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A review of epidemic preparedness for influenza through local vaccine production: national security for Thailand

Identifieur interne : 000101 ( Pmc/Checkpoint ); précédent : 000100; suivant : 000102

A review of epidemic preparedness for influenza through local vaccine production: national security for Thailand

Auteurs : Punnee Pitisuttithum [Thaïlande] ; Ponthip Wirachwong [Thaïlande]

Source :

RBID : PMC:6816430

Abstract

ABSTRACT

Being vigilant of the potential for an influenza pandemic, the Global Action Plan for Influenza Vaccines (GAP) promoted the establishment and maintenance of local vaccine manufacturing capacity. In accordance with this, the Thai government has developed its national strategic plan for influenza pandemic preparedness including the plan for manufacturing influenza vaccine in Thailand. With the support of WHO, the Thai Government Pharmaceutical Organization (GPO) as the developed local production capacity of influenza vaccines. The H1N1 live attenuated influenza vaccine (LAIV) and H5N2 LAIV produced by GPO have been proven to be safe and immunogenic through clinical trials, followed by Thai FDA licensure for pandemic use. The GPO-produced H5N2 LAIV has been proven to have priming effects on an inactivated subunit H5N1 booster vaccine. This Thai local manufacturer is now expanding its capacity to Inactivated Influenza Vaccine (IIV), aiming for sustainable influenza vaccine production for national coverage.


Url:
DOI: 10.1080/21645515.2019.1638205
PubMed: 31335234
PubMed Central: 6816430


Affiliations:


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<p>Being vigilant of the potential for an influenza pandemic, the Global Action Plan for Influenza Vaccines (GAP) promoted the establishment and maintenance of local vaccine manufacturing capacity. In accordance with this, the Thai government has developed its national strategic plan for influenza pandemic preparedness including the plan for manufacturing influenza vaccine in Thailand. With the support of WHO, the Thai Government Pharmaceutical Organization (GPO) as the developed local production capacity of influenza vaccines. The H1N1 live attenuated influenza vaccine (LAIV) and H5N2 LAIV produced by GPO have been proven to be safe and immunogenic through clinical trials, followed by Thai FDA licensure for pandemic use. The GPO-produced H5N2 LAIV has been proven to have priming effects on an inactivated subunit H5N1 booster vaccine. This Thai local manufacturer is now expanding its capacity to Inactivated Influenza Vaccine (IIV), aiming for sustainable influenza vaccine production for national coverage.</p>
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<front>
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<journal-id journal-id-type="nlm-ta">Hum Vaccin Immunother</journal-id>
<journal-id journal-id-type="iso-abbrev">Hum Vaccin Immunother</journal-id>
<journal-id journal-id-type="publisher-id">KHVI</journal-id>
<journal-id journal-id-type="publisher-id">khvi20</journal-id>
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<article-id pub-id-type="pmc">6816430</article-id>
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<article-id pub-id-type="doi">10.1080/21645515.2019.1638205</article-id>
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<subject>Commentary</subject>
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<title-group>
<article-title>A review of epidemic preparedness for influenza through local vaccine production: national security for Thailand</article-title>
<alt-title alt-title-type="running-authors">P. PITISUTTITHUM AND P. WIRACHWONG</alt-title>
<alt-title alt-title-type="running-title">HUMAN VACCINES & IMMUNOTHERAPEUTICS</alt-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<contrib-id contrib-id-type="orcid">http://orcid.org/0000-0003-3215-2183</contrib-id>
<name>
<surname>Pitisuttithum</surname>
<given-names>Punnee</given-names>
</name>
<xref ref-type="corresp" rid="AN0001"></xref>
<xref ref-type="aff" rid="AFF0001">
<sup>a</sup>
</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Wirachwong</surname>
<given-names>Ponthip</given-names>
</name>
<xref ref-type="aff" rid="AFF0002">
<sup>b</sup>
</xref>
</contrib>
<aff id="AFF0001">
<label>a</label>
<institution>Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University</institution>
, Bangkok,
<country>Thailand</country>
</aff>
<aff id="AFF0002">
<label>b</label>
<institution>Research and Development Institute, Government Pharmaceutical Organization</institution>
, Bangkok,
<country>Thailand</country>
</aff>
</contrib-group>
<author-notes>
<corresp id="AN0001">CONTACT Punnee Pitisuttithum
<email xlink:href="punnee.pit@mahidol.ac.th">punnee.pit@mahidol.ac.th</email>
<institution>Faculty of Tropical Medicine, Mahidol University</institution>
,
<addr-line>420/6 Ratchawithi road</addr-line>
, Ratchathewi 10400,
<country>Thailand</country>
</corresp>
</author-notes>
<pub-date pub-type="collection">
<year>2019</year>
</pub-date>
<pub-date pub-type="epub">
<day>5</day>
<month>9</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="pmc-release">
<day>5</day>
<month>9</month>
<year>2019</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on the . </pmc-comment>
<volume>15</volume>
<issue>10</issue>
<fpage seq="25">2440</fpage>
<lpage>2445</lpage>
<history>
<date date-type="received">
<day>25</day>
<month>4</month>
<year>2019</year>
</date>
<date date-type="rev-recd">
<day>14</day>
<month>6</month>
<year>2019</year>
</date>
<date date-type="accepted">
<day>22</day>
<month>6</month>
<year>2019</year>
</date>
</history>
<permissions>
<copyright-statement>© 2019 The Author(s). Published with license by Taylor & Francis Group, LLC.</copyright-statement>
<copyright-year>2019</copyright-year>
<copyright-holder>The Author(s)</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0/">
<license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (
<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0/">http://creativecommons.org/licenses/by-nc-nd/4.0/</ext-link>
), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.</license-p>
</license>
</permissions>
<self-uri content-type="pdf" xlink:href="khvi-15-10-1638205.pdf"></self-uri>
<abstract>
<title>ABSTRACT</title>
<p>Being vigilant of the potential for an influenza pandemic, the Global Action Plan for Influenza Vaccines (GAP) promoted the establishment and maintenance of local vaccine manufacturing capacity. In accordance with this, the Thai government has developed its national strategic plan for influenza pandemic preparedness including the plan for manufacturing influenza vaccine in Thailand. With the support of WHO, the Thai Government Pharmaceutical Organization (GPO) as the developed local production capacity of influenza vaccines. The H1N1 live attenuated influenza vaccine (LAIV) and H5N2 LAIV produced by GPO have been proven to be safe and immunogenic through clinical trials, followed by Thai FDA licensure for pandemic use. The GPO-produced H5N2 LAIV has been proven to have priming effects on an inactivated subunit H5N1 booster vaccine. This Thai local manufacturer is now expanding its capacity to Inactivated Influenza Vaccine (IIV), aiming for sustainable influenza vaccine production for national coverage.</p>
</abstract>
<kwd-group kwd-group-type="author">
<title>KEYWORDS</title>
<kwd>Influenza vaccine</kwd>
<kwd>live attenuated</kwd>
<kwd>national security</kwd>
</kwd-group>
<counts>
<fig-count count="2"></fig-count>
<table-count count="4"></table-count>
<ref-count count="11"></ref-count>
<page-count count="6"></page-count>
</counts>
</article-meta>
</front>
</pmc>
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<li>Thaïlande</li>
</country>
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