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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Safety, Immunogencity and Efficacy of a Cold-Adapted A/Ann Arbor/6/60 (H2N2) Vaccine in Mice and Ferrets</title><author><name sortKey="Chen, Grace L" sort="Chen, Grace L" uniqKey="Chen G" first="Grace L" last="Chen">Grace L. Chen</name><affiliation><nlm:aff id="A1"> Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892</nlm:aff></affiliation></author><author><name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W" last="Lamirande">Elaine W. Lamirande</name><affiliation><nlm:aff id="A1"> Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892</nlm:aff></affiliation></author><author><name sortKey="Jin, Hong" sort="Jin, Hong" uniqKey="Jin H" first="Hong" last="Jin">Hong Jin</name><affiliation><nlm:aff id="A2"> Medimmune, Mountain View, CA 94043</nlm:aff></affiliation></author><author><name sortKey="Kemble, George" sort="Kemble, George" uniqKey="Kemble G" first="George" last="Kemble">George Kemble</name><affiliation><nlm:aff id="A2"> Medimmune, Mountain View, CA 94043</nlm:aff></affiliation></author><author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><affiliation><nlm:aff id="A1"> Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">20034647</idno><idno type="pmc">2823816</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2823816</idno><idno type="RBID">PMC:2823816</idno><idno type="doi">10.1016/j.virol.2009.12.003</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000526</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000526</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Safety, Immunogencity and Efficacy of a Cold-Adapted A/Ann Arbor/6/60 (H2N2) Vaccine in Mice and Ferrets</title><author><name sortKey="Chen, Grace L" sort="Chen, Grace L" uniqKey="Chen G" first="Grace L" last="Chen">Grace L. Chen</name><affiliation><nlm:aff id="A1"> Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892</nlm:aff></affiliation></author><author><name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W" last="Lamirande">Elaine W. Lamirande</name><affiliation><nlm:aff id="A1"> Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892</nlm:aff></affiliation></author><author><name sortKey="Jin, Hong" sort="Jin, Hong" uniqKey="Jin H" first="Hong" last="Jin">Hong Jin</name><affiliation><nlm:aff id="A2"> Medimmune, Mountain View, CA 94043</nlm:aff></affiliation></author><author><name sortKey="Kemble, George" sort="Kemble, George" uniqKey="Kemble G" first="George" last="Kemble">George Kemble</name><affiliation><nlm:aff id="A2"> Medimmune, Mountain View, CA 94043</nlm:aff></affiliation></author><author><name sortKey="Subbarao, Kanta" sort="Subbarao, Kanta" uniqKey="Subbarao K" first="Kanta" last="Subbarao">Kanta Subbarao</name><affiliation><nlm:aff id="A1"> Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892</nlm:aff></affiliation></author></analytic><series><title level="j">Virology</title><idno type="ISSN">0042-6822</idno><idno type="eISSN">1096-0341</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">We studied the attenuation, immunogenicity and efficacy of the cold-adapted A/Ann Arbor/6/60 (AA<italic>ca</italic>) (H2N2) virus in mice and ferrets to evaluate its' use in the event of an H2 influenza pandemic. The AA<italic>ca</italic> virus was restricted in replication in the respiratory tract of mice and ferrets. In mice, 2 doses of vaccine elicited a > 4-fold rise in hemagglutination-inhibition (HAI) titer and resulted in complete inhibition of viral replication following lethal homologous wild-type virus challenge. In ferrets, a single dose of the vaccine elicited a > 4-fold rise in HAI titer and conferred complete protection against homologous wild-type virus challenge in the upper respiratory tract. In both mice and ferrets, the AA<italic>ca</italic> virus provided significant protection from challenge with heterologous H2 virus challenge in the respiratory tract. The AA<italic>ca</italic> vaccine is safe, immunogenic and efficacious against homologous and heterologous challenge in mice and ferrets, supporting the evaluation of this vaccine in clinical trials.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0110674</journal-id><journal-id journal-id-type="pubmed-jr-id">8015</journal-id><journal-id journal-id-type="nlm-ta">Virology</journal-id><journal-title>Virology</journal-title><issn pub-type="ppub">0042-6822</issn><issn pub-type="epub">1096-0341</issn></journal-meta><article-meta><article-id pub-id-type="pmid">20034647</article-id><article-id pub-id-type="pmc">2823816</article-id><article-id pub-id-type="doi">10.1016/j.virol.2009.12.003</article-id><article-id pub-id-type="manuscript">NIHMS167498</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Safety, Immunogencity and Efficacy of a Cold-Adapted A/Ann Arbor/6/60 (H2N2) Vaccine in Mice and Ferrets</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Grace L</given-names></name><email>chengra@niaid.nih.gov</email><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Lamirande</surname><given-names>Elaine W</given-names></name><email>elamirande@niaid.nih.gov</email><xref rid="A1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Jin</surname><given-names>Hong</given-names></name><email>jinh@medimmune.com</email><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Kemble</surname><given-names>George</given-names></name><email>kembleg@medimmune.com</email><xref rid="A2" ref-type="aff">2</xref></contrib><contrib contrib-type="author"><name><surname>Subbarao</surname><given-names>Kanta</given-names></name><email>ksubbarao@niaid.nih.gov</email><xref rid="A1" ref-type="aff">1</xref><xref rid="FN1" ref-type="author-notes">§</xref></contrib></contrib-group><aff id="A1"><label>1</label> Laboratory of Infectious Diseases, NIAID, NIH, Bethesda, MD 20892</aff><aff id="A2"><label>2</label> Medimmune, Mountain View, CA 94043</aff><author-notes><corresp id="FN1"><label>§</label>Corresponding author: Kanta Subbarao, MD, MPH, Laboratory of Infectious Diseases, NIAID, NIH, Bldg 33, Room 3E13C.1, 33 North Drive, MSC 3203, Bethesda, MD 20892-3203, (301) 451-3839, Fax: (301) 480-5722</corresp></author-notes><pub-date pub-type="nihms-submitted"><day>13</day><month>1</month><year>2010</year></pub-date><pub-date pub-type="epub"><day>24</day><month>12</month><year>2009</year></pub-date><pub-date pub-type="ppub"><day>1</day><month>3</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>3</month><year>2011</year></pub-date><volume>398</volume><issue>1</issue><fpage>109</fpage><lpage>114</lpage><abstract><p id="P1">We studied the attenuation, immunogenicity and efficacy of the cold-adapted A/Ann Arbor/6/60 (AA<italic>ca</italic>) (H2N2) virus in mice and ferrets to evaluate its' use in the event of an H2 influenza pandemic. The AA<italic>ca</italic> virus was restricted in replication in the respiratory tract of mice and ferrets. In mice, 2 doses of vaccine elicited a > 4-fold rise in hemagglutination-inhibition (HAI) titer and resulted in complete inhibition of viral replication following lethal homologous wild-type virus challenge. In ferrets, a single dose of the vaccine elicited a > 4-fold rise in HAI titer and conferred complete protection against homologous wild-type virus challenge in the upper respiratory tract. In both mice and ferrets, the AA<italic>ca</italic> virus provided significant protection from challenge with heterologous H2 virus challenge in the respiratory tract. The AA<italic>ca</italic> vaccine is safe, immunogenic and efficacious against homologous and heterologous challenge in mice and ferrets, supporting the evaluation of this vaccine in clinical trials.</p></abstract><kwd-group><kwd>Live attenuated influenza vaccines</kwd><kwd>A/Ann Arbor/6/60 (H2N2)</kwd></kwd-group><contract-num rid="AI1">ZIA AI000933-07
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