Characterization of 2009 H1N1 pandemic influenza in a population of Dutch children with influenza‐like signs and symptoms
Identifieur interne : 000902 ( Pmc/Curation ); précédent : 000901; suivant : 000903Characterization of 2009 H1N1 pandemic influenza in a population of Dutch children with influenza‐like signs and symptoms
Auteurs : Patrick M. Smit ; Karlien M. Bongers ; Rosalie Jl Kuiper ; Ines A. Von Rosenstiel ; Paul Hm Smits ; Dees Pm BrandjesSource :
- Acta Paediatrica (Oslo, Norway : 1992) [ 0803-5253 ] ; 2011.
Abstract
Url:
DOI: 10.1111/j.1651-2227.2011.02406.x
PubMed: 21767303
PubMed Central: 7159360
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<author><name sortKey="Von Rosenstiel, Ines A" sort="Von Rosenstiel, Ines A" uniqKey="Von Rosenstiel I" first="Ines A" last="Von Rosenstiel">Ines A. Von Rosenstiel</name>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<p><bold>Aim: </bold>
To determine causative respiratory pathogens and describe epidemiological and clinical characteristics in a paediatric population with influenza‐like illness during the 2009 H1N1‐pandemic.</p>
<p><bold>Methods: </bold>
Observational study of 412 children visiting an outpatient clinic of a Dutch teaching hospital.</p>
<p><bold>Results: </bold>
From August to December 2009, 412 children were tested at the clinic; 32% proved H1N1‐positive, confirmed by reverse‐transcriptase‐polymerase‐chain‐reaction (RT‐PCR). Pathogens were detected in 65% of samples. Influenza A(H1N1) (n = 132), human rhinovirus (n = 55), respiratory syncytial virus (n = 45) and adenovirus (n = 34) were mostly identified. Co‐infections were seen in 34 children (8.3%). Mean age was 6.8 and 4.2 years in H1N1‐positive and H1N1‐negative cases, respectively (p < 0.01). H1N1‐positive outpatient children reported fever, cough and rhinorrhoea more frequently than their H1N1‐negative counterparts. Of 72 hospitalized children, 31% proved H1N1‐positive; all showed a relatively mild clinical illness. None of the children had been admitted to an intensive care unit or died. Oseltamivir treatment was initiated in 72 children and discontinued in 42 (63%) when RT‐PCR results turned negative.</p>
<p><bold>Conclusion: </bold>
The 2009 H1N1‐pandemic showed a mild clinical course in a Dutch paediatric outpatient clinic population. Respiratory pathogens were detected in the majority of children with influenza‐like illness and influenza A(H1N1) virus was identified in one‐third. Testing symptomatic children during an influenza pandemic has effectively limited the use of oseltamivir.</p>
</div>
</front>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Acta Paediatr</journal-id>
<journal-id journal-id-type="iso-abbrev">Acta Paediatr</journal-id>
<journal-id journal-id-type="doi">10.1111/(ISSN)1651-2227</journal-id>
<journal-id journal-id-type="publisher-id">APA</journal-id>
<journal-title-group><journal-title>Acta Paediatrica (Oslo, Norway : 1992)</journal-title>
</journal-title-group>
<issn pub-type="ppub">0803-5253</issn>
<issn pub-type="epub">1651-2227</issn>
<publisher><publisher-name>Blackwell Publishing Ltd</publisher-name>
<publisher-loc>Oxford, UK</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21767303</article-id>
<article-id pub-id-type="pmc">7159360</article-id>
<article-id pub-id-type="doi">10.1111/j.1651-2227.2011.02406.x</article-id>
<article-id pub-id-type="publisher-id">APA2406</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Regular Articles</subject>
<subj-group subj-group-type="heading"><subject>Influenza</subject>
</subj-group>
</subj-group>
<subj-group subj-group-type="overline"><subject>Regular Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Characterization of 2009 H1N1 pandemic influenza in a population of Dutch children with influenza‐like signs and symptoms</article-title>
<alt-title alt-title-type="left-running-head">Smit et al.</alt-title>
<alt-title alt-title-type="right-running-head"><italic>2009 H1N1 influenza in Dutch children</italic>
</alt-title>
</title-group>
<contrib-group><contrib id="cr1" contrib-type="author"><name><surname>Smit</surname>
<given-names>Patrick M</given-names>
</name>
<xref ref-type="aff" rid="a1"><sup>1</sup>
</xref>
</contrib>
<contrib id="cr2" contrib-type="author"><name><surname>Bongers</surname>
<given-names>Karlien M</given-names>
</name>
<xref ref-type="aff" rid="a2"><sup>2</sup>
</xref>
</contrib>
<contrib id="cr3" contrib-type="author"><name><surname>Kuiper</surname>
<given-names>Rosalie JL</given-names>
</name>
<xref ref-type="aff" rid="a2"><sup>2</sup>
</xref>
</contrib>
<contrib id="cr4" contrib-type="author"><name><surname>von Rosenstiel</surname>
<given-names>Ines A</given-names>
</name>
<xref ref-type="aff" rid="a2"><sup>2</sup>
</xref>
</contrib>
<contrib id="cr5" contrib-type="author"><name><surname>Smits</surname>
<given-names>Paul HM</given-names>
</name>
<xref ref-type="aff" rid="a3"><sup>3</sup>
</xref>
</contrib>
<contrib id="cr6" contrib-type="author"><name><surname>Brandjes</surname>
<given-names>Dees PM</given-names>
</name>
<xref ref-type="aff" rid="a1"><sup>1</sup>
</xref>
</contrib>
</contrib-group>
<aff id="a1"><label><sup>1</sup>
</label>
Department of Internal Medicine, Slotervaart Hospital, Amsterdam, The Netherlands</aff>
<aff id="a2"><label><sup>2</sup>
</label>
Department of Paediatrics, Slotervaart Hospital, Amsterdam, The Netherlands</aff>
<aff id="a3"><label><sup>3</sup>
</label>
Department of Molecular Biology, Slotervaart Hospital, Amsterdam, The Netherlands</aff>
<author-notes><corresp id="correspondenceTo">Patrick M Smit, M.D., Department of Internal Medicine, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam, The Netherlands.
Tel: +0031 20 5125194 |
Fax: +0031 20 5124783 |
Email: <email>patrickmsmit@gmail.com</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>1</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="epub"><day>27</day>
<month>7</month>
<year>2011</year>
</pub-date>
<volume>101</volume>
<issue>1</issue>
<issue-id pub-id-type="doi">10.1111/apa.2011.101.issue-1</issue-id>
<fpage>67</fpage>
<lpage>72</lpage>
<history><bold>Received</bold>
, 22 December 2010; revised 10 June 2011; accepted 4 July 2011.</history>
<permissions><copyright-statement content-type="article-copyright">© 2011 The Author(s)/Acta Pædiatrica © 2011 Foundation Acta Pædiatrica</copyright-statement>
<license><license-p>This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.</license-p>
</license>
</permissions>
<self-uri content-type="pdf" xlink:href="file:APA-101-67.pdf"></self-uri>
<abstract><title>Abstract</title>
<p><bold>Aim: </bold>
To determine causative respiratory pathogens and describe epidemiological and clinical characteristics in a paediatric population with influenza‐like illness during the 2009 H1N1‐pandemic.</p>
<p><bold>Methods: </bold>
Observational study of 412 children visiting an outpatient clinic of a Dutch teaching hospital.</p>
<p><bold>Results: </bold>
From August to December 2009, 412 children were tested at the clinic; 32% proved H1N1‐positive, confirmed by reverse‐transcriptase‐polymerase‐chain‐reaction (RT‐PCR). Pathogens were detected in 65% of samples. Influenza A(H1N1) (n = 132), human rhinovirus (n = 55), respiratory syncytial virus (n = 45) and adenovirus (n = 34) were mostly identified. Co‐infections were seen in 34 children (8.3%). Mean age was 6.8 and 4.2 years in H1N1‐positive and H1N1‐negative cases, respectively (p < 0.01). H1N1‐positive outpatient children reported fever, cough and rhinorrhoea more frequently than their H1N1‐negative counterparts. Of 72 hospitalized children, 31% proved H1N1‐positive; all showed a relatively mild clinical illness. None of the children had been admitted to an intensive care unit or died. Oseltamivir treatment was initiated in 72 children and discontinued in 42 (63%) when RT‐PCR results turned negative.</p>
<p><bold>Conclusion: </bold>
The 2009 H1N1‐pandemic showed a mild clinical course in a Dutch paediatric outpatient clinic population. Respiratory pathogens were detected in the majority of children with influenza‐like illness and influenza A(H1N1) virus was identified in one‐third. Testing symptomatic children during an influenza pandemic has effectively limited the use of oseltamivir.</p>
</abstract>
<kwd-group><kwd id="k1">Epidemiology</kwd>
<kwd id="k2">Influenza A(H1N1)</kwd>
<kwd id="k3">Paediatrics</kwd>
<kwd id="k4">Respiratory pathogens</kwd>
<kwd id="k5">RT‐PCR</kwd>
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