Cross-Protection of Chicken Immunoglobulin Y Antibodies against H5N1 and H1N1 Viruses Passively Administered in Mice▿
Identifieur interne : 000676 ( Pmc/Curation ); précédent : 000675; suivant : 000677Cross-Protection of Chicken Immunoglobulin Y Antibodies against H5N1 and H1N1 Viruses Passively Administered in Mice▿
Auteurs : Michael G. Wallach [Australie] ; Richard J. Webby [États-Unis] ; Fakhrul Islam [Australie] ; Stephen Walkden-Brown [Australie] ; Eva Emmoth [Suède] ; Ricardo Feinstein [Suède] ; Kjell-Olov Gronvik [Suède]Source :
- Clinical and Vaccine Immunology : CVI [ 1556-6811 ] ; 2011.
Abstract
Influenza viruses remain a major threat to global health due to their ability to undergo change through antigenic drift and antigenic shift. We postulated that avian IgY antibodies represent a low-cost, effective, and well-tolerated approach that can easily be scaled up to produce enormous quantities of protective antibodies. These IgY antibodies can be administered passively in humans (orally and intranasally) and can be used quickly and safely to help in the fight against an influenza pandemic. In this study, we raised IgY antibodies against H1N1, H3N2, and H5N1 influenza viruses. We demonstrated that, using whole inactivated viruses alone and in combination to immunize hens, we were able to induce a high level of anti-influenza virus IgY in the sera and eggs, which lasted for at least 2 months after two immunizations. Furthermore, we found that by use of
Url:
DOI: 10.1128/CVI.05075-11
PubMed: 21613458
PubMed Central: 3147324
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Wallach</name><affiliation wicri:level="1"><nlm:aff id="aff1">iThree Institute, University of Technology Sydney, Broadway, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>iThree Institute, University of Technology Sydney, Broadway</wicri:regionArea></affiliation></author><author><name sortKey="Webby, Richard J" sort="Webby, Richard J" uniqKey="Webby R" first="Richard J." last="Webby">Richard J. Webby</name><affiliation wicri:level="2"><nlm:aff id="aff2">St. Jude Children's Research Hospital, Department of Infectious Diseases, Division of Virology, 332 N. Lauderdale, Memphis, Tennessee 38105</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Tennessee</region></placeName><wicri:cityArea>St. Jude Children's Research Hospital, Department of Infectious Diseases, Division of Virology, 332 N. Lauderdale, Memphis</wicri:cityArea></affiliation></author><author><name sortKey="Islam, Fakhrul" sort="Islam, Fakhrul" uniqKey="Islam F" first="Fakhrul" last="Islam">Fakhrul Islam</name><affiliation wicri:level="1"><nlm:aff id="aff3">Centre for Animal Health and Welfare, School of Environmental and Rural Sciences, University of New England, Armidale 2351, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Animal Health and Welfare, School of Environmental and Rural Sciences, University of New England, Armidale 2351</wicri:regionArea></affiliation></author><author><name sortKey="Walkden Brown, Stephen" sort="Walkden Brown, Stephen" uniqKey="Walkden Brown S" first="Stephen" last="Walkden-Brown">Stephen Walkden-Brown</name><affiliation wicri:level="1"><nlm:aff id="aff3">Centre for Animal Health and Welfare, School of Environmental and Rural Sciences, University of New England, Armidale 2351, Australia</nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea>Centre for Animal Health and Welfare, School of Environmental and Rural Sciences, University of New England, Armidale 2351</wicri:regionArea></affiliation></author><author><name sortKey="Emmoth, Eva" sort="Emmoth, Eva" uniqKey="Emmoth E" first="Eva" last="Emmoth">Eva Emmoth</name><affiliation wicri:level="1"><nlm:aff id="aff4">National Veterinary Institute, SVA, Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>National Veterinary Institute, SVA, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Feinstein, Ricardo" sort="Feinstein, Ricardo" uniqKey="Feinstein R" first="Ricardo" last="Feinstein">Ricardo Feinstein</name><affiliation wicri:level="1"><nlm:aff id="aff4">National Veterinary Institute, SVA, Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>National Veterinary Institute, SVA, Uppsala</wicri:regionArea></affiliation></author><author><name sortKey="Gronvik, Kjell Olov" sort="Gronvik, Kjell Olov" uniqKey="Gronvik K" first="Kjell-Olov" last="Gronvik">Kjell-Olov Gronvik</name><affiliation wicri:level="1"><nlm:aff id="aff4">National Veterinary Institute, SVA, Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>National Veterinary Institute, SVA, Uppsala</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff5">Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden</nlm:aff><country xml:lang="fr">Suède</country><wicri:regionArea>Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala</wicri:regionArea></affiliation></author></analytic><series><title level="j">Clinical and Vaccine Immunology : CVI</title><idno type="ISSN">1556-6811</idno><idno type="eISSN">1556-679X</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Influenza viruses remain a major threat to global health due to their ability to undergo change through antigenic drift and antigenic shift. We postulated that avian IgY antibodies represent a low-cost, effective, and well-tolerated approach that can easily be scaled up to produce enormous quantities of protective antibodies. These IgY antibodies can be administered passively in humans (orally and intranasally) and can be used quickly and safely to help in the fight against an influenza pandemic. In this study, we raised IgY antibodies against H1N1, H3N2, and H5N1 influenza viruses. We demonstrated that, using whole inactivated viruses alone and in combination to immunize hens, we were able to induce a high level of anti-influenza virus IgY in the sera and eggs, which lasted for at least 2 months after two immunizations. Furthermore, we found that by use of <italic>in vitro</italic> assays to test for the ability of IgY to inhibit hemagglutination (HI test) and virus infectivity (serum neutralization test), IgYs inhibited the homologous as well as in some cases heterologous clades and strains of viruses. Using an <italic>in vivo</italic> mouse model system, we found that, when administered intranasally 1 h prior to infection, IgY to H5N1 protected 100% of the mice against lethal challenge with H5N1. Of particular interest was the finding that IgY to H5N1 cross-protected against A/Puerto Rico/8/34 (H1N1) both <italic>in vitro</italic> and <italic>in vivo</italic>. Based on our results, we conclude that anti-influenza virus IgY can be used to help prevent influenza virus infection.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Vaccine Immunol</journal-id><journal-id journal-id-type="hwp">cdli</journal-id><journal-id journal-id-type="pmc">cvi</journal-id><journal-id journal-id-type="publisher-id">CVI</journal-id><journal-title-group><journal-title>Clinical and Vaccine Immunology : CVI</journal-title></journal-title-group><issn pub-type="ppub">1556-6811</issn><issn pub-type="epub">1556-679X</issn><publisher><publisher-name>American Society for Microbiology</publisher-name><publisher-loc>1752 N St., N.W., Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21613458</article-id><article-id pub-id-type="pmc">3147324</article-id><article-id pub-id-type="publisher-id">5075-11</article-id><article-id pub-id-type="doi">10.1128/CVI.05075-11</article-id><article-categories><subj-group subj-group-type="heading"><subject>Microbial Immunology</subject></subj-group></article-categories><title-group><article-title>Cross-Protection of Chicken Immunoglobulin Y Antibodies against H5N1 and H1N1 Viruses Passively Administered in Mice<xref ref-type="fn" rid="FN1"><sup>▿</sup></xref></article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Wallach</surname><given-names>Michael G.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Webby</surname><given-names>Richard J.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Islam</surname><given-names>Fakhrul</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Walkden-Brown</surname><given-names>Stephen</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Emmoth</surname><given-names>Eva</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Feinstein</surname><given-names>Ricardo</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Gronvik</surname><given-names>Kjell-Olov</given-names></name><xref ref-type="aff" rid="aff4"><sup>4</sup></xref><xref ref-type="aff" rid="aff5"><sup>5</sup></xref></contrib><aff id="aff1"><label>1</label>iThree Institute, University of Technology Sydney, Broadway, Australia</aff><aff id="aff2"><label>2</label>St. Jude Children's Research Hospital, Department of Infectious Diseases, Division of Virology, 332 N. Lauderdale, Memphis, Tennessee 38105</aff><aff id="aff3"><label>3</label>Centre for Animal Health and Welfare, School of Environmental and Rural Sciences, University of New England, Armidale 2351, Australia</aff><aff id="aff4"><label>4</label>National Veterinary Institute, SVA, Uppsala, Sweden</aff><aff id="aff5"><label>5</label>Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden</aff></contrib-group><author-notes><corresp id="cor1"><label>*</label>Corresponding author. Mailing address: <addr-line>iThree Institute, University of Technology Sydney, Broadway, Sydney, NSE 2007, Australia</addr-line>. Phone: <phone>61 2 95144082</phone>. Fax: <fax>61 2 95144086</fax>. E-mail: <email>Michael.Wallach@uts.edu.au</email>.</corresp></author-notes><pub-date pub-type="ppub"><month>7</month><year>2011</year></pub-date><volume>18</volume><issue>7</issue><fpage>1083</fpage><lpage>1090</lpage><history><date date-type="received"><day>8</day><month>4</month><year>2011</year></date><date date-type="rev-request"><day>5</day><month>5</month><year>2011</year></date><date date-type="accepted"><day>16</day><month>5</month><year>2011</year></date></history><permissions><copyright-statement>Copyright © 2011, American Society for Microbiology</copyright-statement><copyright-year>2011</copyright-year><copyright-holder>American Society for Microbiology</copyright-holder></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zcd00711001083.pdf"></self-uri><abstract><p>Influenza viruses remain a major threat to global health due to their ability to undergo change through antigenic drift and antigenic shift. We postulated that avian IgY antibodies represent a low-cost, effective, and well-tolerated approach that can easily be scaled up to produce enormous quantities of protective antibodies. These IgY antibodies can be administered passively in humans (orally and intranasally) and can be used quickly and safely to help in the fight against an influenza pandemic. In this study, we raised IgY antibodies against H1N1, H3N2, and H5N1 influenza viruses. We demonstrated that, using whole inactivated viruses alone and in combination to immunize hens, we were able to induce a high level of anti-influenza virus IgY in the sera and eggs, which lasted for at least 2 months after two immunizations. Furthermore, we found that by use of <italic>in vitro</italic> assays to test for the ability of IgY to inhibit hemagglutination (HI test) and virus infectivity (serum neutralization test), IgYs inhibited the homologous as well as in some cases heterologous clades and strains of viruses. Using an <italic>in vivo</italic> mouse model system, we found that, when administered intranasally 1 h prior to infection, IgY to H5N1 protected 100% of the mice against lethal challenge with H5N1. Of particular interest was the finding that IgY to H5N1 cross-protected against A/Puerto Rico/8/34 (H1N1) both <italic>in vitro</italic> and <italic>in vivo</italic>. Based on our results, we conclude that anti-influenza virus IgY can be used to help prevent influenza virus infection.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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