
<author><name sortKey="Balogun, Ra" uniqKey="Balogun R">RA Balogun</name>
</author>
<author><name sortKey="Yamada, H" uniqKey="Yamada H">H Yamada</name>
</author>
<author><name sortKey="Zhou, Zh" uniqKey="Zhou Z">ZH Zhou</name>
</author>
<author><name sortKey="Barman, S" uniqKey="Barman S">S Barman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Loverdo, C" uniqKey="Loverdo C">C Loverdo</name>
</author>
<author><name sortKey="Park, M" uniqKey="Park M">M Park</name>
</author>
<author><name sortKey="Schreiber, Sj" uniqKey="Schreiber S">SJ Schreiber</name>
</author>
<author><name sortKey="Lloyd Smith, Jo" uniqKey="Lloyd Smith J">JO Lloyd-Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Loverdo, C" uniqKey="Loverdo C">C Loverdo</name>
</author>
<author><name sortKey="Lloyd Smith, Jo" uniqKey="Lloyd Smith J">JO Lloyd-Smith</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pawelek, Ka" uniqKey="Pawelek K">KA Pawelek</name>
</author>
<author><name sortKey="Huynh, Gt" uniqKey="Huynh G">GT Huynh</name>
</author>
<author><name sortKey="Quinlivan, M" uniqKey="Quinlivan M">M Quinlivan</name>
</author>
<author><name sortKey="Cullinane, A" uniqKey="Cullinane A">A Cullinane</name>
</author>
<author><name sortKey="Rong, L" uniqKey="Rong L">L Rong</name>
</author>
<author><name sortKey="Perelson, As" uniqKey="Perelson A">AS Perelson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Palmer, J" uniqKey="Palmer J">J Palmer</name>
</author>
<author><name sortKey="Dobrovolny, Hm" uniqKey="Dobrovolny H">HM Dobrovolny</name>
</author>
<author><name sortKey="Beauchemin, Caa" uniqKey="Beauchemin C">CAA Beauchemin</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS One</journal-id>
<journal-id journal-id-type="iso-abbrev">PLoS ONE</journal-id>
<journal-id journal-id-type="publisher-id">plos</journal-id>
<journal-id journal-id-type="pmc">plosone</journal-id>
<journal-title-group><journal-title>PLoS ONE</journal-title>
</journal-title-group>
<issn pub-type="epub">1932-6203</issn>
<publisher><publisher-name>Public Library of Science</publisher-name>
<publisher-loc>San Francisco, CA USA</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">28700622</article-id>
<article-id pub-id-type="pmc">5503263</article-id>
<article-id pub-id-type="publisher-id">PONE-D-17-07604</article-id>
<article-id pub-id-type="doi">10.1371/journal.pone.0180582</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Microbiology</subject>
<subj-group><subject>Microbial Control</subject>
<subj-group><subject>Antimicrobial Resistance</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Pharmacology</subject>
<subj-group><subject>Antimicrobial Resistance</subject>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Pharmaceutics</subject>
<subj-group><subject>Drug Therapy</subject>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Physical Sciences</subject>
<subj-group><subject>Chemistry</subject>
<subj-group><subject>Chemical Compounds</subject>
<subj-group><subject>Adamantanes</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Microbiology</subject>
<subj-group><subject>Virology</subject>
<subj-group><subject>Viral Structure</subject>
<subj-group><subject>Virions</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Immunology</subject>
<subj-group><subject>Immune Response</subject>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Immunology</subject>
<subj-group><subject>Immune Response</subject>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Microbiology</subject>
<subj-group><subject>Microbial Mutation</subject>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Infectious Diseases</subject>
<subj-group><subject>Viral Diseases</subject>
<subj-group><subject>Influenza</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Medicine and Health Sciences</subject>
<subj-group><subject>Pharmacology</subject>
<subj-group><subject>Drugs</subject>
<subj-group><subject>Antimicrobials</subject>
<subj-group><subject>Antivirals</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Microbiology</subject>
<subj-group><subject>Microbial Control</subject>
<subj-group><subject>Antimicrobials</subject>
<subj-group><subject>Antivirals</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
<subj-group subj-group-type="Discipline-v3"><subject>Biology and Life Sciences</subject>
<subj-group><subject>Microbiology</subject>
<subj-group><subject>Virology</subject>
<subj-group><subject>Antivirals</subject>
</subj-group>
</subj-group>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Modelling the emergence of influenza drug resistance: The roles of surface proteins, the immune response and antiviral mechanisms</article-title>
<alt-title alt-title-type="running-head">Modelling emergence of drug resistance</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><contrib-id authenticated="true" contrib-id-type="orcid">http://orcid.org/0000-0003-3592-6770</contrib-id>
<name><surname>Dobrovolny</surname>
<given-names>Hana M.</given-names>
</name>
<role content-type="http://credit.casrai.org/">Data curation</role>
<role content-type="http://credit.casrai.org/">Formal analysis</role>
<role content-type="http://credit.casrai.org/">Investigation</role>
<role content-type="http://credit.casrai.org/">Software</role>
<role content-type="http://credit.casrai.org/">Writing – original draft</role>
<role content-type="http://credit.casrai.org/">Writing – review & editing</role>
<xref ref-type="aff" rid="aff001"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
<xref ref-type="corresp" rid="cor001">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Beauchemin</surname>
<given-names>Catherine A. A.</given-names>
</name>
<role content-type="http://credit.casrai.org/">Conceptualization</role>
<role content-type="http://credit.casrai.org/">Funding acquisition</role>
<role content-type="http://credit.casrai.org/">Investigation</role>
<role content-type="http://credit.casrai.org/">Methodology</role>
<role content-type="http://credit.casrai.org/">Project administration</role>
<role content-type="http://credit.casrai.org/">Software</role>
<role content-type="http://credit.casrai.org/">Supervision</role>
<role content-type="http://credit.casrai.org/">Writing – review & editing</role>
<xref ref-type="aff" rid="aff002"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff003"><sup>3</sup>
</xref>
</contrib>
</contrib-group>
<aff id="aff001"><label>1</label>
<addr-line>Department of Physics & Astronomy, Texas Christian University, Fort Worth, TX, United States of America</addr-line>
</aff>
<aff id="aff002"><label>2</label>
<addr-line>Department of Physics, Ryerson University, Toronto, ON, Canada</addr-line>
</aff>
<aff id="aff003"><label>3</label>
<addr-line>Interdisciplinary Theoretical Science (iTHES) Research Group at RIKEN, Wako, Japan</addr-line>
</aff>
<contrib-group><contrib contrib-type="editor"><name><surname>Menéndez-Arias</surname>
<given-names>Luis</given-names>
</name>
<role>Editor</role>
<xref ref-type="aff" rid="edit1"></xref>
</contrib>
</contrib-group>
<aff id="edit1"><addr-line>Universidad Autonoma de Madrid Centro de Biologia Molecular Severo Ochoa, SPAIN</addr-line>
</aff>
<author-notes><fn fn-type="COI-statement" id="coi001"><p><bold>Competing Interests: </bold>
The authors have declared that no competing interests exist.</p>
</fn>
<corresp id="cor001">* E-mail: <email>h.dobrovolny@tcu.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="collection"><year>2017</year>
</pub-date>
<pub-date pub-type="epub"><day>10</day>
<month>7</month>
<year>2017</year>
</pub-date>
<volume>12</volume>
<issue>7</issue>
<elocation-id>e0180582</elocation-id>
<history><date date-type="received"><day>24</day>
<month>2</month>
<year>2017</year>
</date>
<date date-type="accepted"><day>16</day>
<month>6</month>
<year>2017</year>
</date>
</history>
<permissions><copyright-statement>© 2017 Dobrovolny, Beauchemin</copyright-statement>
<copyright-year>2017</copyright-year>
<copyright-holder>Dobrovolny, Beauchemin</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>
, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p>
</license>
</permissions>
<self-uri content-type="pdf" xlink:href="pone.0180582.pdf"></self-uri>
<abstract><p>The emergence of influenza drug resistance has become of particular interest as current planning for an influenza pandemic involves using massive amounts of antiviral drugs. We use semi-stochastic simulations to examine the emergence of drug resistant mutants during the course of a single infection within a patient in the presence and absence of antiviral therapy. We specifically examine three factors and their effect on the emergence of drug-resistant mutants: antiviral mechanism, the immune response, and surface proteins. We find that adamantanes, because they act at the start of the replication cycle to prevent infection, are less likely to produce drug-resistant mutants than NAIs, which act at the end of the replication cycle. A mismatch between surface proteins and internal RNA results in drug-resistant mutants being less likely to emerge, and emerging later in the infection because the mismatch gives antivirals a second chance to prevent propagation of the mutation. The immune response subdues slow growing infections, further reducing the probability that a drug resistant mutant will emerge and yield a drug-resistant infection. These findings improve our understanding of the factors that contribute to the emergence of drug resistance during the course of a single influenza infection.</p>
</abstract>
<funding-group><award-group id="award001"><funding-source><institution-wrap><institution-id institution-id-type="funder-id">http://dx.doi.org/10.13039/501100000038</institution-id>
<institution>Natural Sciences and Engineering Research Council of Canada</institution>
</institution-wrap>
</funding-source>
<award-id>355837-2013</award-id>
<principal-award-recipient><name><surname>Beauchemin</surname>
<given-names>Catherine A. A.</given-names>
</name>
</principal-award-recipient>
</award-group>
<award-group id="award002"><funding-source><institution-wrap><institution-id institution-id-type="funder-id">http://dx.doi.org/10.13039/501100003400</institution-id>
<institution>Ministry of Research and Innovation</institution>
</institution-wrap>
</funding-source>
<award-id>ER13-09-040</award-id>
<principal-award-recipient><name><surname>Beauchemin</surname>
<given-names>Catherine A. A.</given-names>
</name>
</principal-award-recipient>
</award-group>
<funding-statement>This research was supported in part by Discovery Grant 355837-2013 from the Natural Sciences and Engineering Research Council of Canada (to C.A.A.B.), Early Researcher Award ER13-09-040 (to C.A.A.B) from the Ministry of Research and Innovation of the Government of Ontario, with additional support through the iTHES research programme at RIKEN (to C.A.A.B.) The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement>
</funding-group>
<counts><fig-count count="9"></fig-count>
<table-count count="1"></table-count>
<page-count count="26"></page-count>
</counts>
<custom-meta-group><custom-meta id="data-availability"><meta-name>Data Availability</meta-name>
<meta-value>All relevant data are within the paper.</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
<notes><title>Data Availability</title>
<p>All relevant data are within the paper.</p>
</notes>
</front>
</pmc>
</record>
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